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compositionComposition:DEFLAZACORT-6MG
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Prescription Medicine
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Defnalone Suspension is used to treat Duchenne muscular dystrophy in children above 2 years of age. It contains deflazacort, which inhibits the production of chemicals called cytokines responsible for inflammation. Some children may experience side effects such as nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhoea, and fast heartbeats. Before giving this medicine, tell your doctor if your child is allergic to any of its components.

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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DEFLAZACORT-6MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Defnalone Suspension

Defnalone Suspension is a suspension prescribed to treat a wide range of inflammatory and autoimmune conditions in children, including severe allergies, asthma, and certain muscle disorders. This medicine works by calming down the immune system and reducing swelling, redness, and pain throughout the body.

Your child should take this medicine exactly as prescribed by their doctor, usually once a day at the same time. It can be taken with or without food, but taking it with food or milk can help prevent stomach upset. Incorporating a low-sodium diet and ensuring your child gets enough calcium and vitamin D can help support their overall health while on this treatment.

While taking this medicine, your child may experience mild side effects like an increased appetite or mild mood changes. However, if you notice severe side effects such as vision changes, signs of a severe infection, or a severe allergic reaction, you should contact your doctor right away.

Talk to your child's doctor if your child has a history of high blood sugar, high blood pressure, heart problems, or kidney issues before starting this medicine. Do not take this if your child has an active, untreated infection or a known allergy to any of the ingredients in this suspension.

This medicine can interact with other drugs, including certain vaccines, anti-seizure medications, and pain relievers, which may alter how it works or increase side effects. Always inform your doctor or pharmacist about any other medicines, supplements, or vaccines your child is receiving.
 

Uses of Defnalone Suspension

Your doctor may prescribe Defnalone Suspension to treat the following conditions:

  • Duchenne Muscular Dystrophy (DMD): Defnalone Suspension helps improve muscle strength and slows down the progression of muscle weakness in children with this genetic condition.
  • Severe Inflammatory Conditions: It helps reduce severe swelling and tissue irritation caused by autoimmune disorders.
  • Severe Asthma and Allergic Reactions: It helps open up the airways and reduces inflammation in the lungs and throat during severe respiratory episodes.
  • Nephrotic Syndrome: It helps reduce the inflammation in the kidneys to lower protein loss in the urine.

 

Key Benefits

Using Defnalone Suspension as prescribed helps reduce inflammation and improve symptoms in a range of serious conditions. Here are the key benefits you can expect:

  • Reduces inflammation quickly: Defnalone Suspension helps control inflammation, reducing swelling and relieving symptoms in severe respiratory, allergic, and inflammatory conditions, making breathing easier and supporting faster recovery.
  • Supports muscle function in Duchenne muscular dystrophy: Defnalone Suspension helps slow the progression of muscle weakness, allowing children with Duchenne muscular dystrophy to maintain their muscle strength and mobility for longer.
  • Improves daily comfort and activity: By keeping inflammation under control, Defnalone Suspension helps reduce discomfort and enables children to participate more comfortably in everyday activities.
     
Side effects of Defnalone Suspension 30 ml
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Drink six to eight glasses of water per day to be healthy.
  • Healthy urinary habits can help minimize pollakiuria (frequent urinating).
  • Avoid liquids containing caffeine, artificial sweeteners, and soda, as they might cause bladder discomfort.
  • Add bladder-friendly foods such as omega-3 fatty acids, blueberries, and cranberries.
  • Regular cleansing will help get rid of dead skin cells and stop ingrown hairs.
  • Keep your hormones in balance by managing your stress, eating well and exercising regularly.
  • Shaving, waxing, and bleaching are ways to get rid of extra hair.

Directions for Use

  • Defnalone Suspension can be given with or without food.
  • Follow your doctor's instructions regarding the dosage and duration of the medication.
  • Shake well before use. Administer the advised dose to the child using the measuring cup/measuring spoon/dropper.
  • Avoid using regular household spoons, as they may not measure the dose correctly.

