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  3. Cymgal 450 mg Tablet 10's

Cymgal 450 mg Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Cymgal 450 mg Tablet is used to treat cytomegalovirus retinitis (viral infection of the retina). It contains Valganciclovir which works by inhibiting the multiplication of the virus. In some cases, this medicine may cause side effects such as diarrhoea, loss of appetite, cough, headache, stomach pain, nausea, fever, and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

VALGANCICLOVIR-450MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Cymgal 450 mg Tablet

Cymgal 450 mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, Cymgal 450 mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV. Cytomegalovirus (CMV) retinitis is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus.

Cymgal 450 mg Tablet contains Valganciclovir which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.  

Take Cymgal 450 mg Tablet as prescribed by your doctor. You are advised to take Cymgal 450 mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience diarrhea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects of Cymgal 450 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Cymgal 450 mg Tablet or any other medicines, please tell your doctor. Avoid taking Cymgal 450 mg Tablet if you are pregnant, as it may cause birth defects. If you are breastfeeding, do not take Cymgal 450 mg Tablet as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking Cymgal 450 mg Tablet and for 30 days after treatment with Cymgal 450 mg Tablet . Drive only if you are alert, as Cymgal 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness, or confusion.

Uses of Cymgal 450 mg Tablet

Treatment of Cytomegalovirus (CMV) infection of the retina.

Directions for Use

• Cymgal 450 mg Tablet can be taken with food to minimise stomach discomfort or as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Cymgal 450 mg Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Cymgal 450 mg Tablet contains Valganciclovir, an antiviral drug used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Cymgal 450 mg Tablet gets converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.  Additionally, Cymgal 450 mg Tablet is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

How Cymgal 450 mg Tablet Works

Cymgal 450 mg Tablet contains Valganciclovir which works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Storage

Keep Cymgal 450 mg Tablet out of reach and sight of children.
Side effects of Cymgal 450 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Limit sugary drinks and foods to reduce yeast growth.
  • Avoid yeast-rich foods like beer, wine, and sourdough bread.
  • Include probiotic-rich foods like yogurt, kefir, kimchi, and sauerkraut.
  • Eat antifungal foods like garlic, onions, cinnamon, and coconut oil.
  • Focus on nutrient-rich foods high in vitamins C and E.
  • Use a warm saltwater rinse in your mouth several times daily.
  • Practice excellent oral hygiene through regular brushing, flossing, and denture cleaning.
  • Stay hydrated by drinking plenty of water.
  • To manage stress, try relaxation methods like deep breathing exercises, meditation, or yoga to help calm your mind and body.
  • Avoid smoking and tobacco to prevent immune function impairment.
  • Consult a doctor for proper diagnosis and treatment.

What if I have taken an overdose of Cymgal 450 mg Tablet

Take Cymgal 450 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include upset stomach, vomiting, stomach pain, diarrhoea, uncontrolled shaking, seizures, decreased urination, bloody urine, signs of infection (sore throat, fever, chills, cough), excessive tiredness, pale skin, yellowing of skin or eyes, dizziness, fast heartbeat, weakness, and unusual bleeding or bruising. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Cymgal 450 mg Tablet or any other medicines, please tell your doctor. If you have a low number of platelets, white blood cells or red blood cells and kidney problems, inform your doctor before taking Cymgal 450 mg Tablet . Avoid taking Cymgal 450 mg Tablet if you are pregnant as it may cause birth defects. If you are breastfeeding, do not take Cymgal 450 mg Tablet as it may be excreted in human milk and cause adverse effects in the baby. Women are recommended to use effective contraceptive measures while taking Cymgal 450 mg Tablet and 30 days after treatment with Cymgal 450 mg Tablet . Men are advised to continue using contraceptive measures for 90 days after treatment with Cymgal 450 mg Tablet . Drive only if you are alert as Cymgal 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion. If you are having blood dialysis or radiotherapy, please inform your doctor before taking Cymgal 450 mg Tablet .

Drug-Drug Interactions

verifiedApollotooltip
ValganciclovirCidofovir
Critical
ValganciclovirEtanercept
Severe

Drug-Drug Interactions

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ValganciclovirCidofovir
Critical
How does the drug interact with Cymgal 450 mg Tablet:
Taking cidofovir with Cymgal 450 mg Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Cymgal 450 mg Tablet with Cidofovir is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ValganciclovirEtanercept
Severe
How does the drug interact with Cymgal 450 mg Tablet:
The combined use of etanercept and Cymgal 450 mg Tablet can increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Cymgal 450 mg Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
ValganciclovirCladribine
Severe
How does the drug interact with Cymgal 450 mg Tablet:
The combined use of cladribine and Cymgal 450 mg Tablet can increase the risk of infections.

