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Canrib Tablet 60's is used to treat various cancers, including ovarian, breast, pancreatic, and prostate. It contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Avoid taking this medication if you are pregnant or breastfeeding because this can cause harmful effects on the unborn baby. Both women and men using this should use birth control to avoid pregnancy.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

OLAPARIB-100MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Canrib Tablet 60's

Canrib Tablet 60's is an oral prescription medication used to treat certain advanced cancers, including ovarian, breast, prostate, and pancreatic cancers. It is specifically designed for cancers that have specific abnormal genes, such as the BRCA gene. This targeted therapy helps slow down or stop the growth of cancer cells in the body.

You will typically take Canrib Tablet 60's twice a day, with or without food, as directed by your doctor. It is important to take this medication consistently at the same times every day to maintain a steady level of the medicine in your body. To support your body during treatment, focus on staying hydrated, eating small, frequent meals, and getting adequate rest.

While taking Canrib Tablet 60's, you may experience common side effects such as nausea, tiredness, and low red blood cell counts. However, if you develop serious symptoms like severe shortness of breath, a sudden cough, or an unexplained fever, you must contact your doctor immediately.

Before starting Canrib Tablet 60's, talk to your doctor if you have a history of kidney problems or lung conditions. Do not take this if you are pregnant or breastfeeding, as it can cause serious harm to a developing baby.

This medication can interact with other drugs and certain foods like grapefruit, which can alter how the medicine works in your body. It is also important to talk to your doctor or pharmacist if you are elderly or have other chronic health conditions to ensure Canrib Tablet 60's is safe for you.

Uses of Canrib Tablet 60's

Canrib Tablet 60's is used in the treatment of ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. The detailed uses of Canrib Tablet 60's are as follows:

  • Ovarian cancer: Canrib Tablet 60's helps keep the cancer from returning or spreading after it has responded to initial chemotherapy.
  • Breast cancer: It targets specific gene-mutated (BRCA-mutated) breast cancers that have spread to other areas of the body.
  • Prostate cancer: It treats advanced prostate cancer that has spread and no longer responds to standard hormone therapy.
  • Pancreatic cancer: It is used as a maintenance treatment to keep the cancer from progressing after chemotherapy.
     

Key Benefits

Canrib Tablet 60's helps manage certain advanced cancers by targeting specific cancer cells and interfering with their ability to repair themselves.

The following are the benefits of this medication:

  • By blocking specific proteins that cancer cells use to repair themselves, this treatment helps extend the time that the cancer remains stable and controlled.
  • Unlike traditional chemotherapy, which affects all rapidly dividing cells, this targeted therapy focuses primarily on cancer cells with specific genetic mutations, sparing more healthy cells.
  • Because it is taken as a tablet, patients can manage their treatment at home, reducing the need for frequent, time-consuming hospital clinic visits for intravenous therapy.
     
Side effects of Canrib Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Canrib Tablet 60's can be taken with or without food as prescribed by your doctor.
  • It is usually taken twice a day in the morning and evening, or as prescribed by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, crush or chew Canrib Tablet 60's.

How Canrib Tablet 60's Works

Olaparib, the active medicine in Canrib Tablet 60's, belongs to a class of drugs called PARP inhibitors. PARP is an enzyme (a type of protein) that helps cells repair damaged DNA. In normal healthy cells, there are multiple pathways to repair DNA damage. However, certain cancer cells, specifically those with BRCA gene mutations, rely heavily on PARP to repair their DNA and survive. When you take Canrib Tablet 60's, it blocks the PARP enzymes from doing their job. Because the cancer cells already have a broken repair system due to their genetic mutation, blocking PARP leaves them with no way to repair their damaged DNA. This causes the cancer cells to stop growing and eventually die, helping to control the spread of the disease.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Canrib Tablet 60's.

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Pregnancy

Unsafe

Canrib Tablet 60's should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Canrib Tablet 60's and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Canrib Tablet 60's may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Canrib Tablet 60's in pediatric patients have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Canrib Tablet 60's if you have pre-existing heart problems. Your doctor will prescribe Canrib Tablet 60's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Canrib Tablet 60's to geriatric patients. Your doctor will prescribe Canrib Tablet 60's if the benefits outweigh the risks.

