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compositionComposition:CYCLOSERINE-250MG
prescription
Prescription Medicine
info
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Coxerin Capsule is used to treat tuberculosis. It contains Cycloserine which works by inhibiting the growth of tuberculosis-causing bacteria. In some cases, this medicine may cause side effects such as dizziness, drowsiness, mood changes, headache, numbness, and tingling. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CYCLOSERINE-250MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Coxerin Capsule

Coxerin Capsule is a prescription medication used to treat active tuberculosis (TB) in the lungs and other parts of the body when standard treatments have not worked. It is also sometimes prescribed for certain difficult-to-treat urinary tract infections. This medicine works by stopping the growth of the bacteria responsible for these infections.

To achieve the best results, you must take this medication consistently at the exact times prescribed by your healthcare provider. It can be taken with or without food, though taking it with meals can help reduce stomach upset. Incorporating a nutrient-rich diet, resting adequately, and taking prescribed vitamin supplements are key lifestyle changes that support your recovery.

Common side effects of this medicine include mild drowsiness, dizziness, and headache. However, you must contact your doctor immediately if you experience serious side effects such as extreme mood changes, anxiety, confusion, or tremors. Early communication with your healthcare team helps manage these symptoms safely.

Before taking Coxerin Capsule , you should discuss your complete medical history with your doctor, especially if you have a history of mental health conditions, kidney disease, or seizures. Do not take this if you suffer from severe depression, severe anxiety, epilepsy, or severe kidney failure.

This medicine interacts poorly with alcohol, which significantly raises your risk of experiencing seizures, as well as certain other tuberculosis medications. If you are pregnant, breastfeeding, or planning a pregnancy, you must consult your doctor to discuss whether this treatment is safe for you.

Uses of Coxerin Capsule

Here are the main bacterial infections where Coxerin Capsule is used when standard antibiotic treatments are unsuitable or ineffective:

  • Active tuberculosis (TB): Used as a second-line treatment for active tuberculosis in the lungs or other organs when first-line medications are not effective or cannot be used.
  • Urinary tract infections: Prescribed for difficult-to-treat, complex urinary tract infections caused by susceptible bacteria, but only after safer alternative antibiotics have been ruled out.

Key Benefits

Coxerin Capsule provides several important benefits by helping control resistant bacterial infections and supporting recovery:

  • Treats Drug-Resistant Infections: It helps eliminate bacteria that are resistant to standard antibiotics, improving the chances of successful treatment.
  • Relieves Infection Symptoms: As the infection clears, it helps reduce symptoms such as chronic cough, chest pain, night sweats, fatigue, or urinary discomfort.
  • Prevents the Infection From Spreading: When used as part of combination therapy, it helps stop the infection from spreading within the body and reduces the risk of transmitting tuberculosis to others.
  • Supports Complete Recovery: By helping eliminate persistent bacteria, Coxerin Capsule promotes healing of the affected organs and supports long-term recovery when taken exactly as prescribed.

Directions for Use

  • It is advised to take Coxerin Capsule with food to avoid any stomach upset or as advised by a doctor.
  • Generally, Coxerin Capsule is taken twice every day for the best results or as advised by a doctor.
  • Swallow Coxerin Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Coxerin Capsule Works

Coxerin Capsule works by disrupting the way bacteria build their protective outer layer, known as the cell wall. Bacteria rely on a strong, fully formed cell wall to survive, grow, and multiply inside your body. Without a stable wall, the bacterial cells become weak and eventually burst. Specifically, the active component in Coxerin Capsule blocks two key enzymes that the bacteria need to bind structural building blocks together. By preventing these blocks from forming, the medicine stops the bacteria from multiplying. Because human cells do not have cell walls, this process targets the bacteria specifically to clear the infection.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Coxerin Capsule as it could lead to increased dizziness or increase the risk of seizures.

