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  3. COFTON SF 100ML

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COFTON SF 100ML, Pack of 1 LIQUID
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
COFTON SF is a combination medicine which belongs to the class of expectorants. It is used in the treatment of cough. This medicine works by inhibiting the chemical substance, histamine which is responsible for cough. It helps loosen the congestion in the chest and throat by decreasing airway secretion's stickiness. Common side effects include headache, dizziness, nausea, fatigue, restlessness, and dry mouth.
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Composition :

AMMONIUM CHLORIDE-125MG + CHLORPHENIRAMINE MALEATE-2.5MG + SODIUM CITRATE-55MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About COFTON SF

COFTON SF is used to provide relief from cough. Coughing (dry or productive) is a body's way of clearing irritants (like allergens, mucus, or smoke) from airways thereby preventing respiratory infection. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract.

COFTON SF is a combination of three drugs, namely: Ammonium chloride (expectorant), Chlorpheniramine maleate (antihistamine), and Sodium citrate (mucolytic). Ammonium chloride helps loosen the congestion in the chest and throat by decreasing airway secretion's stickiness. Chlorpheniramine maleate works by blocking a chemical substance called histamine, which is responsible for causing allergic reactions. Sodium citrate loosens and thins the phlegm, making it easier to cough out. Together, COFTON SF provides relief from cough. 

You are advised to take COFTON SF for as long as your doctor has prescribed it for you depending on your medical condition. COFTON SF may cause certain common side-effects such as headache, dizziness, nausea, fatigue, and dry mouth in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take COFTON SF if you are pregnant or breastfeeding unless prescribed. COFTON SF may cause dizziness, so drive only if you are alert. COFTON SF is not recommended for children below 6years. Avoid consuming alcohol along with COFTON SF as it could lead to increased dizziness. Keep your doctor informed about your health condition and the medicines you are taking to rule out any side effects/interactions.

Uses of COFTON SF

Treatment of Cough

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Directions for Use

• COFTON SF should be taken with or without food, preferably with food to prevent stomach upset.• It is recommended to take COFTON SF as advised by your doctor. • Measure the prescribed dose using the measuring cup provided with the pack and administer it orally. • Check the label for directions before using it. Shake the bottle well before each use. • Avoid using regular household spoons, as they may not measure the dose correctly.

Medicinal Benefits

COFTON SF is a combination of three drugs, namely: Ammonium chloride, Chlorpheniramine maleate, and Sodium citrate. COFTON SF is used to provide relief from cough. Ammonium chloride is an expectorant that helps loosen the congestion in the chest and throat by decreasing airway secretion's stickiness. Chlorpheniramine maleate is an antihistamine that works by blocking a chemical substance called histamine, which is responsible for causing allergic reactions. Sodium citrate is a mucolytic that loosens and thins the phlegm, making it easier to cough out. Together, COFTON SF provides relief from cough.

How COFTON SF Works

COFTON SF is a combination of three drugs, namely: Ammonium chloride (expectorant), Chlorpheniramine maleate (antihistamine), and Sodium citrate (mucolytic). Ammonium chloride helps loosen the congestion in the chest and throat by decreasing airway secretion's stickiness. Chlorpheniramine maleate works by blocking a chemical substance called histamine, which is responsible for causing allergic reactions. Sodium citrate loosens and thins the phlegm, making it easier to cough out. Together, COFTON SF provides relief from cough.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cofton Sf 100ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of COFTON SF

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sedation, nausea, vomiting, headache, thirst, hyperventilation (rapid or deep breathing), drowsiness, and convulsions. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take COFTON SF if you are allergic to any of its contents, if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14days, or if you have pre-existing hyperchloremia (electrolyte imbalance). Inform your doctor before taking COFTON SF if you have asthma, prostate problems, glaucoma, bronchitis, glucose-galactose malabsorption, sucrase-isomaltase deficiency, fructose intolerance, cardiac insufficiency, pulmonary oedema, severe kidney or liver problems, or if you are taking hypnotics and anxiolytics. Consult your doctor if you are pregnant or breastfeeding. COFTON SF may cause dizziness and drowsiness, so drive only if you are alert. COFTON SF is not recommended for children below 6years. Avoid consuming alcohol along with COFTON SF as it could lead to increased dizziness.

Drug-Drug Interactions

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ChlorpheniraminePotassium chloride
Critical
ChlorpheniraminePotassium citrate
Critical

Drug-Drug Interactions

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ChlorpheniraminePotassium chloride
Critical
How does the drug interact with Cofton Sf 100ml:
Taking Cofton Sf 100ml and Potassium chloride (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Cofton Sf 100ml with Potassium chloride it not recommended as it can lead to an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor. Do not discontinue any medications without a doctor's advice.
ChlorpheniraminePotassium citrate
Critical
How does the drug interact with Cofton Sf 100ml:
Taking Cofton Sf 100ml and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Cofton Sf 100ml with Potassium citrate is not recommended as it can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
Sodium citrateLevofloxacin
Severe
How does the drug interact with Cofton Sf 100ml:
Co-administration of Levofloxacin and Cofton Sf 100ml together may increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Cofton Sf 100ml and Levofloxacin, you can take these medicines together if prescribed by a doctor. However, if you experience flank pain, painful urination, or blood in the urine, consult the doctor. It is advised to drink plenty of fluids during treatment with Levofloxacin. Do not stop using any medications without talking to a doctor.
Sodium citrateDoxycycline
Severe
How does the drug interact with Cofton Sf 100ml:
Coadministration of Cofton Sf 100ml with Doxycycline can reduce the effectiveness of Doxycycline.

