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compositionComposition:ENZALUTAMIDE-40MG
prescription
Prescription Medicine
info
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Capmide 40 Softgel Capsule is used to treat prostate cancer. It contains Enzalutamide, an androgen receptor blocker (inhibitor) that blocks testosterone from reaching prostate cancer cells. Most prostate cancers require testosterone to grow; this can slow the growth of the cancer and may shrink it. Enzalutamide is only for use in men. Men using this medication must use effective birth control whenever they have sex during their treatment and for three months after their final dose.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ENZALUTAMIDE-40MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Capmide 40 Softgel Capsule

Capmide 40 Softgel Capsule is a prescription medicine primarily used to treat advanced types of prostate cancer. It is designed for prostate cancer that has spread to other parts of the body or no longer responds to medical or surgical treatments that lower testosterone. This medicine works by stopping hormone signals that would otherwise allow cancer cells to grow and multiply.

To get the best results, you must take Capmide 40 Softgel Capsule consistently every single day at the same time as prescribed. You can take this medicine with or without food, making it easy to fit into your daily routine. Making small adjustments to your daily life, such as incorporating gentle physical activity and eating a balanced diet, can help your body handle the therapy more effectively.

While taking this medicine, you may experience common side effects like hot flashes, fatigue, and joint discomfort. However, you must contact your doctor immediately if you experience severe symptoms such as sudden confusion, severe dizziness, chest pain, or seizures.

Before starting Capmide 40 Softgel Capsule, you must talk to your doctor if you have a history of seizures, brain injury, stroke, heart disease, or high blood pressure. Do not take this if you are allergic to Capmide 40 Softgel Capsule or any of the inactive ingredients contained in the tablet.

This medicine can interact with other drugs like blood thinners and certain heart medicines, which may change how well they work or increase side effects. It is not approved for use in women, and pregnant or breastfeeding individuals must not handle or touch the tablets. Elderly patients should talk to their doctor to closely monitor their physical strength and heart health, taking extra precautions against falls due to the combined risk of dizziness, fatigue, and bone weakening.

Uses of Capmide 40 Softgel Capsule

Capmide 40 Softgel Capsule is used to treat advanced prostate cancer. The detailed uses of Capmide 40 Softgel Capsule are as follows:

  • Non-metastatic castration-resistant prostate cancer (nmCRPC): Capmide 40 Softgel Capsule treats prostate cancer that is 'castration-resistant' (meaning it continues to grow despite very low testosterone levels) and has not yet spread to other body parts on scans.
  • Metastatic castration-sensitive prostate cancer (mCSPC): Treats prostate cancer that has spread to other body parts (such as bones or lymph nodes) but still responds to medical or surgical treatments that lower testosterone.
  • Metastatic castration-resistant prostate cancer (mCRPC): Treats advanced prostate cancer that has spread to other parts of the body and no longer responds to initial testosterone-lowering treatments.

Key Benefits

Capmide 40 Softgel Capsule helps slow the progression of advanced prostate cancer and supports long-term disease management. The key benefits of Capmide 40 Softgel Capsule are as follows:

  • Slows Cancer Progression: By blocking the hormones that fuel tumour growth, Capmide 40 Softgel Capsule helps slow the progression of advanced prostate cancer, reduces cancer-related pain, and helps prevent the disease from spreading further.
  • Prolongs Survival and Delays Intensive Treatment: Clinical studies have shown that Capmide 40 Softgel Capsule helps prolong survival and may delay the need for more intensive treatments, such as chemotherapy, allowing many patients to maintain their independence and daily routine for longer.
Side effects of Capmide 40 Softgel Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Directions for Use

  • Capmide 40 Softgel Capsule can be taken with or without food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Capmide 40 Softgel Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Capmide 40 Softgel Capsule Works

Capmide 40 Softgel Capsule contains enzalutamide, which belongs to a group of medicines called androgen receptor inhibitors. Male hormones, such as testosterone, act as fuel for prostate cancer cells by attaching to specific receptors on the cancer cells and stimulating their growth. Capmide 40 Softgel Capsule blocks these androgen receptors, preventing testosterone and other male hormones from attaching to them. This interrupts the growth signals that cancer cells rely on, helping slow the spread of prostate cancer, shrink tumours, and reduce prostate-specific antigen (PSA) levels.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Capmide 40 Softgel Capsule.

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Pregnancy

Not applicable

Enzalutamide is only for use in men. Women should not take this medication.

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Breast Feeding

Not applicable

Enzalutamide is only for use in men. Women should not take this medication.

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Driving

Unsafe

Capmide 40 Softgel Capsule may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Unsafe

The safety and effectiveness of Capmide 40 Softgel Capsule in pediatric patients have not been established.

