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Dobustat 250 mg Injection is used to treat Myocardial infarction and Decompensated heart failure. It contains Dobutamine which works by increasing blood flow to the muscles and increasing the pumping efficiency of the heart. Sometimes, Dobustat 250 mg Injection may cause common side effects such as headache, nausea, shortness of breath, chest pain, irregular heartbeat and pain at the site of injection. It is not recommended for children as safety and effectiveness are not established.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOBUTAMINE-250MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dobustat 250 mg Injection

Dobustat 250 mg Injection is a specialised injection used to help the heart pump blood more effectively during sudden, severe heart failure or after heart surgery. It is typically prescribed to treat cardiac decompensation, a condition where the heart cannot circulate enough blood to meet the body's demands.

Since this medicine is delivered directly into a vein, it is given as a continuous infusion in a hospital or clinical setting under close medical supervision. Because of this, the frequency and timing of use are tightly managed by your healthcare team to ensure a steady, consistent effect. Following your doctor's overall guidance on fluid restriction and a low-salt diet is essential to support your heart's recovery during treatment.

While receiving this treatment, you may experience some common side effects such as an increased heart rate, headache, or nausea. However, if you notice any chest pain, severe shortness of breath, or an irregular heartbeat, you must inform your healthcare provider immediately.

Do not take this if you have certain heart conditions, such as a specific type of severe heart muscle thickening that blocks blood flow. It is crucial to inform your doctor if you have high blood pressure, an irregular heart rhythm, or a history of asthma before starting treatment.

Let your doctor know if you are taking other medications, particularly heart medicines like beta-blockers, as they can block the action of Dobustat 250 mg Injection. It is also important to tell your medical team if you are pregnant, breastfeeding, an older adult, or have kidney or liver problems, as you may require closer monitoring during treatment. Dobustat 250 mg Injection may also be used during a specialised heart test called a Dobustat 250 mg Injection stress echocardiogram to assess how well the heart works when exercise is not possible.

Uses of Dobustat 250 mg Injection

Dobustat 250 mg Injection helps improve the heart's pumping ability and maintain blood circulation during serious heart conditions. Your doctor may prescribe it for the following conditions:

  • Acute Heart Failure: Dobustat 250 mg Injection helps by improving the pumping strength of the heart when it is suddenly unable to circulate blood efficiently to the rest of the body.
  • Support After Heart Surgery: It helps the heart recover and maintain stable blood circulation immediately following major cardiac procedures.
  • Cardiogenic Shock: It supports blood pressure and vital organ blood flow when the heart is severely weakened due to a sudden event like a severe heart attack.

Key Benefits

Using Dobustat 250 mg Injection as prescribed helps improve heart function and restore blood circulation during serious heart conditions. Here are the key benefits you can expect:

  • Improves heart pumping function: Dobustat 250 mg Injection strengthens the heart's pumping action, helping deliver oxygen-rich blood to vital organs.
  • Relieves symptoms of acute heart failure: It helps reduce symptoms such as severe shortness of breath and fluid build-up in the lungs, promoting faster stabilisation.
  • Supports recovery after heart surgery: By temporarily assisting the heart when it is weakest, Dobustat 250 mg Injection helps the heart recover while reducing its workload.
  • Maintains vital organ perfusion: Improved blood circulation helps ensure that organs such as the brain and kidneys receive an adequate supply of oxygen and nutrients during critical illness.
Side effects of Dobustat 250 mg Injection
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Limit or avoid intake of stimulants like tobacco, caffeine and alcohol.
  • Drink sufficient water to maintain electrolyte balance.
  • Regularly do aerobic exercises.
  • Practice relaxation techniques such as meditation, or deep breathing to reduce stress.
  • Some medicines may be advised by your doctor such as beta-blockers or calcium channel blockers based on your condition.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Dobustat 250 mg Injection will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Dobustat 250 mg Injection Works

Dobustat 250 mg Injection contains dobutamine, an inotropic medicine that improves the heart's pumping ability during acute heart failure and other serious cardiac conditions. Dobustat 250 mg Injection works by stimulating beta-1 receptors on the heart muscle. This increases the force of each heartbeat, allowing the heart to pump more blood with every contraction. Unlike some other heart medicines, Dobustat 250 mg Injection mainly strengthens the heart's contractions with only a minimal effect on heart rate. This improves blood flow to vital organs, enhances circulation, and helps maintain blood pressure while reducing the symptoms of acute heart failure.
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Alcohol

Caution

Avoid consumption of alcohol. Please discuss with your doctor if you have concerns.

