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  1. Home
  2. Medicine

  3. Diclocure MR 250mg/100mg/325mg Tablet

Prescription drug
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Diclocure MR 250mg/100mg/325mg Tablet, Pack of 1 Tablet
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Extra 15% Off with Bank Offers

Composition :

CHLORZOXAZONE-250MG + DICLOFENAC-100MG + PARACETAMOL-325MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Diclocure MR 250mg/100mg/325mg Tablet

Diclocure MR 250mg/100mg/325mg Tablet is used in the reduction of musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Musculoskeletal pain can be caused due to soft tissue (muscle, tendon, and ligaments) injury.

Diclocure MR 250mg/100mg/325mg Tablet is a combination of Diclofenac, paracetamol, and chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling. Paracetamol enhances the pain-relieving action of Diclofenac. Chlorzoxazone helps by blocking nerve impulses sent by the brain and causes relaxation of muscles.

Like all medicines, Diclocure MR 250mg/100mg/325mg Tablet may cause side effects, although not everybody gets them. Most of the side effects of Diclocure MR 250mg/100mg/325mg Tablet are drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. In case of any discomfort, speak with your doctor.

Diclocure MR 250mg/100mg/325mg Tablet can be taken with or after the meal. To avoid stomach upset Diclocure MR 250mg/100mg/325mg Tablet can be taken with food or milk. It should be swallowed whole with a glass of water. Do not take Diclocure MR 250mg/100mg/325mg Tablet if your pain lasts for more than ten days or if the fever lasts for more than three days. Do not take a double dose if you miss one dose.

Do not take Diclocure MR 250mg/100mg/325mg Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Diclocure MR 250mg/100mg/325mg Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction).

Uses of Diclocure MR 250mg/100mg/325mg Tablet

Diclocure MR 250mg/100mg/325mg Tablet used in the treatment of Musculoskeletal pain. The detailed uses of Diclocure MR 250mg/100mg/325mg Tablet are as follows:

  • Pain Relief: Diclocure MR 250mg/100mg/325mg Tablet provides effective relief from various types of pain, including musculoskeletal pain, muscle pain, joint pain, body pain, toothache, headache, and rheumatic pain, helping to alleviate discomfort and improve daily activities.
  • Muscle Relaxation: Diclocure MR 250mg/100mg/325mg Tablet helps to relieve muscle spasms, providing relaxation and comfort, especially in conditions like muscle strain and joint stiffness.
  • Fever Reduction: Diclocure MR 250mg/100mg/325mg Tablet also helps to reduce the fever associated with pain and discomfort.

Have a query?

Directions for Use

  • Diclocure MR 250mg/100mg/325mg Tablet should be taken with food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Diclocure MR 250mg/100mg/325mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Diclocure MR 250mg/100mg/325mg Tablet is composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone.
  • Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site.
  • Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac.
  • Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

How Diclocure MR 250mg/100mg/325mg Tablet Works

Diclocure MR 250mg/100mg/325mg Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Diclocure MR 250mg/100mg/325mg Tablet

Do not take more than the prescribed dose of Diclocure MR 250mg/100mg/325mg Tablet as it may cause serious side effects. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Intake of Diclocure MR 250mg/100mg/325mg Tablet should be avoided in liver disease (like jaundice) and cardiovascular disease (like coronary heart disease).
  • Contact your doctor if you have signs of liver disease, such as feeling exhausted, dark urine, not feeling hungry, stomach pain or upset, light coloured stools or yellow skin/eyes.
  • After taking if you have possible allergic symptoms like difficulty in breathing, difficulty in swallowing, lips/face/throat swelling, chest tightness, or skin rash, contact the doctor immediately.
  • Ensure your doctor is aware if you are pregnant or planning to get pregnant, breastfeeding, allergic to Diclocure MR 250mg/100mg/325mg Tablet or any other painkillers like aspirin, have a stomach ulcer or gastric bleeding, or taking any other OTC multivitamins or multi-mineral supplements.

Diet & Lifestyle Advise

  • Diclocure MR 250mg/100mg/325mg Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
  • Avoid driving while consuming Diclocure MR 250mg/100mg/325mg Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
  • Avoid concomitant consumption of drugs containing the same chemicals as Diclocure MR 250mg/100mg/325mg Tablet as it can lead to overdosage and unwanted side effects.
  • Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Diclocure MR 250mg/100mg/325mg Tablet.
  • Avoid consuming alcohol while you are on Diclocure MR 250mg/100mg/325mg Tablet.

Habit Forming

No

Therapeutic Class

ANALGESICS

Diclocure MR 250mg/100mg/325mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Alcohol should not be consumed with Diclocure MR 250mg/100mg/325mg Tablet as it leads to excessive drowsiness

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Pregnancy

Consult your doctor

Only consume Diclocure MR 250mg/100mg/325mg Tablet, if you are prescribed by a doctor

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Breast Feeding

Consult your doctor

Diclocure MR 250mg/100mg/325mg Tablet does not pass on to the child significantly via breast milk, consult your doctor before using Diclocure MR 250mg/100mg/325mg Tablet.

