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compositionComposition:CHLORAMBUCIL-2MG
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Prescription Medicine
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CLOKERAN 2MG TABLET is used to treat various cancer conditions such as Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, Chronic lymphocytic leukaemia, Waldenstrom's macroglobulinaemia, Advanced ovarian adenocarcinoma and breast cancer. CLOKERAN 2MG TABLET contains Chlorambucil, works by slowing or stopping the growth of cancer cells in your body. Thus, it treats cancer efficiently.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CHLORAMBUCIL-2MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About CLOKERAN 2MG TABLET

CLOKERAN 2MG TABLET is a prescription medication used to treat certain types of blood and lymphatic cancers, including chronic lymphocytic leukaemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. It belongs to a group of medicines that help slow down or stop the growth of abnormal cancer cells in the body.

For this medicine to work effectively, you must take it consistently and exactly as prescribed by your doctor. It is typically taken on an empty stomach, either one hour before or two hours after a meal, to ensure your body absorbs it properly. Along with your treatment, staying well-hydrated and eating a balanced, fully cooked diet can help support your body and protect your immune system.

While taking CLOKERAN 2MG TABLET, you may experience mild side effects like nausea or a temporary loss of appetite. However, because this medicine affects your immune system, you must contact your doctor immediately if you experience serious side effects like a fever, severe sore throat, or unusual bruising and bleeding.

Do not take this if you have had a severe allergic reaction to this medication in the past. Before starting treatment, tell your doctor if you have a history of seizures, liver damage, or kidney problems, or if you have recently undergone radiation or chemotherapy.

This medicine can interact with other treatments, especially other medications that suppress the immune system or live vaccines. If you are pregnant, planning to become pregnant, or breastfeeding, do not take this medication as it can cause serious harm to an unborn baby. Elderly individuals should consult their doctor closely, as they may be more sensitive to the side effects of this medication.

Uses of CLOKERAN 2MG TABLET

CLOKERAN 2MG TABLET is used to treat certain types of blood and lymphatic cancers. The detailed uses of CLOKERAN 2MG TABLET are as follows:

  • Chronic lymphocytic leukaemia (CLL): CLOKERAN 2MG TABLET helps by slowing down the division and growth of abnormal white blood cells in your bone marrow, helping to manage this slow-growing blood cancer.
  • Hodgkin's lymphoma: CLOKERAN 2MG TABLET targets and destroys cancerous white blood cells in the lymphatic system, helping to shrink swollen lymph nodes and control the disease.
  • Non-Hodgkin's lymphoma: CLOKERAN 2MG TABLET assists in treating other forms of lymphatic cancer by stopping the spread of abnormal lymphocytes throughout the body.

Key Benefits

CLOKERAN 2MG TABLET provides real-world relief by targeting cancer cells directly, which helps manage your symptoms and slow down the progression of the disease.

  • Reduces swelling: By shrinking cancerous lymph nodes, this medication helps relieve physical discomfort and pressure in your neck, underarms, or groin.
  • Eases systemic symptoms: Controlling the underlying cancer helps reduce systemic symptoms such as heavy night sweats, unexplained weight loss, and persistent fatigue.
  • Improves daily energy: As the level of abnormal cells in your blood and lymphatic system stabilises, many patients find they gradually regain their strength and energy for daily tasks.
Side effects of Clokeran 2mg Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

  • Take CLOKERAN 2MG TABLET on an empty stomach, as co-administration with food can reduce its bioavailability. It can be taken 1 hour before a meal or 2 hours after a meal.
  • Follow the prescribed dosage and timing to ensure the medication works effectively.
  • Swallow the whole tablet with a glass of water.
  • Do not crush, chew or break it.

