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  3. Cofross-T Syrup

Prescription drug
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Cofross-T Syrup, Pack of 1 Syrup
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cofross-T Syrup is used to treat cough associated with mucus. It works by increasing the volume of fluid in the airways, reducing the stickiness of mucus and helping to remove it from the airways. Also, it relaxes muscles and widens the airways. Thereby, it makes breathing easier. It thins and loosens phlegm (mucus) in the lungs, windpipe and nose. Thus, it helps cough up easily. Some people may experience side effects such as nausea, vomiting, drowsiness, headache, dizziness, skin rash, tremor, stomach upset and fast heartbeats.

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Composition :

BROMHEXINE-4MG + GUAIFENESIN-50MG + TERBUTALINE-1.25MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Cofross-T Syrup

Cofross-T Syrup is used to treat cough associated with mucus. Coughing (dry or productive) is the body’s way of clearing irritants (such as allergens, mucus, or smoke) from the airways, thereby preventing respiratory infections.

Cofross-T Syrup is a combination of three drugs, namely Guaifenesin, Terbutaline and Bromhexine. Guaifenesin is an expectorant that works by increasing the volume of fluid in the airways, reducing the stickiness of mucus and helping to remove it from the airways. Terbutaline is a bronchodilator that relaxes muscles and widens the airways. Thus, it makes breathing easier. Bromhexine is a mucolytic agent (cough/sputum thinner) that thins and loosens phlegm (mucus) in the lungs, windpipe and nose. Thus, it helps cough up easily.

Use Cofross-T Syrup as prescribed by your doctor. Some people may experience nausea, vomiting, drowsiness, headache, dizziness, skin rash, tremors, stomach upset and fast heartbeats. Most of the side effects of Cofross-T Syrup do not require medical attention and resolve gradually over time. However, if the side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Cofross-T Syrup or any other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Cofross-T Syrup. If you have a history of fits or are suffering from fits, please inform your doctor before taking Cofross-T Syrup as it may increase the risk of recurrent fits. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Cofross-T Syrup.

Uses of Cofross-T Syrup

Cofross-T Syrup is used to treat chesty cough. The detailed uses of Cofross-T Syrup are as follows:

  • Relief from Cough: Cofross-T Syrup is used to treat persistent coughs. It soothes the throat by minimising irritation.
  • Expectorant Properties: Cofross-T Syrup loosens mucus in the respiratory tract, making it easier to expel phlegm and breathe.
  • Eases breathing in respiratory conditions: It relaxes the airway muscles, improving airflow and reducing wheezing or shortness of breath.
  • Breaks down mucus: It thins and dissolves mucus, making it easier to clear from the respiratory tract.

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Directions for Use

  • Cofross-T Syrup can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Measure the prescribed dose using a measuring cup, and administer it orally.
  • Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

Medicinal Benefits

  • Cofross-T Syrup provides relief from cough, chest congestion, and breathing difficulty.
  • Guaifenesin helps loosen and thin mucus, making it easier to cough out.
  • Terbutaline relaxes and widens the airways, improving airflow and breathing.
  • Bromhexine clears the airways effectively by breaking up thick mucus.
  • Promotes easier expectoration and faster recovery from respiratory infections.
  • Syrup form is ideal for both adults and children, improving compliance.

How Cofross-T Syrup Works

Cofross-T Syrup is a combination of three drugs, namely Guaifenesin, Terbutaline and Bromhexine. Guaifenesin belongs to the class of expectorants that work by increasing the volume of fluid in the airways, reducing the stickiness of mucus and helping to remove it from the airways. Terbutaline belongs to the class of bronchodilators that relax muscles and widen the airways. Thus, it makes breathing easier. Bromhexine belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose. Thus, it helps cough up easily.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cofross-T Syrup
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.

What if I have taken an overdose of Cofross-T Syrup

Do not take more than the prescribed dose of Cofross-T Syrup as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • If you are known to be allergic to Cofross-T Syrup or any other medicines, please tell your doctor.
  • If you are pregnant or breastfeeding, it is advised to inform your doctor before using Cofross-T Syrup.
  • If you are suffering from fits (epilepsy) or have a history of fits, please inform your doctor before taking Cofross-T Syrup as it may increase the risk of recurrent fits.
  • If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Cofross-T Syrup.
  • If you have diabetes, high blood pressure, overactive thyroid (hyperthyroidism), stomach ulcers/bleeding, phenylketonuria (a congenital disability with high protein in the body), kidney, liver or heart problems, please inform your doctor before taking Cofross-T Syrup.

