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  3. Divaril-XR-500mg Tablet 10's

Divaril-XR-500mg Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Divaril-XR-500mg Tablet is used to treat seizures. Besides this, it is also used to treat manic episodes associated with bipolar disorder and prevent migraine symptoms. It contains Valproic acid which works by reducing abnormal electrical activity in the brain. It also produces a calming effect and limits the transmission of pain signals. This medicine may sometimes cause side effects such as nausea, upset stomach, tremors, sleepiness, headache, and weight gain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

VALPROIC ACID-500MG

Manufacturer/Marketer :

Mabril Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Divaril-XR-500mg Tablet

Divaril-XR-500mg Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, Divaril-XR-500mg Tablet also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

Divaril-XR-500mg Tablet contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Divaril-XR-500mg Tablet raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Divaril-XR-500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches.

Divaril-XR-500mg Tablet should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in Divaril-XR-500mg Tablet . If you are pregnant, do not take Divaril-XR-500mg Tablet because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking Divaril-XR-500mg Tablet . If you are breastfeeding, inform your doctor before taking Divaril-XR-500mg Tablet . As Divaril-XR-500mg Tablet causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with Divaril-XR-500mg Tablet as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

Uses of Divaril-XR-500mg Tablet

Divaril-XR-500mg Tablet is used for the treatment of Epilepsy (fits), Bipolar disorder, Migraine.

Directions for Use

• Divaril-XR-500mg Tablet can be taken with food to avoid stomach upset.• It is usually taken twice daily; however, your doctor may adjust the dosage and timing based on your medical condition and response to treatment.• Swallow Divaril-XR-500mg Tablet as a whole with a glass of water.• Do not crush or chew this medication.

Medicinal Benefits

Divaril-XR-500mg Tablet contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Divaril-XR-500mg Tablet raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Divaril-XR-500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches.

How Divaril-XR-500mg Tablet Works

Divaril-XR-500mg Tablet contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Divaril-XR-500mg Tablet raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Divaril-XR-500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches.

Storage

Keep Divaril-XR-500mg Tablet out of the sight and reach of children.
Side effects of Divaril-XR-500mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Write things in a notebook or on sticky notes.
  • Be physically and mentally active.
  • Maintain social interaction to avoid stress and depression which could contribute to memory loss.
  • Sleep well as inadequate sleep may also cause memory loss.
  • Maintain a healthy diet which includes fruits, vegetables, whole grains, fish and skinless poultry.
  • Avoid alcohol consumption as it may cause confusion and memory loss.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Divaril-XR-500mg Tablet

Take Divaril-XR-500mg Tablet only as prescribed by the doctor. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sleepiness, irregular heartbeat, and coma (loss of consciousness for a period of time). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Before taking the Divaril-XR-500mg Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving Divaril-XR-500mg Tablet . Consult your doctor immediately if you become pregnant while receiving a Divaril-XR-500mg Tablet . Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving Divaril-XR-500mg Tablet .

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexEsketamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Glycerol phenylbutyrate and Divaril-XR-500mg Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divaril-XR-500mg Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Esketamine and Divaril-XR-500mg Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Divaril-XR-500mg Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexBuprenorphine
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Co-administration of buprenorphine with Divaril-XR-500mg Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Divaril-XR-500mg Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexLeflunomide
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Co-administration of Divaril-XR-500mg Tablet and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Divaril-XR-500mg Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Ketoconazole and Divaril-XR-500mg Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Divaril-XR-500mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexLamotrigine
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Divaril-XR-500mg Tablet and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Divaril-XR-500mg Tablet and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexMipomersen
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Co-administration of Divaril-XR-500mg Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divaril-XR-500mg Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Divaril-XR-500mg Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Divaril-XR-500mg Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Coadministration of Ertapenem with Divaril-XR-500mg Tablet may reduce the blood levels of Divaril-XR-500mg Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Divaril-XR-500mg Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Divaril-XR-500mg Tablet:
Co-administration of Divaril-XR-500mg Tablet and Meropenem can reduce the blood levels of Divaril-XR-500mg Tablet sodium.

How to manage the interaction:
Co-administration of Divaril-XR-500mg Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
  • Exercising on a regular basis aids with weight maintenance and general health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
  • Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
  • Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
  • Understand what causes seizures and try to reduce or avoid them.
  • Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
  • Install an alarm or an emergency gadget to summon help during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Divaril-XR-500mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Do not consume alcohol while taking Divaril-XR-500mg Tablet as alcohol can worsen the side effects of the Divaril-XR-500mg Tablet , including sleepiness and dizziness.

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Pregnancy

Unsafe

Divaril-XR-500mg Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Divaril-XR-500mg Tablet .

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Breast Feeding

Caution

Divaril-XR-500mg Tablet passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Divaril-XR-500mg Tablet . Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Caution

Divaril-XR-500mg Tablet may cause dizziness, drowsiness or tiredness in some people. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Divaril-XR-500mg Tablet .

bannner image

Liver

Caution

Inform your doctor before receiving the Divaril-XR-500mg Tablet if you have a history of liver diseases/conditions. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Divaril-XR-500mg Tablet .

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

bannner image

Children

Consult your doctor

Use is not recommended for children less than ten years. Your doctor will decide the dose based on your child's condition if more than ten years.

Have a query?

FAQs

Divaril-XR-500mg Tablet is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).

Divaril-XR-500mg Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Divaril-XR-500mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Divaril-XR-500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Divaril-XR-500mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Divaril-XR-500mg Tablet . Avoid getting pregnant while taking Divaril-XR-500mg Tablet as it could lead to serious birth defects. Do not stop taking Divaril-XR-500mg Tablet and consult your doctor immediately if you become pregnant.

Divaril-XR-500mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Divaril-XR-500mg Tablet may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.

Divaril-XR-500mg Tablet contains Valproic acid as its active ingredient.

Take Divaril-XR-500mg Tablet with or without food as advised by your doctor.

You are recommended to avoid alcohol consumption while taking Divaril-XR-500mg Tablet as it may worsen the side effects of the Divaril-XR-500mg Tablet , including sleepiness and dizziness.

No, Divaril-XR-500mg Tablet does not cause addiction. However, Divaril-XR-500mg Tablet should be used as per dose and duration prescribed by your doctor. Do not self-medicate.

Divaril-XR-500mg Tablet does not cure epilepsy, it only helps to prevent the seizures. However, you have to take Divaril-XR-500mg Tablet for as long as it is advised by your doctor. If you face any difficulty while taking Divaril-XR-500mg Tablet , consult your doctor.

If you stop taking Divaril-XR-500mg Tablet suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to stop taking Divaril-XR-500mg Tablet , please consult your doctor.

Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Divaril-XR-500mg Tablet in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about the suitable method of contraception.

Divaril-XR-500mg Tablet is safe to take for long time in many patients if prescribed by a doctor. In rare cases, prolonged use of Divaril-XR-500mg Tablet may weaken your bones, thereby increasing their risk of breaking easily (osteopenia and osteoporosis). Get regular checkups done for bone health if you are taking Divaril-XR-500mg Tablet for a long time.

Divaril-XR-500mg Tablet may cause hair thinning, hair colour changes and even hair loss. If you have any concerns regarding this, please ask your doctor if it is possible to lower the dose of Divaril-XR-500mg Tablet . Your hair may regrow after either lowering your dose or changing medication.

Country of origin

India
Other Info - DIV0211

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/valproic-acid.html
  2. https://www.medicines.org.uk/emc/files/pil.6102.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018081s065_018082s048lbl.pdf
  4. https://www.nhs.uk/medicines/valproic-acid/

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