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compositionComposition:PRALIDOXIME-500MG
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Prescription Medicine
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CBCPAM INJECTION is used to treat poisoning caused by organic phosphorus pesticides or chemicals. It is also used to treat an overdose of drugs that treat myasthenia gravis. It contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRALIDOXIME-500MG

Manufacturer/Marketer :

Chandra Bhagat Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About CBCPAM INJECTION

CBCPAM INJECTION is an emergency injection used to treat severe poisoning caused by certain pest-control chemicals, insecticides, or nerve agents. It is also used to treat an accidental overdose of medicines prescribed for muscle weakness. This medicine works by reversing muscle paralysis and helping you breathe normally after exposure to these dangerous substances.

Because this medicine is used in emergency situations, you do not take it on a regular daily schedule. It is injected by a healthcare professional in a hospital or clinic as soon as possible after chemical exposure, and they may give additional doses if your symptoms continue. To help with your recovery, it is vital to stay away from the chemical source and avoid any further exposure to toxic sprays or vapours.

While receiving this medicine, you may experience some temporary side effects such as dizziness, blurred vision, or a fast heartbeat. If you experience severe symptoms like extreme muscle tightness, a very fast pulse, or worsening breathing problems, tell your healthcare team immediately. Your doctor will monitor your vital signs closely during the entire treatment.

Before you receive this injection, tell your healthcare provider if you have kidney disease, as this can affect how your body clears the medicine. You should also inform them if you have a muscle disorder called myasthenia gravis, as this treatment requires extra caution in such cases. Do not receive this injection if you have had a severe allergic reaction to it in the past.

This injection can interact with other medicines, including certain muscle relaxants, strong pain relievers, and barbiturates, so your doctor needs to know all medications you are taking. You should also tell your doctor if you are pregnant, breastfeeding, or if the patient is an elderly individual, so they can adjust the treatment safely.
 

Uses of CBCPAM INJECTION

Your doctor will use CBCPAM INJECTION in specific emergency situations to treat serious poisoning or medicine overdoses. The primary uses include:

  • Organophosphate poisoning: CBCPAM INJECTION helps reverse muscle weakness, breathing difficulties, and paralysis caused by exposure to toxic agricultural sprays, insecticides, or nerve agents.
  • Anticholinesterase drug overdose: CBCPAM INJECTION is used to treat an accidental overdose of medicines used for myasthenia gravis, helping to restore normal muscle function and control.

Key Benefits

CBCPAM INJECTION is an antidote used in the treatment of poisoning caused by organophosphate pesticides and certain other cholinesterase-inhibiting chemicals. It helps restore the activity of cholinesterase enzymes affected by these poisons, particularly when given soon after exposure.

  • Helps Reverse Poisoning Effects: Reactivates cholinesterase enzymes that have been inhibited by organophosphate poisoning, helping reduce excessive cholinergic effects.
  • Supports Muscle Function: Helps restore normal nerve-to-muscle signalling, which may improve muscle weakness, twitching, and paralysis caused by poisoning.
  • Supports Breathing: By improving the function of respiratory muscles, it may help restore effective breathing in people experiencing respiratory muscle weakness due to organophosphate poisoning.
  • Helps Control Severe Poisoning: Supports emergency treatment and recovery when used promptly alongside appropriate supportive care and other antidotal treatment, such as atropine when indicated.
  • Supports Recovery of Neuromuscular Function: May help restore strength and coordination as the effects of the poison are brought under control.
     
Side effects of Cbcpam Injection 20ml
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • CBCPAM INJECTION is given by the doctor or a trained nurse.
  • Do not self-administer.

How CBCPAM INJECTION Works

CBCPAM INJECTION contains pralidoxime. It works by targeting the specific chemical blockage caused by toxic poisons in your body. When you are exposed to certain insecticides or nerve agents, they block an essential enzyme called cholinesterase, which is responsible for controlling muscle movements and nerve signals. Without this enzyme, your body accumulates too much of a chemical messenger, leading to constant muscle stimulation, twitching, and eventually paralysis. When injected, CBCPAM INJECTION acts as a reactivator. It binds directly to the blocked enzyme and frees it from the poison. This allows the enzyme to resume its normal job of breaking down the excess chemical messenger. As a result, nerve-to-muscle communication is restored, muscle spasms may stop, and normal breathing and muscle control can return.
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Alcohol

Caution

Avoid consuming alcohol. Consult your doctor for more information.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing CBCPAM INJECTION.

