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compositionComposition:PENICILLAMINE-250MG
prescriptionPrescription Medicine
Cilamin-250 Capsule 10's
Cilamin-250 Capsule 10's
Cilamin-250 Capsule 10's
Cilamin-250 Capsule 10's
Cilamin-250 Capsule 10's

Cilamin-250 Capsule is used to treat rheumatoid arthritis, Wilson's disease, cystinuria, and lead poisoning. It helps remove excess copper from the body and prevent organ damage.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PENICILLAMINE-250MG

Manufacturer/Marketer :

Panacea Biotec Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cilamin-250 Capsule

Cilamin-250 Capsule is used to treat severe rheumatoid arthritis (a joint disorder in which our immune system attacks our body cells), Wilson's disease (a genetic problem characterised by excess copper deposited in body parts like the eye, brain, and liver), and cystinuria (excess build-up of cystine in the urinary bladder and kidney).

Cilamin-250 Capsule contains Penicillamine, which works by blocking the action of certain chemical messengers. For Wilson's disease, it binds to the extra copper in the body and causes it to leave the body through the urine.

Cilamin-250 Capsule may cause common side effects such as protein in the urine, low platelet counts, stomach upset, diarrhoea, changes in taste, loss of appetite, mouth irritation, and mouth sores. Most of these side effects do not require medical attention. However, talk to your doctor if these side effects persist.

Do not take Cilamin-250 Capsule if you are pregnant or planning a pregnancy, as Cilamin-250 Capsule causes serious congenital disabilities. Cilamin-250 Capsule should not be taken by breastfeeding mothers, as it passes into breast milk. Inform your doctor about your health condition and any medicines you are taking to rule out any unpleasant side effects.

Uses of Cilamin-250 Capsule

Cilamin-250 Capsule used in the treatment of rheumatoid arthritis, Wilson's disease, and cystinuria. The detailed uses of Cilamin-250 Capsule are as follows:

  • Treats Wilson’s Disease: Cilamin-250 Capsule helps to remove excess copper from the body by binding to it and promoting its excretion, preventing damage to the liver, brain, and other organs.
  • Manages Rheumatoid Arthritis: Cilamin-250 Capsule is used to reduce joint inflammation, pain, stiffness, and slow joint damage, and disease progression over time.
  • Prevents Kidney Stone Formation in Cystinuria: Cilamin-250 Capsule reduces urinary cystine levels, helping prevent cystine stone formation in patients with cystinuria.

Health Queries

I am experiencing difficulty speaking and have Wilson's disease. How can it be managed?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Speech difficulties in Wilson's disease are usually managed by reducing copper levels with medications such as penicillamine or trientine, or by using zinc therapy to prevent copper absorption. Alongside this, physiotherapy can help with muscle stiffness, and speech therapy can improve speech clarity. Starting treatment early and attending regular check-ups with your doctor can help manage symptoms, slow disease progression, and prevent complications.

My joints are stiff due to rheumatoid arthritis. Can you suggest a treatment?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

For rheumatoid arthritis, treatment focuses on reducing inflammation, relieving pain, and preventing joint damage. Your doctor may prescribe disease-modifying antirheumatic drugs (such as methotrexate or leflunomide) to slow disease progression, paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief, and physiotherapy to maintain joint movement. In some cases, corticosteroid injections or biologic medicines may be recommended if symptoms are severe. Regular follow-up is essential to monitor your disease activity and adjust your treatment.

Is juvenile rheumatoid arthritis, which is an autoimmune disease, curable with Ayurvedic medicines?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Juvenile rheumatoid arthritis is a long-term autoimmune condition and cannot be fully cured with Ayurvedic medicines. These may help ease some symptoms, but standard treatments are needed to control inflammation and protect the joints. Consulting a paediatric rheumatologist is crucial for proper treatment and to support your child?s overall growth.

Have a query?

Directions for Use

  • Cilamin-250 Capsule should be taken 1 hour before or 2 hours after a meal. Avoid drinking milk while taking Cilamin-250 Capsule .
  • Your doctor will determine the dosage and timing of this medication based on your medical condition. Typically, it is taken 3-4 times daily.
  • Swallow Cilamin-250 Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

Key Benefits

For Rheumatoid Arthritis:

  • Aids in reducing afflicted joints' stiffness, discomfort, and oedema.
  • Reduces joint degeneration and deformity by acting as a disease-modifying agent.
  • Improves everyday activities and mobility by managing symptoms.
  • Beneficial for those who don't react well to other arthritis medications.