How to manage the interaction:
Although taking Cofton Sf 100ml with Doxycycline can possibly result in decreased efficacy, they can be taken together if prescribed by a doctor. It is advised to separate Cofton Sf 100ml and doxycycline by three to four hours. Do not stop using any medications without consulting a doctor.
Sodium citrateAluminium hydroxide
Severe
How does the drug interact with Cofton Sf 100ml:
Co-administration of Aluminium hydroxide and Cofton Sf 100ml may increase aluminum levels and risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Cofton Sf 100ml and Aluminium hydroxide, you can take these medicines together if prescribed by your doctor. However, if you experience symptoms like severe stomach pain, constipation, loss of appetite, pain when you urinate, muscle weakness, tiredness nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Sodium citrateDihydroxialumini sodium carbonate
Severe
How does the drug interact with Cofton Sf 100ml:
Co-administration of Dihydroxialumini sodium carbonate and Cofton Sf 100ml may increase aluminum levels and risk of developing side effects.

How to manage the interaction:
Although taking Cofton Sf 100ml and Dihydroxialumini sodium carbonate together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience severe stomach pain, constipation, loss of appetite, pain when you urinate, tiredness, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
ChlorpheniramineEluxadoline
Severe
How does the drug interact with Cofton Sf 100ml:
Taking Cofton Sf 100ml with Eluxadoline can increase the levels of both the medications, which may the risk of constipation and other stomach related problems.

How to manage the interaction:
There may be a possibility of interaction between Cofton Sf 100ml and Eluxadoline, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ChlorpheniramineIsocarboxazid
Severe
How does the drug interact with Cofton Sf 100ml:
Co-administration of Cofton Sf 100ml with Isocarboxazid can increase the risk of side effects.

How to manage the interaction:
Taking Cofton Sf 100ml with Isocarboxazid can result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of these symptoms - dizziness, drowsiness, confusion, disorientation, memory problems, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, rapid heartbeat, - make sure to consult the doctor right away. Do not stop using any medications without talking to a doctor.
ChlorpheniramineMexiletine
Severe
How does the drug interact with Cofton Sf 100ml:
Co-administration of Cofton Sf 100ml with mexiletine may cause the side effects of mexiletine.

How to manage the interaction:
Although taking Cofton Sf 100ml and mexiletine together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
ChlorpheniramineIdelalisib
Severe
How does the drug interact with Cofton Sf 100ml:
Taking Cofton Sf 100ml with Idelalisib together can increase the levels of Cofton Sf 100ml which may lead to side effects.

How to manage the interaction:
Although taking Cofton Sf 100ml and Idelalisib together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Gargle with salt water for relief from sore throat.
  • Avoid smoking and consumption of alcohol.
  • Avoid dairy products such as milk as they may increase mucus production. Also, avoid processed or refined foods.
  • Replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough. It also helps loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

COFTON SF Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking COFTON SF as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

COFTON SF may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

COFTON SF should be used with caution in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

COFTON SF should be used with caution in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

COFTON SF is not recommended for children below 6years of age.

FAQs

COFTON SF is used to provide relief from cough. Coughing (dry or productive) is a body's way of clearing irritants (like allergens, mucus, or smoke) from airways thereby preventing respiratory infection.

COFTON SF is a combination of three drugs, namely: Ammonium chloride, Chlorpheniramine maleate, and Sodium citrate. Ammonium chloride helps in loosening the congestion in the chest and throat by decreasing the stickiness of airway secretions. Chlorpheniramine maleate works by blocking the action of a chemical substance called histamine, which is responsible for causing allergic reactions. Sodium citrate loosens and thins the phlegm, making it easier to cough out. Together, COFTON SF provides relief from cough.

Do not stop taking COFTON SF on your own as it may worsen cough or cause recurring symptoms. Therefore, take COFTON SF for as long as your doctor has prescribed it. If you experience any difficulty while taking COFTON SF , please consult your doctor.

COFTON SF contains Chlorpheniramine maleate, an antihistamine that helps in treating an allergy. It helps in providing relief from a runny nose, watery eyes, sneezing and sore throat.

COFTON SF should not be taken for longer durations unless prescribed by the doctor. If your condition does not improve despite taking COFTON SF for a week, consult your doctor, he/she may prescribe an alternate medicine.

COFTON SF contains chlorpheniramine maleate, an antihistamine. Therefore, do not take any other antihistamine-containing products such as cold and cough medicines along with COFTON SF .

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013.
Other Info - COF0038

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:24 AM IST

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Reference

  1. https://india-pharma.gsk.com/media/701327/piriton-expectorant.pdf
  2. https://www.drugs.com/mtm/chlorpheniramine.html

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