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Driving

Unsafe

Diclocure MR 250mg/100mg/325mg Tablet may affect driving ability as it causes dizziness.

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Liver

Caution

Diclocure MR 250mg/100mg/325mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Diclocure MR 250mg/100mg/325mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Unsafe

Diclocure MR 250mg/100mg/325mg Tablet is not recommended for children below 12 years of age without doctor's consent. For children above 12 years, dose to be adjusted and recommended by a child specialist only.

FAQs

Diclocure MR 250mg/100mg/325mg Tablet is used to treat musculoskeletal pain due to tissue injury, post-surgery inflammation‚ and oedema (swollen tissue with fluid).

No, Diclocure MR 250mg/100mg/325mg Tablet should not be taken as a long-term medication as it may lead to stomach ulcers/bleeding and kidney problems. For the best results of Diclocure MR 250mg/100mg/325mg Tablet, take it in doses and duration mentioned by your doctor.

No, it is not advisable to take Diclocure MR 250mg/100mg/325mg Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Diclocure MR 250mg/100mg/325mg Tablet.

Yes, Diclocure MR 250mg/100mg/325mg Tablet is a short term medication and if you feel better you can stop taking Diclocure MR 250mg/100mg/325mg Tablet, but only after consulting your doctor.

Diclocure MR 250mg/100mg/325mg Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.

No, Diclocure MR 250mg/100mg/325mg Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer or gastric bleeding. Do not take Diclocure MR 250mg/100mg/325mg Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.

It depends on whether your cough and cold pills contains diclofenac, paracetamol and Chlorzoxazone or not. If it contains these three medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

No, do not take Diclocure MR 250mg/100mg/325mg Tablet until prescribed by your doctor. For example, your shoulder pain may be due to lungs, spleen or gallbladder problem. Your back pain may be due to kidney stone, pancreas swelling, or in women, pelvic disorders. Your arm pain (especially left arm) may be due to heart attack (myocardial infarction).

Diclocure MR 250mg/100mg/325mg Tablet is a combination of a muscle relaxant (Chlorzoxazone) and two pain relieving medicines (Diclofenac and Paracetamol).

Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.

Diclocure MR 250mg/100mg/325mg Tablet is not intended to treat toothache. It is used to reduce musculoskeletal pain.

Avoid simultaneous consumption of other painkillers or cough and cold medicines with this Diclocure MR 250mg/100mg/325mg Tablet, as it may lead to an overdose.

No, it is not indicated to treat gastritis. It may worsen your condition.

It may help ease pain associated with period pain. However, it should only be used if recommended by the doctor.

It may help ease headaches. However, it should be used only if recommended by the doctor.

Diclocure MR 250mg/100mg/325mg Tablet usually takes effect within 30 minutes to an hour of intake.

No, it does not contain steroids. It combines one muscle relaxant medication and two pain relieving medicines.

Yes, in some cases, Diclocure MR 250mg/100mg/325mg Tablet may cause acidity.

Yes, Diclocure MR 250mg/100mg/325mg Tablet may cause drowsiness, although not everybody gets it. If you experience any discomfort, speak with your doctor.

No, Diclocure MR 250mg/100mg/325mg Tablet is not intended to treat loose motion. It is meant to treat musculoskeletal pain.

Yes, it can be used to treat tissue or ligament injury. However, it should be used only if recommended by a doctor.

Diclocure MR 250mg/100mg/325mg Tablet may cause constipation, although not everybody gets it. If you experience any discomfort, speak with your doctor.

Diclocure MR 250mg/100mg/325mg Tablet is safe if used as advised by the doctor. Follow your doctor's instructions.

It may cause common side effects like nausea and vomiting in some patients, although not everybody gets them. If you experience any discomfort, speak with your doctor.

Yes, it may lead to dizziness, although not everybody gets it. If you experience any discomfort, consult your doctor.

Yes, long-term usage of Diclocure MR 250mg/100mg/325mg Tablet may be harmful to the kidney.

Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children.

Yes, it should be taken with food or after food.

Diclocure MR 250mg/100mg/325mg Tablet should not be used during pregnancy and by nursing mothers unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Diclocure MR 250mg/100mg/325mg Tablet.

Diclocure MR 250mg/100mg/325mg Tablet is not recommended for children below 12 years of age without a doctor's consent. For children above 12 years, the dose is to be adjusted and recommended by a child specialist only.

Alcohol should not be consumed with Diclocure MR 250mg/100mg/325mg Tablet as it leads to excessive drowsiness.

Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Country of origin

India
Other Info - DI37137

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 15, 2025 | 9:28 AM IST

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Reference

  1. https://www.unitedpharmacies.md/Dicoliv-MR-Diclofenac-Potassium-Paracetamol-Chlorzoxazone.html
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.medicines.org.uk/emc/files/pil.10547.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/psg/PSG_011300.pdf
  5. https://www.sciencedirect.com/topics/neuroscience/chlorzoxazone
  6. https://www.nhs.uk/conditions/nsaids/
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