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compositionComposition:CANGRELOR-50MG
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Prescription Medicine
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Canreal Injection is used to prevent the formation of blood clots, thereby reducing the chance of Myocardial infarction. It is also used during the percutaneous coronary intervention (PCI) procedure to reduce the chance of blood clot formation. It contains Cangrelor, which works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This results in lower cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST).

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CANGRELOR-50MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Canreal Injection

Canreal Injection is an intravenous medicine used to prevent blood clots during a heart procedure called percutaneous coronary intervention (PCI). This medicine helps lower the risk of serious complications, like heart attacks or sudden blockages in a newly placed stent, while the procedure is being performed. It acts as a temporary protective shield for your blood vessels during this critical treatment.

Because Canreal Injection is delivered directly into your bloodstream, it is only used during your procedure in a hospital setting. It is not a daily medication that you take at home; instead, it is given as a single, continuous infusion in the operating room. To support your recovery, your doctor may suggest adopting a low-salt diet and making healthy lifestyle choices.

The most common side effect of this medicine is bleeding, which can range from minor bruising to serious blood loss. You must immediately notify your healthcare team if you experience shortness of breath, blood in your urine, or unusual bruising. Your medical team will monitor you closely during the infusion to ensure your safety.

Do not take this if you have active, serious bleeding, or if you are allergic to this medicine. Before your procedure, tell your doctor if you have a history of bleeding disorders, stroke, or severe liver damage. This helps your healthcare team plan the safest possible treatment for your heart.

This medicine can interact with other blood thinners or pain relievers, which can increase your risk of bleeding. If you are pregnant, breastfeeding, or an older adult, consult your doctor to discuss the risks and benefits. Your team will ensure all your medications are safely managed before and after the procedure.

Uses of Canreal Injection

Your doctor may use Canreal Injection during percutaneous coronary intervention (PCI), a procedure used to open narrowed or blocked arteries that supply blood to the heart.

  • Prevention of blood clots during PCI: Canreal Injection helps prevent platelets from clumping together and forming clots while the coronary artery is being treated.
  • Reduction of clot-related complications during PCI: By rapidly preventing platelet clumping, Canreal Injection helps reduce the risk of complications such as a heart attack or a clot forming inside a newly placed coronary stent during and around the procedure.

Key Benefits

This medication offers critical advantages that help ensure a safer and smoother recovery during complex heart procedures:

  • Immediate protection: Canreal Injection starts working within minutes of being injected, providing instant defence against blood clots at the exact moment your heart arteries are being treated.
  • Rapid recovery of clotting function: Once the injection is stopped, the blood-thinning effect wears off quickly, usually within an hour. This allows your body's natural clotting ability to return to normal rapidly, which helps prevent prolonged bleeding after your procedure.
  • Reliable delivery: Because it is given directly into a vein, it is highly reliable for patients who cannot swallow pills or those who require immediate clot prevention before oral tablets can take effect.
Side effects of Canreal Injection
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Apply an ice pack to slow bleeding and reduce swelling.
  • Keep your head raised to help blood drain away from your eye.
  • Take rest and avoid intense activities that raise pressure in the eye.
  • If the bleeding is severe or does not improve within 24 hours, consult a doctor.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Canreal Injection will be administered by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Canreal Injection Works

Canreal Injection contains cangrelor. It is an antiplatelet medicine that temporarily prevents platelets, small blood cells involved in clot formation, from sticking together. Cangrelor blocks P2Y12 receptors (specific sites on platelets that receive signals to become activated). Blocking these receptors prevents a chemical called ADP from activating platelets and causing them to clump together. This reduces the formation of unwanted blood clots during PCI. Cangrelor acts rapidly, and its effect is reversible. Once the infusion is stopped, the medicine is cleared quickly, and platelet function generally begins returning towards normal within about one hour.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Canreal Injection to prevent unpleasant side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Canreal Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Canreal Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Canreal Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Canreal Injection does not affect your ability to drive. However, do not drive or operate heavy machinery if you are not alert.

