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  3. D-Flaxene ER-50 Tablet 10's

D-Flaxene ER-50 Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
D-Flaxene ER-50 Tablet is used to treat a major depressive disorder (depression). It contains Desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DESVENLAFAXINE-50MG

Manufacturer/Marketer :

Vanprom Lifesciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About D-Flaxene ER-50 Tablet

D-Flaxene ER-50 Tablet is used to treat a major depressive disorder (depression). Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking.
 
D-Flaxene ER-50 Tablet contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression. 
 
You are advised to take D-Flaxene ER-50 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition and response to the treatment. In some cases, you may experience certain common side effects such as nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders. Talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking D-Flaxene ER-50 Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving as D-Flaxene ER-50 Tablet may cause sleepiness and dizziness. D-Flaxene ER-50 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with D-Flaxene ER-50 Tablet as it could lead to increased sleepiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of D-Flaxene ER-50 Tablet

Treatment of Depression

Directions for Use

• D-Flaxene ER-50 Tablet can be taken with or without food as advised by your doctor.• It is usually taken once a day or as directed by the doctor.• Swallow D-Flaxene ER-50 Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

D-Flaxene ER-50 Tablet belongs to a group of antidepressant medicines indicated for the treatment of a major depressive disorder. D-Flaxene ER-50 Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps in regulating mood, and treats depression. 

How D-Flaxene ER-50 Tablet Works

D-Flaxene ER-50 Tablet contains desvenlafaxine, which works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain. This maintains mental balance, helps regulate mood, and treats depression.

Storage

Keep D-Flaxene ER-50 Tablet out of reach and sight of children.
Side effects of D-Flaxene ER-50 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.

What if I have taken an overdose of D-Flaxene ER-50 Tablet

Do not take more than the prescribed dose of D-Flaxene ER-50 Tablet as it may cause overdose. The symptoms of overdose include drowsiness, coma, seizures, vomiting, agitation, hallucinations, fever, sweating, severe muscle stiffness or twitching, confusion, fast heartbeat, shivering, loss of coordination, fast/slow/irregular heartbeat, nausea, vomiting, or diarrhea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take D-Flaxene ER-50 Tablet if you are allergic to any of its contents; if you are taking linezolid, intravenous methylene blue, other serotonergic agents, monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days. Inform your doctor before taking D-Flaxene ER-50 Tablet if you have heart problems, hypotension, bipolar disorder, glaucoma, epilepsy, lung or breathing problems, bleeding problems, or low sodium levels in the blood. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. D-Flaxene ER-50 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with D-Flaxene ER-50 Tablet as it could lead to increased sleepiness and dizziness. 

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
DesvenlafaxineTranylcypromine
Critical

Drug-Drug Interactions

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DesvenlafaxineSafinamide
Critical
How does the drug interact with D-Flaxene ER-50 Tablet:
Taking Safinamide with D-Flaxene ER-50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Flaxene ER-50 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with D-Flaxene ER-50 Tablet:
Taking tranylcypromine with D-Flaxene ER-50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and D-Flaxene ER-50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with D-Flaxene ER-50 Tablet:
Combining Procarbazine and D-Flaxene ER-50 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and D-Flaxene ER-50 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with D-Flaxene ER-50 Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with D-Flaxene ER-50 Tablet:
Combining Isocarboxazid and D-Flaxene ER-50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and D-Flaxene ER-50 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with D-Flaxene ER-50 Tablet:
Taking rasagiline with D-Flaxene ER-50 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Flaxene ER-50 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineCyclobenzaprine
Severe
How does the drug interact with D-Flaxene ER-50 Tablet:
Co-administration of cyclobenzaprine and D-Flaxene ER-50 Tablet might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Cyclobenzaprine and D-Flaxene ER-50 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any fever, excessive sweating, shivering, muscle spasm, stomach cramp, or vomiting, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineZolmitriptan
Severe
How does the drug interact with D-Flaxene ER-50 Tablet:
Co-administration of Zolmitriptan and D-Flaxene ER-50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Zolmitriptan and D-Flaxene ER-50 Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineAmitriptyline
Severe
How does the drug interact with D-Flaxene ER-50 Tablet:
Combining D-Flaxene ER-50 Tablet with Amitriptyline might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although using D-Flaxene ER-50 Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineClomipramine
Severe
How does the drug interact with D-Flaxene ER-50 Tablet:
Coadministration of D-Flaxene ER-50 Tablet with clomipramine might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking clomipramine and D-Flaxene ER-50 Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineDextromethorphan
Severe
How does the drug interact with D-Flaxene ER-50 Tablet:
Co-administration of Dextromethorphan and D-Flaxene ER-50 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Dextromethorphan and D-Flaxene ER-50 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizure (fits), confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramps, and diarrhea, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improves mood, boosts self-esteem, and provides restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

D-Flaxene ER-50 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking D-Flaxene ER-50 Tablet as it may cause increased sleepiness and dizziness.

