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compositionComposition:INCLISIRAN-284MG
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Crenzlo Injection 1.5 ml is used as part of a comprehensive treatment plan, which includes a balanced diet and other medications, to help control cholesterol levels. It lowers LDL cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C. Some individuals may experience side effects such as headache, dizziness, cough, injection site reactions, and diarrhoea. Let the doctor know if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

INCLISIRAN-284MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Crenzlo Injection 1.5 ml

Crenzlo Injection 1.5 ml is an injectable prescription medicine used to lower low-density lipoprotein (LDL) cholesterol, commonly known as 'bad' cholesterol, in the blood. It is prescribed for adults with high cholesterol or heart disease who require additional treatment when other therapies and diet changes are not enough. This medicine is used alongside a low-fat diet and other cholesterol-lowering medicines to help manage your overall cardiovascular health.

This long-acting injection is given at regular intervals by a healthcare professional to ensure consistent cholesterol control. Because the medicine is injected under your skin by a provider, you do not need to worry about taking it with or without food. To achieve the best possible results, you should maintain a heart-healthy diet, exercise regularly, and make recommended lifestyle adjustments while receiving this treatment.

Most people tolerate this injection well, but some may experience mild side effects, such as redness, pain, or swelling at the injection site. If you notice signs of a severe allergic reaction, such as swelling of your face, lips, tongue, or throat, or trouble breathing, contact your doctor immediately. Always talk to your healthcare team if you experience any unusual or persistent symptoms after your injection.

Do not receive this injection if you have had a severe allergic reaction to Crenzlo Injection 1.5 ml or any of its inactive ingredients (excipients). Before starting your treatment, tell your doctor if you have severe kidney problems or severe liver damage. It is important to discuss your complete medical history with your doctor to confirm that this treatment is safe and appropriate for your specific health needs.

This injection has a very low risk of interacting with other medicines because of how it is processed by the body, but you should still tell your doctor about all drugs, supplements, alcohol use, or smoking habits. Crenzlo Injection 1.5 ml is not approved for use in children or adolescents under 18 years of age. Pregnant or breastfeeding individuals should consult their doctor before receiving this injection, as its safety during pregnancy is not fully established. Elderly individuals should also talk to their doctor to ensure the treatment is suitable for their overall health profile.

Uses of Crenzlo Injection 1.5 ml

Crenzlo Injection 1.5 ml is used to help manage high cholesterol and reduce cardiovascular risk. The detailed uses of Crenzlo Injection 1.5 ml are as follows:

  • High Cholesterol (Primary Hyperlipidemia): Helps lower bad cholesterol levels in the blood when diet changes and other oral medicines are not sufficient to reach target levels.
  • Heart Disease (Atherosclerotic Cardiovascular Disease): Helps reduce cholesterol in adults who have a history of heart attacks, strokes, or blocked arteries to help prevent further cardiovascular complications.
  • Inherited High Cholesterol (Heterozygous Familial Hypercholesterolemia): Works to lower extremely high cholesterol levels caused by genetic conditions passed down through families. (Note: Efficacy and safety have not been established in patients with Homozygous Familial Hypercholesterolemia, a rarer and more severe genetic condition).

Key Benefits

Crenzlo Injection 1.5 ml provides important benefits by helping manage cholesterol levels and support long-term cardiovascular health. The key benefits of Crenzlo Injection 1.5 ml are as follows:

  • Long-Term Cholesterol Control: Crenzlo Injection 1.5 ml provides continuous, long-term control of your bad cholesterol levels, helping to keep your blood vessels clear and reducing the build-up of fatty deposits in your arteries.
  • Convenient Dosing: Because this medicine is injected only a few times a year by a healthcare professional, it provides great convenience and removes the daily worry of remembering to take another cholesterol pill.
  • Additional Cardiovascular Support: It works effectively in combination with your current cholesterol-lowering therapies, giving you an extra layer of protection to help manage your long-term cardiovascular risks.
Side effects of Crenzlo Injection 1.5 ml
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Crenzlo Injection 1.5 ml is administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Crenzlo Injection 1.5 ml Works

Crenzlo Injection 1.5 ml contains Crenzlo Injection 1.5 ml. Crenzlo Injection 1.5 ml works directly in your liver to help clear bad cholesterol from your bloodstream. It belongs to a class of medicines that target a specific protein in the liver. This protein normally blocks the liver's natural ability to remove excess cholesterol from your body. By stopping the production of this protein, Crenzlo Injection 1.5 ml allows your liver to set up more 'clearing stations' (receptors) on its surface. These receptors grab the bad cholesterol from your blood and break it down, resulting in a significant and steady decrease in your overall cholesterol levels.
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Alcohol

Caution

It is unknown if alcohol interacts with Crenzlo Injection 1.5 ml. Please consult a doctor if you have any concerns.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

There is limited data on the use of Crenzlo Injection 1.5 ml during breastfeeding. Consult your healthcare provider to assess risks and benefits.

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Driving

Caution

Crenzlo Injection 1.5 ml is unlikely to impair your ability to drive or operate machinery. However, sometimes, Crenzlo Injection 1.5 ml makes you feel tired and dizzy; if it happens to you, do not drive or operate machinery.

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Liver

Caution

Inform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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Children

Caution

Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

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Heart

Caution

Inform your doctor if you have heart disease before using Crenzlo Injection 1.5 ml. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Crenzlo Injection 1.5 ml can be used in the elderly when prescribed by a doctor. If you have any concerns about using Crenzlo Injection 1.5 ml, please consult a doctor.

