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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Cardiomart AP 5mg/4mg Tablet belongs to the class of antihypertensive medicines used in the treatment of high blood pressure and stable coronary artery disease. It also helps reduce the chances of heart problems such as heart attack and stroke. It is a combination medicine which suppress the contraction of blood vessels and promote smooth blood flow. It also alters the response to nerve impulses in the heart thereby making the heart pump blood easier. Common side effects include oedema, headache, dizziness, nausea, and abdominal pain.
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Not Returnable

About Cardiomart AP 5mg/4mg Tablet

Cardiomart AP 5mg/4mg Tablet is used to treat high blood pressure (hypertension). Additionally, it is also used to treat stable coronary artery disease. High blood pressure is a condition in which the blood exerts increased pressure on the walls of blood vessels. Stable coronary artery disease is a condition in which the blood supply to the heart is blocked or reduced.
 
Cardiomart AP 5mg/4mg Tablet is a combination of two drugs: Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps lower the blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke.  
 
You are advised to take Cardiomart AP 5mg/4mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as oedema, headache, dizziness, nausea, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers and children. Cardiomart AP 5mg/4mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.

Uses of Cardiomart AP 5mg/4mg Tablet

Treatment of Hypertension (high blood pressure), stable coronary artery disease

Directions for Use

• Cardiomart AP 5mg/4mg Tablet can be taken before food for better absorption.• It is recommended to take Cardiomart AP 5mg/4mg Tablet once daily in the morning or as advised by your doctor.• Swallow the Cardiomart AP 5mg/4mg Tablet as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Cardiomart AP 5mg/4mg Tablet is a combination of two drugs: Amlodipine and Perindopril erbumine. Cardiomart AP 5mg/4mg Tablet belongs to the group of anti-hypertensive medicines used to treat high blood pressure (hypertension) and/or stable coronary artery disease. Amlodipine is a calcium channel blocker that relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine is an angiotensin-converting enzyme inhibitor that widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps treat hypertension, thereby reducing the chances of heart problems such as heart attack and stroke.

How Cardiomart AP 5mg/4mg Tablet Works

Cardiomart AP 5mg/4mg Tablet is a combination of two drugs: Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels, making it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps lower the blood pressure, thereby reduces the chances of heart problems such as heart attack and stroke.

Storage

• Store in a cool and dry place away from sunlight.• Keep Cardiomart AP 5mg/4mg Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cardiomart AP 5mg/4mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Cardiomart AP 5mg/4mg Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include fast/slow heartbeat, severe dizziness, and fainting. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Cardiomart AP 5mg/4mg Tablet if you are allergic to any of its contents; if you have angioedema, severe water retention, low blood pressure, or low blood potassium. Inform your doctor if you have diabetes, heart problems, gout, parathyroid gland problems, heart failure, collagen disease, atherosclerosis (hardening of arteries), excess acid in the blood, liver/kidney problems, if you are on a low-salt diet, if you are taking lithium/potassium-sparing diuretics, or if you are taking any other blood pressure-lowering medicines. Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers and children. Cardiomart AP 5mg/4mg Tablet may cause dizziness, so drive with caution. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using Cardiomart AP 5mg/4mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Combining Aliskiren with Cardiomart AP 5mg/4mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Co-administration of Cardiomart AP 5mg/4mg Tablet can make Sirolimus may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between Cardiomart AP 5mg/4mg Tablet and Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
AmlodipineEnzalutamide
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using a combination of Cardiomart AP 5mg/4mg Tablet and enzalutamide may drastically lower Cardiomart AP 5mg/4mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineNitisinone
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Cardiomart AP 5mg/4mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineDolasetron
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using dolasetron together with Cardiomart AP 5mg/4mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Cardiomart AP 5mg/4mg Tablet and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineMitotane
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Using Cardiomart AP 5mg/4mg Tablet and mitotane together may drastically lower Cardiomart AP 5mg/4mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Cardiomart AP 5mg/4mg Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and rifampicin together may lower Cardiomart AP 5mg/4mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Cardiomart AP 5mg/4mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AmlodipineIdelalisib
Severe
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of Cardiomart AP 5mg/4mg Tablet and Idelalisib may raise Cardiomart AP 5mg/4mg Tablet levels in the blood this may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, heart failure, and abnormally low blood pressure).

How to manage the interaction:
Although taking Cardiomart AP 5mg/4mg Tablet with idelalisib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness or fainting, sudden, unexplained weight gain, swelling of the hands, ankles, or feet, chest discomfort, or trouble breathing while taking these drugs, consult the doctor. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cardiomart AP 5mg/4mg Tablet:
Coadministration of lemborexant and Cardiomart AP 5mg/4mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Cardiomart AP 5mg/4mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL ERBUMINE-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Cardiomart AP 5mg/4mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Cardiomart AP 5mg/4mg Tablet.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet. 

  • Regular exercise is also recommended.

  • Eat a diet rich in whole grains, vegetables, and fruits.

  • Avoid smoking and alcohol consumption.

  • Maintain a healthy weight with proper diet and exercise.

  • Practice meditation or yoga as it helps in managing stress.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Cardiomart AP 5mg/4mg Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid consuming alcohol as it might cause increased dizziness.

