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compositionComposition:TIPIRACIL-8.19MG+TRIFLURIDINE-20MG
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Prescription Medicine
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Comtripsy 20 Tablet 10's is used to treat certain types of stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) that has spread to other parts of the body in people who have already received at least two different chemotherapy treatments. It contains Trifluridine and Tipiracil, which works by stopping cancer growth. This medicine may cause side effects such as nausea, vomiting, diarrhoea, stomach pain, headache, excessive tiredness, and muscle or bone pain. Let the doctor know if you are taking any other medication, are pregnant or breastfeeding, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TIPIRACIL-8.19MG+TRIFLURIDINE-20MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Comtripsy 20 Tablet 10's

Comtripsy 20 Tablet 10's is a prescription anticancer medicine used to treat adults with advanced colorectal cancer or advanced gastric (stomach) or gastro-oesophageal junction cancer that has spread to other parts of the body. It contains trifluridine and tipiracil and is marketed under brand names such as Lonsurf in many countries, including India. It is usually prescribed when previous cancer treatments are no longer effective or are no longer suitable. This medicine helps slow the growth and spread of cancer cells.

Comtripsy 20 Tablet 10's is taken in treatment cycles, usually twice a day on specific treatment days followed by a planned rest period. Take each dose within 1 hour after finishing your morning and evening meals, exactly as prescribed by your doctor. Staying well hydrated, eating small, frequent meals, and getting adequate rest may help you cope with treatment-related side effects such as fatigue or nausea.

While taking this medicine, your doctor will monitor your blood counts regularly because it can reduce the number of white blood cells, red blood cells, and platelets. Common side effects include nausea, tiredness, diarrhoea, and reduced appetite. Contact your healthcare team immediately if you develop a fever of 38°C or higher, chills, severe vomiting, severe diarrhoea, unusual bruising or bleeding, or any signs of infection.

Before starting treatment, tell your doctor if you have kidney disease, liver disease, or any other long-term medical condition. Do not take this medicine if you are allergic to trifluridine, tipiracil, or any of the other ingredients in this medicine. Do not take this medicine if you are pregnant because it can seriously harm an unborn baby. Breastfeeding is not recommended during treatment or for 1 day after the final dose.

Tell your doctor or pharmacist about all the medicines, vitamins, herbal products, and supplements you are taking before starting treatment. Some medicines may affect how this medicine works or increase the risk of side effects. Women who can become pregnant should use effective contraception during treatment and for at least 6 months after the final dose. Men with female partners who can become pregnant should use effective contraception during treatment and for at least 3 months after the final dose. Older adults may require closer monitoring during treatment.

Uses of Comtripsy 20 Tablet 10's

Your doctor may prescribe Comtripsy 20 Tablet 10's to help manage the following conditions: 

  • Metastatic colorectal cancer: Comtripsy 20 Tablet 10's helps by slowing the growth and spread of colon or rectal cancer cells in patients who have already received other standard chemotherapy treatments.
  • Metastatic gastric or gastroesophageal junction adenocarcinoma: Comtripsy 20 Tablet 10's works to control the progression of stomach cancer or cancer of the area where the esophagus meets the stomach in cases where previous therapies did not stop the disease.

Key Benefits

When used as directed as part of your treatment plan, Comtripsy 20 Tablet 10's may provide the following benefits:

  • Delaying cancer progression: Comtripsy 20 Tablet 10's helps to extend the time during which the cancer does not grow or spread, providing more stable periods of health.
  • Convenient oral administration: Because this medicine comes in tablet form, patients can take their chemotherapy treatment at home rather than requiring continuous intravenous infusions at a clinic.
  • Managing advanced disease: It offers an active treatment option for patients who have already completed other standard chemotherapy lines, helping to manage symptoms of advanced cancer.
Side effects of Comtripsy 20 Tablet
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Comtripsy 20 Tablet 10's can be taken with or without, as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Comtripsy 20 Tablet 10's as a whole with a glass of water.
  • Do not crush, break or chew Comtripsy 20 Tablet 10's.