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Pregnancy

Caution

Dobustat 250 mg Injection is considered safe to be used in pregnancy. However, if you are pregnant or planning pregnancy, inform your doctor before receiving Dobustat 250 mg Injection.

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Breast Feeding

Caution

Limited data are available on the effect of Dobustat 250 mg Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Dobustat 250 mg Injection.

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Driving

Not applicable

Dobustat 250 mg Injection is generally intended for use in hospitalized patients.

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Liver

Caution

If you have liver problems, inform your doctor before receiving Dobustat 250 mg Injection. Your doctor may adjust the dose of this medicine if necessary or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney problems, inform your doctor before receiving Dobustat 250 mg Injection. Your doctor may adjust the dose of this medicine if necessary or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Dobustat 250 mg Injection is not recommended for children as safety and effectiveness were not established in children.

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Heart

Safe if prescribed

Dobustat 250 mg Injection is often used to treat heart failure and improve cardiac output under medical supervision. It can cause arrhythmias or blood pressure changes, so close monitoring is essential during treatment.

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Geriatrics

Caution

Geriatric patients may receive Dobustat 250 mg Injection, but only under close medical supervision. Older adults are more sensitive to its effects on heart rate and blood pressure, so careful monitoring is essential during treatment.

What if I have taken an overdose of Dobustat 250 mg Injection

An overdose is rare because your heart rate, blood pressure, and infusion rate are continuously monitored in a clinical setting. If you experience symptoms of an overdose, such as severe headache, extreme anxiety, a racing heart, or severe shortness of breath, the healthcare team will immediately slow down or stop the infusion to reverse the effects.

Diet & Lifestyle Advise

  • Limit salt intake: Consuming too much sodium causes your body to hold onto water, which places extra strain on your heart. Follow a low-salt diet as directed by your clinical team.
  • Monitor fluid intake: Your doctor may restrict the amount of fluids you drink to prevent fluid buildup in your lungs and tissues while your heart is recovering.
  • Track your daily weight: Weigh yourself daily at the same time to check for sudden weight gain, which can be an early sign of fluid retention.
  • Rest and pace your activities: Avoid strenuous physical exertion during and immediately after receiving this medication to allow your heart muscle time to heal.
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How Soon It Starts Working

The time required for Dobustat 250 mg Injection to start to work: Dobustat 250 mg Injection ideally shows its action within 1 to 2 minutes after administration. The time for which the effects of Dobustat 250 mg Injection last: The duration of action for Dobustat 250 mg Injection is clinically unknown.

What if you forget to take Dobustat 250 mg Injection

Because this medicine is given as a continuous infusion by healthcare professionals in a hospital, it is highly unlikely that you will miss a dose. If the infusion is interrupted for any reason, notify your nurse or doctor immediately to restart it safely.

Storage

• Dobustat 250 mg Injection is typically stored in a hospital or clinical setting at 15°C to 30°C.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Watch the injection site: Tell your healthcare provider immediately if you feel pain, burning, swelling, or redness where the IV is inserted, as the fluid can cause tissue damage if it leaks out of the vein.
  • Check the solution: Before injection, the solution should be visually inspected. It should be clear and light yellow; do not use it if it contains particles or is severely discoloured.
  • Avoid sudden movements: Since your blood pressure can change during treatment, try not to stand up or sit up too quickly to prevent dizziness.
  • Stay connected to monitors: Do not attempt to adjust the IV pump settings or disconnect the tubing yourself.
  • Report chest changes: Speak up immediately if you feel any tightness in your chest, a fluttering sensation, or a sudden change in your breathing.

Drug-Drug Interactions

verifiedApollotooltip
  • Beta-blockers: May block the beneficial cardiac effects of Dobustat 250 mg Injection, preventing it from strengthening your heartbeat.
  • MAO inhibitors (antidepressants): Can cause a dangerous, sudden rise in blood pressure when combined with this medicine.
  • Inhalation anaesthetics: May increase the risk of developing irregular heart rhythms during surgery.

