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  3. Cycloglob 50mg Tablet

Cycloglob 50mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cycloglob 50mg Tablet is used to treat cancer and nephrotic syndrome (kidney disease). It contains Cyclophosphamide that stops the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

CYCLOPHOSPHAMIDE-50MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Cycloglob 50mg Tablet

Cycloglob 50mg Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Cycloglob 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Cycloglob 50mg Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Cycloglob 50mg Tablet helps treat cancer by killing the cancer cells.
 
You are advised to take Cycloglob 50mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Cycloglob 50mg Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Cycloglob 50mg Tablet if you are pregnant or breastfeeding. Cycloglob 50mg Tablet may cause dizziness, so drive only if you are alert. Cycloglob 50mg Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Cycloglob 50mg Tablet

Cycloglob 50mg Tablet is used for the treatment of cancer and nephrotic syndrome (kidney disease). The detailed uses of Cycloglob 50mg Tablet are as follows:

  • Cancer treatment: Cycloglob 50mg Tablet is used to treat various cancers, including lymphomas, leukaemia, and breast cancer, by slowing or stopping cancer cell growth.
  • Autoimmune disorders: Cycloglob 50mg Tablet helps manage autoimmune diseases like lupus and rheumatoid arthritis by suppressing the immune response and reducing inflammation.
  • Organ Transplantation: Cycloglob 50mg Tablet is used in organ transplant patients to prevent rejection by suppressing the immune system.
  • Nephrotic Syndrome: Cycloglob 50mg Tablet is used to treat nephrotic syndrome, especially in cases resistant to standard treatments, by reducing proteinuria and improving kidney function.
  • Scleroderma Treatment: Cycloglob 50mg Tablet is involved in managing scleroderma by alleviating symptoms and slowing disease progression through immune system suppression.

Directions for Use

• It is generally recommended to take Cycloglob 50mg Tablet with food to prevent stomach upset or as advised by the doctor. • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety. • Swallow Cycloglob 50mg Tablet as a whole with a glass of water. • Do not chew, crush or break it.

Medicinal Benefits

Cycloglob 50mg Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Cycloglob 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Cycloglob 50mg Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Cycloglob 50mg Tablet helps to treat cancer by killing the cancer cells.

How Cycloglob 50mg Tablet Works

Cycloglob 50mg Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Cycloglob 50mg Tablet helps treat cancer by killing the cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Cycloglob 50mg Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cycloglob 50mg Tablet
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • If you are concerned about impaired spermatogenesis, talk to your doctor. They may adjust the dose if necessary or prescribe alternative medication.
  • Limit exposure to environmental toxins, smoking, and excessive alcohol consumption.
  • Regularly monitor hormone levels, such as testosterone and follicle-stimulating hormone (FSH), to detect any changes.
  • Ensure adequate zinc and folate intake, as these nutrients are essential for spermatogenesis.
  • Consume omega-3 fatty acid-rich foods or supplements, such as fish oil, to support reproductive health.

