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compositionComposition:ETOFYLLINE-346MG+THEOPHYLLINE-104MG
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Prescription Medicine
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Deriphyllin OD 450 Tablet is a bronchodilator used to treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). It contains the active ingredients theophylline and etofylline, which help relax the muscles in the airways, improving airflow to the lungs. This action helps alleviate symptoms such as coughing, wheezing, and shortness of breath. Common side effects may include nausea, vomiting, headache, restlessness, dizziness, irregular heartbeat, and stomach upset.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

ETOFYLLINE-346MG+THEOPHYLLINE-104MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Deriphyllin OD 450 Tablet

Deriphyllin OD 450 Tablet is a prescription medicine used to treat and prevent symptoms of asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This oral tablet helps by opening up the airways in your lungs, making it much easier to breathe when you experience shortness of breath or wheezing.

To get the most benefit, you must take it regularly at the same times every day, even if you are not currently experiencing breathing difficulties. This tablet is typically taken with food to prevent stomach upset. Making lifestyle adjustments, such as avoiding known allergens, staying hydrated, and performing gentle breathing exercises, can further support your lung health while taking this medicine.

While taking it, you might experience side effects such as a mild headache or a slightly unsettled stomach. These are usually temporary, but if you experience any serious side effects, such as a rapid or irregular heartbeat, severe dizziness, or muscle weakness, you must contact your doctor immediately.

Talk to your doctor before starting it if you have a history of heart disease, high blood pressure, thyroid issues, or stomach ulcers. Do not take this medicine if you have a known allergy to any of its ingredients or similar airway-opening medications.

It can interact with other substances; for instance, smoking can change how quickly your body processes this medicine, and consuming caffeine or alcohol can increase the risk of side effects like a racing heart. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to ensure this tablet is safe for you.

Uses of Deriphyllin OD 450 Tablet

Your doctor may recommend this medicine to help manage the following conditions:

  • Asthma: It helps by relaxing the muscles around your airways, preventing sudden asthma attacks and relieving persistent wheezing and chest tightness.
  • Chronic Obstructive Pulmonary Disease (COPD): This medicine reduces breathing difficulties by keeping your air passages open, helping you manage chronic cough and phlegm.
  • Chronic Bronchitis: It eases long-term airway inflammation and congestion, allowing air to flow more freely into and out of your lungs.

Key Benefits

When taken consistently as directed, this medicine may provide the following physiological benefits:

  • Easier, smoother breathing: By directly relaxing the bronchial muscles, it provides sustained relief from chest tightness and shortness of breath, helping you go about your day with less effort.
  • Prevention of sudden flare-ups: Consistent daily use of this medication reduces the frequency and severity of sudden breathing emergencies, giving you greater peace of mind.
  • Improved physical stamina: With clearer airways, you may find it easier to engage in daily physical activities, walk longer distances, or perform light exercises without constantly needing to stop for air.

Directions for Use

  • Deriphyllin OD 450 Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow the Deriphyllin OD 450 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Deriphyllin OD 450 Tablet Works

This medicine contains theophylline and etofylline that work together to improve your breathing. The first active ingredient, theophylline, is a bronchodilator that relaxes the smooth muscles surrounding your airways. It also helps reduce your lungs' sensitivity to allergens and other triggers that cause swelling. The second active ingredient, etofylline, is a derivative of theophylline that works alongside it. It is thought to provide mild additional bronchodilation, helping widen the air passages and making breathing easier. It is also generally better tolerated by the stomach than theophylline. Together, these two ingredients help improve airflow into the lungs, providing continuous relief from breathing distress.
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Alcohol

Caution

The interaction of Deriphyllin OD 450 Tablet with alcohol is unknown. Please consult a doctor before consuming alcohol while using Deriphyllin OD 450 Tablet .

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Pregnancy

Caution

Please consult a doctor if you are pregnant. Deriphyllin OD 450 Tablet is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Deriphyllin OD 450 Tablet is excreted in human milk. Deriphyllin OD 450 Tablet is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Drive only if you are alert after taking Deriphyllin OD 450 Tablet as it may cause dizziness in some people.

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Liver

Caution

Take Deriphyllin OD 450 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Deriphyllin OD 450 Tablet if you have severe liver disease.

