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Combimist LD Respule 5X2.5 ml is used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD), like shortness of breath, coughing or wheezing (whistling sound while breathing). It contains Levosalbutamol and Ipratropium bromide, which work by relaxing muscles and widening the airways of the lungs. Some people may experience headache, sore throat, dry mouth, runny or stuffy nose, cough with mucus, and vomiting. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Bayer Zydus Pharma Pvt Ltd

Consume Type :

Inhalation

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combimist LD Respule 5X2.5 ml

Combimist LD Respule 5X2.5 ml is a prescription inhalation medicine used to relieve breathing difficulties in people with chronic obstructive pulmonary disease (COPD) and asthma. It works by opening up the airways in your lungs, making it much easier to breathe during flare-ups. This medicine helps manage symptoms like wheezing, shortness of breath, and chest tightness.

Your doctor will determine how often you need to use this medicine, but it is typically taken on a regular schedule or as needed for sudden breathing issues. Because it is inhaled directly into the lungs using a nebulizer machine, its action is not affected by food, meaning you can take it before or after meals. To get the best results, it is highly beneficial to combine this treatment with lifestyle changes like avoiding environmental triggers and stopping smoking.

While using Combimist LD Respule 5X2.5 ml, you may experience mild, temporary side effects like dry mouth, a mild cough, or slight shakiness in your hands. Most people tolerate it well, but you should contact your doctor immediately if you notice serious issues such as a rapid heart rate, chest pain, or severe dizziness.

Talk to your doctor before starting this medicine if you have a history of heart problems, high blood pressure, diabetes, thyroid disorders, or glaucoma. Do not take this if you are allergic to any of the active ingredients, atropine, or similar medicines.

Certain medicines, like beta-blockers used for blood pressure, can block the effects of Combimist LD Respule 5X2.5 ml, while drinking alcohol or smoking can worsen lung irritation and increase your heart rate. If you are pregnant, breastfeeding, or managing health conditions in your older years, please consult your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Combimist LD Respule 5X2.5 ml

This medicine is used to relax the airway muscles and improve airflow, helping relieve breathing difficulties associated with obstructive lung diseases. The detailed uses of Combimist LD Respule 5X2.5 ml are as follows:

  • Chronic Obstructive Pulmonary Disease (COPD): Combimist LD Respule 5X2.5 ml helps relax and widen the airways, making it easier to breathe for people with chronic bronchitis or emphysema.
  • Asthma: Combimist LD Respule 5X2.5 ml helps relieve bronchospasm, reducing wheezing, chest tightness, and shortness of breath during asthma symptoms, as prescribed by a doctor.
     

Key Benefits

Combimist LD Respule 5X2.5 ml helps improve breathing by opening the airways and providing effective relief from symptoms of obstructive airway diseases. Its benefits include:

  • Helps relax and widen the airways, providing rapid relief from wheezing, chest tightness, and shortness of breath.
  • Improves airflow, making it easier to breathe and perform daily activities with greater comfort.
  • Helps reduce the frequency and severity of breathing flare-ups when used regularly as prescribed.
  • Delivers the medicine directly to the lungs through inhalation, allowing it to act quickly at the site of action.
  • Uses a lower inhaled dose than oral medicines, which helps reduce the risk of body-wide side effects while providing effective symptom control.
Side effects of Combimist LD Respule 5X2.5 ml
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consult your doctor to identify the medication causing abnormal contractions of your gut, and consider reducing the dosage or switching to alternative drugs with fewer side effects.
  • Your doctor may recommend medications to help with your symptoms, like anticholinergics, antispasmodics, or prokinetic agents.
  • Avoid foods high in fibre, like oranges and broccoli, as they may cause a blockage in your gut.
  • Gradually add more fibre to your diet by eating vegetables, whole grains, fruits, and beans to help improve your bowel movements.
  • Eat smaller meals throughout the day to reduce stress on your digestive system.
  • Choose low-fat foods and cook fruits and vegetables well to make them easier to digest.
  • Drink lots of water or other fluids to help with your digestion.
  • Try moderate exercise and stress-relief activities like deep breathing or meditation to help keep your gut running smoothly.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use as advised by the doctor. Twist off the top of the respule and squeeze the solution into the nebuliser. This solution is formulated into a fine mist for inhalation. Inhale the medicine through the nebuliser's mouthpiece.
  • The respule should be opened only before actual use, and any solution remaining after use should be discarded.
  • To prevent any fungal infections in your mouth and throat, gargle with warm water after each inhalation.