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Breast Feeding

Caution

Caution is advised. Let your doctor know if you are a nursing mother before taking CBCPAM INJECTION; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Unsafe

CBCPAM INJECTION may cause blurred vision and diplopia (double vision). It impacts your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving CBCPAM INJECTION if you have had a liver impairment/disorder history. Your doctor will weigh the benefits and potential risks before prescribing CBCPAM INJECTION.

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Kidney

Caution

Caution should be exercised. Inform your doctor before receiving CBCPAM INJECTION if you have had a kidney impairment/disorder history. Your doctor will weigh the benefits and potential risks before prescribing CBCPAM INJECTION.

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Children

Consult your doctor

Please consult your doctor. The doctor will decide the dose based on your child's age and condition.

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Heart

Caution

CBCPAM INJECTION may be used in heart patients when medically necessary, but requires close monitoring for cardiac side effects. Your doctor will weigh the benefits against any potential risks before administering it.

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Geriatrics

Caution

CBCPAM INJECTION may be used in elderly patients when medically necessary, with careful monitoring for age-related sensitivity. Your doctor will tailor the treatment to ensure safety and effectiveness.

What if I have taken an overdose of CBCPAM INJECTION

Since this medicine is injected by trained medical staff, they will monitor you closely to prevent an overdose. However, if too much medicine is injected too quickly, it can cause symptoms like severe muscle weakness, high blood pressure, or breathing problems. If you suspect an overdose or experience severe side effects, seek immediate medical attention from the hospital staff.

Diet & Lifestyle Advise

  • Remove contaminated clothing immediately: If your poisoning was due to skin contact, discard or safely wash contaminated clothing to avoid re-exposure.
  • Wash your skin thoroughly: Use plenty of soap and water to wash any areas of your skin or hair that may have come into contact with the chemical.
  • Avoid toxic areas: Stay away from fields, gardens, or storage spaces that have recently been treated with chemical sprays until it is declared safe by authorities.
  • Stay hydrated: Drink plenty of water and clear fluids during your recovery to help your kidneys flush out any remaining toxins from your system.
  • Rest completely: Give your muscles and nervous system time to recover by avoiding heavy physical labour or strenuous exercise for several days after treatment.
     
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How Soon It Starts Working

The time required for CBCPAM INJECTION to start to work: CBCPAM INJECTION ideally shows its action within 2 to 20 minutes after administration. The time for which the effects of CBCPAM INJECTION last: The duration of action for CBCPAM INJECTION is unknown.

What if you forget to take CBCPAM INJECTION

Because CBCPAM INJECTION is given in a hospital or emergency setting by healthcare professionals, it is highly unlikely that you will miss a dose. If your treatment plan requires multiple doses and you believe a dose was delayed, inform your healthcare team immediately.

Storage

• Store in a cool and dry place away from sunlight.• Keep CBCPAM INJECTION out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Inject slowly: Ensure the healthcare provider injects the medicine slowly into the vein, as rapid injection can lead to a sudden rise in blood pressure or a fast heart rate.
 

  • Inspect the liquid: Always check the injection solution before use; it should be clear and free from visible particles or discolouration. Do not use if the liquid is cloudy or contains floating specks.
  • Monitor kidney function: If you have kidney problems, your doctor must monitor your blood work closely, as the dose may need to be lowered to prevent buildup in your body.
  • Use with atropine: This medicine is almost always used together with another injection called atropine to treat severe poisoning effectively; do not rely on CBCPAM INJECTION alone.
  • Keep emergency contacts handy: If you work closely with agricultural chemicals, keep emergency medical numbers and the product information sheet nearby for quick access.
     

