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  3. Coldnac 650/10/4/30 Tab 10'S

Coldnac 650/10/4/30 Tab 10'S, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Coldnac 650/10/4/30 Tab is used to treat the common cold and allergic symptoms like sneezing, watery eyes, or itchy/watery nose and throat. It works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps in shrinking the blood vessels in the nasal passage, thereby reducing the stuffy nose. Also, it inhibits the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever. Some people may experience drowsiness, sleepiness, nausea, fatigue, difficulty in sleeping, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

CAFFEINE-30MG + CHLORPHENIRAMINE-4MG + PARACETAMOL-650MG + PHENYLEPHRINE-10MG

Manufacturer/Marketer :

Kristal Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Coldnac 650/10/4/30 Tab

Coldnac 650/10/4/30 Tab is used to treat the common cold and allergic symptoms like sneezing, watery eyes, or itchy/watery nose and throat. The common cold is a respiratory illness affecting the nose and throat, caused mainly by viruses known as 'rhinovirus.' The virus attacks the body through the mouth, nose, or eyes and spreads quickly through droplets in the air when a person who is sick sneezes, coughs, or talks.

Coldnac 650/10/4/30 Tab contains Chlorpheniramine (an antihistamine), Phenylephrine (a decongestant), Paracetamol (a mild analgesic and antipyretic), and Caffeine (a stimulant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that work by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing the stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins', responsible for pain and fever. Caffeine acts as a common stimulant, decreasing sleepiness caused by Chlorpheniramine and speeding up the action of all medicines in Coldnac 650/10/4/30 Tab .

Your doctor will recommend how often you take Coldnac 650/10/4/30 Tab based on your medical condition. Some people may experience drowsiness, sleepiness, nausea, fatigue, difficulty sleeping, and headaches. Most of these side effects may not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult the doctor.

Inform your doctor if you are pregnant, planning for pregnancy, or breastfeeding before starting Coldnac 650/10/4/30 Tab . If you have high blood pressure (hypertension),  liver or kidney disease, or coronary artery disease (heart disease), avoid using Coldnac 650/10/4/30 Tab as it may worsen your existing condition and symptoms. Consumption of alcohol should be avoided as it may lead to excessive drowsiness and sleepiness.

Uses of Coldnac 650/10/4/30 Tab

Coldnac 650/10/4/30 Tab is used in the treatment of the common cold and allergies. The detailed uses of Coldnac 650/10/4/30 Tab are as follows:

  • Common Cold: Coldnac 650/10/4/30 Tab helps relieve symptoms like blocked nose, sneezing, runny nose, and watery eyes and reduces nasal congestion and improves breathing.
  • Sinusitis: Coldnac 650/10/4/30 Tab alleviates sinus pain and pressure caused by inflammation, helps clear mucus buildup in the sinuses.
  • Allergic Rhinitis (Hay Fever): Coldnac 650/10/4/30 Tab treats seasonal allergies triggered by pollen, dust, or pet dander and reduces itchy nose, throat irritation, and sneezing.
  • Upper Respiratory Tract Infections: Coldnac 650/10/4/30 Tab provides relief from cough, sore throat, and chest congestion, helps manage mild fever and headaches associated with infections.
  • Nasal Congestion Due to Allergies: Coldnac 650/10/4/30 Tab shrinks swollen blood vessels in the nasal passages to improve airflow and eases breathing difficulties caused by allergic reactions.

Directions for Use

• Coldnac 650/10/4/30 Tab can be taken with or without food, as advised by your doctor. • Follow your doctor's instructions on the dosage and timing of this medication. • Swallow Coldnac 650/10/4/30 Tab as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Coldnac 650/10/4/30 Tab is primarily used to treat common cold symptoms and allergic symptoms like sneezing, watery eyes, or itchy/watery nose and throat. It is composed of four medicines: Chlorpheniramine (anti-histamine), Phenylephrine (decongestant), Paracetamol (mild analgesic and antipyretic), and Caffeine (a stimulant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels in the nasal passage, thereby reducing stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever. Caffeine acts as a common stimulant, which decreases sleepiness caused by Chlorpheniramine and speeds up the action of all the medicines present in Coldnac 650/10/4/30 Tab . 

How Coldnac 650/10/4/30 Tab Works

Coldnac 650/10/4/30 Tab is composed of Chlorpheniramine (an antihistamine), Phenylephrine (a decongestant), Paracetamol (a mild analgesic and antipyretic), and Caffeine (a stimulant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that work by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps shrink the blood vessels in the nasal passage, thereby reducing the stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins', responsible for pain and fever. Caffeine acts as a common stimulant, which decreases sleepiness caused by Chlorpheniramine and speeds up the action of all medicines in Coldnac 650/10/4/30 Tab .