How CLOKERAN 2MG TABLET Works

CLOKERAN 2MG TABLET contains chlorambucil, which works by interfering with the genetic material (DNA) inside rapidly dividing cells, including cancer cells. It attaches itself to the DNA strands, which damages them and stops the cells from multiplying. Because cancer cells grow and divide much faster than normal cells, they are highly sensitive to this action. Over time, these damaged cancer cells are unable to repair themselves and die off, which helps control the disease and prevents it from spreading further in your body.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with CLOKERAN 2MG TABLET.

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Pregnancy

Unsafe

CLOKERAN 2MG TABLET is not recommended for use during pregnancy, especially in the first trimester. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

CLOKERAN 2MG TABLET should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

It is unknown whether CLOKERAN 2MG TABLET alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Caution

Patients with liver impairment should be closely monitored for signs and symptoms of toxicity. If you have a pre-existing or a history of liver disease, inform your doctor before taking CLOKERAN 2MG TABLET. Your doctor will weigh the benefits and potential risks before prescribing CLOKERAN 2MG TABLET.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking CLOKERAN 2MG TABLET. Your doctor may titrate the dose if required based on your condition.

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Children

Consult your doctor

CLOKERAN 2MG TABLET can be used to treat Hodgkin's disease and non-Hodgkin's lymphomas in children. Please consult your doctor for more information.

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Heart

Consult your doctor

CLOKERAN 2MG TABLET should be used cautiously in people with heart problems, as it may increase side effect risks. Always consult your doctor to determine if it's safe based on your specific cardiac condition.

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Geriatrics

Caution

CLOKERAN 2MG TABLET can be used in geriatric patients, but older adults may be more sensitive to its side effects. Doctors often start with a lower dose and monitor closely to ensure safe and effective treatment.

What if I have taken an overdose of CLOKERAN 2MG TABLET

If you take more than your prescribed dose, seek emergency medical care immediately. An overdose can cause serious damage to your blood cells and nervous system.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Try to drink plenty of water throughout the day to keep your kidneys functioning well and to help flush the medication out of your system.
  • Avoid crowds and sick people: Because this medicine lowers your white blood cell count, your body cannot fight off infections easily. Avoid close contact with anyone who has a cold, flu, or other contagious illness.
  • Eat thoroughly cooked food: Protect your weakened immune system by avoiding raw foods like sushi, rare meats, unpasteurized dairy products, or unwashed produce.
  • Practice gentle dental hygiene: Use a soft-bristled toothbrush and avoid flossing roughly to prevent your gums from bleeding, as your blood's clotting ability may be reduced during treatment.
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Have a query?

How Soon It Starts Working

The time required for CLOKERAN 2MG TABLET to start to work: The onset time of CLOKERAN 2MG TABLET has not been clinically established. The time for which the effects of CLOKERAN 2MG TABLET last: The duration of CLOKERAN 2MG TABLET’s effect is clinically not established.

What if you forget to take CLOKERAN 2MG TABLET

If you miss a dose, skip the missed dose and take your next scheduled dose at your regular time. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store CLOKERAN 2MG TABLET tablets in the refrigerator between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do not break, crush, or split the tablets; handling damaged tablets can allow the active medicine to absorb through your skin or be inhaled.
  • Always verify your blood test schedule with your doctor; regular blood tests are absolutely necessary to monitor your bone marrow function safely.
  • Use highly effective birth control during treatment and for a period afterwards as advised by your doctor, as this medicine can cause severe birth defects.
  • Avoid getting live vaccines (such as the shingles or nasal spray flu vaccine) while taking this medicine, as they can cause serious infections when your immune system is weak.

Drug-Drug Interactions

verifiedApollotooltip
  • Other immunosuppressants or chemotherapy drugs: May significantly increase the risk of severe infections and dangerous bone marrow suppression.
  • Live vaccines: May cause serious, life-threatening infections because CLOKERAN 2MG TABLET lowers your body's immune defence.