For Wilson’s Disease:

  • Binds to excess copper in the body and aids in its excretion through the urine.
  • Prevents major problems by lowering copper accumulation in the liver, brain, and other organs.
  • Helps heal liver-related illnesses and reduces liver inflammation.
  • May help with speech, mobility, and tremors caused by copper buildup.

For Cystinuria:

  • Makes it easier to pass in urine by binding to cystine to form a more soluble molecule.
  • Reduces the risk of recurrent cystine-induced kidney stones.
  • Lessens discomfort and obstruction brought on by stone development.
  • Beneficial for patients who don't react well to dietary modifications and other therapies.

How Cilamin-250 Capsule Works

Cilamin-250 Capsule contains penicillamine as a active ingredient. For rheumatoid arthritis, it blocks the action of certain chemical messengers responsible for inflammation and slowing the progress of the condition with certain joint diseases. It works in Wilson's disease by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function and mental, mood, and nerve problems (like confusion and difficulty speaking or walking) caused by Wilson's disease.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cilamin-250 Capsule
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

What if I have taken an overdose of Cilamin-250 Capsule

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

  • Do not take Cilamin-250 Capsule if you are allergic (hypersensitive) to penicillamine or any of the other ingredients in it.
  • Inform your doctor if you have severe kidney problems, lupus erythematosus, agranulocytosis (a low white cell blood count), aplastic anaemia or thrombocytopenia (a blood disorder which causes bleeding into your skin, bruising and bleeding more than normal).
  • Do not take Cilamin-250 Capsule if you are pregnant or planning to get pregnant and breastfeeding. This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • Caution should be required while taking Cilamin-250 Capsule by elderly patients as they may be at greater risk of suffering side effects if you are taking Cilamin-250 Capsule over a long time, especially if you are on a restricted diet, as this medicine increases the requirement for pyridoxine (Vitamin B6) so your doctor may also prescribe this vitamin for you.
  • If you are taking iron tablets, antacids, or digoxin (used to treat heart failure), please maintain two hours gap between these tablets and Cilamin-250 Capsule .
  • Low blood cell counts have happened while taking Cilamin-250 Capsule .
  • If blood cell counts get very low, this can lead to bleeding problems, infections, or anaemia, and sometimes, these have been deadly. 

Drug-Drug Interactions

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PenicillamineIoversol
Severe
PenicillamineLeflunomide
Severe

Drug-Drug Interactions

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PenicillamineIoversol
Severe
How does the drug interact with Cilamin-250 Capsule:
Using ioversol together with Cilamin-250 Capsule can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Cilamin-250 Capsule and ioversol, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineLeflunomide
Severe
How does the drug interact with Cilamin-250 Capsule:
Using Cilamin-250 Capsule with leflunomide can increase the risk of low blood levels.

How to manage the interaction:
There may be a possibility of interaction between Leflunomide and Cilamin-250 Capsule, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineTenofovir disoproxil
Severe
How does the drug interact with Cilamin-250 Capsule:
Coadministration of Tenofovir disoproxil with Cilamin-250 Capsule can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Cilamin-250 Capsule can possibly result in an interaction, it can be taken when your doctor has advised it. However, if you experience vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PenicillamineCladribine
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking cladribine with Cilamin-250 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Cilamin-250 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PenicillamineSodium aurothiomalate
Severe
How does the drug interact with Cilamin-250 Capsule:
Using Cilamin-250 Capsule together with sodium aurothiomalate can increase the severity of adverse effects of Cilamin-250 Capsule.

How to manage the interaction:
There may be a possibility of interaction between Sodium aurothiomalate and Cilamin-250 Capsule, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PenicillamineDeferiprone
Severe
How does the drug interact with Cilamin-250 Capsule:
Deferiprone when taken with Cilamin-250 Capsule can cause an increased risk of low blood levels.

How to manage the interaction:
Co-administration of Cilamin-250 Capsule with Deferiprone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineMetrizamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule together with metrizamide can cause severe kidney problems.