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Kidney

Caution

Take Deriphyllin OD 450 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Deriphyllin OD 450 Tablet if you have severe kidney disease.

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Children

Caution

Please consult a doctor if you have any concerns regarding the usage of Deriphyllin OD 450 Tablet in children.

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Heart

Caution

Deriphyllin OD 450 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Deriphyllin OD 450 Tablet .

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Geriatrics

Caution

Deriphyllin OD 450 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Deriphyllin OD 450 Tablet

If you suspect an overdose, seek immediate emergency medical attention. Symptoms of an overdose may include severe vomiting, a very fast or irregular heartbeat, extreme restlessness, or seizures.

Diet & Lifestyle Advise

  • Limit caffeine intake: Avoid consuming excessive amounts of coffee, tea, chocolate, or energy drinks, as caffeine can compound the stimulant effects of this medicine, leading to shakiness and a rapid heart rate.
  • Avoid smoking: Quit smoking and avoid secondhand smoke, as tobacco smoke can speed up how fast your liver clears this medication from your system, making it less effective.
  • Stay hydrated: Drink plenty of water throughout the day to help thin mucus in your airways, making it easier to cough up and clear.
  • Track your triggers: Keep a daily log of potential triggers like pollen, dust, or cold air, and try to minimise your exposure to them.
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How Soon It Starts Working

The time required for Deriphyllin OD 450 Tablet to start to work: Deriphyllin OD 450 Tablet ideally shows its action within 15 to 60 minutes after administration. The time for which the effects of Deriphyllin OD 450 Tablet last: The duration of action for Deriphyllin OD 450 Tablet is clinically unknown.

What if you forget to take Deriphyllin OD 450 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store this medicine according to the instructions on the product packaging. •Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Keep your rescue inhaler with you: This medicine helps control breathing problems but does not replace a quick-relief (rescue) inhaler for sudden asthma attacks. Always keep your rescue inhaler available and use it as directed by your doctor.
  • Attend regular blood tests: Theophylline has a narrow therapeutic range, which means the level of this medicine in your blood must stay within a small safe range to work effectively while reducing the risk of side effects. Have your blood monitored regularly if your doctor recommends it.
  • Inform your healthcare provider: Inform any healthcare provider you visit, including dentists, that you are taking this medication before undergoing any procedures or receiving new prescriptions.
  • Avoid driving if affected: Avoid driving or operating machinery if you experience dizziness or shakiness after taking this medicine.
  • Check the medicine before use: Check the expiration date on the pack before taking a tablet, and never take a tablet that is damaged, discoloured, or crumbling.

Drug-Drug Interactions

verifiedApollotooltip
  • Beta-blockers (such as propranolol): These medicines may reduce the bronchodilator effect of this medicine, making it less effective at relieving breathing difficulties. They may also increase the risk of side effects in some patients.
  • Certain antibiotics (such as ciprofloxacin or erythromycin): These medicines can significantly increase the level of theophylline in your blood, raising the risk of serious side effects such as nausea, vomiting, tremors, seizures, or an irregular heartbeat. Tell your doctor if you are prescribed these antibiotics. 
Theophylline + Etofylline nicotinateRiociguat
Critical
Theophylline + Etofylline nicotinateSotalol
Severe

Drug-Drug Interactions

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Theophylline + Etofylline nicotinateRiociguat
Critical
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate with Riociguat can increase the risk side effects.

How to manage the interaction:
Taking Theophylline, Etofylline nicotinate with Riociguat can lead to an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, flushing (a sudden redness of face), headache, or stuffy nose. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateSotalol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Sotalol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Sotalol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinatePropranolol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Propranolol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Propranolol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateBupropion
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Bupropion can increase the risk of seizures (fits).

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Bupropion can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms like unusual staring, stiffening of the legs and limbs, loss of consciousness, difficulty in breathing, or fainting, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateBisoprolol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Bisoprolol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Bisoprolol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, sleeplessness, shaking of hands and legs, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinatePindolol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Pindolol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Pindolol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateLabetalol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Labetalol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Labetalol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateAtenolol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Atenolol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Atenolol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, sleeplessness, shaking of hands and legs, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateMetoprolol Tartrate
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Metoprolol Tartrate can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Metoprolol Tartrate can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.
Theophylline + Etofylline nicotinateTimolol
Severe
How does the drug interact with Deriphyllin OD 450 Tablet:
Co-administration of Theophylline, Etofylline nicotinate and Timolol can increase the blood levels of Theophylline, Etofylline nicotinate.

