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BUPRIGESIC 0.6MG INJECTION is used to treat opioid dependence (addiction to opioid drugs). It contains Buprenorphine which prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It may also provide pain relief by acting on specific receptors in the brain. This medicine may sometimes cause side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPRENORPHINE-0.6MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About BUPRIGESIC 0.6MG INJECTION

BUPRIGESIC 0.6MG INJECTION belongs to a class of drugs called 'opioid analgesic' primarily used to treat opioid addiction (narcotics) like morphine, heroin, etc. In some cases, it is also used to treat, prevent and treat moderate to severe pain. Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behaviour and leads to an inability to control the use of a legal or illegal drug or medication.

BUPRIGESIC 0.6MG INJECTION contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

BUPRIGESIC 0.6MG INJECTION will be administered by a trained healthcare professional. Hence, do not self-administer. This medicine may cause certain side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Most of these side effects of BUPRIGESIC 0.6MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

BUPRIGESIC 0.6MG INJECTION should be avoided if you are allergic to it. Do not use BUPRIGESIC 0.6MG INJECTION if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. This medicine is not recommended for children below 18 years of age. BUPRIGESIC 0.6MG INJECTION is a habit-forming drug, and there is a risk of dependence on BUPRIGESIC 0.6MG INJECTION. Hence, do not stop receiving BUPRIGESIC 0.6MG INJECTION without consulting a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors or general unwell feeling. BUPRIGESIC 0.6MG INJECTION may decrease fertility in men and women. Do not consume alcohol with BUPRIGESIC 0.6MG INJECTION as it may increase the risk of side effects. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease before starting treatment with BUPRIGESIC 0.6MG INJECTION.

Uses of BUPRIGESIC 0.6MG INJECTION

BUPRIGESIC 0.6MG INJECTION is used in the treatment of Opioid (drug) addiction and pain. The detailed uses of BUPRIGESIC 0.6MG INJECTION are as follows:

  • Moderate to Severe Pain: BUPRIGESIC 0.6MG INJECTION is used when non-opioid analgesics are ineffective, especially in post-operative or trauma settings.
  • Opioid Use Disorder (OUD): BUPRIGESIC 0.6MG INJECTION reduces cravings and withdrawal symptoms; used as part of a comprehensive addiction treatment program.

Key Benefits

The BUPRIGESIC 0.6MG INJECTION contains Buprenorphine as a substitution (replacement) treatment in patients addicted to opioid drugs (heroin and morphine, etc.). It prevents or reduces the unpleasant withdrawal symptoms experienced when addicts stop using opioid drugs. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain. Compared to other opioid analgesics like methadone, BUPRIGESIC 0.6MG INJECTION has the advantage of having less sedation (sleepiness), decreased respiratory depression, decreased risk of diversion, fewer withdrawal symptoms and lower risk of toxicity at higher doses. 

Side effects of Buprigesic 0.6mg Injection

Directions for Use

  • Your doctor will determine the dosage and timing of BUPRIGESIC 0.6MG INJECTION based on your medical condition.
  • BUPRIGESIC 0.6MG INJECTION is administered subcutaneously (under the skin) by a healthcare professional in a medical setting.
  • Do not self-administer it.

How BUPRIGESIC 0.6MG INJECTION Works

BUPRIGESIC 0.6MG INJECTION contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.
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Alcohol

Unsafe

BUPRIGESIC 0.6MG INJECTION may cause dizziness, drowsiness, blurred vision, or impaired thinking in some people. Alcohol consumption may even worsen these effects. Hence, do not consume alcohol while on treatment with this medicine.