How Comtripsy 20 Tablet 10's Works

This combination tablet contains two active ingredients that work together to fight cancer cells inside the body. Trifluridine is absorbed directly into the DNA of rapidly growing cancer cells. Once inside, it damages the DNA structure, which prevents the cancer cells from dividing and multiplying. Tipiracil acts as a protective shield. It blocks the natural enzymes in your body that would normally break down the first active ingredient. This keeps the cancer-fighting medicine active in your bloodstream for a longer period, making the overall treatment much more effective.
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Alcohol

Consult your doctor

It is not known whether it is safe to consume alcohol with Comtripsy 20 Tablet 10's. However, as a precautionary measure, it is advisable to limit or avoid alcohol consumption. Consult your doctor for more information.

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Pregnancy

Caution

Consult the doctor before using Comtripsy 20 Tablet 10's in pregnancy as it may harm your fetus.

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Breast Feeding

Caution

If you are breastfeeding, consult the doctor before using Comtripsy 20 Tablet 10's as it may pass into breast milk and harm your infant.

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Driving

Caution

If you are taking Comtripsy 20 Tablet 10's, you should exercise caution when driving or performing any other activity because it may cause fatigue.

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Liver

Caution

Comtripsy 20 Tablet 10's to be taken with caution, especially if you have a pre-existing or a history of liver disease.

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Kidney

Caution

Comtripsy 20 Tablet 10's to be given with caution, especially if you have a pre-existing or a history of kidney disease.

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Children

Consult your doctor

Safety and efficacy have not been established in children. Please consult your doctor about using Comtripsy 20 Tablet 10's in children.

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Heart

Consult your doctor

If you have a heart disease or any related concerns, Please consult your doctor before using Comtripsy 20 Tablet 10's.

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Geriatrics

Consult your doctor

Please consult your doctor before giving Comtripsy 20 Tablet 10's to elderly people.

What if I have taken an overdose of Comtripsy 20 Tablet 10's

In case of an accidental overdose, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating five to six small meals throughout the day instead of three large ones can help you maintain your strength and nutrition.
  • Stay hydrated: Drink plenty of water, clear broths, or electrolyte solutions daily to prevent dehydration, especially if you experience diarrhoea or vomiting.
  • Prioritise rest and gentle movement: Fatigue is a common effect of this treatment. Balance quiet rest periods with light, low-impact activities like short walks to help maintain your energy levels.
  • Practice strict hand hygiene: Because this medicine can lower your white blood cell count, wash your hands frequently with soap and water, and avoid close contact with people who are sick.
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How Soon It Starts Working

The time required for Comtripsy 20 Tablet 10's to start to work: Comtripsy 20 Tablet 10's starts to show its action within 1 hour of administration. The time for which the effects of Comtripsy 20 Tablet 10's last: Comtripsy 20 Tablet 10's effect lasts up to 6-12 hours.

What if you forget to take Comtripsy 20 Tablet 10's

If you miss a dose of Comtripsy 20 Tablet 10's, do not take the missed dose to catch up. Skip the missed dose entirely and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Comtripsy 20 Tablet 10's tablets at room temperature, safely between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Monitor your temperature regularly: A fever may be the first sign of a serious infection caused by low white blood cell counts. Contact your healthcare team immediately if your temperature reaches 38°C or higher.
  • Keep all blood test appointments: Your doctor will regularly check your blood cell counts before and during treatment. Treatment may sometimes be delayed if your white blood cell or neutrophil count becomes too low until it is safe to continue.
  • Handle the tablets carefully: If you are pregnant or planning a pregnancy, avoid handling the tablets. Caregivers should wear disposable gloves when handling the medicine whenever possible.
  • Use effective contraception: Women should use effective contraception during treatment and for at least 6 months after the final dose. Men with partners who could become pregnant should use effective contraception during treatment and for at least 3 months after the final dose.
  • Inspect the tablets before use: Do not take tablets that are broken, cracked, or discoloured.

