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compositionComposition:CIDOFOVIR-75MG/ML
prescription
Prescription Medicine
info
Cidonat 375 mg Injection 5 ml

Cidonat 375 mg Injection 5 ml is used in the treatment of cytomegalovirus (CMV) retinitis. It contains Cidofovir, which works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis. It works by slowing the growth of the cytomegalovirus. Thus, it helps treat Cytomegalovirus (CMV) retinitis. This medicine is contraindicated in patients with renal insufficiency and patients who cannot receive probenecid or other sulfa-containing products. This medicine should not be used for conditions other than CMV retinitis.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CIDOFOVIR-75MG/ML

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Cidonat 375 mg Injection 5 ml

Cidonat 375 mg Injection 5 ml is an antiviral medicine used in the treatment of cytomegalovirus (CMV) retinitis. Cytomegalovirus (CMV) retinitis is a viral infection that affects the retina of the eye caused by a virus called Cytomegalovirus (CMV), especially in AIDS patients. It is a serious infection that can lead to blindness. Cidonat 375 mg Injection 5 ml is used in combination with oral probenecid.

Cidonat 375 mg Injection 5 ml contains Cidofovir, which works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis. It works by slowing the growth of the cytomegalovirus. Thus, it helps treat Cytomegalovirus (CMV) retinitis.

Cidonat 375 mg Injection 5 ml may cause certain side effects such as nausea, vomiting, headache, hair loss, rash, weakness, fever, inflammation of the eye, shortness of breath, diarrhoea, chills, and pain at the injection site. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please inform your doctor. A healthcare professional will administer Cidonat 375 mg Injection 5 ml; hence, do not self-administer.

Cidonat 375 mg Injection 5 ml should be avoided if you are allergic to it. This medicine is contraindicated in patients with renal insufficiency and patients who cannot receive probenecid or other sulfa-containing products. This medicine should not be used for conditions other than CMV retinitis. Let your doctor know about your complete medical and medication history to rule out any interactions. Inform your doctor if you have a weakened immune system, an electrolyte imbalance, diabetes, and liver or kidney diseases before starting the use of Cidonat 375 mg Injection 5 ml. Cidonat 375 mg Injection 5 ml is not recommended for use in pregnant and breastfeeding women.

Uses of Cidonat 375 mg Injection 5 ml

Cidonat 375 mg Injection 5 ml is used in the treatment of Cytomegalovirus (CMV) retinitis. The detailed use of Cidonat 375 mg Injection 5 ml is as follows:

  • Cytomegalovirus (CMV) Retinitis in AIDS Patients: Cidonat 375 mg Injection 5 ml helps slow the progression of CMV-related vision loss in people with AIDS.

Key Benefits

Cidonat 375 mg Injection 5 ml treats viral infection of the eye caused by Cytomegalovirus (CMV) retinitis. Cidonat 375 mg Injection 5 ml consists of Cidofovir, which works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis. It helps kill the virus and eventually stop the growth of the cytomegalovirus. Thus, helps to treat Cytomegalovirus (CMV) retinitis. This medicine is only used in treating CMV retinitis but is not used for other conditions. It does not help in treating HIV infection.

Side effects of Cidonat 375 mg Injection 5 ml
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Drink adequate water to stay hydrated and support kidney function.
  • Limit sodium intake and avoid processed foods to reduce blood pressure.
  • Consume moderate amounts of high-quality protein from sources like lean meats, fish, and plant-based options.
  • Restrict potassium-rich foods and control phosphorus intake to minimize kidney strain.
  • Include antioxidant-rich foods like fruits, vegetables, and omega-3 fatty acids in your diet.
  • Avoid consuming processed and high-sugar foods that can worsen kidney damage.
  • Limit alcohol consumption and caffeine intake to reduce kidney stress.
  • Quit smoking to significantly lower the risk of kidney damage.
  • Engage in regular exercise to control weight, improve circulation, and lower blood pressure.
  • Consider taking nutritional supplements like omega-3 fatty acids, vitamin D, and antioxidants under medical guidance.
  • Regularly schedule medical checkups to monitor kidney function and adjust your plan as needed.
  • Collaborate with a healthcare provider to develop a personalized diet and lifestyle plan tailored to your needs.
  • Low bicarbonate levels can lead to more acid buildup in your blood, so your doctor may administer sodium bicarbonate through an IV to help balance it.
  • Drink lots of fluids or water to reduce acid load in your blood, and make sure your urine is clear or light yellow.
  • Limit alcohol intake, as it can dehydrate you and increase acid buildup.
  • If you are diabetic, keep your blood sugar levels in a healthy range.
  • Eat high-alkaline foods, like fruits, nuts, legumes, and vegetables.
  • Avoid foods that can cause your body to produce more acids, including eggs, meats, cheese, and grains.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Cidonat 375 mg Injection 5 ml will be administered by a nurse or doctor.
  • Do not self-administer.