How Combimist LD Respule 5X2.5 ml Works

Combimist LD Respule 5X2.5 ml contains Levosalbutamol and Ipratropium bromide. Levosalbutamol: It is a short-acting bronchodilator that stimulates beta-2 receptors in the airway muscles, causing them to relax. This quickly widens the airways, improves airflow, and relieves symptoms such as wheezing, chest tightness, and shortness of breath. Ipratropium Bromide: It is an anticholinergic bronchodilator that blocks the action of acetylcholine, a chemical messenger that causes the airway muscles to tighten. This helps keep the airways open and may also reduce mucus secretion in the airways.
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Alcohol

Consult your doctor

The interaction of Combimist LD Respule 5X2.5 ml with alcohol is unknown. Please consult a doctor before consuming alcohol with Combimist LD Respule 5X2.5 ml.

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Pregnancy

Consult your doctor

The safety of Combimist LD Respule 5X2.5 ml in pregnant women is unknown. Please consult your doctor if you are pregnant. It is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Combimist LD Respule 5X2.5 ml is excreted in human milk. Please consult your doctor if you are breastfeeding. It is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Combimist LD Respule 5X2.5 ml may cause blurred vision or dizziness in some people. Therefore, avoid driving if you notice any changes in vision or feel dizzy after taking Combimist LD Respule 5X2.5 ml.

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Liver

Caution

Combimist LD Respule 5X2.5 ml should be used with caution in patients with liver impairment. If you have any concerns regarding the use of Combimist LD Respule 5X2.5 ml in patients with liver problems, please consult a doctor.

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Kidney

Caution

Dose adjustment may be needed. If you have any concerns regarding the use of Combimist LD Respule 5X2.5 ml in patients with kidney problems, please consult a doctor.

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Children

Consult your doctor

The safety of Combimist LD Respule 5X2.5 ml in children below 12 years is unknown. Please consult a doctor before giving Combimist LD Respule 5X2.5 ml to children.

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Heart

Caution

Combimist LD Respule 5X2.5 ml should be used with caution in patients with heart disease due to increased risk of side effects. Therefore please consult your doctor before using Combimist LD Respule 5X2.5 ml.

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Geriatrics

Consult your doctor

Combimist LD Respule 5X2.5 ml can be used in elderly patients; however, consult your healthcare provider to determine the appropriate dose and duration of treatment.

What if I have taken an overdose of Combimist LD Respule 5X2.5 ml

If you use too much of this medicine, you may experience severe shakiness, chest pain, a rapid heart rate, or a severe headache. Seek immediate medical attention or call your local poison control center if you suspect an overdose.

Diet & Lifestyle Advise

  • Avoid respiratory triggers: Stay indoors when air pollution or pollen counts are high, and avoid exposure to dust, pet dander, and strong chemicals.
  • Avoid tobacco smoke: Stop smoking and avoid areas with secondhand smoke, as smoke damages lung tissue and makes your medication less effective.
  • Stay hydrated: Drink plenty of water throughout the day to help thin the mucus in your lungs, making it easier to clear.
  • Practice deep breathing: Learn techniques like pursed-lip breathing from a physical therapist to help improve your lung capacity and manage shortness of breath.
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How Soon It Starts Working

The time required for Combimist LD Respule 5X2.5 ml to start to work: Combimist LD Respule 5X2.5 ml ideally shows its action within 5 to 15 minutes after inhalation. The time for which the effects of Combimist LD Respule 5X2.5 ml last: The effect of Combimist LD Respule 5X2.5 ml lasts for 4 to 6 hours.

What if you forget to take Combimist LD Respule 5X2.5 ml

If you miss a scheduled dose, use it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular routine. Do not use two doses at the same time to make up for a missed one.

Storage

•Store Combimist LD Respule 5X2.5 ml respules below 25°C in a dry place.

Drug Warnings

  • Check the liquid first: Always inspect the solution before use. It should be clear and colorless; do not use it if it looks cloudy, discolored, or contains visible particles.
  • Never swallow or inject: This medicine is strictly for inhalation through a nebulizer. It must never be swallowed or injected.
  • Protect your eyes: Keep the nebulizer mist away from your eyes. Use a mouthpiece or a tight-fitting mask, as the medicine can cause eye irritation or trigger narrow-angle glaucoma if it enters the eyes.
  • Keep equipment clean: Wash and dry your nebulizer chamber and mask after every use to prevent the growth of bacteria that can cause lung infections.
  • Rinse and spit: Always rinse your mouth with plain water and spit it out after your inhalation session to prevent dry mouth and throat irritation.

Drug-Drug Interactions

verifiedApollotooltip
  • Beta-blockers (like propranolol or metoprolol): May block the airway-dilating effects of Combimist LD Respule 5X2.5 ml, which can cause severe narrowing of the airways in people with asthma or COPD.
  • Diuretics (water pills): May increase the risk of low potassium levels in your blood when used together with this medicine.
  • Other bronchodilators: May increase the risk of cardiovascular side effects, such as a rapid heart rate and tremors.

Drug-Drug Interactions

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How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with nadolol can decrease the bronchodilatory activities(relaxation of bronchial smooth muscle in order to alleviate respiratory symptoms of conditions such as asthma) of Levosalbutamol, leading to breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol, and nadolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with levobunolol can decrease the effectiveness of both medications, which leads to an increased risk of breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and levobunolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with propranolol can decrease the bronchodilatory activities(relaxation of bronchial smooth muscle in order to alleviate respiratory symptoms of conditions such as asthma) of Levosalbutamol, leading to breathing problems.