How to manage the interaction:
Although taking Cilamin-250 Capsule and Metrizamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineIodamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Using iodamide together with Cilamin-250 Capsule can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Cilamin-250 Capsule and iodamide, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineTenofovir alafenamide
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule and tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Cilamin-250 Capsule and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineClozapine
Severe
How does the drug interact with Cilamin-250 Capsule:
Taking Cilamin-250 Capsule with Clozapine can increase the risk of low blood levels.

How to manage the interaction:
Taking Cilamin-250 Capsule with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Diet:

  • Limit consumption of spinach, wheat bran, nuts, beets and dairy products.
  • Avoid high salt intake and foods containing baking soda.
  • Drink plenty of fluids.
  • For Wilson’s disease: Try to avoid high-copper foods like shellfish, liver, nuts, chocolate, and mushrooms.

Lifestyle changes:

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Avoid smoking and alcohol consumption.
  • Try to strengthen muscles and relieve joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

Physical activity:

  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.

Safety tips:

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Follow work safety regulations if you are at risk of occupational exposure.
  • Wear necessary protective gear while working and do not take any contaminated material such as clothing or work gear to home. 

Habit Forming

No

Therapeutic Class

[CHELATING AGENTS]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Cilamin-250 Capsule . It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Cilamin-250 Capsule is a pregnancy category D drug. It is not recommended to take Cilamin-250 Capsule while you are pregnant. Cilamin-250 Capsule may cause serious birth defects.

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Breast Feeding

Unsafe

Cilamin-250 Capsule should not be used in breastfeeding mothers as Cilamin-250 Capsule passes into breast milk.

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Driving

Caution

Cilamin-250 Capsule may cause dizziness, drowsiness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Unsafe

Cilamin-250 Capsule is not recommended for the liver patients.

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Kidney

Caution

Cilamin-250 Capsule should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.

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Children

Consult your doctor

Cilamin-250 Capsule should be used in children under the care of the doctor. The dose may depend on the weight and age of the child.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Cilamin-250 Capsule . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Cilamin-250 Capsule should be used with extreme caution in elderly patients due to an increased risk of adverse effects.

FAQs

Cilamin-250 Capsule is used to treat‚ severe rheumatoid arthritis, Wilsons disease, and cystinuria. Rheumatoid arthritis is a joint disorder in which our immune system attacks our body cells. Wilson disease is a genetic problem characterized by excess copper deposited in body parts like the eye, brain, and liver, leading to metal toxicity. Cystinuria is the excess build-up of an amino acid called cystine in the urinary bladder and kidney, leading to harmful effects.

Cilamin-250 Capsule works by blocking the actions of certain chemical messengers responsible for inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

Wilson's disease is a condition where the body cannot get rid of copper properly, causing damage to the liver, brain, and other organs. Cilamin-250 Capsule contains penicillamine, which helps the body remove excess copper.

Avoid taking other medicines at the same time while taking Cilamin-250 Capsule . If you take an iron supplement, take it at least 2 hours before or after you take Cilamin-250 Capsule . Iron can make it harder for your body to absorb Cilamin-250 Capsule . Avoid taking mineral supplements unless your doctor advises you to. Do not drink milk within 1 hour before or after you take Cilamin-250 Capsule . Do not take copper-containing foods like shellfish, chocolate, nuts, mushrooms, and organ meats (liver pate, sweetbreads, etc.)

Cilamin-250 Capsule may cause side effects such as protein in urine, low platelet counts, stomach upset or vomiting, diarrhoea, changes in taste, loss of appetite, mouth irritation, and mouth sores. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, inform your doctor immediately.

Cilamin-250 Capsule should not be taken during pregnancy or if you are trying to become pregnant, as Cilamin-250 Capsule can cause birth defects, miscarriages or harm to unborn babies. Avoid becoming pregnant for at least 6 months after stopping the treatment with Cilamin-250 Capsule .

Cilamin-250 Capsule belongs to the class of medications called disease-modifying antirheumatic drugs (DMARDs). It is used to treat various conditions, including Wilson's disease, rheumatoid arthritis, and cystinuria.

No, Cilamin-250 Capsule is not an antibiotic. It is actually a disease-modifying antirheumatic drug (DMARD) used to treat conditions like Wilson's disease, rheumatoid arthritis, and cystinuria.

Country of origin

INDIA

Manufacturer/Marketer address

Ambala- Chandigarh Highway, Lalru – 140501, Punjab
Other Info - CIL0001

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