How Cidonat 375 mg Injection 5 ml Works

Cidonat 375 mg Injection 5 ml contains Cidofovir, which works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis. It works by slowing the growth of the cytomegalovirus. Thus, it helps treat Cytomegalovirus (CMV) retinitis.
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Alcohol

Consult your doctor

There is limited information on how alcohol consumption affects Cidonat 375 mg Injection 5 ml. Please consult your doctor.

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Pregnancy

Unsafe

Cidonat 375 mg Injection 5 ml may cause fetal toxicity and impairment of fertility in males and females. Hence, inform your doctor if you are pregnant before receiving Cidonat 375 mg Injection 5 ml.

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Breast Feeding

Unsafe

Cidonat 375 mg Injection 5 ml is not recommended for use in nursing mothers as it can cause serious side effects to newborn infants. Hence, inform your doctor if you are breastfeeding.

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Driving

Unsafe

Cidonat 375 mg Injection 5 ml may cause fatigue and drowsiness. Hence, do not drive or operate machinery that requires mental alertness until you are not alert.

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Liver

Caution

Inform your doctor if you have any history of liver diseases or hepatic impairment before receiving Cidonat 375 mg Injection 5 ml. Your doctor will advise this medicine only if the benefits outweigh the risks.

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Kidney

Caution

Cidonat 375 mg Injection 5 ml is known to cause kidney damage. Hence, inform your doctor if you have any history of kidney problems before receiving Cidonat 375 mg Injection 5 ml. This medicine is contraindicated in patients with severe renal disease or renal insufficiency.

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Children

Unsafe

The use of Cidonat 375 mg Injection 5 ml is not recommended for children below 18 years of age as the safety and efficacy data are not established.

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Heart

Caution

Cidonat 375 mg Injection 5 ml should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Cidonat 375 mg Injection 5 ml.

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Geriatrics

Caution

Cidonat 375 mg Injection 5 ml should be used with caution in geriatric patients due to increased risk of age-related side effects. Therefore, please consult your doctor before giving Cidonat 375 mg Injection 5 ml to elderly individuals.

What if I have taken an overdose of Cidonat 375 mg Injection 5 ml

As Cidonat 375 mg Injection 5 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Cidonat 375 mg Injection 5 ml may cause a change in the amount of urine.

Diet & Lifestyle Advise

  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Know your allergy triggers, such as pollen, dust and other factors.
  • Do not rub your eyes even though some ophthalmic drugs make your eye itchy.
  • Try to drink plenty of water to keep your body hydrated.

Have a query?

How Soon It Starts Working

The time required for Cidonat 375 mg Injection 5 ml to start to work: The time required for Cidonat 375 mg Injection 5 ml to show its action is not clinically established. The time for which the effects of Cidonat 375 mg Injection 5 ml last: The duration of action for Cidonat 375 mg Injection 5 ml is not clinically established.

