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Combunex 800 Tablet belongs to the group of medications called ‘antituberculosis agents’ primarily used in the treatment of tuberculosis (TB). Tuberculosis is an infectious bacterial disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Combunex 800 Tablet does not work against infections caused by the virus.
Combunex 800 Tablet contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating). Thereby, bacteria get killed without a cell wall and burst due to disruption in their metabolism.
Take Combunex 800 Tablet exactly as prescribed by the doctor. Combunex 800 Tablet may cause side effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side effects persist or get worse.
It is not recommended to take Combunex 800 Tablet if you are allergic to any contents of it. Combunex 800 Tablet is not recommended for patients with severe liver problems and sight problems. Before taking Combunex 800 Tablet , inform your doctor if you have kidney problems, epilepsy (fits), diabetes, alcohol abuse, psychosis, malnourishment, HIV infection, and extra-pulmonary TB (TB infection outside the lungs). Combunex 800 Tablet should be used with caution in pregnant and breastfeeding women. Dose adjustments may be required in children and elderly people. Combunex 800 Tablet may interact with alcohol and increase the risk of liver damage. Combunex 800 Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.
Combunex 800 Tablet is used in the treatment of Tuberculosis. The detailed uses of Combunex 800 Tablet are as follows:
Combunex 800 Tablet contains Isoniazid and Ethambutol, which is a fixed-dose combination used to treat tuberculosis (TB). Combination therapy reduces the development of drug resistance (reduction in the effectiveness of medication) as the bacteria causing TB develops drug resistance easily when monotherapy is given even for shorter periods. Combunex 800 Tablet helps to reduce the symptoms and control the disease effectively.
Caution
Consumption of alcohol may increase the risk of side-effects and worsen the condition.
Caution
Combunex 800 Tablet should be used with caution in pregnant women. It is given to pregnant women only if clinically needed when the benefits outweigh the risks.
Caution
Combunex 800 Tablet should be used with caution in breastfeeding mothers. It is given to breastfeeding mothers only when the benefits outweigh the risks.
Caution
Combunex 800 Tablet may cause dizziness in some people. So, do not drive or operate heavy machinery if you are not fully alert.
Caution
Combunex 800 Tablet is not recommended for patients with severe liver problems. In mild to moderate liver diseases, the dose may have to be adjusted by your doctor.
Caution
Combunex 800 Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.
Caution
Combunex 800 Tablet should be used with caution in children. The dose may have to be adjusted based on age, body weight and healthy history of the child.
Caution
Combunex 800 Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.
Consult your doctor
Combunex 800 Tablet should be given to elderly patients only if recommended by a doctor. Please consult your doctor before using Combunex 800 Tablet .
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It is advised to get your eyesight checked before taking Combunex 800 Tablet . If you notice any changes in your vision while using this medicine, stop taking this medicine and immediately inform your doctor. In most cases, the vision change is temporary and sight returns to normal. However, it might take a longer time for eyesight to recover in some cases or the change might be permanent. If you develop jaundice (yellowing of the skin and whites of the eyes), loss of appetite, nausea, vomiting, or malaise, inform your doctor immediately, as these effects may be a sign of hepatitis (liver disease). In these cases, the doctor may advise you to undergo liver function tests and provide the necessary treatment.
Drug-Drug Interactions: Combunex 800 Tablet may interact with antacid (aluminium hydroxide), anti-HIV drug (stavudine), medicines used to treat fits (carbamazepine, phenytoin, and primidone), a medicine used to treat alcoholism (disulfiram), other antitubercular drugs (rifampicin and para-aminosalicylic acid), an anti-anxiety medication (diazepam), a medicine used to treat Parkinson’s disease (levodopa), and antifungal drugs (itraconazole and ketoconazole).
Drug-Food Interactions: Avoid alcohol consumption with Combunex 800 Tablet as it may increase the risk of liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, fish such as tuna, salmon, mackerel, wine and beer while taking Combunex 800 Tablet . The interaction of Combunex 800 Tablet with these foods may result in dizziness, headache, uneven heartbeat and flushing (reddening of the skin).
Drug-Disease Interactions: Combunex 800 Tablet is not recommended for use in patients with severe liver problems and eyesight problems. It should be used with caution in patients with kidney problems, epilepsy (fits), diabetes, alcohol abuse, psychosis, malnourishment, HIV infection and extra-pulmonary TB (TB infection outside the lungs).
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Combunex 800 Tablet is used in the treatment of tuberculosis (TB).
Combunex 800 Tablet contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating, which is necessary for bacteria's survival).
It is advised to take Combunex 800 Tablet on an empty stomach. So, you should take this medicine at least 30 minutes before a meal or after 2 hours of taking a meal for better absorption.
You are recommended to avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, fish such as tuna, salmon and mackerel, wine and beer as they may interact with Combunex 800 Tablet and cause adverse effects such as sweating, headache, dizziness, flushing (reddening of the skin) and uneven heartbeat.
Combunex 800 Tablet may cause side-effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side-effects persist or get worse.
Combunex 800 Tablet may affect liver function, so it is not prescribed in patients with severe liver problems and alcohol abuse unless clinically needed. Also, do not consume excessive amounts of alcohol while using Combunex 800 Tablet as it may increase the risk of liver damage.
Yes, ethambutol in Combunex 800 Tablet may rarely cause vision problems like blurred/decreased vision, color blindness. Consult your doctor immediately if there is a problem in vision.
Yes, Combunex 800 Tablet can affect the action of birth control pills. Combunex 800 Tablet contains isoniazid and ethambutol, which can increase the breakdown of hormones in birth control pills, making them less effective. This could potentially result in an unwanted pregnancy. Please discuss with your doctor if you have any concerns.
No, do not stop taking Combunex 800 Tablet even if you feel better as it can result in the infection not being fully treated and potentially developing drug resistance. Therefore, complete the full course of treatment as prescribed by your doctor.
Yes, Combunex 800 Tablet can cause urine discolouration. As Combunex 800 Tablet contains isoniazid and ethambutol, which can lead to dark-coloured urine as a common but non-harmful side effect. If the discolouration persists, please consult your doctor.
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