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Liver

Caution

Canreal Injection should be used with caution in patients with liver impairment. Please consult your doctor if you have liver disease or any concerns regarding this.

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Kidney

Caution

Canreal Injection should be used with caution in patients with kidney impairment. Please consult your doctor if you have kidney disease or any concerns regarding this.

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Children

Unsafe

Canreal Injection is not recommended for use in children, as efficacy and safety have not been established.

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Heart

Caution

Canreal Injection may be given to heart patients during procedures like angioplasty, but only under specialist care. It helps prevent clots but can increase bleeding risk, requiring close monitoring.

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Geriatrics

Caution

Geriatric patients may receive Canreal Injection during heart procedures, but only under specialist supervision. Age-related risks like bleeding or kidney issues require close monitoring and dose adjustments.

What if I have taken an overdose of Canreal Injection

An overdose of Canreal Injection is extremely rare because the injection is precisely programmed and monitored by medical staff. However, if an overdose does occur, it can lead to an increased risk of bleeding. The healthcare team will immediately stop the infusion and support your body until the medicine naturally clears from your system, which typically happens within an hour.

Diet & Lifestyle Advise

  • Eat a heart-healthy diet: Focus on low-sodium, nutrient-rich foods like whole grains, vegetables, and lean proteins to support your recovery after a heart procedure.
  • Avoid activities that cause injury: Because your blood's ability to clot may be affected for a short time after the procedure, avoid contact sports or activities that put you at risk for falls or cuts.
  • Use a soft-bristled toothbrush: To prevent your gums from bleeding, use a soft toothbrush and gentle dental floss in the days following your procedure.
  • Stay hydrated: Drink plenty of water as recommended by your healthcare team to help your kidneys clear any fluids or contrast dyes used during your heart procedure.
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How Soon It Starts Working

The time required for Canreal Injection to start to work: Canreal Injection ideally shows its action within few minutes after administration. The time for which the effects of Canreal Injection last: The effect of Canreal Injection lasts for 1 to 2 hours.

What if you forget to take Canreal Injection

Since Canreal Injection is given as a continuous infusion by healthcare professionals during a medical procedure, it is highly unlikely that you will miss a dose. If the infusion is temporarily interrupted, hospital staff will quickly restart it or transition you to an oral medication as planned.

Storage

• Canreal Injection vials are stored at controlled room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Healthcare providers should always inspect the vial before preparation; the solution must be clear and colourless to pale yellow, without any visible particles.
  • Monitor the injection site: Watch the area where the IV is placed for signs of swelling, redness, pain, or active bleeding, and alert your nurse immediately if you notice these.
  • Transition to oral blood thinners carefully: Your doctor will plan the exact timing of your switch from Canreal Injection to oral blood-thinning tablets. Make sure you take your oral medications exactly as prescribed to keep your heart protected.
  • Inform other healthcare providers: Tell any dentist, surgeon, or other doctors that you recently received an intravenous blood thinner before undergoing any medical procedures.

Drug-Drug Interactions

verifiedApollotooltip
  • Other blood thinners (like heparin or warfarin): May significantly increase the risk of serious bleeding.
  • Certain pain relievers (like NSAIDs, including ibuprofen or naproxen): Can increase your risk of stomach bleeding when used around the exact time of your treatment.
  • Oral P2Y12 inhibitors (like clopidogrel or prasugrel): If taken during the infusion of Canreal Injection, they may not work properly. These oral medications should generally be taken only after the infusion of Canreal Injection is stopped.
CangrelorHeparin
Severe
CangrelorReteplase
Severe

Drug-Drug Interactions

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CangrelorHeparin
Severe
How does the drug interact with Canreal Injection:
Co-administration of Canreal Injection with Heparin can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Although there is a possible interaction between Heparin and Canreal Injection, you can take these medicines together if prescribed by a doctor. However, if you have any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, you should seek immediate medical attention. Do not stop using any medications without a doctor's advice.
CangrelorReteplase
Severe
How does the drug interact with Canreal Injection:
Co-administration of Canreal Injection with Reteplase can increase the risk of bleeding.