Drug-Drug Interactions

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TerbutalineCarvedilol
Severe
TerbutalineAmisulpride
Severe

Drug-Drug Interactions

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TerbutalineCarvedilol
Severe
How does the drug interact with Cofross-T Syrup:
Taking Carvedilol and Cofross-T Syrup may reduce the beneficial effects of both medications.

How to manage the interaction:
There may be a possibility of interaction between Cofross-T Syrup and Carvedilol, but it can be taken if prescribed by a doctor. Consult your doctor immediately if you experience shortness of breath, palpitations, or chest discomfort. Do not stop using any medications without a doctor's advice.
TerbutalineAmisulpride
Severe
How does the drug interact with Cofross-T Syrup:
Using Cofross-T Syrup together with amisulpride can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Amisulpride and Cofross-T Syrup can cause an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
TerbutalineMoxifloxacin
Severe
How does the drug interact with Cofross-T Syrup:
Using moxifloxacin together with Cofross-T Syrup can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Cofross-T Syrup, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without first consulting your doctor.
TerbutalineLinezolid
Severe
How does the drug interact with Cofross-T Syrup:
Using Cofross-T Syrup together with linezolid may increase cardiovascular side effects (heart palpitations, chest pain, increased heart and pulse rates, and blood pressure elevations).

How to manage the interaction:
Although taking linezolid with Cofross-T Syrup together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you're diagnosed with a history of heart disease or high blood pressure, see your doctor before taking these medications. Do not discontinue any medication without consulting a doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor.
TerbutalineGatifloxacin
Severe
How does the drug interact with Cofross-T Syrup:
Taking Gatifloxacin and Cofross-T Syrup can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Cofross-T Syrup together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbutalinePropranolol
Severe
How does the drug interact with Cofross-T Syrup:
Using propranolol together with Cofross-T Syrup may reduce the benefits of both medications, since they have opposing effects in the body. In addition, propranolol can sometimes cause breathing problems.

How to manage the interaction:
Although taking Propranolol together with Cofross-T Syrup can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
TerbutalineEfavirenz
Severe
How does the drug interact with Cofross-T Syrup:
Taking Efavirenz and Cofross-T Syrup can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Cofross-T Syrup together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbutalineNilotinib
Severe
How does the drug interact with Cofross-T Syrup:
Combining Cofross-T Syrup and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Cofross-T Syrup and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TerbutalineSotalol
Severe
How does the drug interact with Cofross-T Syrup:
Using sotalol together with Cofross-T Syrup may reduce the benefits of both medications since they have opposing effects in the body.

How to manage the interaction:
Taking Sotalol with Cofross-T Syrup together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
TerbutalineLabetalol
Severe
How does the drug interact with Cofross-T Syrup:
Co-administration of Labetalol and Cofross-T Syrup together can decrease the medical benefits of both medications.

How to manage the interaction:
Although taking Labetalol and Cofross-T Syrup together can result in an interaction, it can be taken if a doctor has prescribed it. Do not forget to inform the doctor if you have severe chronic obstructive pulmonary disease (COPD) or a history of asthma, as labetalol is often not advised in these conditions. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production. Also, avoid processed or refined foods to relieve a cough.
  • Replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid a dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

All Substitutes & Brand Comparisons

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Alcohol

Consult your doctor

The interaction of alcohol with Cofross-T Syrup is unknown. Please consult a doctor before consuming alcohol with Cofross-T Syrup.

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Pregnancy

Consult your doctor

The safety of Cofross-T Syrup in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Cofross-T Syrup is excreted in human milk. Cofross-T Syrup is given to breastfeeding mothers only if the doctor believes the benefits outweigh the risks.

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Driving

Caution

Cofross-T Syrup may cause dizziness or drowsiness in some people. Therefore, drive only if you are alert after taking Cofross-T Syrup.

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Liver

Caution

Take Cofross-T Syrup with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Cofross-T Syrup with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

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Children

Caution

Cofross-T Syrup should be used with caution in children and only in doses as prescribed by a doctor.

