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  3. Clostop 500 mg Tablet 10's

Clostop 500 mg Tablet 10's, Pack of 10
Clostop 500 mg Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Clostop 500 mg Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, it is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. It contains two medicines, namely Tranexamic acid and Mefenamic acid. It may cause common side effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache.

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Composition :

MEFENAMIC ACID-250MG + TRANEXAMIC ACID-500MG

Manufacturer/Marketer :

Alembic Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Clostop 500 mg Tablet

Clostop 500 mg Tablet is a combination medicine used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, Clostop 500 mg Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Menstrual cramps, also known as dysmenorrhea, are characterized by cramps and pain during menstruation. Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods.

Clostop 500 mg Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

You are advised to take Clostop 500 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Clostop 500 mg Tablet may cause dizziness, so drive with caution. Clostop 500 mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Clostop 500 mg Tablet as it could lead to increased drowsiness and dizziness, it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Clostop 500 mg Tablet

Clostop 500 mg Tablet is used in the treatment of dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). The detailed uses of Clostop 500 mg Tablet are as follows:

  • Management of Menstrual Disorders: Clostop 500 mg Tablet is used to help regulate menstrual cycles in women experiencing irregular periods or hormonal imbalances.
  • Relief from Menopausal Symptoms: Clostop 500 mg Tablet can alleviate symptoms associated with menopause, such as hot flashes and mood swings.
  • PMS Symptom Relief: Clostop 500 mg Tablet is effective in minimising premenstrual syndrome (PMS) symptoms, including cramps, anxiety, and other mood-related issues associated with the menstrual cycle.

Directions for Use

• Clostop 500 mg Tablet can be taken with or without food. • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness. • Swallow Clostop 500 mg Tablet as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Clostop 500 mg Tablet is a combination of two drugs, namely: Tranexamic acid and Mefenamic acid. Clostop 500 mg Tablet is used to treat abdominal pain, dysmenorrhea (period pain), and menorrhagia (heavy menstrual bleeding). Additionally, Clostop 500 mg Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Tranexamic acid is an anti-fibrinolytic agent that helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid is an NSAID that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. By blocking the COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Clostop 500 mg Tablet helps treat heavy bleeding and pains/cramps during periods.

How Clostop 500 mg Tablet Works

Clostop 500 mg Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Clostop 500 mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Include omega-3 rich foods like fatty fish, ground flax, flaxseed oil, and walnuts.
  • Consume calcium-rich dairy products for bone health.
  • Eat green and leafy vegetables for essential nutrients.
  • Include lean protein sources like eggs and whole grains.
  • Use herbs and spices for added flavor and nutrition.
  • Choose fortified foods for extra nutritional benefits.
  • Get plenty of sleep for overall health and well-being.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Lie down or take a nap in dark and quiet room.
  • To avoid dehydration, drink plenty of fluids.
  • In case of mild to moderate migraine, you can take over-the-counter pain relievers like paracetamol or ibuprofen.
  • Apply an ice pack or cool cloth on your forehead.
  • Try relaxation techniques such as yoga, meditation, or deep breathing to reduce stress and relax.
  • Avoid foods and drinks that trigger migraine such as chocolate, alcohol, cheese, caffeine, processed meats, artificial sweeteners and dried fruits.
  • Manage your stress by eating healthy, exercising and a regular sleep schedule.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Clostop 500 mg Tablet

Do not take more than the prescribed dose of Clostop 500 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Clostop 500 mg Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Clostop 500 mg Tablet may cause dizziness and drowsiness, so drive only if you are alert. Clostop 500 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Clostop 500 mg Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Do not take any other NSAIDs for pain relief along with Clostop 500 mg Tablet unless prescribed.

Drug-Drug Interactions

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Tranexamic acidDrospirenone
Critical
Tranexamic acidEtonogestrel
Critical

Drug-Drug Interactions

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Tranexamic acidDrospirenone
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking drospirenone with Clostop 500 mg Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Drospirenone is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidEtonogestrel
Critical
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Clostop 500 mg Tablet may cause blood clotting when taken with Etonogestrel.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Etonogestrel is not recommended, as it can lead to an interaction but can be taken if prescribed by the doctor. However, If you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Tranexamic acidLevonorgestrel
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Levonorgestrel with Clostop 500 mg Tablet may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Clostop 500 mg Tablet with Levonorgestrel may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidEthinylestradiol
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Ethinylestradiol with Clostop 500 mg Tablet may increase the risk of blood clot formation.

How to manage the interaction:
Taking Ethinylestradiol with Clostop 500 mg Tablet is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
Tranexamic acidMedroxyprogesterone
Critical
How does the drug interact with Clostop 500 mg Tablet:
Taking Medroxyprogesterone acetate with Clostop 500 mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Clostop 500 mg Tablet is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
Tranexamic acidCarfilzomib
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Carfilzomib with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking carfilzomib with Clostop 500 mg Tablet is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidEstramustine
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Estramustine with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking Estramustine with Clostop 500 mg Tablet possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidChlorotrianisene
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Chlorotrianisene with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking chlorotrianisene with Clostop 500 mg Tablet is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidConjugated Estrogens
Severe
How does the drug interact with Clostop 500 mg Tablet:
Co-administration of Conjugated estrogen with Clostop 500 mg Tablet can increase the risk of blood clots.