How to manage the interaction:
Although taking Canreal Injection and Reteplase together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
CangrelorMifepristone
Severe
How does the drug interact with Canreal Injection:
Co-administration of Canreal Injection with Mifepristone may increase the risk and/or severity of vaginal bleeding in women.

How to manage the interaction:
Although there is an interaction, Canreal Injection can be taken with Mifepristone if prescribed by the doctor. Consult the prescriber if you notice prolonged or heavy bleeding. Do not discontinue the medication without consulting a doctor.
CangrelorLepirudin
Severe
How does the drug interact with Canreal Injection:
Co-administration of Lepirudin and Canreal Injection may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Canreal Injection with Lepirudin can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without a doctor's advice.
CangrelorAbciximab
Severe
How does the drug interact with Canreal Injection:
Co-administration of Abciximab with Canreal Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Canreal Injection with Abciximab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
CangrelorUrokinase
Severe
How does the drug interact with Canreal Injection:
Co-administration of Urokinase with Cangrelo can enhance the blood-thinning effects of Canreal Injection.

How to manage the interaction:
Although taking Urokinase and Canreal Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: bleeding, problems, bruising, feeling dizzy or lightheaded, stools that are red or black and sticky, intense headache, weakness, bleeding, or vomiting. Do not stop using any medications without a doctor's advice.
CangrelorDesirudin
Severe
How does the drug interact with Canreal Injection:
Co-administration of Desirudina and Canreal Injection may increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Canreal Injection and Desirudin, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding and vomiting. Do not stop using any medications without a doctor's advice.
CangrelorPrasugrel
Severe
How does the drug interact with Canreal Injection:
Co-administration of Canreal Injection with Prasugrel and reduce its effectiveness if used at the same time.

How to manage the interaction:
Taking Canreal Injection may block the action of prasugrel and reduce its effectiveness if used at the same time. Therefore, prasugrel should be given after the Canreal Injection infusion is complete. Do not discontinue the medication without consulting a doctor.
CangrelorApixaban
Severe
How does the drug interact with Canreal Injection:
Coadministration of Canreal Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Canreal Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
CangrelorAlteplase
Severe
How does the drug interact with Canreal Injection:
Co-administration of Canreal Injection with Alteplase can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Canreal Injection and Alteplase, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Canreal Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PLATELET AGGREGATION INHIBITOR]

FAQs

Canreal Injection is used to treat Myocardial infarction (heart attack).
Canreal Injection works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST).
Canreal Injection may cause anaemia (low haemoglobin and low red blood cell count). So it would be best if you include iron-rich food in your diet to prevent anaemia.
Canreal Injection is an intravenous blood thinner used during a heart procedure (PCI) to prevent blood clots from forming in your arteries or stents. Talk to your doctor if you have questions about your specific procedure.
Canreal Injection clears from your body very quickly. Your blood's normal clotting ability usually begins to return to normal within one hour after the infusion is stopped. Talk to your doctor if you are concerned about bleeding risks.
The safety of this medicine during pregnancy or breastfeeding is not fully established. Your doctor will weigh the urgent benefits of the heart procedure against any potential risks to your baby. Talk to your doctor to discuss your options.
Yes, because Canreal Injection is a powerful blood thinner, it can cause you to bleed or bruise more easily, even from minor bumps. Your medical team will monitor you closely during and after the procedure. Talk to your doctor if you notice any unusual bleeding.
Shortness of breath is a known side effect of this medicine. You should alert your hospital care team immediately if you feel short of breath or have difficulty breathing. Talk to your doctor about how this is managed.
Some common pain medicines, like ibuprofen or naproxen, can increase bleeding risks. You should consult your healthcare team before taking any pain relievers after your procedure. Talk to your doctor or pharmacist for safe alternatives.
Canreal Injection is given directly into a vein, works instantly, and wears off in about an hour, whereas oral blood thinners are swallowed as tablets, take longer to start working, and stay in your system for several days. Talk to your doctor to learn how they transition you from one to the other.

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Country of origin

INDIA

Manufacturer/Marketer address

Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - CAN0628
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