What if I have taken an overdose of Canrib Tablet 60's

If you accidentally take more than your prescribed dose, seek emergency medical care immediately or contact your local poison control centre. An overdose can increase the risk of severe side effects, especially affecting your blood counts.

Diet & Lifestyle Advise

  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as they can significantly raise the level of the drug in your body and increase side effects.
  • Manage nausea with small meals: Eat small, frequent meals throughout the day rather than three large ones. Stick to bland foods like crackers, toast, or rice if you feel sick.
  • Stay well-hydrated: Drink plenty of fluids, such as water or clear broths, to prevent dehydration, especially if you experience diarrhoea or vomiting.
  • Incorporate gentle exercise: Engage in light physical activity, like short daily walks, to help combat fatigue and improve your physical well-being, but listen to your body and rest when needed.
     
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How Soon It Starts Working

The time required for Canrib Tablet 60's to start to work: Canrib Tablet 60's ideally shows its action within few hours after administration. The time for which the effects of Canrib Tablet 60's last: The duration of action for Canrib Tablet 60's is unknown.

What if you forget to take Canrib Tablet 60's

If you miss a dose of Canrib Tablet 60's, skip the missed dose entirely. Take your next scheduled dose at your regular time. Do not take an extra dose or a double dose to make up for the one you missed. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

• Store the tablets at room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid handling damaged tablets during pregnancy: If you are pregnant or planning to become pregnant, do not handle broken or crushed tablets. The medicine may be absorbed through the skin and could harm an unborn baby.
  • Check the tablets before use: Make sure each tablet is intact and looks normal. Do not take it if it is cracked, discoloured, or crumbling.
  • Use reliable contraception: Use effective birth control while taking Canrib Tablet 60's and for at least 6 months after your last dose. Men with partners who could become pregnant should also use reliable contraception during treatment and for 3 months after the last dose.
  • Check your temperature: Monitor your temperature regularly during treatment. Seek immediate medical attention if you develop a fever of 38°C (100.4°F) or higher, as this may be a sign of a serious infection.
  • Attend all blood tests: Keep all scheduled appointments for blood tests. Your doctor will use these tests to check your blood cell counts, as Canrib Tablet 60's can significantly lower red and white blood cells.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that block the CYP3A liver enzyme (e.g.,  ketoconazole, itraconazole, clarithromycin, ritonavir): These medications can slow down how your body breaks down Canrib Tablet 60's, which may increase the risk of severe side effects.
  • Medicines that strongly increase CYP3A enzyme activity (e.g., rifampin, phenytoin, carbamazepine, St. John's wort): These medicines may speed up how your body clears Canrib Tablet 60's, making Canrib Tablet 60's less effective against your cancer.
     

Drug-Drug Interactions

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How does the drug interact with Canrib Tablet:
Taking filgrastim together with Canrib Tablet can reduce the effects of filgrastim.

How to manage the interaction:
Co-administration of Filgrastim with Canrib Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Canrib Tablet:
Using Natalizumab together with Canrib Tablet may increase the risk of infections.

How to manage the interaction:
Combining Natalizumab and Canrib Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Canrib Tablet:
Fluconazole may increase the blood levels of Canrib Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low blood cell count.

How to manage the interaction:
Although there is a possible interaction, fluconazole can be taken with Canrib Tablet if prescribed by the doctor. Consult the doctor if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.
How does the drug interact with Canrib Tablet:
When Canrib Tablet is taken with Infliximab, it can cause Canrib Tablet to be broken down faster in the body. This can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Canrib Tablet with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, trouble breathing, losing weight, or pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
OlaparibNafcillin
Severe
How does the drug interact with Canrib Tablet:
Using Nafcillin together with Canrib Tablet can reduce the blood levels of Canrib Tablet.

How to manage the interaction:
Taking Canrib Tablet with Nafcillin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Canrib Tablet:
Taking Clarithromycin and Canrib Tablet can increase the blood levels of Canrib Tablet. This can increase the risk and/or severity of side effects.