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Pregnancy

Unsafe

BUPRIGESIC 0.6MG INJECTION is not recommended during pregnancy as it may cause life-threatening withdrawal symptoms in the newborn. Hence, inform your doctor before administering BUPRIGESIC 0.6MG INJECTION if you are pregnant or planning pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It may be unsafe to use during breastfeeding as it passes into breastmilk and may cause sleepiness and decreased heart rate in your infant. It is not recommended for use in breastfeeding. Hence, if you are breastfeeding, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

BUPRIGESIC 0.6MG INJECTION may cause dizziness, blurred vision or drowsiness in some people. It is an offence to drive if BUPRIGESIC 0.6MG INJECTION affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience vision problems after administration of BUPRIGESIC 0.6MG INJECTION.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

BUPRIGESIC 0.6MG INJECTION is not recommended for use in children below 18 years of age as the safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using BUPRIGESIC 0.6MG INJECTION. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of BUPRIGESIC 0.6MG INJECTION in elderly patients. Please consult your doctor.

What if I have taken an overdose of BUPRIGESIC 0.6MG INJECTION

Overdose of BUPRIGESIC 0.6MG INJECTION may cause narrowing or widening of the pupils (black circles in the centre of the eye), slowed/shallow/difficulty breathing, extreme sleepiness or drowsiness, unable to respond or wake up, coma (loss of consciousness for a period of time), and slow heartbeat. Since BUPRIGESIC 0.6MG INJECTION is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any of these symptoms.

Diet & Lifestyle Advise

  • Do regular exercise such as swimming or walking.
  • Drink plenty of water while on treatment with BUPRIGESIC 0.6MG INJECTION to avoid dry mouth.
  • Maintain a fibre-rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while receiving BUPRIGESIC 0.6MG INJECTION.
  • Avoid consumption of alcohol and quit smoking.

Have a query?

How Soon It Starts Working

The time required for BUPRIGESIC 0.6MG INJECTION to start to work: BUPRIGESIC 0.6MG INJECTION ideally shows its action within 15 minutes after an intramuscular administration and 1 hour after intravenous administration of the dose. The time for which the effects of BUPRIGESIC 0.6MG INJECTION last: The effect of BUPRIGESIC 0.6MG INJECTION lasts for 6 hours.

What if you forget to take BUPRIGESIC 0.6MG INJECTION

If you miss a dose or appointment for BUPRIGESIC 0.6MG INJECTION, contact your doctor to receive the dose as soon as possible. Your next dose should be administered at least 26 days later.

Storage

• Store in a cool and dry place away from sunlight. • Keep BUPRIGESIC 0.6MG INJECTION out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Please do not stop receiving BUPRIGESIC 0.6MG INJECTION suddenly, as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to BUPRIGESIC 0.6MG INJECTION or any other medicines, please tell your doctor.  Do not use BUPRIGESIC 0.6MG INJECTION if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. BUPRIGESIC 0.6MG INJECTION is not recommended for children below 18 years of age.  Avoid consuming alcohol with BUPRIGESIC 0.6MG INJECTION as it may increase the risk of side effects. Do not use this medicine if you have used an MAO inhibitor (antidepressants) in the past 14 days, as a dangerous drug interaction could occur. BUPRIGESIC 0.6MG INJECTION should be used with extreme caution in patients who have a history of alcoholism or drug abuse. Inform your doctor if you have severe breathing problems, asthma, delirium tremens (confusion and shaking after stopping drinking alcohol), hallucinations (seeing and hearing things that are not there), kidney or liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression or other conditions that are treated with antidepressants. 

Drug-Drug Interactions

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Drug-Drug Interaction: BUPRIGESIC 0.6MG INJECTION may have interaction with benzodiazepines (diazepam, temazepam ), pain killers (pentazocine, nalbuphine, codeine, morphine), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline), antihistamine (promethazine, chlorphenamine), blood thinners (warfarin), anti-anxiety drugs (alprazolam), fits related medicines (carbamazepine), medicines used to prevent nausea (ondansetron), antifungal drugs (ketoconazole), antibiotic (ciprofloxacin, erythromycin), anticancer drugs (ceritinib, lapatinib), immunosuppressants (fingolimod), antipsychotics (droperidol), and HIV/AIDS drugs (saquinavir).