Drug-Drug Interactions

verifiedApollotooltip
  • Other bone marrow suppressing medicines: Taking Comtripsy 20 Tablet 10's alongside other drugs that lower blood cell counts can increase your risk of severe infections and bleeding. Always provide your pharmacist with a complete list of all your prescription and over-the-counter medications.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Taking with food: Comtripsy 20 Tablet 10's must be taken within one hour after a meal. Taking it on an empty stomach can change how the medicine is absorbed and may decrease its effectiveness or increase side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Comtripsy 20 Tablet 10's is used to treat certain types of stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) that has spread to other parts of the body in people who have already received at least two other chemotherapy treatments.
Comtripsy 20 Tablet 10's works by preventing cancer cells from growing and dividing. Tipiracil is a thymidine phosphorylase inhibitor. It helps by slowing down the breakdown of trifluridine in the body.
Avoid using it if you are allergic to Comtripsy 20 Tablet 10's or any of its components. If you have further information, consult your doctor.
Comtripsy 20 Tablet 10's contains Trifluridine and Tipiracil, primarily used to treat metastatic colorectal cancer who have been previously treated with other treatments like chemotherapy.
Before taking Comtripsy 20 Tablet 10's, it is essential to inform your doctor about any allergies to Comtripsy 20 Tablet 10's or ingredients, current medications, vitamins, and supplements, and your medical history, including conditions like low blood cell counts, anemia, bleeding problems, and liver or kidney disease. Additionally, tell your doctor if you are pregnant or plan to become pregnant or if you are breastfeeding.
No, you should not stop taking Comtripsy 20 Tablet 10's even if you feel better. Always follow the duration prescribed by your doctor to treat your medical condition effectively.
Yes, Comtripsy 20 Tablet 10's may cause constipation. If you experience this symptom, drink plenty of water to stay hydrated, eat a fibre-rich diet, limit processed foods, manage stress, and exercise regularly.
The common side effects of Comtripsy 20 Tablet 10's include nausea, vomiting, diarrhea, stomach pain, headache, excessive tiredness, and muscle or bone pain. Most of these side effects of Comtripsy 20 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
No, you should not crush, chew, or split Comtripsy 20 Tablet 10's tablets. They must be swallowed whole to ensure the medicine is released correctly in your body. If you cannot swallow them whole, talk to your doctor.
If you vomit after taking your dose, do not take an additional dose to replace it. Simply take your next scheduled dose at your normal time and inform your healthcare team. Talk to your doctor if you experience persistent vomiting.
You should avoid or significantly limit alcohol while taking Comtripsy 20 Tablet 10's. Alcohol can worsen side effects like nausea, dehydration, and fatigue, and may put extra strain on your liver. Talk to your doctor for personalised advice.
Your doctor will determine how many cycles of Comtripsy 20 Tablet 10's you need based on how your body responds to the treatment and whether you experience any severe side effects. Talk to your doctor to understand your specific treatment plan.
Some patients experience temporary hair thinning or hair loss while taking Comtripsy 20 Tablet 10's, though it is typically less severe than with some other chemotherapies. Talk to your doctor if you have concerns about hair loss.
You should avoid live vaccines while taking this medicine, as your immune system may be weakened. Always consult your doctor before receiving any vaccine during your treatment.
Taking Comtripsy 20 Tablet 10's after food helps your body absorb the medicine properly and reduces the risk of stomach irritation and nausea. Always take it within 1 hour after finishing your morning and evening meals.
Comtripsy 20 Tablet 10's can cause severe fatigue or weakness in some people. If you feel tired, dizzy, or weak, avoid driving or operating machinery until you feel fully alert. Talk to your doctor if these symptoms persist.
Do not take this medicine if you are allergic to trifluridine, tipiracil, or any of its ingredients, or if you are pregnant. Breastfeeding is not recommended during treatment. Your doctor may also delay or temporarily stop treatment if your blood tests show very low blood cell counts until it is safe to restart. Consult your healthcare team if you are unsure whether this medicine is suitable for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Lonsurf Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A615049 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 207981S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Trifluridine and Tipiracil [Prescribing Information]. 2019. [Accessed on 25th Nov. 2022]Check here
  5. Trifluridine and Tipiracil [Summary of Product Characteristics]. 2016. [Accessed on 25th Nov. 2022]Check here
  6. Taiho Pharma Canada, Inc. [Revised on January 23, 2018] [Accessed on September 12th, 2024] pm/00043592.PDFCheck here
  7. Lonsurf. [Accessed on September 12th, 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - COM0835
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