How to manage the interaction:
Taking Conjugated estrogen with Clostop 500 mg Tablet may result in interaction, it can be taken only if your doctor has advised it. However, if you experience chest pain, shortness of breath, coughing up blood, or weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Tranexamic acidNorethisterone
Severe
How does the drug interact with Clostop 500 mg Tablet:
Using Clostop 500 mg Tablet together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking norethisterone with Clostop 500 mg Tablet can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.

  • Stay hydrated; drink plenty of water.

  • Cut down on sugars, salts, spicy food, coffee, and alcohol.

  • A heating pad can help ease the pain by placing it on the belly or lower back.

  • Exercise can help ease the pain of menstrual cramps.

  • Avoid stress by performing meditation or yoga.

  • Massage your lower back or abdomen to relieve the pain.

  • Take proper rest.

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

Clostop 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Clostop 500 mg Tablet as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.

bannner image

Pregnancy

Caution

Please consult your doctor if you are pregnant or if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Consult your doctor before taking Clostop 500 mg Tablet if you are breastfeeding, your doctor will decide if Clostop 500 mg Tablet can be taken by breastfeeding mothers or not.

bannner image

Driving

Caution

Clostop 500 mg Tablet may cause drowsiness and dizziness. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with renal disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Clostop 500 mg Tablet should not be given to children as the safety and effectiveness were not established.

Have a query?

FAQs

Clostop 500 mg Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, it is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache.

Clostop 500 mg Tablet contains Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clot process by preventing the breakdown of fibrin, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

Diarrhoea might be a side-effect of Clostop 500 mg Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience severe diarrhoea or if you find blood in stools.

Clostop 500 mg Tablet should not be taken for longer durations unless prescribed by the doctor. Clostop 500 mg Tablet is usually prescribed for a few days at the time of heavy bleeding and cramps.

Clostop 500 mg Tablet is used to treat dysmenorrhea (period pain), pain due to heavy bleeding during periods, and menstrual cramps. Take Clostop 500 mg Tablet only as prescribed and do not overdose.

Consult your doctor before taking contraceptive pills along with Clostop 500 mg Tablet . When taken together, there is an increased risk of deep vein thrombosis (blood clot in the deep vein, usually legs).

Clostop 500 mg Tablet contains mefenamic acid, an NSAID which might increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Therefore, avoid taking Clostop 500 mg Tablet if you have heart-related problems unless prescribed by the doctor.

Clostop 500 mg Tablet typically starts to show its effects within 1-2 hours of taking it, and it helps to reduce heavy menstrual bleeding by improving blood clotting but does not stop bleeding. However, the exact duration for bleeding to stop can vary from one person to other.

Yes, Clostop 500 mg Tablet can cause acidity. If you experience heartburn and indigestion, it's advisable to take Clostop 500 mg Tablet with food to minimize discomfort. If the symptoms persist, please consult your doctor.

Yes, Clostop 500 mg Tablet is safe if you take as per the dose and duration prescribed by your doctor. However, it's important to be aware of potential side effects and contraindications. Always consult your doctor before starting any new medication to ensure it is safe for you, especially if you have pre-existing conditions or are taking other medications.

Always follow your doctor's instructions regarding dosage and duration. Usually it is prescribed for a short duration. Do not exceed the prescribed duration. As overuse can lead to side effects and other health issues.

Clostop 500 mg Tablet is a combination of two drugs, tranexamic acid (anti-fibrinolytic) and mefenamic acid (NSAID).

Yes, do not take Clostop 500 mg Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Do not take any other NSAIDs for pain relief along with Clostop 500 mg Tablet unless prescribed.

Store Clostop 500 mg Tablet at a temperature not exceeding 25°C. Protect it from light and moisture. Keep out of reach of children.

Yes, you can take Clostop 500 mg Tablet with food. It is often recommended to take it after a meal to avoid stomach upset or other gastrointestinal side effects.

Please consult your doctor if you are pregnant. Your doctor will prescribes Clostop 500 mg Tablet only if the benefits outweigh the risks.

The common side effects of Clostop 500 mg Tablet are nausea, vomiting, diarrhoea, indigestion, heartburn, and headache. If any of these side effects persist or worsen, please consult your doctor.

You are recommended to consult your doctor before taking other medicines with Clostop 500 mg Tablet to avoid possible interactions.

Country of origin

India

Manufacturer/Marketer address

Alembic Road, Vadodara - 390 003, Gujarat,INDIA
Other Info - CLO1255

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Aug 6, 2025 | 12:32 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://http://www.salvavidaspharma.com/product/tranexamic-acid-mefenamic-tablets/
  2. https://www.nhs.uk/medicines/tranexamic-acid/
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/015034s040lbl.pdf
  4. https://www.drugs.com/mtm/mefenamic-acid.html

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