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Pregnancy

Caution

D-Flaxene ER-50 Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning for pregnancy, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

D-Flaxene ER-50 Tablet may pass into breastmilk. Consult your doctor before taking D-Flaxene ER-50 Tablet your doctor will decide whether D-Flaxene ER-50 Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

D-Flaxene ER-50 Tablet causes sleepiness and dizziness. Do not drive or operate machinery.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

D-Flaxene ER-50 Tablet should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

D-Flaxene ER-50 Tablet is used to treat a major depressive disorder (depression).

D-Flaxene ER-50 Tablet works by increasing the levels of certain chemical messengers (serotonin and norepinephrine) in the brain, which maintain mental balance, thereby regulating mood that treats depression.

Do not discontinue D-Flaxene ER-50 Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking D-Flaxene ER-50 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking D-Flaxene ER-50 Tablet .

D-Flaxene ER-50 Tablet may cause decreased sex drive (libido) and problems with ejaculation and orgasm. Consult your doctor if you have any concerns regarding this.

Hypertension should be controlled before starting treatment with D-Flaxene ER-50 Tablet . Therefore, consult your doctor if you have high blood pressure. Regular monitoring of blood pressure levels is advised while taking D-Flaxene ER-50 Tablet .

D-Flaxene ER-50 Tablet may increase the chances of bleeding and bruising. The risk increases when D-Flaxene ER-50 Tablet is taken along with painkillers and blood thinners. Consult your doctor if you notice unusual bleeding or bruising.

When taken along with other medicines, D-Flaxene ER-50 Tablet may cause a rare but potentially life-threatening condition called serotonin syndrome. This condition causes changes in how the brain, blood vessels, muscles and digestive system work. Avoid taking D-Flaxene ER-50 Tablet along with MAOIs (used to treat depression), linezolid, intravenous methylene blue and other serotonergic agents.

D-Flaxene ER-50 Tablet may dilate your pupils (widen the dark centres of your eyes). This can trigger a glaucoma attack. Before taking D-Flaxene ER-50 Tablet , consult your doctor if you have glaucoma.

D-Flaxene ER-50 Tablet may cause seizures. If you’ve ever had a seizure, tell your doctor before taking D-Flaxene ER-50 Tablet .

Many people have sexual side effects when using antidepressants. Working together with your doctor will help you find a solution that addresses both your mental and sexual wellness.

You may have to take D-Flaxene ER-50 Tablet for several weeks before you begin to feel better.

D-Flaxene ER-50 Tablet can begin lowering anxiety symptoms in as little as one week, according to one clinical study. Generally, you'll start to feel the full effects after taking it for eight weeks.

Although D-Flaxene ER-50 Tablet is only officially allowed to treat depression, doctors frequently prescribe it to treat anxiety as well.

Take D-Flaxene ER-50 Tablet exactly as prescribed by your healthcare practitioner. Take D-Flaxene ER-50 Tablet once a day, about the same time every day. D-Flaxene ER-50 Tablet can be taken with or without food. Swallow D-Flaxene ER-50 Tablet pills whole and with drink.

It should be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.

D-Flaxene ER-50 Tablet works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance. Thus, it helps to treat depression.

D-Flaxene ER-50 Tablet doesn't typically cause weight gain for most people. In very rare case, people taking it experience weight changes (gain or loss) of less than 2 kgs.

D-Flaxene ER-50 Tablet may cause sexual dysfunction; however, men are more affected than women. If it happens to you, please seek medical attention from your doctor.

Common side effects of D-Flaxene ER-50 Tablet may include nausea, dizziness, insomnia (sleep problems), constipation, sleepiness, loss of appetite, anxiety and male sexual dysfunction disorders.

Country of origin

India

Manufacturer/Marketer address

Gc Complex, 1St Floor, Jwala Heri Market, Paschim Vihar, New Delhi, Delhi - 110063, India
Other Info - DFL0023

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204150s005lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a608022.html#:~:text=Desvenlafaxine%20is%20used%20to%20treat,that%20help%20maintain%20mental%20balance
  3. https://www.drugs.com/mtm/desvenlafaxine.html
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