How to manage the interaction:
Although taking Theophylline, Etofylline nicotinate and Timolol can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing, contact the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: They can alter the rate at which this medicine is absorbed into your body, potentially causing a sudden release of the drug.
  • Limit caffeine: It can worsen side effects like heart palpitations.
ETOFYLLINE-346MG+THEOPHYLLINE-104MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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ETOFYLLINE-346MG+THEOPHYLLINE-104MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Consumption of caffeine-containing foods/drinks while on the treatment with Theophylline, Etofylline nicotinate can increase the risk of Theophylline, Etofylline nicotinate and cause nausea, vomiting, headache, loose stools, sleeplessness, shaking of hands and legs, fits, restlessness, increased or decreased heartbeat, or difficulty in breathing. Avoid or limit consumption of caffeine-containing foods/drinks while on the treatment with Theophylline, Etofylline nicotinate.

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Therapeutic Class

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FAQs

Deriphyllin OD 450 Tablet belongs to the class of drugs called bronchodilators used to prevent and treat symptoms of asthma and chronic obstructive pulmonary disease (COPD).
Deriphyllin OD 450 Tablet works by relaxing muscles and widening the airways of the lungs. Thus, it makes breathing easier.
You are not recommended to take linezolid with Deriphyllin OD 450 Tablet as it may increase the risk of adverse effects of Deriphyllin OD 450 Tablet . However, please consult a doctor before using other medicines with Deriphyllin OD 450 Tablet .
You are recommended to avoid taking Deriphyllin OD 450 Tablet if you are allergic to theophylline, etofylline, or suffering from irregular heart rhythm, severe liver or kidney diseases or have a history of a heart attack. However, inform your doctor if you have any of these conditions before taking Deriphyllin OD 450 Tablet .
You are not recommended to stop taking Deriphyllin OD 450 Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Deriphyllin OD 450 Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Deriphyllin OD 450 Tablet , please consult your doctor.
Deriphyllin OD 450 Tablet may help relieve symptoms such as dry cough associated with asthma or chronic obstructive pulmonary disease (COPD). However, it is not specifically intended for treating dry cough. Dry cough may be caused by various factors, so other treatments, like cough suppressants or addressing the underlying cause, might be more effective. Always consult your doctor to determine the right treatment.
Deriphyllin OD 450 Tablet should be used with caution in patients with heart disorders. Deriphyllin OD 450 Tablet may cause serious side effects, such as an increased heart rate and arrhythmias (irregular heartbeats) in some cases. In patients with pre-existing heart disorders, Deriphyllin OD 450 Tablet may exacerbate the symptoms or worsen the condition. It is essential to consult a doctor before using Deriphyllin OD 450 Tablet to assess the associated risks and benefits.
Deriphyllin OD 450 Tablet can generally be used in diabetic patients if recommended by a doctor. However, Theophylline, in particular, may increase blood sugar levels due to its potential to inhibit insulin release. Close monitoring of blood glucose levels is recommended when prescribed to diabetic patients, especially if the patient has poorly controlled diabetes or other comorbidities.
No, Deriphyllin OD 450 Tablet does not contain steroids. It is a combination of two bronchodilators, Theophylline and Etofylline, used to treat asthma and chronic obstructive pulmonary disease (COPD). They work by relaxing the muscles in the airways to improve breathing, but they do not have the anti-inflammatory properties associated with steroids.
Deriphyllin OD 450 Tablet does not cause drowsiness. However, side effects like restlessness or insomnia (trouble sleeping) are common. If you experience drowsiness while using Deriphyllin OD 450 Tablet , please ask your doctor for advice.
Please consult your doctor to determine whether you should take Deriphyllin OD 450 Tablet on an empty stomach. Usually, it is best to take Deriphyllin OD 450 Tablet with a full glass of water at least 1 hour before or 2 hours after eating.
Yes, Deriphyllin OD 450 Tablet can be taken twice a day, but your doctor should determine the exact dosing schedule based on the severity of your condition. It is important to follow your doctor's advice regarding the timing and dosage to ensure safety and effectiveness, as this medication can cause side effects if not taken properly.
No, Deriphyllin OD 450 Tablet is not an antibiotic. It is a combination medication consisting of two bronchodilators: Theophylline and Etofylline. Neither of these ingredients has antibacterial properties.