How to manage the interaction:
Taking Cladribine with Cymgal 450 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirCertolizumab
Severe
How does the drug interact with Cymgal 450 mg Tablet:
Taking Cymgal 450 mg Tablet and Certolizumab may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Cymgal 450 mg Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
ValganciclovirMaribavir
Severe
How does the drug interact with Cymgal 450 mg Tablet:
When Cymgal 450 mg Tablet is used with Maribavir, it may make Cymgal 450 mg Tablet less effective in treating your condition

How to manage the interaction:
Although there is a possible interaction between Cymgal 450 mg Tablet and Maribavir, you can take these medicines together if prescribed by your doctor. If you're having any unusual symptoms, contact a doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirZidovudine
Severe
How does the drug interact with Cymgal 450 mg Tablet:
Combining Cymgal 450 mg Tablet with Zidovudine can increase the risk of side effects.

How to manage the interaction:
Although taking Cymgal 450 mg Tablet and Zidovudine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience any complications or symptoms, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirClozapine
Severe
How does the drug interact with Cymgal 450 mg Tablet:
Taking Clozapine and Cymgal 450 mg Tablet may increase the risk of severe infections.

How to manage the interaction:
Taking Clozapine with Cymgal 450 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
ValganciclovirGolimumab
Severe
How does the drug interact with Cymgal 450 mg Tablet:
The combined use of golimumab and Cymgal 450 mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking Cymgal 450 mg Tablet and Golimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.
ValganciclovirTenofovir alafenamide
Severe
How does the drug interact with Cymgal 450 mg Tablet:
When Cymgal 450 mg Tablet is taken with Tenofovir alafenamide it may increase the risk of kidney problems.

How to manage the interaction:
Although taking Tenofovir alafenamide and Cymgal 450 mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
ValganciclovirDeferiprone
Severe
How does the drug interact with Cymgal 450 mg Tablet:
Taking Cymgal 450 mg Tablet and Deferiprone may increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Cymgal 450 mg Tablet and Deferiprone, but it can be taken if prescribed by a doctor. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, trouble breathing, losing weight, or pain while peeing - contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark-green, yellow, orange, and red vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.

  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.

  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.

Habit Forming

No

Therapeutic Class

ANTIVIRALS

Cymgal 450 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

The interaction of alcohol with Cymgal 450 mg Tablet is unknown. Please consult a doctor before consuming alcohol while using Cymgal 450 mg Tablet .

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Pregnancy

Unsafe

Cymgal 450 mg Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Cymgal 450 mg Tablet as it may pass into breast milk. Therefore, please consult a doctor if you are breastfeeding.

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Driving

Caution

Cymgal 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience any of these symptoms after taking Cymgal 450 mg Tablet .

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Liver

Caution

Take Cymgal 450 mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Cymgal 450 mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

Cymgal 450 mg Tablet should be used in children only if recommended by a doctor.

Have a query?

FAQs

Cymgal 450 mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina of the eye in adult AIDS patients. Also, it is used to prevent CMV infection in patients who received an organ transplant from a donor infected with CMV.

Cymgal 450 mg Tablet contains Valganciclovir that works by getting converted to ganciclovir in the body and inhibits the multiplication of the virus. Thereby, it helps to control the infection.

Cymgal 450 mg Tablet may be used to prevent cytomegalovirus infection in patients who received an organ transplant from a donor infected with CMV.

Cymgal 450 mg Tablet may cause diarrhoea as a temporary side effect. However, if the condition persists or worsens, please consult a doctor.

Cymgal 450 mg Tablet should be used with caution in patients with kidney problems and only in doses as prescribed by a doctor. However, regular blood tests are recommended while taking Cymgal 450 mg Tablet to monitor kidney functioning.

You are not recommended to take Cymgal 450 mg Tablet with tacrolimus (immunosuppressant) as it may increase the risk of kidney or nerve damage, cause side effects affecting bone marrow function leading to a low number of blood cells. Therefore, please consult a doctor before taking Cymgal 450 mg Tablet with other medicines.

Cymgal 450 mg Tablet is classed as a cytotoxic medicine and will therefore require special handling.

Common side effects of Cymgal 450 mg Tablet may include diarrhea, loss of appetite, cough, headache, stomach pain, nausea, fever, tiredness, or sinusitis (sinus infection). Most of these side effects of Cymgal 450 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Yes, it also have activity against the alpha herpesviruses. But it should be taken only if recommended by the healthcare professional.

Cymgal 450 mg Tablet contains Valganciclovir as an active ingredient.

It is a viral infection of the retina (light-sensing cells) caused by cytomegalovirus. In serious cases, it may lead to blindness. CMV retinitis is more likely to affect people with a weakened immune system from HIV/AIDS. The symptoms include blurred vision, a blind spot in vision, floaters in the eye, loss of peripheral vision or flashes in the eye.

Cymgal 450 mg Tablet is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or have any concerns.

If you are breastfeeding, do not take Cymgal 450 mg Tablet as it may be excreted in human milk and cause adverse effects in the baby.

Cymgal 450 mg Tablet may cause dizziness, tiredness, drowsiness, shakiness or confusion in some people. Therefore, avoid driving or operating heavy machinery if you experience these symptoms after taking Cymgal 450 mg Tablet .

Country of origin

India

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - CYM0019

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.8177.pdf
  2. https://www.medicines.org.uk/emc/files/pil.6508.pdf

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