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Heart

Caution

Cofross-T Syrup can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Exercise caution while giving Cofross-T Syrup in geriatric patients. Close monitoring of the individual is required.

FAQs

Cofross-T Syrup is used to treat cough associated with mucus.

Cofross-T Syrup contains Guaifenesin, Terbutaline and Bromhexine. Guaifenesin works by increasing the volume of fluid in the airways, reducing the stickiness of mucus and helping to remove it from the airways. Terbutaline relaxes muscles and widens the airways. Thereby, it makes breathing easier. Bromhexine works by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose. Thus, it helps cough up easily.

Cofross-T Syrup should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if you have hyperthyroidism before taking Cofross-T Syrup so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Cofross-T Syrup.

Cofross-T Syrup should be used with caution in patients with diabetes, as it may alter blood glucose levels. Your doctor may monitor your blood glucose levels while you are taking this medicine.

No, you are not recommended to take propranolol with Cofross-T Syrup as it may reduce the effectiveness of both medicines. Also, propranolol may cause a narrowing of airways sometimes, which may trigger severe asthmatic attacks or worsen breathing problems. However, you are recommended to consult a doctor before using other medicines with Cofross-T Syrup.

You are recommended to take Cofross-T Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen, with rash, fever, or persistent headache, after 1 week of using Cofross-T Syrup, please consult your doctor.

No, you are not recommended to stop taking Cofross-T Syrup without consulting your doctor, as it may worsen the cough or cause recurring symptoms. Therefore, take Cofross-T Syrup for as long as your doctor has prescribed it, and if you experience any difficulty while taking Cofross-T Syrup, please consult your doctor.

Your doctor will advise the dose and frequency based on your medical condition. Follow your doctor’s instructions.

Your doctor will decide the best time to take Cofross-T Syrup. Follow your doctor’s instructions.

Yes, Cofross-T Syrup may cause drowsiness. Avoid alcohol intake as it may increase drowsiness. This does not require any medical treatment, as this will gradually reduce over time. Please consult the doctor if it persists for more than a few days.

Elderly patients are more susceptible to the side effects of Cofross-T Syrup. Additionally, conditions such as glaucoma, prostate issues, and liver or kidney diseases are more common in this age group, which can worsen Cofross-T Syrup side effects. Please consult a doctor before administering it to elderly patients.

Cofross-T Syrup is used to manage chesty cough (wet cough). Avoid using Cofross-T Syrup for any purpose other than the condition for which it is prescribed.

Cofross-T Syrup can be taken with or without food or as advised by your doctor.

Cofross-T Syrup contains bromhexine, guaifenesin, and terbutaline as its active substances.

Store Cofross-T Syrup at a temperature below 30°C in a cool and dry place. Protect from light. Keep it out of reach of children. Cofross-T Syrup should be disposed, by following local guidelines or asking your pharmacist how to properly dispose of any unused medicine.

Cofross-T Syrup may interact with propranolol (lowers high blood pressure), epinephrine (affects heart rate), furosemide, promethazine (anti-allergic), oxytocin (uterine stimulant), bronchodilators (formoterol), and ondansetron (anti-sickness). Therefore, consult a doctor before taking other medicines while on treatment with Cofross-T Syrup.

No, higher than the recommended dose of Cofross-T Syrup will not be more effective, instead it can lead to increased side effects. Therefore, do not exceed the recommended dose. It can lead to symptoms like hypertension, hyperglycaemia, tremors and seizures. If you suspect you have taken overdose or experience any of these symptoms, please consult your doctor.

Cofross-T Syrup causes side effects such as nausea, vomiting, drowsiness, headache, dizziness, skin rash, tremors, stomach upset, and fast heartbeat. Please, consult a doctor if these persist longer.

Country of origin

India

Manufacturer/Marketer address

20, Goyal Intercity Row House, Opp. T.V. Tower, Drive-In Road
Other Info - CO15504

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 21, 2025 | 11:23 AM IST

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Reference

  1. https://www.drugs.com/guaifenesin.html
  2. https://www.drugs.com/mtm/terbutaline-oral-injection.html
  3. https://www.mims.com/malaysia/drug/info/bromhexine/patientmedicine/bromhexine%2B-%2Boral
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