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compositionComposition:CIDOFOVIR-75MG/ML
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Cidonat 375 mg Injection 5 ml is used in the treatment of cytomegalovirus (CMV) retinitis. It contains Cidofovir, which works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis. It works by slowing the growth of the cytomegalovirus. Thus, it helps treat Cytomegalovirus (CMV) retinitis. This medicine is contraindicated in patients with renal insufficiency and patients who cannot receive probenecid or other sulfa-containing products. This medicine should not be used for conditions other than CMV retinitis.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CIDOFOVIR-75MG/ML

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Cidonat 375 mg Injection 5 ml

Cidonat 375 mg Injection 5 ml is an antiviral injection used to treat cytomegalovirus (CMV) retinitis, a serious viral eye infection, in patients with acquired immunodeficiency syndrome (AIDS). By stopping the virus from spreading, it helps protect your eyesight from further damage. This medicine is not a cure for CMV, but it is an important tool in managing the infection and preserving your vision.

Because this medicine is given as an injection into a vein, you will receive it at a clinic or hospital. It is typically given once a week for the first two weeks, followed by a maintenance schedule of once every two weeks. Since it is injected, food does not affect how it works, but staying very well hydrated before and after each treatment is vital to protect your kidneys. Making simple lifestyle adjustments, such as drinking plenty of water, plays a key role in the success of your therapy.

While Cidonat 375 mg Injection 5 ml is highly effective, it carries a risk of side effects, particularly kidney damage. Common side effects include fever, nausea, and hair loss. If you notice signs of kidney issues, such as changes in how often you urinate, or if you experience vision changes, you must consult your doctor immediately.

Do not take this if you have pre-existing kidney problems or if you cannot take probenecid, a medicine that must be given alongside Cidonat 375 mg Injection 5 ml to protect your kidneys. Your doctor will perform tests to make sure this medicine is safe for you before starting.

Tell your healthcare provider about all other medications you are taking, especially any that can affect your kidneys, as combining them can be dangerous. Women who are pregnant or breastfeeding, as well as elderly individuals, should consult their doctor before starting treatment, as special precautions are required.

Uses of Cidonat 375 mg Injection 5 ml

Cidonat 375 mg Injection 5 ml may be prescribed for the following condition:

  • CMV Retinitis in patients with AIDS: Cidonat 375 mg Injection 5 ml helps by stopping the growth of cytomegalovirus (CMV) in the retina of the eye, which helps prevent vision loss and blindness in people with weakened immune systems.

Key Benefits

Cidonat 375 mg Injection 5 ml provides crucial benefits for managing viral eye infections:

  • Protects your vision: By halting the replication of the virus, this medicine helps prevent the infection from spreading across your retina, preserving your remaining eyesight.
  • Targeted viral control: It acts directly against the virus, helping to keep the infection inactive so you can focus on your overall recovery.
  • Convenient schedule: After the initial weekly doses, the maintenance injections are given only once every two weeks, reducing the number of clinic visits.
Side effects of Cidonat 375 mg Injection 5 ml
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Drink adequate water to stay hydrated and support kidney function.
  • Limit sodium intake and avoid processed foods to reduce blood pressure.
  • Consume moderate amounts of high-quality protein from sources like lean meats, fish, and plant-based options.
  • Restrict potassium-rich foods and control phosphorus intake to minimize kidney strain.
  • Include antioxidant-rich foods like fruits, vegetables, and omega-3 fatty acids in your diet.
  • Avoid consuming processed and high-sugar foods that can worsen kidney damage.
  • Limit alcohol consumption and caffeine intake to reduce kidney stress.
  • Quit smoking to significantly lower the risk of kidney damage.
  • Engage in regular exercise to control weight, improve circulation, and lower blood pressure.
  • Consider taking nutritional supplements like omega-3 fatty acids, vitamin D, and antioxidants under medical guidance.
  • Regularly schedule medical checkups to monitor kidney function and adjust your plan as needed.
  • Collaborate with a healthcare provider to develop a personalized diet and lifestyle plan tailored to your needs.
  • Low bicarbonate levels can lead to more acid buildup in your blood, so your doctor may administer sodium bicarbonate through an IV to help balance it.
  • Drink lots of fluids or water to reduce acid load in your blood, and make sure your urine is clear or light yellow.
  • Limit alcohol intake, as it can dehydrate you and increase acid buildup.
  • If you are diabetic, keep your blood sugar levels in a healthy range.
  • Eat high-alkaline foods, like fruits, nuts, legumes, and vegetables.
  • Avoid foods that can cause your body to produce more acids, including eggs, meats, cheese, and grains.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Cidonat 375 mg Injection 5 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Cidonat 375 mg Injection 5 ml Works

Cidonat 375 mg Injection 5 ml contains cidofovir. It is an antiviral medicine that works by blocking the virus's ability to copy itself. The virus relies on a specific enzyme to replicate its genetic material (DNA). Cidonat 375 mg Injection 5 ml blocks this enzyme, effectively shutting down the virus's reproduction process. Once the virus can no longer duplicate its DNA, it cannot spread to healthy cells in your eye. This stops the active infection, allowing your body to control the virus and helping prevent further damage to your retina.
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Alcohol

Consult your doctor

There is limited information on how alcohol consumption affects Cidonat 375 mg Injection 5 ml. Please consult your doctor.