Drug-Drug Interactions

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How does the drug interact with Clokeran 2mg Tablet:
Coadministration of baricitinib and Clokeran 2mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Clokeran 2mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Clokeran 2mg Tablet:
When Etanercept is used with Clokeran 2mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Clokeran 2mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Clokeran 2mg Tablet:
Taking Tofacitinib with Clokeran 2mg Tablet may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Clokeran 2mg Tablet, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blo, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clokeran 2mg Tablet:
Taking thalidomide together with Clokeran 2mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Clokeran 2mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Clokeran 2mg Tablet:
The combined Cladribine with Clokeran 2mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Clokeran 2mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Taking this medicine with meals can decrease how much of the drug your body absorbs, making the treatment less effective. Always take it on an empty stomach.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

CLOKERAN 2MG TABLET is used to treat Cancer.
CLOKERAN 2MG TABLET contains Chlorambucil, which works by slowing or stopping the growth of cancer cells in your body. Thus, it treats cancer efficiently.
Attend all your doctor's appointments while taking CLOKERAN 2MG TABLET to ensure the therapy is effective. Regular blood tests and weight checks must be performed. While taking the CLOKERAN 2MG TABLET, both men and women should use an effective means of contraception. Do not use any other medications unless prescribed by the doctor.
Do not stop taking CLOKERAN 2MG TABLET on your own. Take CLOKERAN 2MG TABLET for as long as your doctor prescribes it, depending on your medical condition. Do not hesitate to speak with your doctor if you experience difficulty taking CLOKERAN 2MG TABLET.
Chlorambucil can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment.
Chlorambucil may increase the risk that you will develop other cancers. Talk to your doctor about this risk.
Some dietary changes can help you manage side effects; for example, in case of diarrhoea-Choose foods or drinks with sodium (sports drinks or broth) and potassium (bananas and all-natural fruit juices).
CLOKERAN 2MG TABLET should be taken orally. Swallow CLOKERAN 2MG TABLET as a whole with a glass of water. Do not break, crush or chew it.
CLOKERAN 2MG TABLET doesn’t have the potential to cause hair loss or constipation. However, if you experience hair loss or constipation, consult your doctor immediately.
CLOKERAN 2MG TABLET is metabolised in the liver and excreted in the urine.
Yes, CLOKERAN 2MG TABLET should be stored at 2-8°C (36-46°F). Keep it out of sight and reach of children.
The common side effects of CLOKERAN 2MG TABLET may include feeling sick (nausea), being sick (vomiting), sores in the mouth and throat, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.
No, you should take CLOKERAN 2MG TABLET on an empty stomach, either one hour before or two hours after a meal. Taking it with food can prevent your body from absorbing the medicine properly, making it less effective. Talk to your doctor or pharmacist if you struggle with nausea when taking it on an empty stomach.
You must contact your doctor or seek emergency medical care immediately if your temperature rises. A fever is often the first sign of a serious infection, which can become life-threatening very quickly when your white blood cell count is low. Talk to your doctor right away.
You can usually receive the inactive flu shot (the injection), but you must strictly avoid the live nasal spray flu vaccine. Always tell the health provider giving you the vaccine that you are taking CLOKERAN 2MG TABLET. Talk to your doctor before scheduling any vaccination.
Yes, CLOKERAN 2MG TABLET can cause temporary or permanent infertility in both men and women. It can also disrupt menstrual cycles in women. If you plan to have children in the future, discuss fertility preservation options with your doctor before starting treatment. Talk to your doctor for personalised advice.
No, CLOKERAN 2MG TABLET can cause severe harm and birth defects in an unborn baby. You must use effective birth control while taking this medicine. If you suspect you have become pregnant during treatment, contact your doctor immediately. Talk to your doctor for advice on safe family planning.
Do not touch the powder or broken pieces with your bare hands. Wear disposable gloves, place the broken tablet into a sealed plastic bag, and return it to your pharmacy for safe disposal. Thoroughly wash your hands afterwards. Talk to your doctor or pharmacist if you need a replacement dose.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CLO0029
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