What is the use of Cfara 20 mg Injection 20 ml?

Cfara 20 mg Injection 20 ml is used to treat Acute lymphocytic leukemia (ALL).

How does Cfara 20 mg Injection 20 ml work?

Cfara 20 mg Injection 20 ml contains Clofarabine, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Is Cfara 20 mg Injection 20 ml suitable for adults?

Cfara 20 mg Injection 20 ml is used only in children and adolescents 1-21 years. It is not recommended for adults.

can Cfara 20 mg Injection 20 ml cause Hemorrhage?

Treatment with Cfara 20 mg Injection 20 ml may result in cerebral, gastric, and pulmonary hemorrhage that is severe and fatal. Keep track of platelets and coagulation parameters and treat as needed.

When should I call my doctor right away while using Cfara 20 mg Injection 20 ml?

Call your doctor immediately if you notice any signs of an allergic reaction, like a rash, swelling of your face or throat, or difficulty breathing. Also, contact your doctor if you develop a fever, unusual bleeding or bruising, signs of infection, or any other side effects. Always inform your doctor about any new or concerning symptoms during your treatment to ensure prompt care.

Can Cfara 20 mg Injection 20 ml damage my liver?

Although liver damage from Cfara 20 mg Injection 20 ml is rare, serious liver problems such as hepatitis (inflammation of the liver) and liver failure have been reported. Your doctor will monitor your liver function during treatment and watch for signs such as yellowing of the skin or eyes (jaundice). Your doctor may stop the therapy if liver enzyme or bilirubin levels increase. Be sure to inform your doctor if you have any pre-existing liver problems before starting Cfara 20 mg Injection 20 ml, as they may conduct additional tests and adjust your treatment if needed.

I am experiencing nausea and extreme tiredness. Is this due to Cfara 20 mg Injection 20 ml?

Yes, nausea and extreme tiredness (fatigue) are common side effects of Cfara 20 mg Injection 20 ml. If these symptoms persist or become severe, please tell your doctor. Your doctor may adjust your treatment, provide medication to help with these symptoms or suggest lifestyle changes.

How to get relief from diarrhoea while on treatment with Cfara 20 mg Injection 20 ml?

If you experience diarrhoea while receiving Cfara 20 mg Injection 20 ml, it is important to stay hydrated by drinking plenty of fluids daily, such as water or oral rehydration solutions. However, if the diarrhoea becomes severe or continues, you should inform your doctor immediately. Your doctor may adjust your treatment plan or recommend additional treatments to help manage this side effect.

I have noticed some changes in my skin after taking Cfara 20 mg Injection 20 ml. What should I do?

Some individuals may experience skin changes such as a rash, peeling, lesions, or blisters after taking Cfara 20 mg Injection 20 ml. If you notice any skin changes, contact your doctor right away. They will help determine the cause and recommend the best course of action.

I can sense slight warmth in my face, ears, and neck after receiving Cfara 20 mg Injection 20 ml. Is this normal?

Yes, feeling a slight warmth (flushing) in your face, ears, or neck is a common side effect after receiving Cfara 20 mg Injection 20 ml. This is temporary and usually goes away shortly after the treatment is stopped. However, if it becomes uncomfortable or you notice anything unusual, contact your doctor immediately for guidance.

Should I avoid any food and drinks while taking Cfara 20 mg Injection 20 ml?

You should avoid fast food, fried foods, processed meats, refined carbs, and added sugars while taking Cfara 20 mg Injection 20 ml. It is also important to avoid alcohol, as it may cause severe side effects when combined with the treatment.

What should I avoid during my treatment with Cfara 20 mg Injection 20 ml?

During your treatment with Cfara 20 mg Injection 20 ml, you should avoid alcohol, as it may increase the risk of severe side effects. It is also recommended to avoid becoming pregnant, as Cfara 20 mg Injection 20 ml can harm an unborn baby. If you are breastfeeding, you should stop breastfeeding during treatment and for at least two weeks after the last dose, as it could harm your child. Always follow your doctor’s advice regarding other medications, herbal supplements, or vaccines that should be avoided while receiving Cfara 20 mg Injection 20 ml.

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Cfara 20 mg Injection 20 ml

Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cfara 20 mg Injection 20 ml used to treat acute lymphoblastic leukemia (ALL). It contains Clofarabine, which works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, it stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Also Explore

Composition :

CLOFARABINE-20MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cfara 20 mg Injection 20 ml

Cfara 20 mg Injection 20 ml is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Cfara 20 mg Injection 20 ml is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.

Cfara 20 mg Injection 20 ml contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Cfara 20 mg Injection 20 ml may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Cfara 20 mg Injection 20 ml. Do not self-administer.

Cfara 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.

Uses of Cfara 20 mg Injection 20 ml

Cfara 20 mg Injection 20 ml is used in the treatment of Acute lymphocytic leukemia (ALL). The detailed use of Cfara 20 mg Injection 20 ml is as follows:

Acute Lymphoblastic Leukemia (ALL): Cfara 20 mg Injection 20 ml is for use in children and young adults up to 21 years old who have relapsed or refractory ALL, especially when other treatments have failed.

Directions for Use

Follow your doctor's instructions on the dosage and timing of this medication.
Cfara 20 mg Injection 20 ml will be administered by a nurse or doctor.
Do not self-administer.