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Heart

Caution

Capmide 40 Softgel Capsule may increase the risk of heart problems. Therefore, please consult your doctor if you have any heart-related problems before using Capmide 40 Softgel Capsule.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Capmide 40 Softgel Capsule to geriatric patients. Your doctor will prescribe Capmide 40 Softgel Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Capmide 40 Softgel Capsule

If you accidentally take more than your prescribed dose, seek emergency medical care immediately. An overdose can increase your risk of severe side effects, especially seizures.

Diet & Lifestyle Advise

  • Protect your bones: Since hormone therapies can weaken bones, talk to your doctor about taking calcium and vitamin D supplements to lower your risk of bone loss and fractures.
  • Discuss fertility options early: Because Capmide 40 Softgel Capsule can significantly impair sperm production and male fertility, speak with your oncologist before starting therapy if family planning is important to you, and consider options like sperm banking.
  • Stay active safely: Regular, low-impact exercise like daily walking can help reduce treatment-related fatigue and maintain your muscle strength.
  • Manage hot flashes: Wear loose, layered clothing made from natural fibres like cotton, and limit triggers like hot beverages, spicy foods, alcohol, and caffeine.
  • Monitor your blood pressure: Keep a regular home log of your blood pressure readings, as this medicine can cause your numbers to rise. Share these readings with your healthcare team.
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How Soon It Starts Working

The time required for Capmide 40 Softgel Capsule to start to work: Capmide 40 Softgel Capsule ideally shows its action within 1 hour after administration. The time for which the effects of Capmide 40 Softgel Capsule last: The duration of action for Capmide 40 Softgel Capsule is unknown.

What if you forget to take Capmide 40 Softgel Capsule

If you forget to take your dose of Capmide 40 Softgel Capsule, take it as soon as you remember on that same day. If you do not remember until the next day, skip the missed dose entirely and take your regular dose at your usual time. Do not take two doses at once to make up for a missed one. If you miss doses for multiple days, talk to your doctor or pharmacist for advice.

Storage

• Store Capmide 40 Softgel Capsule at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Be aware of seizure and fall risks: This medicine can increase your risk of seizures, severe dizziness, and fatigue. Take extra precautions to prevent falls, and avoid activities like driving, climbing, or operating heavy machinery if you feel lightheaded.
  • Handle with care: Pregnant women, those planning a pregnancy, or breastfeeding individuals should not touch or handle broken, cracked, or damaged tablets of Capmide 40 Softgel Capsule to prevent the drug from absorbing through the skin.
  • Use reliable birth control and consider fertility: If you are sexually active with a female partner who could become pregnant, you must use a highly effective birth control method (such as a condom) during treatment and for 3 months after your last dose. Because Capmide 40 Softgel Capsule can impair male fertility, discuss sperm banking options with your doctor before starting treatment if desired.
  • Inspect your tablets: Always check your pills before taking them. Do not take any tablets that look damaged, broken, or moist.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners: Taking Capmide 40 Softgel Capsule with medicines like warfarin can alter how your blood clots, increasing your risk of bleeding or reducing the drug's effectiveness.
  • Seizure medicines: Combining this medicine with certain anticonvulsants can lower the seizure threshold or affect how both medicines work.
  • Certain heart, cholesterol, and daily medicines: Capmide 40 Softgel Capsule is a strong liver enzyme inducer, meaning it speeds up how your liver processes many other medicines, making them less effective. Your doctor will regularly monitor your liver function and review all your medicines.
EnzalutamideRanolazine
Critical
EnzalutamideRegorafenib
Critical

Drug-Drug Interactions

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EnzalutamideRanolazine
Critical
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Capmide 40 Softgel Capsule may decrease the blood levels of Ranolazine, which may make Ranolazine less effective.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule with Ranolazine is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideRegorafenib
Critical
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Capmide 40 Softgel Capsule with Regorafenib may decrease the blood levels of Regorafenib, which may make Regorafenib less effective in treating your condition.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule with Regorafenib is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideLurasidone
Critical
How does the drug interact with Capmide 40 Softgel Capsule:
Co-administration of Lurasidone with Capmide 40 Softgel Capsule may result in significantly lower blood levels of Lurasidone, making the medication less effective.

How to manage the interaction:
Taking Lurasidone with Capmide 40 Softgel Capsule is not recommended as it may lead to interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EnzalutamideDronedarone
Critical
How does the drug interact with Capmide 40 Softgel Capsule:
Co-administration of Capmide 40 Softgel Capsule and Dronedarone together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule and Dronedarone together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EnzalutamideZiprasidone
Critical
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Capmide 40 Softgel Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule with Ziprasidone is not recommended, as it may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
EnzalutamideNimodipine
Severe
How does the drug interact with Capmide 40 Softgel Capsule:
Co-administration of Nimodipine with Capmide 40 Softgel Capsule may make the medication less effective.