What if I have taken an overdose of Crenzlo Injection 1.5 ml

Since this medicine is prepared and injected by a trained healthcare professional in a clinical setting, an overdose is highly unlikely. However, if you suspect you have received too much or experience unusual symptoms, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat a heart-healthy diet: Focus on foods low in saturated fats and cholesterol, such as whole grains, fresh fruits, vegetables, lean proteins, and soluble fibre to help support your treatment.
  • Stay physically active: Aim for at least 150 minutes of moderate aerobic exercise, like brisk walking, swimming, or cycling, every week to strengthen your cardiovascular system.
  • Avoid smoking: Quitting smoking helps improve your 'good' cholesterol (HDL) levels and significantly lowers your overall risk of heart attacks and strokes.
  • Limit alcohol intake: Keep your alcohol consumption within recommended limits, as excessive drinking can raise your cholesterol and triglyceride levels.
health query

Have a query?

How Soon It Starts Working

The time required for Crenzlo Injection 1.5 ml to start to work: The time required for Crenzlo Injection 1.5 ml to show its action is unknown. The time for which the effects of Crenzlo Injection 1.5 ml last: The duration of action for Crenzlo Injection 1.5 ml is unknown.

What if you forget to take Crenzlo Injection 1.5 ml

Because this medicine is given by a healthcare professional, contact your doctor's clinic immediately to reschedule your appointment if you miss a scheduled dose. Do not wait until your next planned appointment to address a missed injection.

Storage

• Crenzlo Injection 1.5 ml is stored by your clinic or healthcare provider at room temperature between 20°C to 25°C (68°F to 77°F). This medicine must never be frozen.

Drug Warnings

  • Inspect the Injection: Always make sure your healthcare provider visually inspects the injection syringe before use; the liquid should be clear and colourless to pale yellow, without any visible floating particles.
  • Rotate Injection Sites: Ensure your healthcare provider rotates the injection site with each visit (for example, switching from the abdomen to the thigh) to reduce the risk of skin irritation.
  • Choose the Injection Site Carefully: Do not receive the injection in skin areas that are actively sunburned, injured, infected, or showing signs of skin disease.
  • Keep Appointment Reminders: Set calendar reminders for your injection appointments, as keeping a consistent schedule is crucial for maintaining stable cholesterol control.
  • Monitor Lipid Levels: Expect your healthcare provider to order regular blood tests (lipid panels) to track your LDL cholesterol levels and evaluate how effectively the medicine is working.
  • Inform Healthcare Providers: Inform any new healthcare provider, dentist, or specialist you visit that you are currently receiving Crenzlo Injection 1.5 ml injections.

Drug-Drug Interactions

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  • Other Medicines and Supplements: There are no clinically significant drug interactions known for this medicine. However, you should still provide your healthcare provider with a complete list of all prescription medicines, over-the-counter drugs, vitamins, and herbal supplements you take.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No clinically significant food interactions are known with Crenzlo Injection 1.5 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTILIPEMICS]

FAQs

Crenzlo Injection 1.5 ml is used to reduce low-density lipoprotein cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C.
Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by lowering the amount of LDL cholesterol in the blood, decreasing the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Crenzlo Injection 1.5 ml is usually given as an initial dose, followed by a second dose after 3 months, and then administered every 6 months thereafter.
If a dose is missed by less than 3 months, the doctor will administer Crenzlo Injection 1.5 ml and continue the original dosing schedule. If more than 3 months are missed, a new schedule will be started with an initial dose, another dose at 3 months, and then every 6 months.
No dose adjustment is required for elderly patients, but caution is advised when administering Crenzlo Injection 1.5 ml to individuals with severe renal disease, as they may be at a higher risk for complications. Close monitoring is important during treatment.
Some people may experience reactions at the injection site, such as pain, redness, or swelling, but these typically resolve on their own. Seek medical advice if the reactions persist.
PCSK9 is a protein that regulates the number of LDL receptors on cells. These receptors help control cholesterol levels by binding to LDL particles, which carry cholesterol in the blood. Most of these receptors are in the liver, where they remove excess cholesterol from the body.
Pregnant or breastfeeding women should consult their healthcare provider before using Crenzlo Injection 1.5 ml, as its safety during pregnancy and breastfeeding is not fully established.
The side effects of Crenzlo Injection 1.5 ml may include headache, dizziness, cough, bronchitis, diarrhoea, back pain, or pain in a joint. Seek medical care if the side effects persist or worsen.
Crenzlo Injection 1.5 ml may increase the risk of urinary tract infections. Consult the doctor if you experience symptoms of urinary tract infection like frequent urination, pain/burning sensation during urination, pelvic/rectal pain, discoloured urine or smelly urine.
No, this medicine is a subcutaneous injection that must be prepared and given by a trained healthcare professional in a clinic or doctor's office. Talk to your doctor about scheduling your appointments.
If you miss an appointment, call your doctor's clinic right away to reschedule. It is important to receive your dose as close to the scheduled time as possible to keep your cholesterol levels controlled. Talk to your doctor if you have questions about missed appointments.
No, this medicine does not cure high cholesterol; it manages it over the long term. If you discontinue treatment, your bad (LDL) cholesterol levels will gradually rise back toward your pre-treatment baseline over time. You should continue receiving scheduled injections as directed by your doctor to maintain cholesterol control.
You should never stop or change the dose of your daily cholesterol-lowering pills without consulting your healthcare provider first. This injection is designed to work alongside your current treatments. Talk to your doctor before making any changes to your medicines.
There are no specific foods you must avoid while receiving this treatment. However, maintaining a low-fat, heart-healthy diet is essential to help the medicine work effectively. Talk to your doctor or pharmacist for personalised dietary advice.
This injection is generally not recommended during pregnancy because it can affect cholesterol levels, which are necessary for the development of an unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - CRE0424
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