Drug-Drug Interactions

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Inform your doctor about all medicines, supplements, and other treatments you are receiving before CBCPAM INJECTION is administered:

  • Barbiturates: This medicine can increase the effects of barbiturates, which may cause extreme drowsiness or slowed breathing.
  • Morphine and strong pain relievers: Avoid using these strong pain medicines while receiving treatment, as they can worsen muscle weakness and breathing difficulties.
  • Succinylcholine and other muscle relaxants: CBCPAM INJECTION may prolong or change the effects of these muscle relaxants, leading to prolonged muscle paralysis.
  • Theophylline: Combining these treatments may increase the risk of rapid heart rate or other heart-related side effects.
     
PralidoximePramlintide
Critical

Drug-Drug Interactions

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PralidoximePramlintide
Critical
How does the drug interact with Cbcpam Injection 20ml:
Cbcpam Injection 20ml and Pramlintide when used together may enhance the effects of the other, which may increase the risk of side effects. .

How to manage the interaction:
Co-administration of Cbcpam Injection 20ml with Pramlintide is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No clinically significant food interactions are known with CBCPAM INJECTION when used as directed.
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDOTES]

FAQs

CBCPAM INJECTION is used treat Organophosphate poisoning.
CBCPAM INJECTION contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compounds and medicines.
CBCPAM INJECTION is an antidote Antidote for organophosphorus nerve agent poisoning, including chlorosarin, cyclosarin (GF), R-VX, tabun (GA), sarin (GB), VX, soman (GD), chlorosoman and organophosphorus pesticides.
Pralidoxime injection is also used to treat an overdose of medicines (such as neostigmine, ambenonium, and pyridostigmine) that treat myasthenia gravis.
The common side effects of CBCPAM INJECTION may include mild to moderate pain at the site of injection, blurred vision, diplopia (double vision), impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia (fast heartbeat), increased systolic and diastolic blood pressure, hyperventilation (rapid or deep breathing), and muscular weakness. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, inform your doctor.
CBCPAM INJECTION is a cholinesterase reactivator that belongs to the oxime class of drugs. It is used to treat poisoning caused by organic phosphorus pesticides or chemicals, often in combination with atropine.
CBCPAM INJECTION is typically administered intravenously (through a vein) or intramuscularly (into a muscle). It is usually given in a hospital setting by a healthcare professional. The administration route and dosage may vary depending on the specific situation and medical guidance.
CBCPAM INJECTION is given as an injection, either into a large muscle or slowly through a needle into a vein. It is always given by a trained healthcare professional in an emergency or hospital setting. Talk to your doctor if you have questions about the injection process.
No, CBCPAM INJECTION is specifically designed to treat poisoning caused by organophosphate pesticides, certain chemical nerve agents, or overdoses of specific muscle-weakness drugs. It does not work for other types of chemical or food poisoning. Talk to your doctor to understand if this treatment is right for your situation.
Yes, in many cases of severe poisoning, a single injection is not enough. Your doctor will monitor your symptoms and may give additional injections every few hours if your breathing difficulties or muscle weakness return. Talk to your doctor about your specific treatment plan.
In life-threatening poisoning emergencies, CBCPAM INJECTION is used because saving the mother's life is the primary concern. However, you must inform the medical team if you are pregnant or breastfeeding so they can take extra precautions. Talk to your doctor or pharmacist about the risks and benefits.
After treatment, you should avoid going back to the area where the chemical exposure occurred until it has been thoroughly cleaned and cleared. You should also avoid drinking alcohol and taking any new medicines without checking with your medical team. Talk to your doctor for specific recovery advice.
No, CBCPAM INJECTION is almost always given in combination with another medicine called atropine to fully control the severe symptoms of chemical poisoning. These two medicines work together to save lives. Talk to your doctor for more information.
Yes, CBCPAM INJECTION can be given to children who have been accidentally exposed to toxic pesticides, but the dose must be carefully calculated by a paediatrician based on the child's exact weight. Talk to your doctor if you have concerns about paediatric use.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

T.T.K Road, 1st Floor, Diwan Shahib Garden, Royapettah, Chennai - 600 014.
Other Info - CBC0001
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