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Pregnancy

Caution

Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. It is unknown whether Coxerin Capsule can cause fetal harm when administered to a pregnant woman. Coxerin Capsule should be used only when clearly needed. Discuss the risks and benefits with your doctor.

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Breast Feeding

Unsafe

Coxerin Capsule may pass into breast milk. Consult your doctor before breast-feeding.

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Driving

Unsafe

Coxerin Capsule may cause dizziness, mood changes, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this.

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Kidney

Unsafe

Do not use the Coxerin Capsule if you have severe kidney disease. Please consult your doctor if you have any concerns regarding this.

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Children

Unsafe

Do not use Coxerin Capsule in children younger than 18 years old.

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Heart

Unsafe

This medicine is not recommended for cardiac patients due to its adverse effects.

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Geriatrics

Caution

Coxerin Capsule should be taken with caution in geriatric patients. Dose adjustments may be needed.

What if I have taken an overdose of Coxerin Capsule

If you suspect an accidental overdose, seek immediate medical attention or contact a poison control centre. Watch for signs of severe toxicity, which may include extreme drowsiness, confusion, slurred speech, or seizures.

Diet & Lifestyle Advise

  • Take Vitamin B6 (pyridoxine): Your doctor will likely prescribe a daily Vitamin B6 supplement while you are taking Coxerin Capsule to help protect your nervous system and reduce the risk of nerve damage.
  • Avoid alcohol entirely: Drinking alcohol while taking this medicine highly increases your risk of experiencing brain toxicity and seizures.
  • Eat nutrient-dense meals: Recovering from tuberculosis requires extra energy; eat balanced meals rich in protein and vitamins to help your body heal.
  • Rest and stay hydrated: Prioritise sleep to support your immune system, and drink plenty of fluids to help your kidneys flush out waste.
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Have a query?

How Soon It Starts Working

The time required for Coxerin Capsule to start to work: Coxerin Capsule ideally shows its action within 4 to 8 hours after administration. The time for which the effects of Coxerin Capsule last: The effect of Coxerin Capsule lasts for 12 hours.

What if you forget to take Coxerin Capsule

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Coxerin Capsule capsules at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the container tightly closed to protect the medication from moisture and direct light.

Drug Warnings

  • Take Vitamin B6 as Prescribed: Always take your prescribed Vitamin B6 supplement daily to help prevent nerve-related side effects.
  • Attend Regular Monitoring Appointments: Attend all scheduled doctor visits and laboratory appointments, as your doctor must check the medicine levels in your blood to ensure safety.
  • Monitor for Mood or Behaviour Changes: Ask a close family member or friend to watch for any changes in your mood, behaviour, or mental clarity while you are taking this medication.
  • Avoid Driving Until You Know Its Effects: Do not drive, operate machinery, or perform tasks requiring deep concentration until you know how this medicine affects your alertness.
  • Do Not Share Your Medicine: Never share your medication with anyone else, even if they have the exact same symptoms you do.

Drug-Drug Interactions

verifiedApollotooltip

Here are the medicines that may interact with Coxerin Capsule and increase the risk of side effects or affect treatment:

  • Isoniazid or Ethionamide: Combining these tuberculosis medications with Coxerin Capsule can increase the risk of central nervous system toxicity, leading to drowsiness, dizziness, or seizures.
  • Phenytoin: This medicine may increase the levels of phenytoin in your body, which can raise the risk of phenytoin side effects.
CycloserineIomeprol
Severe
CycloserineIohexol
Severe

