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compositionComposition:CYTARABINE-1GM
prescriptionPrescription Medicine
Cytosar 1 gm Injection 10 ml
Cytosar 1 gm Injection 10 ml
Cytosar 1 gm Injection 10 ml

Cytosar 1gm Injection is an anticancer medicine used to treat leukemia (blood cancer). It contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in cancer cells, which is essential for cell growth, repair, and multiplication. Thus, It stops the multiplication of abnormal cells, leads to the development of cells in an unbalanced way and causes the death of cells.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYTARABINE-1GM

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cytosar 1gm Injection

Cytosar 1gm Injection is an anticancer medicine used in the treatment of leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Cytosar 1gm Injection is used in the treatment of different types of leukemias, such as acute non-lymphocytic leukemia, acute lymphocytic leukemia, chronic myelocytic leukemia and meningeal leukemia.

Cytosar 1gm Injection contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for the growth, repair and multiplication of cells. Thus, Cytosar 1gm Injection stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Cytosar 1gm Injection may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dark-coloured urine, stomach pain, hair loss, dizziness, weakness, and pain at the site of injection, prescribed by your doctor. Most of these side effects of Cytosar 1gm Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please seek medical help. A trained healthcare professional will administer Cytosar 1gm Injection. Hence, do not self-administer.

If you are allergic to Cytosar 1gm Injection, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Cytosar 1gm Injection. Cytosar 1gm Injection is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have/had kidney or liver disease. Avoid alcohol consumption with Cytosar 1gm Injection as it may increase the risk of liver damage. Avoid excessive exposure to sunlight as Cytosar 1gm Injection may cause sensitivity to sunlight. You are advised to use sunscreen and wear protective clothing while going out.

Uses of Cytosar 1gm Injection

Cytosar 1gm Injection is used to treat certain blood cancers. The detailed uses of Cytosar 1gm Injection are as follows:

  • Treats leukaemia: Cytosar 1gm Injection is used to manage various types of leukaemia, cancers that affect the white blood cells.
  • Used for non-Hodgkin’s lymphoma: Cytosar 1gm Injection may also be given to treat certain forms of non-Hodgkin’s lymphoma, a cancer of lymphatic white blood cells.
  • Helps stop cancer cell growth: Cytosar 1gm Injection works by interfering with the growth and multiplication of cancer cells in the body.

Key Benefits

Cytosar 1gm Injection contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Cytosar 1gm Injection stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Side effects of Cytosar 1 gm Injection 10 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Cytosar 1gm Injection will be administered in the hospital setting by a trained healthcare professional.
  • Do not self-administer.

How Cytosar 1gm Injection Works

Cytosar 1gm Injection contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for the growth, repair and multiplication of cells. Thus, Cytosar 1gm Injection stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.
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Alcohol

Unsafe

Avoid consumption of alcohol with Cytosar 1gm Injection as it may increase the risk of liver damage.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cytosar 1gm Injection. You should not become pregnant while on treatment with Cytosar 1gm Injection.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Cytosar 1gm Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

Cytosar 1gm Injection causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Cytosar 1gm Injection.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Cytosar 1gm Injection. It may lead to CNS toxicity in high doses.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Cytosar 1gm Injection as it may lead to kidney failure. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Cytosar 1gm Injection, combined with other approved anti-cancer medications, is suggested for inducing remission in adults and children with acute non-lymphocytic leukemia. Consult your doctor for more information.

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Heart

Caution

Cytosar 1gm Injection may be used in patients with heart problems, but only with close medical supervision. It can cause cardiac symptoms like fast or uneven heartbeat and chest pain, so monitoring is essential.

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Geriatrics

Caution

Geriatric patients can receive Cytosar 1gm Injection, but it may be more susceptible to side effects like low blood counts and neurotoxicity. Careful dosing and close medical monitoring are essential during treatment.

What if I have taken an overdose of Cytosar 1gm Injection

Since Cytosar 1gm Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Cytosar 1gm Injection may cause confusion, mental/mood changes.

Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking Cytosar 1gm Injection as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Have a query?

How Soon It Starts Working

The time required for Cytosar 1gm Injection to start to work: Cytosar 1gm Injection ideally shows its action within 15 minutes of administration. The time for which the effects of Cytosar 1gm Injection last: Cytosar 1gm Injection effect lasts for 12-24 hours.