Deriphyllin OD 450 Tablet does not directly relieve nasal congestion. However, in some cases, its anti-inflammatory properties may provide mild relief from breathing difficulties associated with nasal congestion. Decongestants or nasal sprays are more effective for this purpose. Please consult your doctor for the appropriate treatment of nasal congestion.
Deriphyllin OD 450 Tablet may cause kidney problems if used in high doses or for prolonged periods, especially in individuals with pre-existing kidney conditions. Monitoring kidney function while using Deriphyllin OD 450 Tablet to avoid potential complications is essential. Your doctor may adjust the dose as needed.
No, Deriphyllin OD 450 Tablet does not decrease appetite. However, it may cause gastrointestinal disturbances, such as nausea, vomiting, and stomach upset, which could indirectly affect your appetite. It is important to monitor any changes and consult your doctor if you have concerns.
Deriphyllin OD 450 Tablet is not indicated for treating a common cold or pneumonia. While Deriphyllin OD 450 Tablet can help open airways and improve breathing, it does not treat viral infections like the common cold or bacterial infections like pneumonia. Please consult your doctor for appropriate treatment of a cold or pneumonia.
Deriphyllin OD 450 Tablet should be stored at room temperature, away from moisture and direct sunlight. Keep this medication out of reach of children.
Yes, high doses of Deriphyllin OD 450 Tablet may lead to serious side effects, such as tachycardia (increased or rapid heart rate), seizures (a sudden surge of electrical activity in the brain, causing abnormal movements or behaviour), and arrhythmias (irregular heartbeat), due to the stimulant effects of Theophylline. Please inform your doctor immediately if you have taken a high dose of Deriphyllin OD 450 Tablet or experience any of these symptoms.
No, Medicine is a long-acting medicine designed to prevent breathing problems and is not meant to stop a sudden, acute asthma attack. You must use your quick-relief rescue inhaler for sudden breathing emergencies. Talk to your doctor if you are unsure which medicine to use in an emergency.
It is best to limit your intake of coffee, tea, and other caffeinated drinks. Both caffeine and this medication can stimulate your central nervous system, and combining them may lead to side effects like a rapid heart rate, nervousness, or difficulty sleeping. Talk to your doctor or pharmacist for personalised dietary advice.
You must inform your doctor immediately if your smoking habits change. Tobacco smoke increases the speed at which your liver processes this medication, meaning your doctor may need to adjust your dose if you start or stop smoking.
You should only take medicine during pregnancy if your doctor determines that the benefits outweigh the potential risks to your baby. If you are pregnant or planning to become pregnant, talk to your doctor before using this medicine.
Your doctor may perform periodic blood tests to measure the exact amount of the active ingredients in your system. This helps ensure that you are receiving a dose that is high enough to be effective but low enough to avoid serious side effects.
Yes, because of its mild stimulant-like effects, this medicine can sometimes cause insomnia or restlessness, especially if taken close to bedtime. If you experience trouble sleeping, talk to your doctor about the best timing for your doses.
It can interact with several common medications, including certain antibiotics, blood pressure drugs, and cough preparations. Always share a complete list of all medicines you take with your doctor or pharmacist before starting it.
A rapid or irregular heartbeat can be a sign that the medication level in your body is too high. Do not stop taking medicine abruptly and seek medical advice immediately. Talk to your doctor as soon as possible to evaluate your dose.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.7719 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. PubChem PubChem. [Accessed on 01 Apr. 2019]Check here
  3. Uniphyllin Continus 200 mg prolonged release tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 21 November 2021]Check here
  4. Etofylline nicotinate: Uses, Interactions, Mechanism of Action - DrugBank Online [Internet]. Go.drugbank.com. 2021 [Accessed on 21 November 2021]Check here
  5. Peter J. Barnes. Theophylline. [Accessed on 8th August 2021]Check here
  6. J Zuidema, J Verhoeven, F W Merkus. Pharmacokinetics of etofylline after intravenous and oral administration to humans. [Accessed on 8th August 2021]Check here
  7. Napp Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in January 2019] [Accessed on 8th August 2021]Check here

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - DER0010
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