Drug-Drug Interactions

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CycloserineIomeprol
Severe
How does the drug interact with Coxerin Capsule:
Combining Coxerin Capsule with Iomeprol can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Iomeprol, but it can be taken if prescribed by a doctor. If you are elderly, going through alcohol or drug withdrawal, have a history of seizures (fits), or have a brain related condition, you may be more vulnerable. If you experience symptoms like confusion, a gazing spell, or Uncontrollable twitching movements of the arms and legs, loss of awareness or consciousness, alterations in emotions, consult a doctor. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
CycloserineIohexol
Severe
How does the drug interact with Coxerin Capsule:
Combining Coxerin Capsule with Iohexol can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Iohexol, but it can be taken if prescribed by a doctor. If you experience symptoms like confusion, a gazing spell, or Uncontrollable twitching movements of the arms and legs, loss of awareness or consciousness, alterations in emotions, consult a doctor. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
CycloserineEthanol
Severe
How does the drug interact with Coxerin Capsule:
Using Coxerin Capsule together with alcohol may increase the risk or severity of central nervous system side effects.

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Ethanol, but it can be taken if prescribed by a doctor. However, if you experience feeling dizzy or sleepy, depressed, having trouble remembering things, feeling confused, or having convulsions, contact a doctor right away. Do not stop using any medications without talking to a doctor.
CycloserineMetrizamide
Severe
How does the drug interact with Coxerin Capsule:
Combining Coxerin Capsule with Metrizamide can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Metrizamide, but it can be taken if prescribed by a doctor. If you are elderly, going through alcohol or drug withdrawal, have a history of seizures (fits), or have a brain related condition, you may be more vulnerable. If you experience symptoms like confusion, a gazing spell, or Uncontrollable twitching movements of the arms and legs, loss of awareness or consciousness, alterations in emotions, consult a doctor. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
CycloserineIopamidol
Severe
How does the drug interact with Coxerin Capsule:
Combining Coxerin Capsule with Iopamidol can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Iopamidol, but it can be taken if prescribed by a doctor. If you are elderly, going through alcohol or drug withdrawal, have a history of seizures (fits), or have a brain related condition, you may be more vulnerable. If you experience symptoms like confusion, a gazing spell, or Uncontrollable twitching movements of the arms and legs, loss of awareness or consciousness, alterations in emotions, consult a doctor. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
CycloserineBupropion
Severe
How does the drug interact with Coxerin Capsule:
Bupropion can cause seizures (fits) in rare cases but combining Bupropion with Coxerin Capsule may enhance that risk.

How to manage the interaction:
Co-administration of bupropion along with Coxerin Capsule can lead to an interaction, but it can be taken if recommended by a doctor. However, if you experience Memory loss, Confusion, Insomnia (difficulty in sleeping), Retching, Difficulty, speaking, Dizziness, Headache, or Convulsion consult a doctor. Do not discontinue any medications without consulting a doctor.
CycloserineCholera, live attenuated
Severe
How does the drug interact with Coxerin Capsule:
The effects of Cholera, live attenuated can be decreased when used in combination with Coxerin Capsule.

How to manage the interaction:
Co-administration of Cholera, live attenuated along with Coxerin Capsule can lead to an interaction, but it can be taken if recommended by a doctor. However, if you experience any unusual side effects, consult a doctor. Do not discontinue any medications without first consulting your doctor.
CycloserineTramadol
Severe
How does the drug interact with Coxerin Capsule:
Combining Coxerin Capsule with Tramadol can increase the risk of seizures (fits).

How to manage the interaction:
There may be a possibility of interaction between Coxerin Capsule and Tramadol, but it can be taken if prescribed by a doctor. If you are elderly, going through alcohol or drug withdrawal, have a history of seizures (fits), or have a brain related condition, you may be more vulnerable. If you experience symptoms like confusion, a gazing spell, or Uncontrollable twitching movements of the arms and legs, loss of awareness or consciousness, alterations in emotions, consult a doctor. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

Here are the important food and drink considerations while taking Coxerin Capsule :

  • Alcohol: Drinking alcohol while on this medication significantly increases the risk of severe central nervous system side effects, including seizures.
CYCLOSERINE-250MGCaffeine containing foods/drinks
Severe