What if you forget to take Cytosar 1gm Injection

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Cytosar 1gm Injection out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Cytosar 1gm Injection should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with Cytosar 1gm Injection. Cytosar 1gm Injection is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have/had any pre-existing liver or kidney disease. Avoid taking Cytosar 1gm Injection if you are pregnant, as it may harm the foetus. Avoid alcohol consumption with Cytosar 1gm Injection as it may increase the risk of liver damage. Avoid excessive exposure to sunlight as Cytosar 1gm Injection may cause sensitivity to sunlight. You are advised to use sunscreen and wear protective clothing while going out. If you are about to receive any vaccinations, inform your doctor that you are taking Cytosar 1gm Injection as it may cause infection.

Drug-Drug Interactions

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Drug-Drug Interactions: Cytosar 1gm Injection may interact with medicines used to treat ulcerative colitis (mesalazine, olsalazine), anti-inflammatory drugs (sulfasalazine), aminoglycosides (gentamicin, amikacin, neomycin), cardiac glycoside, cholera vaccine, typhoid vaccine.

Drug-Food Interactions: Cytosar 1gm Injection may interact with alcohol. Therefore, avoid alcohol consumption with Cytosar 1gm Injection as it may increase the risk of liver damage.

Drug-Disease Interactions: Inform your doctor if you have liver or kidney disease before starting treatment with Cytosar 1gm Injection.

CytarabineBaricitinib
Severe
CytarabineThalidomide
Severe

Drug-Drug Interactions

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CytarabineBaricitinib
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Coadministration of Cytosar 1 gm Injection 10 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cytosar 1 gm Injection 10 ml and Baricitinib, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CytarabineThalidomide
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Taking thalidomide together with Cytosar 1 gm Injection 10 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Cytosar 1 gm Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
CytarabineCladribine
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
The combined use of cladribine with Cytosar 1 gm Injection 10 ml can increase the risk and severity of side effects.

How to manage the interaction:
Although taking Cytosar 1 gm Injection 10 ml and Cladribine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
CytarabineInfliximab
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Combining Infliximab with Cytosar 1 gm Injection 10 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Cytosar 1 gm Injection 10 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
CytarabineClozapine
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Combining Cytosar 1 gm Injection 10 ml with Clozapine can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Cytosar 1 gm Injection 10 ml and Clozapine, but it can be taken if prescribed by a doctor. If you notice any of these symptoms - such as fever, sore throat, or muscle aches - contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CytarabineTofacitinib
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Taking Tofacitinib with Cytosar 1 gm Injection 10 ml may increase the risk of serious infection.

How to manage the interaction:
Taking Tofacitinib with Cytosar 1 gm Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CytarabineEtanercept
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
When Etanercept is used with Cytosar 1 gm Injection 10 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Cytosar 1 gm Injection 10 ml with Etanercept together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CytarabineKetoconazole
Severe
How does the drug interact with Cytosar 1 gm Injection 10 ml:
Taking Cytosar 1 gm Injection 10 ml with Ketoconazole can increase the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Cytosar 1 gm Injection 10 ml and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Cytosar 1gm Injection is used to treat Chronic myeloid leukemia, Acute lymphocytic leukemia, Acute non-lymphocytic leukemia, and meningeal leukemia.

Cytosar 1gm Injection contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Cytosar 1gm Injection as it may cause infections.

Cytosar 1gm Injection may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Cytosar 1gm Injection if you are planning to become pregnant.

Cytosar 1gm Injection contains cytarabine as its active component. It is an anticancer medicine which belongs to the class of anti-metabolites.

Cytosar 1gm Injection is not considered a vesicant (irritant), but it should be administered carefully to prevent any potential issues.

No, ototoxicity (hearing damage) has not been reported with Cytosar 1gm Injection use. However, if you experience any related symptoms, it is important to consult your doctor.

Yes, Cytosar 1gm Injection is a cytotoxic (cell-damaging).

Yes, Cytosar 1gm Injection may cause hair loss as this is one of its side effects. However, please, consult a doctor if this persists for longer durations.

Cytosar 1gm Injection causes side effects such as nausea, vomiting, mouth ulcers, loss of appetite, diarrhoea, dark-coloured urine, confusion, dizziness, stomach pain, weakness, and injection site reactions. These will gradually reduce over time. However, consult a doctor if any of these persists longer.

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - CYT0073
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