How Defnalone Suspension Works

Defnalone Suspension contains deflazacort, a corticosteroid that works by reducing inflammation and controlling an overactive immune response. After the oral suspension is absorbed into the body, Defnalone Suspension acts on immune cells to block the production of chemicals that cause swelling, redness, pain, and inflammation. In addition, Defnalone Suspension suppresses excessive immune system activity, making it effective in treating autoimmune and inflammatory conditions where the body's immune system mistakenly attacks its own tissues. By reducing inflammation and preventing further tissue damage, Defnalone Suspension helps control symptoms and improves overall function.
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Alcohol

Not applicable

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Caution

Blood levels of Defnalone Suspension may rise in children with hepatic impairment. Consequently, it is essential to closely monitor and modify the deflazacort dosage to the lowest adequate level.

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Kidney

Consult your doctor

Limited information is available. If your child has kidney problems, inform the doctor beforehand.

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Children

Safe if prescribed

Defnalone Suspension is safe if prescribed by your doctor. However, please consult your doctor before giving Defnalone Suspension to your child. Defnalone Suspension is not recommended for children below 2 years of age.

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Heart

Consult your doctor

If your child has any heart disease, please consult a doctor before giving Defnalone Suspension.

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Geriatrics

Not applicable

Defnalone Suspension is for paediatric patients only.

What if I have taken an overdose of Defnalone Suspension

If you suspect your child has taken more than the prescribed dose of this medicine, seek immediate medical attention right away.

Diet & Lifestyle Advise

  • Limit salt intake: This medicine can cause the body to hold onto extra water and salt. Limit salty snacks, processed foods, and added table salt.
  • Boost calcium and vitamin D: Long-term steroid use can weaken bones. Ensure your child eats foods rich in calcium and vitamin D, such as milk, cheese, yoghurt, and leafy green vegetables.
  • Avoid sick contacts: Because this medicine can lower your child's ability to fight off infections, try to keep them away from people who are sick with contagious illnesses like chickenpox, shingles, or measles.
  • Monitor growth regularly: Since long-term use of this medicine can affect physical growth, keep regular appointments with your paediatrician to monitor your child's height and weight.

 

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How Soon It Starts Working

  • The time required for Defnalone Suspension to start to work: The effect of Defnalone Suspension can be observed within 1 to 2 hours of administration.
  • The time for which the effects of Defnalone Suspension last: Defnalone Suspension effects lasts for approximately 12 to 24 hours.

What if you forget to take Defnalone Suspension

If you miss giving a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not give a double dose to make up for a missed one.

Storage

• Store the oral suspension at 20°C to 25°C (68°F to 77°F). Protect it from direct heat, moisture, and sunlight.

Drug Warnings

  • Shake well before each dose: Shake the bottle thoroughly before measuring each dose to ensure the medicine is evenly mixed.
  • Do not stop treatment suddenly: Never stop giving Defnalone Suspension abruptly. Your doctor will gradually reduce the dose to allow your child's body to resume normal hormone production.
  • Inform healthcare providers: Tell all doctors, dentists, and emergency healthcare professionals that your child is taking Defnalone Suspension before any medical or dental treatment.
  • Avoid live vaccines: Do not give your child live vaccines, such as the measles, mumps, rubella (MMR) or chickenpox vaccine, while they are taking Defnalone Suspension unless advised by your doctor.
  • Keep track of doses: Maintain a written record or use a reminder to ensure your child receives each dose on time and to help prevent missed or double doses.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medications (such as phenytoin or phenobarbital): May speed up how your child's body processes Defnalone Suspension, making it less effective.
  • Rifampin (an antibiotic): Can lower the levels of this medicine in the body, reducing its ability to treat inflammation.
  • Live vaccines: Taking this medicine can weaken the immune system, making live vaccines unsafe or less effective.
     

Drug-Drug Interactions

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How does the drug interact with Defnalone Suspension 30 ml:
Co-administration of Defnalone Suspension 30 ml and Desmopressin may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Taking Nevirapine with Defnalone Suspension 30 ml may significantly reduce the blood levels of Defnalone Suspension 30 ml, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Nevirapine and Defnalone Suspension 30 ml together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Co-administration Bempedoic acid and Defnalone Suspension 30 ml can result in tendinitis (inflammation of the thick fibrous cords that connect muscle to bone) and tendon rupture.