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Coldnac 650/10/4/30 Tab

Do not take more than the prescribed dose of Coldnac 650/10/4/30 Tab as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Please tell your doctor if you are allergic to Coldnac 650/10/4/30 Tab or any other medicines. If you are pregnant, it is advised to inform your doctor before using Coldnac 650/10/4/30 Tab . Do not use Coldnac 650/10/4/30 Tab in breastfeeding mothers without a doctor’s advice, as it contains caffeine, which may be excreted in breast milk and cause harm to the baby. Coldnac 650/10/4/30 Tab is not recommended for children below 4 years. Please do not take more than the prescribed dose of Coldnac 650/10/4/30 Tab as it may cause liver damage and can be lethal.  If you have high blood pressure, diabetes, hyperthyroidism (overactive thyroid), asthma, chronic obstructive pulmonary disease (COPD), stomach ulcer, enlarged prostate gland,  kidney, liver, heart, or urinary problems, inform your doctor before taking Coldnac 650/10/4/30 Tab . Do not take Coldnac 650/10/4/30 Tab if you have taken an MAO inhibitor (antidepressant medication) in the past 14 days. Also, avoid the intake of chocolate, alcohol, and caffeine-containing beverages like coffee, as they may increase the severity of side effects. Do not take Coldnac 650/10/4/30 Tab if you have taken any MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days. Cetirizine present in the Coldnac 650/10/4/30 Tab can make you sleepy, so do not drive or operate heavy machinery after taking Coldnac 650/10/4/30 Tab . Phenylephrine in Coldnac 650/10/4/30 Tab should be used cautiously in patients with occlusive vascular disease (nerve/artery blockage), including Raynaud's phenomenon (decreased blood flow to the fingers). 

Drug-Drug Interactions

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ChlorpheniraminePotassium chloride
Critical
ChlorpheniraminePotassium citrate
Critical

Drug-Drug Interactions

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ChlorpheniraminePotassium chloride
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking Coldnac 650/10/4/30 Tab and Potassium chloride (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Potassium chloride it not recommended as it can lead to an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor. Do not discontinue any medications without a doctor's advice.
ChlorpheniraminePotassium citrate
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking Coldnac 650/10/4/30 Tab and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Potassium citrate is not recommended as it can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
CaffeinePhenelzine
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Coadministration of tranylcypromine with Coldnac 650/10/4/30 Tab can in cause severe high blood pressure.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineLinezolid
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
PhenylephrineTranylcypromine
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking Tranylcypromine with Coldnac 650/10/4/30 Tab can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Coldnac 650/10/4/30 Tab is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting Do not discontinue any medications without consulting a doctor.
PhenylephrinePropofol
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking Coldnac 650/10/4/30 Tab with Propofol may lead to increased levels of Coldnac 650/10/4/30 Tab leading to side effects like high blood pressure.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Propofol is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PhenylephrineSevoflurane
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Co-administration of Coldnac 650/10/4/30 Tab with Sevoflurane can increase the levels of Coldnac 650/10/4/30 Tab and lead to side effects.

How to manage the interaction:
Taking Coldnac 650/10/4/30 Tab with Sevoflurane is not recommended, it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PhenylephrineFurazolidone
Critical
How does the drug interact with Coldnac 650/10/4/30 Tab:
Taking Furazolidone with Coldnac 650/10/4/30 Tab can cause an increase in high blood pressure.

How to manage the interaction:
Taking Furazolidone with Coldnac 650/10/4/30 Tab is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sweating, lightheadedness, fainting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, consult the doctor immediately. It is advised to use Coldnac 650/10/4/30 Tab only after 14 days of stopping Furazolidone.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands with soap and water regularly to prevent the spread of germs.
  • Eat plenty of foods rich in good bacteria like yogurt to improve overall health.
  • Drink plenty of fluids to avoid dehydration and keep the throat lubricated.
  • Gargle with salt water for relief from sore throat.
  • Avoid alcohol consumption with Coldnac 650/10/4/30 Tab as it may cause tiredness, drowsiness, or lack of concentration.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Coldnac 650/10/4/30 Tab Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Coldnac 650/10/4/30 Tab to avoid excessive drowsiness and sleepiness.