What if I have taken an overdose of Cycloglob 50mg Tablet

Take Cycloglob 50mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include black/tarry stools, red urine, unusual bleeding/bruising, unusual tiredness/weakness, signs of infection (sore throat, cough, fever), chest pain, and swelling in the ankles, feet or legs. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Cycloglob 50mg Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Cycloglob 50mg Tablet if you are pregnant or breastfeeding. Cycloglob 50mg Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Cycloglob 50mg Tablet:
Co-administration of Cycloglob 50mg Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Cycloglob 50mg Tablet:
Co-administration of Nalidixic acid with Cycloglob 50mg Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Cycloglob 50mg Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideCladribine
Severe
How does the drug interact with Cycloglob 50mg Tablet:
The combined use of Cladribine with Cycloglob 50mg Tablet can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Cycloglob 50mg Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.
CyclophosphamideLeflunomide
Severe
How does the drug interact with Cycloglob 50mg Tablet:
Taking Cycloglob 50mg Tablet with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Cycloglob 50mg Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Cycloglob 50mg Tablet:
When Cycloglob 50mg Tablet is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Cycloglob 50mg Tablet and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Cycloglob 50mg Tablet:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Cycloglob 50mg Tablet may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Cycloglob 50mg Tablet can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideTofacitinib
Severe
How does the drug interact with Cycloglob 50mg Tablet:
Taking Cycloglob 50mg Tablet with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Cycloglob 50mg Tablet can be taken with Tofacitinib if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Cycloglob 50mg Tablet:
Co-administration of Ropivacaine with Cycloglob 50mg Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Cycloglob 50mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Cycloglob 50mg Tablet:
Co-administration of Cycloglob 50mg Tablet with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Cycloglob 50mg Tablet and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.
CyclophosphamideInfliximab
Severe
How does the drug interact with Cycloglob 50mg Tablet:
When Cycloglob 50mg Tablet is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Infliximab and Cycloglob 50mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Cycloglob 50mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol affects Cycloglob 50mg Tablet. Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Cycloglob 50mg Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

bannner image

Breast Feeding

Unsafe

Cycloglob 50mg Tablet passes into breastmilk. Avoid breastfeeding while taking Cycloglob 50mg Tablet.

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Driving

Caution

Cycloglob 50mg Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed. Cycloglob 50mg Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Cycloglob 50mg Tablet should be given to children only if prescribed by a doctor.

Have a query?

FAQs

Cycloglob 50mg Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia, nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Cycloglob 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.

Cycloglob 50mg Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Cycloglob 50mg Tablet helps to treat cancer by killing the cancer cells.

Do not stop taking Cycloglob 50mg Tablet on your own. You are advised to take Cycloglob 50mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Cycloglob 50mg Tablet.

Cycloglob 50mg Tablet might interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm) and could impair fertility. Before starting treatment with Cycloglob 50mg Tablet, talk to your doctor regarding cryopreservation/freezing of eggs/sperm if you consider becoming parents.

Cycloglob 50mg Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.

No, it is not safe to father a child while taking Cycloglob 50mg Tablet. Use effective contraception while taking Cycloglob 50mg Tablet and for at least four months after treatment. Women of childbearing age taking Cycloglob 50mg Tablet should use highly effective contraceptives while taking Cycloglob 50mg Tablet up to 1 year after the treatment.

Cycloglob 50mg Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Cycloglob 50mg Tablet are advised.

During treatment with Cycloglob 50mg Tablet, stay protected from sun and avoid excessive sun exposure. It’s best to use sunscreen, sunglasses and protective clothing to prevent skin damage, if your immune system is weakened.

Cancer treatments like chemotherapy and radiation therapy can increase the chance of developing other cancers, which may appear years after treatment with Cycloglob 50mg Tablet. The use of Cycloglob 50mg Tablet is associated with a higher risk of bladder cancer. Rarely, it may also increase the risk of other cancers like acute leukaemia, and ureter cancer.

Cycloglob 50mg Tablet is a chemotherapy medicine which belongs to the class of alkylating agents. It works by destroying cancer cells.

Yes, Cycloglob 50mg Tablet may be used to treat nephrotic syndrome in children, especially in cases where the condition has not improved, or has recurred after using other medications. It is also an option for children who have experienced severe side effects from other treatments. However, its safety and effectiveness for nephrotic syndrome in adults have not been established.

Cycloglob 50mg Tablet may cause weight loss due to decreased appetite and may be due to underlying cancer. Consult a doctor if you experience significant weight loss.

Cycloglob 50mg Tablet may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - CY43642

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 10:26 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/012141s090,012142s112lbl.pdf
  2. https://www.medicines.org.uk/emc/medicine/30161#gref
  3. https://www.drugs.com/mtm/cyclophosphamide-oral-and-injection.html
  4. https://mri.cts-mrp.eu/human/downloads/NL_H_2814_002_FinalPL.pdf
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