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Pregnancy

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant as it may cause serious harm to the baby. Please consult your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended for breastfeeding mothers. Talk to your doctor if you have any concerns.

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Driving

Caution

Cardiomart AP 5mg/4mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid taking Cardiomart AP 5mg/4mg Tablet if you have severe liver disease or hepatic encephalopathy.

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Kidney

Caution

Dose adjustment may be needed. Avoid taking Cardiomart AP 5mg/4mg Tablet if you have severe kidney problems. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Cardiomart AP 5mg/4mg Tablet is not recommended for children as safety and effectiveness have not been established.

Have a query?

FAQs

Cardiomart AP 5mg/4mg Tablet is used to treat high blood pressure (hypertension). Additionally, it is also used to treat stable coronary artery disease.

Cardiomart AP 5mg/4mg Tablet contains Amlodipine and Perindopril erbumine. Amlodipine relaxes the blood vessels, thereby improving blood flow. Perindopril erbumine widens the blood vessels; this makes it easier for the heart to pump blood through them. Together, Cardiomart AP 5mg/4mg Tablet helps treat high blood pressure.

Cardiomart AP 5mg/4mg Tablet may cause palpitations, a sensation that the heart is racing, pounding, or fluttering. A minor fluctuation should not be a worry; however, if palpitations continue or you begin to feel unwell, speak with your doctor.

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the blood vessels of the heart, brain, and kidney and might result in stroke, heart failure or kidney failure. Hypertension increases the risk of heart attacks. Therefore, anti-hypertensives such as Cardiomart AP 5mg/4mg Tablet are used to lower the blood pressure to normal; this reduces the risk of developing these disorders.

Do not stop taking Cardiomart AP 5mg/4mg Tablet without consulting your doctor, as it may lead to a rise in blood pressure. To treat your condition effectually, continue taking Cardiomart AP 5mg/4mg Tablet for as long as your doctor has prescribed it. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Cardiomart AP 5mg/4mg Tablet.

Light-headedness could be a side-effect of Cardiomart AP 5mg/4mg Tablet. It occurs due to low blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Cardiomart AP 5mg/4mg Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Avoid consuming grapefruit and grapefruit juice whilst taking Cardiomart AP 5mg/4mg Tablet as it might increase the blood levels of amlodipine; this can lead to an unpredictable increase in the blood pressure-lowering effect of Cardiomart AP 5mg/4mg Tablet. Inform your doctor if you are on a salt-restricted diet, use salt substitutes or if you are taking potassium supplements.

Cardiomart AP 5mg/4mg Tablet can affect kidney function, especially in individuals with pre-existing kidney conditions or those taking certain medications. Please consult your doctor if you have kidney problems or concerns, as dose adjustments may be needed.

The best time to take Cardiomart AP 5mg/4mg Tablet is typically in the morning, as it helps control blood pressure throughout the day. However, depending on your individual needs and medical conditions, your doctor may sometimes recommend taking it at bedtime. Consistency is key, so take it at the same time every day. Always follow your doctor's personalized instructions.

Amlodipine + Perindopril Erbumine contains two active ingredients: Amlodipine, a calcium channel blocker, and Perindopril Erbumine, an angiotensin-converting enzyme inhibitor. Together, they provide therapeutic benefits.

Do not stop taking Cardiomart AP 5mg/4mg Tablet as stopping it suddenly may cause your blood pressure to rise again, increasing the risk of heart attack or stroke. Therefore, please consult your doctor before stopping the medication to avoid potential health risks.

If you forget to take Cardiomart AP 5mg/4mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Cardiomart AP 5mg/4mg Tablet is not recommended during early pregnancy and should not be taken when more than 3 months pregnant, as it may cause serious harm to the baby. It is also not recommended for breastfeeding mothers and children. Cardiomart AP 5mg/4mg Tablet may cause dizziness, so drive or operate heavy machinery with caution. Avoid consuming alcohol, as it might cause increased dizziness. Inform your doctor about all your medicines and pre-existing health conditions to rule out any unpleasant side effects.

Do not drink alcohol while taking Cardiomart AP 5mg/4mg Tablet as it may cause unpleasant side effects. Please consult a doctor for personalized advice.

Accidentally taking more than the prescribed dose of Cardiomart AP 5mg/4mg Tablet may lead to low blood pressure (hypotension), which can cause dizziness or fainting. In such cases, lying down with your legs elevated and seeking immediate medical attention is essential. Contact your doctor or visit the nearest emergency department without delay.

Cardiomart AP 5mg/4mg Tablet is usually prescribed for daily use to manage blood pressure and heart conditions. However, always follow the instructions of your doctor regarding dosage and duration to ensure safe and effective treatment.

Yes, Cardiomart AP 5mg/4mg Tablet may cause ankle swelling as a common side effect. This medication contains amlodipine, which is known to cause peripheral oedema (swelling of the ankles or feet) in some patients. If you experience significant or persistent swelling, it is crucial to consult your doctor for further evaluation and management.

The common side effects of Cardiomart AP 5mg/4mg Tablet include cough, dizziness, headache, and swelling in your hands or feet. Most of these side effects gradually resolve over time. However, consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

No. 10, 2nd Cross, Maravaneri, Salem - 636007, Tamil Nadu.
Other Info - CA73432

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