bannner image

Pregnancy

Caution

The safety of Coldnac 650/10/4/30 Tab in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Coldnac 650/10/4/30 Tab is known to pass through milk in small amounts. Use in breastfeeding women is not recommended as it may cause unpleasant side effects to the baby like unusual irritability, excitement.

bannner image

Driving

Unsafe

Coldnac 650/10/4/30 Tab is known to cause drowsiness, so please do not drive or operate any machinery which requires concentration.

bannner image

Liver

Caution

Take Coldnac 650/10/4/30 Tab with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Coldnac 650/10/4/30 Tab with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

Coldnac 650/10/4/30 Tab is not recommended for children below 4 years. However, it can be given to the children more than 4 years of age only if the doctor has prescribed it.

Have a query?

FAQs

Coldnac 650/10/4/30 Tab is used to treat the common cold and allergy symptoms like sneezing, watery eyes, or itchy/watery nose and throat.Â

Coldnac 650/10/4/30 Tab is composed of four medicines, namely: Chlorpheniramine (anti-histamine), Phenylephrine (decongestant), Paracetamol (mild analgesic and antipyretic), and Caffeine (a stimulant). Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels in the nasal passage, thereby reducing stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.  Caffeine acts as a common stimulant, which decreases sleepiness caused by Chlorpheniramine and speeds up the action of all the medicines present in Coldnac 650/10/4/30 Tab .

Do not use Coldnac 650/10/4/30 Tab if you have used an MAO inhibitor in the past 14 days, like isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Tell your doctor before taking Coldnac 650/10/4/30 Tab if you have nausea, stomach pain, itchy skin, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes). In rare cases, paracetamol present in Coldnac 650/10/4/30 Tab may cause a severe skin allergic reaction. So, if you observe any skin blisters or redness, or rash, immediately contact your doctor and stop taking Coldnac 650/10/4/30 Tab .

Coldnac 650/10/4/30 Tab contains caffeine. So, avoid taking medicines or food containing caffeine like cold drinks, coffee, chocolate, and tea. Also, avoid consumption of alcohol while taking Coldnac 650/10/4/30 Tab as it might increase drowsiness.

You are not recommended to stop taking Coldnac 650/10/4/30 Tab without consulting your doctor as it may worsen the cough or cause recurring cough. Therefore, take Coldnac 650/10/4/30 Tab for as long as your doctor has prescribed it, and if you experience any difficulty while taking Coldnac 650/10/4/30 Tab , please consult your doctor.

No, it is not advisable to breastfeed while using Coldnac 650/10/4/30 Tab as it contains an antihistamine drug Chlorpheniramine, and also it contains caffeine, which can pass through the breast milk and may harm the baby.

Coldnac 650/10/4/30 Tab is a combination medication containing four active ingredients: Chlorpheniramine (antihistamine), Phenylephrine (decongestant), Paracetamol (mild pain reliever and fever reducer), and Caffeine (stimulant). It treats common cold and allergic symptoms such as sneezing, runny nose, and itchy throat.

Store Coldnac 650/10/4/30 Tab in by keeping it cool, dry, and out of sunlight. Keep it out of the reach of children. Regularly check the expiration date. When you need to dispose of the medicine, place it in a plastic bag and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink to prevent harm to others and the environment.

In rare cases, some side effects may become serious, such as severe headaches, allergic reactions, fatigue, severe stomach problems, vomiting, difficulty sleeping, liver problems, and kidney issues. If you experience any of these symptoms, seek medical attention immediately.

No, taking a higher than the recommended dose of Coldnac 650/10/4/30 Tab will not be more effective and may increase the risk of side effects.

Yes, some contraindications are associated with using Coldnac 650/10/4/30 Tab ; it should be used cautiously in certain situations. People who are allergic to any of its ingredients should inform their doctor. It should be used with caution in pregnancy, breastfeeding women, and in children under 4 years. Additionally, individuals with certain medical conditions, such as high blood pressure, diabetes, hyperthyroidism, asthma, and kidney or liver problems, should inform their doctor before taking this medication.

The common side effects of Coldnac 650/10/4/30 Tab are drowsiness, sleepiness, nausea, fatigue, allergic reactions, difficulty sleeping, and headache. Most of these side effects may not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, consult the doctor.

Country of origin

India
Other Info - COL1316

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 12:08 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.2887.pdf
  2. https://www.medicines.org.uk/emc/files/pil.8283.pdf
  3. https://www.drugs.com/cdi/acetaminophen-caffeine-and-phenylephrine.html
  4. https://www.drugs.com/paracetamol.html

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