How to manage the interaction:
Although taking Bempedoic acid and Defnalone Suspension 30 ml together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have pain, swelling, or inflammation in a muscle location such as the back of the ankle, shoulder, or biceps. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Coadministration of Voriconazole with Defnalone Suspension 30 ml can increase the levels of Defnalone Suspension 30 ml in the body, which increases risk/severity of side effects.

How to manage the interaction:
Taking Voriconazole with Defnalone Suspension 30 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Using Aspirin together with Defnalone Suspension 30 ml may increase the risk of gastric and intestinal ulcers, bleeding and perforation.

How to manage the interaction:
Co-administration of Aspirin with Defnalone Suspension 30 ml can result in an interaction, but it can be taken if a doctor has advised it. If you have any symptoms unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without consulting a doctor.
DeflazacortVoclosporin
Severe
How does the drug interact with Defnalone Suspension 30 ml:
Co-administration of Defnalone Suspension 30 ml with Voclosporin may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Defnalone Suspension 30 ml and Voclosporin, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Defnalone Suspension 30 ml:
Coadministration of Atazanavir with Defnalone Suspension 30 ml can increase the levels of Defnalone Suspension 30 ml in the body. This increases the risk of side effects.

How to manage the interaction:
Taking Atazanavir with Defnalone Suspension 30 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Co-administration of Infliximab with Certolizumab may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Defnalone Suspension 30 ml and Infliximab, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Defnalone Suspension 30 ml:
Taking Rifampicin with Defnalone Suspension 30 ml may reduce the blood levels of Defnalone Suspension 30 ml, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between Defnalone Suspension 30 ml and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Defnalone Suspension 30 ml:
Coadministration of Darunavir with Defnalone Suspension 30 ml can increase the levels of Defnalone Suspension 30 ml in the body. This increases the risk of side effects.

How to manage the interaction:
Taking Darunavir with Defnalone Suspension 30 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit or grapefruit juice: May increase the amount of this medicine in your child's body, which can raise the risk of experiencing side effects.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Defnalone Suspension is used to treat Duchenne muscular dystrophy. It may also be used to treat allergic and inflammatory disorders.
You should not give Defnalone Suspension if your child has taken live vaccines of mumps, measles, rubella (MMR), polio, rotavirus, yellow fever, typhoid, nasal flu (influenza), varicella (chickenpox), and zoster (shingles). Do not give Defnalone Suspension if your child has a compromised immune system, eye problems, or weak bones.
Yes, Defnalone Suspension is a steroid medication. It's a corticosteroid, also known as a glucocorticoid.
No, Defnalone Suspension is not a painkiller. It is a steroid medication.
Yes, it is safe to use Defnalone Suspension if prescribed by the doctor. Give it in the dose and duration prescribed by the doctor.
Common side effects of Defnalone Suspension may include nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremors, nervousness, diarrhea, and fast heartbeats. Most of these side effects of Defnalone Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Store in a cool and dry place away from sunlight. Please keep it away from pets and children.
Yes, your child can take this medicine with or without food. However, if it causes stomach upset, it is best to give it with a meal or a glass of milk. Talk to your doctor if stomach upset continues.
If your child vomits shortly after taking their dose, do not give them another dose immediately. Contact your doctor or pharmacist to ask if you should repeat the dose or wait until the next scheduled time.
Stopping this medicine suddenly can make your child very ill because their body stops producing its own natural steroids while taking this medicine. Your doctor will guide you on gradually decreasing the dose to allow the body to adjust safely. Talk to your doctor if you have concerns.
Yes, weight gain and an increased appetite are common side effects of this class of medicine. You can help manage this by offering healthy, low-calorie snacks and limiting sugary or salty foods. Talk to your doctor for personalised dietary advice.
Your child can usually receive routine non-live vaccines, but live vaccines (like chickenpox or MMR) should generally be avoided while on this medication because of a weakened immune system. Always talk to your doctor before scheduling any vaccinations.
Long-term use of oral corticosteroids can sometimes slow down a child's physical growth. Your paediatrician will monitor your child's height and weight closely during routine visits. Talk to your doctor if you have concerns about your child's growth.
Taking pain relievers like ibuprofen or aspirin along with this medicine can increase the risk of stomach irritation or ulcers. You should check with your doctor before giving any other pain relievers. Talk to your doctor or pharmacist for safe alternatives.

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Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info - DEF0034
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