Medicinal Benefits

Cfara 20 mg Injection 20 ml contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Cfara 20 mg Injection 20 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

How Cfara 20 mg Injection 20 ml Works

Storage

• Store in a cool and dry place away from sunlight.• Keep Cfara 20 mg Injection 20 ml out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Cfara 20 mg Injection 20 ml

As Cfara 20 mg Injection 20 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Cfara 20 mg Injection 20 ml may cause rash, vomiting and yellowing of the skin or eyes.

Drug Warnings

Cfara 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Cfara 20 mg Injection 20 ml is given in children above one year of age only if prescribed by the doctor. Cfara 20 mg Injection 20 ml may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.

Drug-Drug Interactions

ClofarabineEtanercept

Severe

ClofarabineBaricitinib

Severe

Drug-Drug Interactions

ClofarabineEtanercept

Severe

How does the drug interact with Cfara 20 mg Injection 20 ml:
When Etanercept is used with Cfara 20 mg Injection 20 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Cfara 20 mg Injection 20 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

ClofarabineBaricitinib

Severe

How does the drug interact with Cfara 20 mg Injection 20 ml:
Coadministration of Cfara 20 mg Injection 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Taking Baricitinib with Cfara 20 mg Injection 20 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

ClofarabineLeflunomide

Severe

How does the drug interact with Cfara 20 mg Injection 20 ml:
Combining Cfara 20 mg Injection 20 ml with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Although taking Leflunomide and Cfara 20 mg Injection 20 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - such as fever, diarrhea, or muscle aches - contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

After beginning your treatment, several dietary adjustments can help you control side effects.
Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
Get optimal sleep; rest well.
Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

Therapeutic Class

ANTINEOPLASTIC

Cfara 20 mg Injection 20 ml Substitute

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by Others

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₹9183.18per tablet

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₹13200.00per tablet

Product Substitutes

Cfara Injection

₹11893.2

MRP ₹14503.9

Clofalon 20mg Injection

₹9183.18

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Farabine 20 mg Injection 20 ml

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MRP ₹15000

Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Cfara 20 mg Injection 20 ml as it may cause severe side effects.

Pregnancy

Unsafe

Cfara 20 mg Injection 20 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are under 21 and pregnant or planning pregnancy, inform your doctor before receiving Cfara 20 mg Injection 20 ml. You should not become pregnant while you are taking Cfara 20 mg Injection 20 ml. Using effective birth control methods while on treatment is suggested.

Breast Feeding

Unsafe

There are no data on the presence of clofarabine in human milk, its effects on breastfed children, or its impact on milk supply; due to the possibility of serious adverse events in breastfed children, including genotoxicity, patients are advised not to breastfeed during therapy and for at least two weeks following the final dosage.

Driving

Not applicable

Cfara 20 mg Injection 20 ml is administered to hospitalized patients.

Liver

Caution

Cfara 20 mg Injection 20 ml has not been studied in patients with liver impairment. However, inform your doctor if you have liver problems.

Kidney

Caution

If you have a history of kidney disease or have a pre-existing condition, notify your doctor before getting Cfara 20 mg Injection 20 ml. Based on your situation, your doctor may adjust the dose of this medication or prescribe a suitable alternative. Cfara 20 mg Injection 20 ml has the potential to cause renal toxicity, which presents as high creatinine levels and sudden renal failure. Monitor renal function and adjust or discontinue Clolar as needed.

Children

Safe if prescribed

Cfara 20 mg Injection 20 ml is recommended for children and adolescents below 21 years of age only if prescribed by the oncologist.

Heart

Please consult your doctor before receiving Cfara 20 mg Injection 20 ml if you have pre-existing heart problems. Your doctor will prescribe Cfara 20 mg Injection 20 ml if the benefits outweigh the risks.

Geriatrics

Consult your doctor

Please consult a doctor before administering Cfara 20 mg Injection 20 ml to geriatric patients. Your doctor will prescribe Cfara 20 mg Injection 20 ml if the benefits outweigh the risks.

Have a query?

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.

Other Info - CFA0006

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Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

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FAQs

What is the use of Cfara 20 mg Injection 20 ml?

How does Cfara 20 mg Injection 20 ml work?

Is Cfara 20 mg Injection 20 ml suitable for adults?

can Cfara 20 mg Injection 20 ml cause Hemorrhage?

Are there any side effects of Cfara 20 mg Injection 20 ml?

When should I call my doctor right away while using Cfara 20 mg Injection 20 ml?

Can Cfara 20 mg Injection 20 ml damage my liver?

I am experiencing nausea and extreme tiredness. Is this due to Cfara 20 mg Injection 20 ml?

How to get relief from diarrhoea while on treatment with Cfara 20 mg Injection 20 ml?

I have noticed some changes in my skin after taking Cfara 20 mg Injection 20 ml. What should I do?

I can sense slight warmth in my face, ears, and neck after receiving Cfara 20 mg Injection 20 ml. Is this normal?

Should I avoid any food and drinks while taking Cfara 20 mg Injection 20 ml?

What should I avoid during my treatment with Cfara 20 mg Injection 20 ml?

Disclaimer

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Reference