How to manage the interaction:
Combining Clarithromycin and Canrib Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Canrib Tablet:
Using Darunavir and Canrib Tablet can increase the blood levels of Canrib Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Darunavir and Canrib Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Canrib Tablet:
Taking Ritonavir and Canrib Tablet may significantly increase the blood levels of Canrib Tablet.

How to manage the interaction:
There may be a possibility of interaction between Canrib Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination contact a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Canrib Tablet:
Coadministration of Baricitinib and Canrib Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Canrib Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Canrib Tablet:
Taking leflunomide with Canrib Tablet may increase the risk of infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Canrib Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Grapefruit and Seville oranges: Avoid eating these fruits or drinking their juices while taking Canrib Tablet 60's, as they can significantly increase the concentration of the medicine in your bloodstream.
OLAPARIB-100MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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OLAPARIB-100MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Canrib Tablet levels in the blood may rise if it is consumed with grapefruit juice. This may increase possibility of side effects include nausea, vomiting, diarrhea, indigestion, appetite loss, abdominal pain or discomfort. Avoid the consumption of grapefruit juice along with Canrib Tablet. If you’re experiencing nausea, vomiting, diarrhea, indigestion, appetite loss, abdominal pain or discomfort, contact the doctor immediately.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Canrib Tablet 60's is used to treat ovarian, breast, pancreatic, and prostate cancers.
Canrib Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Canrib Tablet 60's.
Yes, Canrib Tablet 60's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Canrib Tablet 60's is not a traditional chemotherapy pill. It's a targeted therapy, also known as a PARP inhibitor, which works differently from chemotherapy.
When taking Canrib Tablet 60's, avoid or limit foods high in grapefruit or grapefruit juice, as these can interact with the medication. Additionally, consult your doctor or pharmacist for personalized dietary advice.
The duration of Canrib Tablet 60's treatment can vary depending on the type of cancer being treated and the patient's response to the medication. Generally, Canrib Tablet 60's is taken until disease progression, unacceptable toxicity, or completion of a specified treatment period. Therefore, follow your doctor's instructions carefully.
Before taking Canrib Tablet 60's, inform your doctor about all your medical conditions, sensitivities, and medications. Also, mention if you're pregnant, planning to become pregnant, or breastfeeding. This will ensure safe use and help avoid any potential interactions.
Canrib Tablet 60's can interact with other medications, so do not use any other medications unless your doctor advises. Your doctor will check for potential interactions and advise you on how to take them safely with Canrib Tablet 60's.
No, Canrib Tablet 60's is not recommended for use during pregnancy and breastfeeding, and it causes unwanted side effects. However, please consult your doctor if you have any concerns.
The common side effects of Canrib Tablet 60's are feeling very tired, pale skin, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Please consult your doctor if any of these side effects persist or worsen.
Yes, you can take Canrib Tablet 60's with or without food. Taking it with a light meal may help manage mild stomach upset or nausea. Talk to your doctor or pharmacist if you struggle with nausea.
If you vomit after taking your dose, do not take an extra dose to replace it. Simply wait and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist if vomiting persists.
While hair thinning can occasionally occur, complete hair loss is not a common side effect of Canrib Tablet 60's. If you notice significant changes in your hair texture or volume, talk to your doctor or pharmacist.
It is highly recommended to limit or avoid alcohol while taking Canrib Tablet 60's. Alcohol can worsen common side effects such as nausea, dizziness, and fatigue. Talk to your doctor or pharmacist before drinking alcohol.
Yes, Canrib Tablet 60's can potentially affect fertility in both men and women, making it harder to conceive a child. If you plan to have children in the future, talk to your doctor or pharmacist about fertility preservation options before starting treatment.
Canrib Tablet 60's can significantly lower your blood cell counts, which can lead to anaemia, a higher risk of infection, or bleeding issues. Regular blood tests allow your doctor to monitor these levels and adjust your treatment if necessary. Talk to your doctor or pharmacist for more information.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Adley Formulation, Sco- 42, Sector 12, Panchkula-134112, Haryana, India
Other Info - CAN0758
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