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compositionComposition:VALPROIC ACID-200MG
prescriptionPrescription Medicine
Divex ER 250 Tablet 10's

Divex ER 250 Tablet is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-200MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Divex ER 250 Tablet

Divex ER 250 Tablet is used to treat epilepsy/seizures/fits. In addition, Divex ER 250 Tablet also treats manic episodes associated with bipolar disorder. Additionally, it can prevent migraine symptoms (such as headache).

Divex ER 250 Tablet contains valproic acid, which helps stabilise abnormal brain activity. It supports effective seizure control and helps calm overactive neural activity. It also helps manage mood changes in bipolar disorder and reduces the frequency of migraine attacks. This improves neurological balance and supports better functioning.

Administer Divex ER 250 Tablet with food to prevent gastrointestinal upset. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are allergic to any components present in Divex ER 250 Tablet . If you are pregnant, do not take Divex ER 250 Tablet because it may cause serious congenital defects. Divex ER 250 Tablet is generally not recommended during breastfeeding; consult your physician before taking Divex ER 250 Tablet .

Uses of Divex ER 250 Tablet

Divex ER 250 Tablet is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Divex ER 250 Tablet are as follows:

  • Controls Seizures: Divex ER 250 Tablet helps prevent and control seizures by calming overactive neural activity.
  • Manages Bipolar Disorder: Divex ER 250 Tablet helps to control manic episodes and stabilise mood in individuals with bipolar disorder.
  • Prevents Migraine Headaches: Divex ER 250 Tablet is also prescribed as a preventive treatment to reduce the frequency and severity of migraine attacks.

Have a query?

Directions for Use

  • Divex ER 250 Tablet can be taken with food to avoid stomach upset.
  • It is usually taken twice daily; however, your doctor may adjust the dosage and timing based on your medical condition and response to treatment.
  • Swallow Divex ER 250 Tablet as a whole with a glass of water.
  • Do not crush or chew this medication.

Key Benefits

Divex ER 250 Tablet , when used as prescribed, may provide the following benefits:

For Controls Seizures:

  • Helps stabilise abnormal electrical activity in the brain.
  • Reduces sudden episodes of excessive brain stimulation

For Managing Bipolar Disorder:

  • Helps maintain emotional balance.
  • Reduces the intensity and frequency of extreme mood changes

For Preventing Migraine Headaches:

  • Helps reduce the risk of recurrent severe headaches.
  • Reduces the impact of migraine on daily life.

How Divex ER 250 Tablet Works

Divex ER 250 Tablet contains valproic acid, which helps calm excessive nerve activity in the brain. As a result, it aids in controlling seizures. In bipolar disorder, Divex ER 250 Tablet raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. In migraine, Divex ER 250 Tablet limits the transmission of pain, thereby preventing migraine.

Storage

Store in a cool and dry place away from sunlight
Side effects of Divex ER 250 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Divex ER 250 Tablet

Avoid exceeding the prescribed dose, as this may lead to adverse effects. Symptoms of adverse effects may include sleepiness, an irregular heartbeat, and coma (loss of consciousness). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Before taking the Divex ER 250 Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using.
  • Inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding.
  • You should not become pregnant during treatment with Divex ER 250 Tablet .
  • Consult your doctor immediately if you become pregnant while taking Divex ER 250 Tablet .
  • Alcohol should be avoided during treatment with this medicine.
  • You must not drive or operate machinery while taking Divex ER 250 Tablet .

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexTeriflunomide
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divex ER 250 Tablet:
Coadministration of Glycerol phenylbutyrate and Divex ER 250 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divex ER 250 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexTeriflunomide
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of Divex ER 250 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divex ER 250 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexLomitapide
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of Divex ER 250 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divex ER 250 Tablet and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of buprenorphine with Divex ER 250 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Divex ER 250 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexDoripenem
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of Divex ER 250 Tablet and Doripenem can reduce the blood levels of Divex ER 250 Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divex ER 250 Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of Sodium phenylbutyrate and Divex ER 250 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Divex ER 250 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Divex ER 250 Tablet:
Coadministration of Ketoconazole and Divex ER 250 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Divex ER 250 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBexarotene
Severe
How does the drug interact with Divex ER 250 Tablet:
Co-administration of Divex ER 250 Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Divex ER 250 Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexErtapenem
Severe
How does the drug interact with Divex ER 250 Tablet:
Coadministration of Ertapenem with Divex ER 250 Tablet may reduce the blood levels of Divex ER 250 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Divex ER 250 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Divex ER 250 Tablet:
Coadministration of Esketamine and Divex ER 250 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Divex ER 250 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Diet:

  • Follow a high-fat, low-carbohydrate diet if advised by your doctor.
  • Maintain a balanced meal plan to support overall health.

Physical Activity:

  • Exercise regularly to help maintain a healthy weight and general fitness.

Safety & Preparedness:

  • Keep a seizure response plan and inform people around you.
  • Make simple home safety changes to reduce injury risk.
  • Identify and avoid known seizure triggers.
  • Use an alarm or emergency device to call for help during a seizure.

Rest & Sleep:

  • Get enough rest and sleep to reduce seizure risk.

Habits:

  • Avoid smoking and alcohol consumption.

Stress Management:

  • Practice meditation or yoga to reduce stress and improve coping ability.

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Do not consume alcohol while taking Divex ER 250 Tablet as alcohol can worsen the side effects of the Divex ER 250 Tablet , including sleepiness and dizziness.

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Pregnancy

Unsafe

Divex ER 250 Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Divex ER 250 Tablet .

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Breast Feeding

Caution

Divex ER 250 Tablet passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Divex ER 250 Tablet . Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Divex ER 250 Tablet may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Divex ER 250 Tablet .

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Liver

Caution

Inform your doctor before taking the Divex ER 250 Tablet if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Divex ER 250 Tablet .

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Divex ER 250 Tablet can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Divex ER 250 Tablet can be given to elderly patients with extreme caution if prescribed by a physician.

FAQs

Divex ER 250 Tablet is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).

Divex ER 250 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Divex ER 250 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Divex ER 250 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.

Divex ER 250 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Divex ER 250 Tablet . Avoid getting pregnant while taking Divex ER 250 Tablet as it could lead to serious birth defects. Do not stop taking Divex ER 250 Tablet and consult your doctor immediately if you become pregnant.

Divex ER 250 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Divex ER 250 Tablet may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.

Divex ER 250 Tablet contains Valproic acid as its active ingredient.

Take Divex ER 250 Tablet with food to avoid stomach upset or as advised by your doctor.

You are recommended to avoid alcohol consumption while taking Divex ER 250 Tablet as it may worsen the side effects of the Divex ER 250 Tablet , including sleepiness and dizziness.

No, Divex ER 250 Tablet does not cause addiction. However, Divex ER 250 Tablet should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.

Divex ER 250 Tablet does not cure epilepsy; it only helps prevent seizures. However, you must take Divex ER 250 Tablet for as long as your doctor advises. If you face any difficulty while taking Divex ER 250 Tablet , consult your doctor.

If you stop taking Divex ER 250 Tablet suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Divex ER 250 Tablet , please consult your physician.

Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Divex ER 250 Tablet in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.

Divex ER 250 Tablet is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Divex ER 250 Tablet may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Divex ER 250 Tablet for a long time.

Divex ER 250 Tablet may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Divex ER 250 Tablet . Your hair may regrow after either lowering your dose or changing medication.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad €“ 380015 Gujarat, India.
Other Info - DIV0071

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