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  3. Comtripsy 20 Tablet 10's

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Comtripsy 20 Tablet 10's, Pack of 1
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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Comtripsy 20 Tablet 10's is used to treat certain types of stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) that has spread to other parts of the body in people who have already received at least two different chemotherapy treatments. It contains Trifluridine and Tipiracil, which works by stopping cancer growth. This medicine may cause side effects such as nausea, vomiting, diarrhoea, stomach pain, headache, excessive tiredness, and muscle or bone pain. Let the doctor know if you are taking any other medication, are pregnant or breastfeeding, or have any pre-existing medical conditions.

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Synonym :

LONSURF

Composition :

TIPIRACIL-8.19MG + TRIFLURIDINE-20MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Comtripsy 20 Tablet 10's

Comtripsy 20 Tablet 10's is a combination medication that contains Trifluridine, a nucleoside metabolic inhibitor, and Tipiracil, a thymidine phosphorylase inhibitor. It is used to treat patients with metastatic colorectal cancer who have been previously treated with other treatments, like chemotherapy.

Comtripsy 20 Tablet 10's is a combination medication that contains Trifluridine and Tipiracil. Trifluridine belongs to a group of drugs known as thymidine-based nucleoside analogues. It works by preventing cancer cells from growing and dividing. Tipiracil is a thymidine phosphorylase inhibitor. It helps by slowing down the breakdown of trifluridine in the body. Thus, it stays active longer and works more effectively against cancer cells.

Take Comtripsy 20 Tablet 10's in the dose and duration as advised by your doctor. Taking food with food at a fixed time is recommended to achieve maximum effect. Sometimes, you may experience nausea, vomiting, diarrhoea, stomach pain, headache, excessive tiredness, and muscle or bone pain. Most of these side effects of Comtripsy 20 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor. Please consult your doctor immediately if you experience any allergic reactions or unusual symptoms.

It is not advisable to stop taking Comtripsy 20 Tablet 10's suddenly to avoid unpleasant side effects. The full course prescribed by the doctor should be completed. Inform your doctor if you have low white blood cell counts, anemia, bleeding problems, or liver and kidney disease.

Uses of Comtripsy 20 Tablet 10's

Comtripsy 20 Tablet 10's is used in the treatment of metastatic colorectal cancer. The detailed use of Comtripsy 20 Tablet 10's is as follows:

  • Treatment of cancer: Comtripsy 20 Tablet 10's is used primarily for the treatment of metastatic colorectal cancer and gastric cancer.

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Directions for Use

  • Comtripsy 20 Tablet 10's can be taken with or without, as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Comtripsy 20 Tablet 10's as a whole with a glass of water.
  • Do not crush, break or chew Comtripsy 20 Tablet 10's.

Medicinal Benefits

Comtripsy 20 Tablet 10's is a combination medication, containing Trifluridine and Tipiracil. Trifluridine belongs to a group of drugs known as thymidine-based nucleoside analogues. It works by preventing cancer cells from growing and dividing. Tipiracil is a thymidine phosphorylase inhibitor. It helps by slowing down the breakdown of trifluridine in the body.

How Comtripsy 20 Tablet 10's Works

Comtripsy 20 Tablet 10's is a combination medication that contains Trifluridine and Tipiracil. Trifluridine belongs to a group of drugs known as thymidine-based nucleoside analogues. It works by preventing cancer cells from growing and dividing. Tipiracil is a thymidine phosphorylase inhibitor. It helps by slowing down the breakdown of trifluridine in the body. Collectively, they help prevent the disease effectively.

Storage

• Store in a cool and dry place away from sunlight.• keep it away from children's reach.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Comtripsy 20 Tablet
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Comtripsy 20 Tablet 10's

Do not take more than the recommended dose, as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Inform your doctor if you are allergic to Trifluridine, Tipiracil, or any other of its components. Please inform your doctor if you face any difficulty while taking Comtripsy 20 Tablet 10's. Inform your doctor if you have low white blood cell counts, anemia, bleeding problems, or liver and kidney disease. Inform your doctor if you are pregnant or plan to become pregnant or breastfeed. Monitor blood counts regularly and adjust treatment as needed. Do not take any vaccines without a doctor’s advice, as they may interact. Always wear gloves to prevent exposure while handling Comtripsy 20 Tablet 10's.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat foods rich in antioxidants, such as berries, spinach, kidney beans, dark chocolate, and those with high fiber content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Consult your doctor

It is not known whether it is safe to consume alcohol with Comtripsy 20 Tablet 10's. However, as a precautionary measure, it is advisable to limit or avoid alcohol consumption. Consult your doctor for more information.

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Pregnancy

Caution

Consult the doctor before using Comtripsy 20 Tablet 10's in pregnancy as it may harm your fetus.

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Breast Feeding

Caution

If you are breastfeeding, consult the doctor before using Comtripsy 20 Tablet 10's as it may pass into breast milk and harm your infant.

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Driving

Caution

If you are taking Comtripsy 20 Tablet 10's, you should exercise caution when driving or performing any other activity because it may cause fatigue.

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Liver

Caution

Comtripsy 20 Tablet 10's to be taken with caution, especially if you have a pre-existing or a history of liver disease.

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Kidney

Caution

Comtripsy 20 Tablet 10's to be given with caution, especially if you have a pre-existing or a history of kidney disease.

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Children

Consult your doctor

Safety and efficacy have not been established in children. Please consult your doctor about using Comtripsy 20 Tablet 10's in children.

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Heart

If you have a heart disease or any related concerns, Please consult your doctor before using Comtripsy 20 Tablet 10's.

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Geriatrics

Consult your doctor

Please consult your doctor before giving Comtripsy 20 Tablet 10's to elderly people.

FAQs

Comtripsy 20 Tablet 10's is used to treat certain types of stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) that has spread to other parts of the body in people who have already received at least two other chemotherapy treatments.

Comtripsy 20 Tablet 10's works by preventing cancer cells from growing and dividing. Tipiracil is a thymidine phosphorylase inhibitor. It helps by slowing down the breakdown of trifluridine in the body.

Avoid using it if you are allergic to Comtripsy 20 Tablet 10's or any of its components. If you have further information, consult your doctor.

Comtripsy 20 Tablet 10's contains Trifluridine and Tipiracil, primarily used to treat metastatic colorectal cancer who have been previously treated with other treatments like chemotherapy.

Before taking Comtripsy 20 Tablet 10's, it is essential to inform your doctor about any allergies to Comtripsy 20 Tablet 10's or ingredients, current medications, vitamins, and supplements, and your medical history, including conditions like low blood cell counts, anemia, bleeding problems, and liver or kidney disease. Additionally, tell your doctor if you are pregnant or plan to become pregnant or if you are breastfeeding.

No, you should not stop taking Comtripsy 20 Tablet 10's even if you feel better. Always follow the duration prescribed by your doctor to treat your medical condition effectively.

Yes, Comtripsy 20 Tablet 10's may cause constipation. If you experience this symptom, drink plenty of water to stay hydrated, eat a fibre-rich diet, limit processed foods, manage stress, and exercise regularly.

The common side effects of Comtripsy 20 Tablet 10's include nausea, vomiting, diarrhea, stomach pain, headache, excessive tiredness, and muscle or bone pain. Most of these side effects of Comtripsy 20 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - COM0835

Disclaimer

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Reference

  1. https://www.drugs.com/pro/lonsurf.html#s-43684-0
  2. https://medlineplus.gov/druginfo/meds/a615049.html#other-uses
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207981s000lbl.pdf

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