Drug-Food Interactions

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CYCLOSERINE-250MGCaffeine containing foods/drinks
Severe
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Co-administration of Cyclosporine and caffeine containing products can lead to increased risk of negative effects. Avoid consumption of caffeine containing products while on Cyclosporine. If you experience symptoms like sleeplessness, irritability, shaking, anxiety, psychoses, and seizures(fits), consult a doctor. Do no stop taking the medication without consulting a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Coxerin Capsule is used to treat tuberculosis. It is also used to treat kidney infections.
Cycloserine is a broad-spectrum antibiotic, which may be bacteriostatic or bactericidal. It works by blocking peptidoglycan's formation (a substance important for forming the cell walls of bacteria). Eventually, the walls of the bacteria become weak and lead to the death of the bacteria.
Do not stop taking Coxerin Capsule despite symptomatic relief. Treat your condition effectually, continue taking Coxerin Capsule for as long as it has been prescribed for you.
Coxerin Capsule might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Coxerin Capsule . Consult your doctor if you have any concerns regarding this, your doctor may suggest an alternate contraception method.
After taking Coxerin Capsule , one may rarely experience mood changes like confusion, depressed mood, unusual thoughts or behaviour. Inform your doctor right away if you notice/experience any of these symptoms.
Cycloserine might interfere with live bacterial vaccines and cause them not to work as well. Do not have any immunizations /vaccinations while on this medication unless you say to.
Coxerin Capsule has been associated in a few instances with vitamin B12 and/or folic acid deficiency, megaloblastic anaemia and sideroblastic anaemia. Consult your doctor for further advice.
Do not use Coxerin Capsule in patients with kidney diseases without consulting your doctor as Coxerin Capsule contains cycloserine, which can affect kidney function. Therefore, please consult your doctor before taking Coxerin Capsule . Your doctor may need to adjust your dose.
No, Coxerin Capsule is not habit-forming. However, it’s important to follow your doctor's instructions regarding the dosage and frequency. Do not exceed the recommended dose.
Coxerin Capsule should be used with caution in patients with liver disease if prescribed by your doctor. Your doctor will need to monitor your condition closely and may adjust the dosage based on your liver function and overall health.
Coxerin Capsule may be taken with or without food as prescribed by your doctor. However, it's important to take it at the same time each day, as directed by your doctor, to maintain consistent levels of Coxerin Capsule in the body.
Coxerin Capsule should not be taken if you are allergic to Coxerin Capsule , if you have a history of seizure disorder and kidney problems. If you have a psychiatric disorder (e.g. depression or anxiety disorder). Please consult your doctor if you have any concerns.
Yes, Coxerin Capsule is a prescription drug. You need a doctor's prescription to buy it.
No, you should avoid alcohol while taking Coxerin Capsule . Consuming alcohol can increase the risk of seizures and may cause adverse reactions such as nausea, dizziness, and fatigue.
The common side effects of Coxerin Capsule are dizziness, drowsiness, mood changes, headache, numbness, and tingling. If any of these side effects persist or worsen, please consult your doctor.
itamin B6 (pyridoxine) is prescribed alongside this medicine to protect your nervous system. It helps prevent side effects like numbness, tingling, tremors, and mental changes. Talk to your doctor to find out the exact dose of Vitamin B6 you should take.
Tingling, numbness, or a "pins and needles" feeling in your extremities can be a sign of nerve irritation. You should contact your doctor right away, as they may need to adjust your dose or check your Vitamin B6 intake. Talk to your doctor before making any changes on your own
This medicine is generally only prescribed during pregnancy if your doctor determines the benefits outweigh the risks to the unborn baby. If you are pregnant, planning to become pregnant, or are currently breastfeeding, talk to your doctor to discuss your treatment options safely.
No, this medicine is reserved for difficult-to-treat, resistant urinary tract infections when standard, safer antibiotics cannot be used. It is not used as a first-line treatment for common or simple bladder infections. Talk to your doctor to determine the most appropriate antibiotic for your condition.

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Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - COX0003
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