How to manage the interaction:
Although there is an interaction between propranolol, ipratropium bromide, and levosalbutamol, they can be taken together if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Coadministration of ipratropium bromide and levosalbutamol with penbutolol can increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and penbutolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with timolol can decrease the bronchodilatory activities(relaxation of bronchial smooth muscle in order to alleviate respiratory symptoms of conditions such as asthma) of Levosalbutamol, leading to breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and timolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Coadministration of ipratropium bromide and levosalbutamol with ribociclib can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and ribociclib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe or prolonged diarrhea or vomiting, dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Coadministration of ipratropium bromide and levosalbutamol with metipranolol can increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and metipranolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with labetalol can decrease the effectiveness levosalbutamol, which leads to an increased risk of breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and labetalol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with Pindolol can decrease the bronchodilatory activities(relaxation of bronchial smooth muscle in order to alleviate respiratory symptoms of conditions such as asthma) of Levosalbutamol, leading to breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol and pindolol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combimist LD Respule 5X2.5 ml:
Taking ipratropium bromide and levosalbutamol with sotalol can decrease the bronchodilatory activities(relaxation of bronchial smooth muscle in order to alleviate respiratory symptoms of conditions such as asthma) of Levosalbutamol, leading to breathing problems.

How to manage the interaction:
Although there is an interaction between ipratropium bromide, levosalbutamol, and sotalol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Consuming large amounts of coffee, tea, or caffeinated sodas while using this medicine can increase the risk of side effects like a rapid heart rate and shakiness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[BRONCHODILATOR]

FAQs

Combimist LD Respule 5X2.5 ml is used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD), like shortness of breath, coughing or wheezing (whistling sound while breathing).
Combimist LD Respule 5X2.5 ml is a combination of two bronchodilators: Levosalbutamol and Ipratropium bromide. It works by relaxing muscles and widening the airways of the lungs. Thereby, Combimist LD Respule 5X2.5 ml makes breathing easier.
Combimist LD Respule 5X2.5 ml should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Combimist LD Respule 5X2.5 ml as it may increase blood sugar levels.
Combimist LD Respule 5X2.5 ml should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if you have hyperthyroidism before taking Combimist LD Respule 5X2.5 ml so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Combimist LD Respule 5X2.5 ml.
No, Combimist LD Respule 5X2.5 ml does not relieve sudden symptoms such as shortness of breath. Therefore, it is advised to carry a rescue inhaler always to treat sudden symptoms.
Combimist LD Respule 5X2.5 ml may cause side effects such as headache, sore throat, dry mouth, and respiratory issues like cough, sneezing, and difficulty breathing. Other possible side effects include dizziness, nervousness, tiredness, irregular heartbeats, and vomiting. In most cases, these side effects are temporary and resolve on their own. However, if they persist or worsen, it's essential to consult your doctor for proper guidance.
No, you are not recommended to stop using Combimist LD Respule 5X2.5 ml without consulting your doctor, as it may worsen the condition or cause recurring symptoms. Therefore, take Combimist LD Respule 5X2.5 ml for as long as your doctor has prescribed it, and if you experience any difficulty while taking Combimist LD Respule 5X2.5 ml, please consult your doctor.
No, the liquid inside the respule is designed strictly for inhalation using a nebulizer machine. Swallowing the medicine will not help your breathing and can cause serious side effects. If the medicine is swallowed by accident, contact a doctor or seek medical help immediately.
If the mist gets into your eyes, rinse them immediately with cool, clean water. This medicine can cause blurred vision or increase pressure in your eyes, especially if you have glaucoma. If you experience eye pain or changes in your vision, talk to your doctor right away.
You should use this medicine with caution if you have high blood pressure or heart problems. One of the active ingredients can occasionally increase your heart rate or blood pressure. Talk to your doctor to ensure this medicine is safe for your specific cardiovascular health.
Rinsing your mouth and throat with water and spitting it out after each nebulizer session is highly recommended. This simple step helps prevent common local side effects like dry mouth, throat irritation, and hoarseness.
The safety of this medicine during pregnancy or breastfeeding is not fully established. It should only be used if the potential benefit justifies the potential risk to the baby. Talk to your doctor before starting this medicine if you are pregnant or nursing.
You should never mix different liquid medicines in your nebulizer chamber unless your doctor has specifically instructed you to do so. Mixing certain medications can make them less effective or cause unwanted chemical reactions. Talk to your doctor or pharmacist if you have questions about your nebulizer routine.

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Country of origin

India

Manufacturer/Marketer address

Bayer Ag, Mã¼Llerstr. 178, 13353 Berlin
Other Info - COM0657
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