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Pregnancy

Unsafe

Cidonat 375 mg Injection 5 ml may cause fetal toxicity and impairment of fertility in males and females. Hence, inform your doctor if you are pregnant before receiving Cidonat 375 mg Injection 5 ml.

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Breast Feeding

Unsafe

Cidonat 375 mg Injection 5 ml is not recommended for use in nursing mothers as it can cause serious side effects to newborn infants. Hence, inform your doctor if you are breastfeeding.

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Driving

Unsafe

Cidonat 375 mg Injection 5 ml may cause fatigue and drowsiness. Hence, do not drive or operate machinery that requires mental alertness until you are not alert.

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Liver

Caution

Inform your doctor if you have any history of liver diseases or hepatic impairment before receiving Cidonat 375 mg Injection 5 ml. Your doctor will advise this medicine only if the benefits outweigh the risks.

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Kidney

Caution

Cidonat 375 mg Injection 5 ml is known to cause kidney damage. Hence, inform your doctor if you have any history of kidney problems before receiving Cidonat 375 mg Injection 5 ml. This medicine is contraindicated in patients with severe renal disease or renal insufficiency.

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Children

Unsafe

The use of Cidonat 375 mg Injection 5 ml is not recommended for children below 18 years of age as the safety and efficacy data are not established.

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Heart

Caution

Cidonat 375 mg Injection 5 ml should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Cidonat 375 mg Injection 5 ml.

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Geriatrics

Caution

Cidonat 375 mg Injection 5 ml should be used with caution in geriatric patients due to increased risk of age-related side effects. Therefore, please consult your doctor before giving Cidonat 375 mg Injection 5 ml to elderly individuals.

What if I have taken an overdose of Cidonat 375 mg Injection 5 ml

Since this medicine is injected by healthcare professionals in a medical clinic, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe side effects after an infusion, seek immediate medical attention or contact emergency services.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Staying well-hydrated is the most important step you can take. Drink plenty of water before and after your injection to help flush the medicine through your kidneys.
  • Protect your eyes: Wear sunglasses when outdoors, as your eyes may become more sensitive to light during treatment.
  • Eat nutrient-rich foods: A balanced diet rich in vitamins and minerals helps support your immune system while your body fights the virus.
  • Avoid alcohol: Alcohol can place extra stress on your kidneys and liver, so it is best to avoid it during your treatment.
health query

Have a query?

How Soon It Starts Working

The time required for Cidonat 375 mg Injection 5 ml to start to work: The time required for Cidonat 375 mg Injection 5 ml to show its action is not clinically established. The time for which the effects of Cidonat 375 mg Injection 5 ml last: The duration of action for Cidonat 375 mg Injection 5 ml is not clinically established.

What if you forget to take Cidonat 375 mg Injection 5 ml

If you miss an appointment for your injection, contact your clinic or healthcare provider immediately to reschedule. It is important to receive this medicine on a consistent schedule to keep the virus from multiplying.

Storage

• The vials of Cidonat 375 mg Injection 5 ml must be stored at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the Infusion Before Use: The solution should be clear and colourless. Do not use it if it appears cloudy, discoloured, or contains visible particles.
  • Follow Kidney-Protective Measures: Take oral probenecid and receive intravenous fluids exactly as prescribed before each Cidonat 375 mg Injection 5 ml treatment to reduce the risk of kidney damage.
  • Attend Regular Monitoring: Keep all scheduled blood and urine tests so your doctor can closely monitor your kidney function and adjust treatment if needed.
  • Avoid Pregnancy During and After Treatment: Cidonat 375 mg Injection 5 ml can harm an unborn baby. Women who could become pregnant should use effective contraception during treatment and for at least 1 month after the final dose.
  • Use Effective Contraception if Male: Men should use effective barrier contraception, such as condoms, during treatment and for at least 3 months after the last dose if their partner could become pregnant.
  • Avoid Kidney-Harming Medicines: Do not take other medicines that may damage the kidneys unless specifically approved by your doctor.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all medicines you are taking before receiving Cidonat 375 mg Injection 5 ml, especially the following:

  • Kidney-damaging medicines: Taking Cidonat 375 mg Injection 5 ml with other medicines that can harm the kidneys (such as certain antibiotics, antifungals like amphotericin B, or other antivirals) can greatly increase the risk of severe kidney damage.
  • Zidovudine: If you are taking zidovudine for HIV, your doctor may ask you to temporarily stop taking it or reduce the dose on the days you receive Cidonat 375 mg Injection 5 ml to avoid interactions with probenecid.
CidofovirCiclosporin
Critical
CidofovirFenoprofen
Critical

Drug-Drug Interactions

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CidofovirCiclosporin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking cyclosporine with Cidonat 375 mg Injection 5 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Ciclosporin with Cidonat 375 mg Injection 5 ml is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CidofovirFenoprofen
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Cidonat 375 mg Injection 5 ml with Fenoprofen can increase the risk of kidney problems

How to manage the interaction:
Taking Fenoprofen with Cidonat 375 mg Injection 5 ml is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirMesalazine
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Mesalazine with Cidonat 375 mg Injection 5 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesalazine with Cidonat 375 mg Injection 5 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirTacrolimus
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking Cidonat 375 mg Injection 5 ml with tacrolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacrolimus with Cidonat 375 mg Injection 5 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
CidofovirTobramycin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Coadministration of Cidonat 375 mg Injection 5 ml with Tobramycin can cause kidney problems.

How to manage the interaction:
Taking Tobramycin with Cidonat 375 mg Injection 5 ml is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without consulting a doctor.
CidofovirPiroxicam
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Cidonat 375 mg Injection 5 ml with Piroxicam can increase the risk of kidney problems.

How to manage the interaction:
Taking Piroxicam with Cidonat 375 mg Injection 5 ml is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirTenofovir alafenamide
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Coadministration of Cidonat 375 mg Injection 5 ml and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Cidonat 375 mg Injection 5 ml and Tenofovir alafenamide together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
CidofovirDeferoxamine
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Deferoxamine and Cidonat 375 mg Injection 5 ml may increase the risk of kidney problems.

How to manage the interaction:
Taking Deferoxamine with Cidonat 375 mg Injection 5 ml is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CidofovirVancomycin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Coadministration of Vancomycin with Cidonat 375 mg Injection 5 ml can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Cidonat 375 mg Injection 5 ml is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop signs such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
CidofovirAciclovir
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Cidonat 375 mg Injection 5 ml with Acyclovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Aciclovir with Cidonat 375 mg Injection 5 ml is not recommended, please consult your doctor before taking it. You should consult a doctor if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, weakness, and palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Cidonat 375 mg Injection 5 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Cidonat 375 mg Injection 5 ml is used to treat Cytomegalovirus (CMV) retinitis.
Cidonat 375 mg Injection 5 ml works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis.
Inform your doctor if you are pregnant or a nursing mother before starting treatment with Cidonat 375 mg Injection 5 ml. Maintain caution if you have kidney, liver, or blood disorders, a weakened immune system, diabetes, or an electrolyte imbalance, as it may worsen your condition. Your doctor will administer Cidonat 375 mg Injection 5 ml only when the benefits outweigh the risks.
Cidonat 375 mg Injection 5 ml is given as an intravenous infusion (a slow drip into a vein) by a healthcare professional in a medical clinic or hospital. Talk to your doctor for more details about your schedule.
Probenecid pills and intravenous fluids are given to protect your kidneys from the side effects of Cidonat 375 mg Injection 5 ml. They help your kidneys process the medicine safely. Talk to your doctor if you have concerns.
No, Cidonat 375 mg Injection 5 ml does not cure CMV retinitis, but it controls the virus to help prevent further damage to your vision. Talk to your doctor about your long-term treatment plan.
Early signs include urinating less frequently, swelling in your ankles or feet, and feeling unusually tired. If you notice these, seek medical attention immediately. Talk to your doctor.
No, this medicine should not be used during pregnancy because it can cause severe birth defects. Talk to your doctor about safe contraceptive options.
It is highly recommended to avoid alcohol while receiving this treatment, as alcohol can strain your kidneys and liver, which are already working hard. Talk to your doctor.
Your doctor will check your kidney function through blood and urine tests before every single dose of Cidonat 375 mg Injection 5 ml. Talk to your doctor about your test schedule.
If you notice any changes in your sight, such as new blind spots, blurred vision, or eye pain, contact your eye doctor or healthcare provider immediately. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 020638S003Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db00369 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A696037 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Cidofovir Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. 2012. [Accessed on 02 Jan. 2026]Check here
  6. S Safrin 1, J Cherrington, HS Jaffe. Clinical uses of cidofovir. NCBI; PMC US National Library of Medicine, National Institute of Health. September 1997. [Accessed on 22nd August 2024]Check here
  7. MIAS Pharma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2023] [Accessed on 22nd August 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CID0082
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