How to manage the interaction:
Although taking Nimodipine and Capmide 40 Softgel Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EnzalutamideMacitentan
Severe
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Capmide 40 Softgel Capsule with Macitentan may decrease the blood levels of Macitentan, which may make Macitentan less effective in treating your condition.

How to manage the interaction:
Although taking Capmide 40 Softgel Capsule and Macitentan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms like- watery eyes, a runny nose, sneezing, yawning, sweating heavily, fever, chills, flushing, restlessness, irritability, anxiety, eye problems, shaking, rapid heartbeat, body aches, involuntary twitching and kicking, stomach pain, diarrhea, consult the doctor. Do not discontinue any medications without a doctor's advice.
EnzalutamideGatifloxacin
Severe
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Capmide 40 Softgel Capsule and Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule and Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EnzalutamideEscitalopram
Severe
How does the drug interact with Capmide 40 Softgel Capsule:
Using escitalopram together with Capmide 40 Softgel Capsule can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Capmide 40 Softgel Capsule and Escitalopram together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
EnzalutamideImatinib
Severe
How does the drug interact with Capmide 40 Softgel Capsule:
Taking Imatinib and Capmide 40 Softgel Capsule together may possibly reduce the blood levels of Imatinib, which could reduce its capacity to treat cancer.

How to manage the interaction:
Although there is a possible interaction between Capmide 40 Softgel Capsule and Imatinib, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Limit high amounts of caffeine, as it can worsen hot flashes, raise your blood pressure, or interfere with your sleep patterns during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Capmide 40 Softgel Capsule is used to treat prostate cancer in men.
Most prostate cancers require testosterone to grow. Capmide 40 Softgel Capsule contains Enzalutamide, which blocks testosterone, a hormone, from reaching prostate cancer cells. Thus, Capmide 40 Softgel Capsule can slow the cancer's growth and cause it to shrink.
Capmide 40 Softgel Capsule is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breast-feeding.
In some cases, Capmide 40 Softgel Capsule may cause decreased fertility in men. However, you should not assume that your female partner cannot become pregnant. Please discuss with your doctor if you have any concerns.
Seizures may occur in patients receiving Capmide 40 Softgel Capsule. So, patients who have had a seizure, please inform your doctor about your condition. Your doctor may monitor your condition closely.
Yes, you can take Capmide 40 Softgel Capsule with or without food. Taking it at the same time every morning or evening is the best way to help you remember your dose. Talk to your doctor or pharmacist if you need help planning your schedule.
Capmide 40 Softgel Capsule does not cure prostate cancer, but it is highly effective at slowing down the growth and spread of the disease. This helps control your symptoms and prolongs survival. Talk to your doctor to understand your specific treatment goals.
Dizziness is a known side effect of this medicine. If you feel dizzy, sit or lie down immediately, and avoid driving or operating tools until you feel completely clear-headed. Talk to your doctor if the dizziness does not go away.
If your partner is pregnant, planning to become pregnant, or breastfeeding, they must not handle or touch Capmide 40 Softgel Capsule tablets, especially if they are broken or damaged, as the medicine can be absorbed through the skin. Talk to your doctor or pharmacist if you have concerns about safe handling.
Your doctor will keep you on Capmide 40 Softgel Capsule as long as it continues to effectively control your cancer and you tolerate the medicine well. Your progress will be tracked through regular blood tests (including PSA and liver function checks), blood pressure monitoring, and periodic imaging. If the cancer eventually progresses, your doctor will guide you through subsequent options—such as chemotherapy or other targeted therapies—noting that cross-resistance can occur with similar hormone therapies like abiraterone. Talk to your doctor about what to expect during your follow-up visits.
This medicine works by lowering the effects of male hormones, which can naturally lead to weaker bones and joint pain. Talk to your doctor about safe over-the-counter pain relievers or if you need calcium and vitamin D supplements to protect your bones.
Yes, if your partner can become pregnant, you must use highly effective birth control, such as condoms, during your treatment and for 3 months after you take your final dose. Talk to your doctor if you have questions about family planning.
It is highly recommended to limit or avoid alcohol while taking Capmide 40 Softgel Capsule, as alcohol can worsen side effects like dizziness, hot flashes, and liver strain. Talk to your doctor or pharmacist for personalised guidance regarding alcohol use.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A612033 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 203415Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Enzalutamide Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. CiplaMed: Enzalutamide [Prescribing Information]. 2022. [Accessed on 20 Feb. 2024]Check here
  5. Enzalutamide [Prescribing Information]. 2018. [Accessed on 14 Mar. 2026]Check here
  6. DailyMed - XTANDI- enzalutamide capsuleXTANDI- enzalutamide tablet [Internet]. Dailymed.nlm.nih.gov. 2025 [Accessed on 19 February 2025]Check here
  7. Enzalutamide Astellas 40 mg film coated tablets (previously named Xtandi) - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 12 Jan 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - CAP0231
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