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Cotrim 5Ml Inj is a combination medicine used in the treatment of bacterial infections of the urinary tract, respiratory tract, ear, lungs, skin, brain and toxoplasmosis. It contains trimethoprim and sulfamethoxazole which stops the production of tetrahydrofolic acid and dihydrofolic acid and thereby stops the growth of the infection-causing bacteria. Sometimes, your may experience common side effects like headache, nausea, diarrhoea, and skin rashes.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Zyphar's Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cotrim 5Ml Inj

Cotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Cotrim 5Ml Inj does not work against infections caused by the virus, including cold and flu. 

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim and Sulfamethoxazole. Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Cotrim 5Ml Inj will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Cotrim 5Ml Inj, please inform your doctor if you have any allergy (against any antibiotic), severe kidney or liver problems, porphyria (blood disorder), or blood problems which may cause bleeding or bruising. Inform your doctor if you are pregnant or breastfeeding before receiving this injection. Cotrim 5Ml Inj is not recommended for infants below 6 weeks. Keep your doctor informed about your medical history and your ongoing medications to rule out any side effects/interactions.

Uses of Cotrim 5Ml Inj

Cotrim 5Ml Inj is used to treat a variety of bacterial infections. The detailed uses of Cotrim 5Ml Inj are as follows:

  • Urinary tract infections (UTIs): Cotrim 5Ml Inj effectively treats UTIs by targeting and killing bacteria in the urinary tract.
  • Respiratory tract infections: It is used to manage conditions like bronchitis and pneumonia by eliminating the responsible bacterial pathogens.
  • Ear infections (Otitis media): Cotrim 5Ml Inj helps relieve bacterial ear infections, especially in children.
  • Skin and soft tissue infections: It is effective in treating bacterial infections of the skin caused by susceptible organisms.
  • Toxoplasmosis: Cotrim 5Ml Inj is also prescribed in the treatment and prevention of toxoplasmosis, a parasitic infection caused by Toxoplasma gondii:Broad-spectrum antibacterial action: As a combination of Trimethoprim and Sulfamethoxazole, Cotrim 5Ml Inj works synergistically to inhibit the bacterial synthesis of folic acid, which is essential for their growth and survival.

Key Benefits

Cotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Cotrim 5Ml Inj is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Cotrim 5Ml Inj will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Cotrim 5Ml Inj Works

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim and Sulfamethoxazole. Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.
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Alcohol

Caution

Avoid alcohol consumption while taking Cotrim 5Ml Inj to prevent unpleasant side effects.

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Pregnancy

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you are pregnant. Cotrim 5Ml Inj may cause fetal harm. Your doctor will prescribe Cotrim 5Ml Inj only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Cotrim 5Ml Inj as it may cause bilirubin displacement and kernicterus (brain damage resulting from high levels of bilirubin in the blood). Please consult your doctor if you have any concerns.

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Driving

Caution

It is unknown whether Cotrim 5Ml Inj affects your ability to drive and operate machinery. Drive only if you are physically stable and mentally focused.

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Liver

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you have liver impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you have kidney impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Children

Caution

Cotrim 5Ml Inj is not recommended for infants below 6 weeks.

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Heart

Caution

Cotrim 5Ml Inj can be used in heart patients, but with caution due to potential drug interactions. It may increase levels of medications like digoxin or procainamide, so close monitoring is essential.

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Geriatrics

Caution

Geriatric patients can receive Cotrim 5Ml Inj, but it may be more prone to side effects like kidney impairment or electrolyte imbalances. Dose adjustments and regular monitoring help ensure safe use.

What if I have taken an overdose of Cotrim 5Ml Inj

Cotrim 5Ml Inj is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Overdose of Cotrim 5Ml Inj may cause nausea/vomiting, headache, mental depression, confusion, thrombocytopenia, uremia, and loss of appetite. Your doctor will initiate necessary measures when an overdose is suspected.

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

 

Have a query?

How Soon It Starts Working

The time required for Cotrim 5Ml Inj to start to work: The onset time of Cotrim 5Ml Inj has not been clinically established. The time for which the effects of Cotrim 5Ml Inj last: The duration of Cotrim 5Ml Inj’s effect is clinically not established.

What if you forget to take Cotrim 5Ml Inj

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Cotrim 5Ml Inj out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Cotrim 5Ml Inj if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (a rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Cotrim 5Ml Inj if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. 

Drug-Drug Interactions

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Drug-Drug Interactions: Cotrim 5Ml Inj may have interaction with a blood thinner (warfarin), anticonvulsants (phenytoin), digitalis glycoside (digoxin), oral hypoglycemic agents, anti-HIV (zidovudine), anti-arrhythmic (procainamide).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), hematologic (blood) toxicity, hypersensitivity reactions, porphyria (rare blood problem that affects the skin or nervous system), folate deficiency, crystalluria (cloudy urine), dialysis, urinary obstruction, kidney and liver dysfunction.

Drug-Drug Interactions

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How does the drug interact with Cotrim 5Ml Inj:
Using trimethoprim and sulfamethoxazole with BCG vaccine can reduce the effect of BCG vaccine

How to manage the interaction:
Taking Trimethoprim and sulfamethoxazole with BCG vaccine may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cotrim 5Ml Inj:
Taking Losartan with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Losartan with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Bupivacaine with Trimethoprim and sulfamethoxazole can lead to increased risk of side effects.

How to manage the interaction:
Although taking Bupivacaine with sulfamethoxazole and trimethoprim may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience gray coloured skin, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, difficulty in breathing, increased heartrate, anxiety or confusion . Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Clozapine with Trimethoprim and sulfamethoxazole can lead to increased risk of infections.

How to manage the interaction:
Although taking Clozapine with trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience fever, chills, loose stools, muscle pains, shortness or breath, blood in cough fluid, body sores or difficulty while passing urine . Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Irbesartan with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Irbesartan with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking phenytoin with Trimethoprim and sulfamethoxazole can increase the blood levels of Fosphenytoin.

How to manage the interaction:
Although taking phenytoin with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience symptoms like nausea, vomiting, unintentional eye movements, blurred eyesight, difficulty in speaking, loss of body balance, shaking of hands or legs, or confusion. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Tetracaine with Trimethoprim and sulfamethoxazole can lead to increased risk of side effects.

How to manage the interaction:
Although taking Tetracaine with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience gray coloured skin, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, difficulty in breathing, increased heartrate, anxiety or confusion . Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Benazepril with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Benazepril with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Potassium chloride with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Potassium chloride with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Methotrexate with Trimethoprim and sulfamethoxazole can lead to increased risk of infections.

How to manage the interaction:
Although taking Methotrexate with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience fever, chills, loose stools, muscle pains, shortness or breath, blood in cough fluid, body sores or difficulty while passing urine . Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTIC COMBINATION]

FAQs

Cotrim 5Ml Inj belongs to the group of medicines called antibiotics used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Cotrim 5Ml Inj kills the bacteria and stops their growth. Thus, it helps to treat bacterial infections.

Cotrim 5Ml Inj causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Cotrim 5Ml Inj. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, inform your doctor. Do not take anti-diarrheal medicine on your own.

Cotrim 5Ml Inj may affect certain laboratory test results. Inform the lab technician that you are taking Cotrim 5Ml Inj.

Cotrim 5Ml Inj may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Cotrim 5Ml Inj.

Disclaimer

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Author Details

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Country of origin

India

Manufacturer/Marketer address

102/103, Park Plaza, Opp. Kamla Nehru Park, Off. Bhandarkar Road, Pune - 411004, Maharashtra (India)
Other Info - COT0162
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