What if you forget to take Cidonat 375 mg Injection 5 ml

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Cidonat 375 mg Injection 5 ml out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Cidonat 375 mg Injection 5 ml should be avoided if you are allergic to it. Let your doctor know about your medical history and medication history to rule out any interactions. This medicine is contraindicated in patients with renal insufficiency, patients who cannot receive probenecid or other sulfa-containing products, and the use of Cidonat 375 mg Injection 5 ml in conditions other than CMV retinitis. Inform your doctor if you have a weakened immune system, an electrolyte imbalance, diabetes, and liver or kidney diseases before starting Cidonat 375 mg Injection 5 ml. Cidonat 375 mg Injection 5 ml is not recommended for use in pregnant and breastfeeding women. Hence, inform your doctor before starting Cidonat 375 mg Injection 5 ml.  Cidonat 375 mg Injection 5 ml may cause nephrotoxicity, haematological toxicity, decreased intraocular pressure, and metabolic acidosis in some patients. Hence, patients should be monitored carefully for any changes during the treatment. Cidonat 375 mg Injection 5 ml is not recommended for use in children below 16 years of age as the safety and efficacy are not established. Avoid driving and operating machines, as it can cause fatigue and dizziness.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Cidonat 375 mg Injection 5 ml may interact with antiviral drugs (Zidovudine, adefovir, tenofovir), anti-gout medicines (Probenecid), nephrotoxic drugs (foscarnet, amikacin, amphotericin B, vancomycin, gentamycin, tobramycin, pentamidine, ibuprofen, naproxen), etc.

Drug-Food Interactions: No drug-food interactions were found.

Drug-Disease Interactions: Cidonat 375 mg Injection 5 ml may have interactions with liver disease, kidney dysfunction, blood disorders, cancer patients, and diabetes.

CidofovirGanciclovir
Critical
CidofovirNaproxen
Critical

Drug-Drug Interactions

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CidofovirGanciclovir
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Coadministration of Cidonat 375 mg Injection 5 ml with ganciclovir can increase the risk of kidney problems.

How to manage the interaction:
Although there is a interaction between Ganciclovir and Cidonat 375 mg Injection 5 ml hence it is not recommended to be taken together, but it can be taken only if advised by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirNaproxen
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking Cidonat 375 mg Injection 5 ml with naproxen may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Naproxen with Cidonat 375 mg Injection 5 ml is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
CidofovirIfosfamide
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking Cidonat 375 mg Injection 5 ml with ifosfamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Ifosfamide with Cidonat 375 mg Injection 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Cidofovirvalacyclovir
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking Cidonat 375 mg Injection 5 ml with Valaciclovir can increase the risk of kidney problems.

How to manage the interaction:
Taking valacyclovir with Cidonat 375 mg Injection 5 ml is not recommended as it can lead to an interaction, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirOlsalazine
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Cidonat 375 mg Injection 5 ml with Olsalazine can increase the risk of kidney problems.

How to manage the interaction:
Taking Olsalazine with Cidonat 375 mg Injection 5 ml is not recommended, please consult your doctor before taking it. but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirCapreomycin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Taking Cidonat 375 mg Injection 5 ml with capreomycin can increase the risk of kidney problems.

How to manage the interaction:
Taking Capreomycin with Cidonat 375 mg Injection 5 ml is not recommended, but can be taken if prescribed by a doctor. However, if you experience s nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CidofovirLithium
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Cidonat 375 mg Injection 5 ml can cause higher levels of Lithium carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithium with Cidonat 375 mg Injection 5 ml is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
CidofovirTenofovir alafenamide
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Coadministration of Cidonat 375 mg Injection 5 ml and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Cidonat 375 mg Injection 5 ml and Tenofovir alafenamide together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
CidofovirStreptomycin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Using Cidonat 375 mg Injection 5 ml with streptomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Streptomycin with Cidonat 375 mg Injection 5 ml is not recommended, please consult your doctor before taking it. If you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
CidofovirAmikacin
Critical
How does the drug interact with Cidonat 375 mg Injection 5 ml:
Co-administration of Cidonat 375 mg Injection 5 ml with Amikacin can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Cidonat 375 mg Injection 5 ml with Amikacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, dizziness, or palpitations, consult a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Cidonat 375 mg Injection 5 ml is used to treat Cytomegalovirus (CMV) retinitis.

Cidonat 375 mg Injection 5 ml works by inhibiting the CMV polymerase enzyme responsible for viral DNA synthesis.

No,Cidonat 375 mg Injection 5 ml will be administered by the trained healthcare professional. Do not self-administer it.

Inform your doctor if you are pregnant or a nursing mother before starting treatment with Cidonat 375 mg Injection 5 ml. Maintain caution if you have kidney, liver, or blood disorders, a weakened immune system, diabetes, or an electrolyte imbalance, as it may worsen your condition. Your doctor will administer Cidonat 375 mg Injection 5 ml only when the benefits outweigh the risks.

Disclaimer

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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We provide you with authentic, trustworthy and relevant information.
See our editorial policy

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CID0082

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