Drug-Drug Interactions

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How does the drug interact with Dobustat 250 mg Injection:
Coadministration of Nortriptyline with Dobustat 250 mg Injection can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Nortriptyline with Dobustat 250 mg Injection together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience throbbing headaches, tremors, palpitations, or chest pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dobustat 250 mg Injection:
Coadministration of Amitriptyline with Dobustat 250 mg Injection can enhance the blood pressure-raising effects of Dobustat 250 mg Injection.

How to manage the interaction:
Although there is a possible interaction between Amitriptyline and Dobustat 250 mg Injection, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your blood pressure regularly. If you notice any of these symptoms like Itchy skin or red skin rash, swollen eyes, lips, hands, and feet, feeling lightheaded or dizzy, swelling of the mouth, throat, or tongue, which can cause breathing and swallowing difficulty, coughing, stomach discomfort, nausea, vomiting, or unconsciousness, make sure to consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dobustat 250 mg Injection:
Co-administration of Dobustat 250 mg Injection and Linagliptin may interfere with blood glucose control and reduce the effectiveness of linagliptin.

How to manage the interaction:
Co-administration of Linagliptin with Dobustat 250 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dobustat 250 mg Injection:
Taking clomipramine with Dobustat 250 mg Injection can increase the effects of Dobustat 250 mg Injection.

How to manage the interaction:
Although taking Dobustat 250 mg Injection and Clomipramine together can cause an interaction, it can be taken if your doctor has suggested it. It's important to keep an eye on your blood pressure regularly. If you notice any unusual symptoms, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dobustat 250 mg Injection:
Doxepin can enhance the blood pressure-raising effects of Dobustat 250 mg Injection.

How to manage the interaction:
There may be a possibility of interaction between Dobustat 250 mg Injection and Doxepin, but it can be taken if prescribed by a doctor. If you experience any symptoms contact your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Dobustat 250 mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[VASOPRESSORS]

FAQs

Dobustat 250 mg Injection is used to treat Myocardial infarction and Decompensated heart failure.
Dobustat 250 mg Injection contains Dobutamine which works by increasing blood flow to the muscles and increasing the pumping efficiency of the heart.
Dobustat 250 mg Injection should be used with caution in diabetic patients as it may cause Dobutamine stress echocardiography. Therefore, if you have diabetes, inform your doctor before receiving Dobustat 250 mg Injection.
The common side effects of Dobustat 250 mg Injection include headache, nausea, shortness of breath, chest pain, irregular heartbeat and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
Dobustat 250 mg Injection can be used for children if recommended by a doctor or paediatrician. It is generally used for the treatment of low cardiac output and systemic blood pressure in children of all ages. However, the dosage will be determined by the doctor based on the child's weight, age, and specific medical condition.
Dobustat 250 mg Injection is not a steroid. It belongs to a class of medicines called vasopressors and works by increasing blood flow to the muscles and improving the pumping efficiency of the heart. It does not have anti-inflammatory properties like steroids.
It is given as a continuous liquid drip (infusion) directly into a vein through an intravenous (IV) line by a doctor or nurse in a clinical setting. Talk to your doctor if you have questions about the IV setup.
In almost all cases, this medicine is only given in a hospital or specialised clinic where your heart rhythm and blood pressure can be continuously monitored. Talk to your doctor if you want to understand your specific treatment location.
The solution may turn slightly pink over time due to normal chemical properties, which is generally safe. However, if the solution is cloudy or has floating particles, it must not be used. Talk to your doctor or nurse if you notice any changes in the injection fluid.
Yes, it can cause an increase in blood pressure and heart rate as it helps your heart pump more effectively. Your medical team will monitor your blood pressure closely during treatment. Talk to your doctor if you feel dizzy or have a headache.
Beta-blockers can cancel out the effects of this medicine, making it less effective. Your doctor will carefully review your current medications before starting the infusion. Talk to your doctor or pharmacist about all the medicines you are taking.
There is limited information on the safety of this medicine in pregnant women, so it is only used if the benefits clearly outweigh the potential risks to the baby. Talk to your doctor if you are pregnant or planning to become pregnant.
Dobustat 250 mg Injection may be used during a Dobustat 250 mg Injection stress echocardiogram, a specialised heart ultrasound performed when you cannot exercise adequately. The medicine temporarily makes your heart work harder so doctors can assess blood flow and how well your heart muscle functions. The test is performed under close medical supervision with continuous monitoring.

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Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - DOB0017
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