Drug-Food Interaction: BUPRIGESIC 0.6MG INJECTION may interact with grapefruit juice. Therefore, avoid grapefruit juice intake with BUPRIGESIC 0.6MG INJECTION as it may increase BUPRIGESIC 0.6MG INJECTION levels in the body. Also, avoid St. John's wort (antidepressants plant), and alcohol consumption while receiving BUPRIGESIC 0.6MG INJECTION as it may increase the risk of adverse effects such as drowsiness, dizziness and difficulty concentrating.

Drug-Disease Interaction: People with asthma or any other breathing problems, kidney problems, liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression should consult a doctor before receiving BUPRIGESIC 0.6MG INJECTION.

BuprenorphineAlvimopan
Critical

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
How does the drug interact with Buprigesic 0.6mg Injection:
Using alvimopan together with Buprigesic 0.6mg Injection can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buprigesic 0.6mg Injection is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Ziprasidone with Buprigesic 0.6mg Injection can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buprigesic 0.6mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
BuprenorphineParamethadione
Severe
How does the drug interact with Buprigesic 0.6mg Injection:
Using Buprigesic 0.6mg Injection together with Paramethadione can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Paramethadione and Buprigesic 0.6mg Injection, you can take these medicines together if prescribed by a doctor. Doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Buprigesic 0.6mg Injection:
Using Buprigesic 0.6mg Injection together with Nabilone can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Nabilone and Buprigesic 0.6mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. It's important to keep an eye on your health and be aware of any changes. Doctor can recommend other options that won't cause any problems. If you notice any symptoms like feeling very tired or having trouble breathing, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
BuprenorphinePethidine
Severe
How does the drug interact with Buprigesic 0.6mg Injection:
Using Buprigesic 0.6mg Injection together with Pethidine can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Pethidine and Buprigesic 0.6mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Buprigesic 0.6mg Injection along with carbamazepine may increase the risk of side effects such as breathing problems.

How to manage the interaction:
Although taking carbamazepine and Buprigesic 0.6mg Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, anxiety, depression, rapid heart beat, body aches, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
When Buprigesic 0.6mg Injection is used with diazepam, it may lead to significant adverse effects such as respiratory difficulties.

How to manage the interaction:
Concomitant administration of Buprigesic 0.6mg Injection alongside diazepam can result in an interaction, it can be taken if a doctor has advised it. You should avoid driving or operating hazardous machinery until you're aware of how these drugs affect you. Do not discontinue any medications without consulting a doctor.
BuprenorphineSuvorexant
Severe
How does the drug interact with Buprigesic 0.6mg Injection:
When Buprigesic 0.6mg Injection is used with suvorexant, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of Buprigesic 0.6mg Injection alongside suvorexant can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Do not discontinue any medications without consulting a doctor.
BuprenorphineAnagrelide
Severe
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Buprigesic 0.6mg Injection with anagrelide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of Buprigesic 0.6mg Injection with anagrelide can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
When Buprigesic 0.6mg Injection is used with aripiprazole, it may possibly lead to significant adverse effects such as respiratory distress, unconsciousness.

How to manage the interaction:
Co-administration of Buprigesic 0.6mg Injection alongside aripiprazole can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

BUPRIGESIC 0.6MG INJECTION is used to treat opioid addiction.

BUPRIGESIC 0.6MG INJECTION consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.

Yes, BUPRIGESIC 0.6MG INJECTION may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while receiving BUPRIGESIC 0.6MG INJECTION, do not stop administration suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.

Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with BUPRIGESIC 0.6MG INJECTION if you think you may want to have a baby in the future.

No, you are not recommended to use BUPRIGESIC 0.6MG INJECTION with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with BUPRIGESIC 0.6MG INJECTION may cause life-threatening respiratory depression and death have occurred. However, please consult a doctor before receiving BUPRIGESIC 0.6MG INJECTION with other medicines.

Yes, BUPRIGESIC 0.6MG INJECTION may cause addiction, especially if used for a prolonged time. Therefore, BUPRIGESIC 0.6MG INJECTION should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. BUPRIGESIC 0.6MG INJECTION should be administered only as advised by a doctor as overuse, or misuse of BUPRIGESIC 0.6MG INJECTION can lead to overdose or death.

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Author Details

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Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - BUP0006
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