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BUPRIGESIC 0.6MG INJECTION is used to treat opioid dependence (addiction to opioid drugs). It contains Buprenorphine, which prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It may also provide pain relief by acting on specific receptors in the brain. This medicine may sometimes cause side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPRENORPHINE-0.6MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About BUPRIGESIC 0.6MG INJECTION

BUPRIGESIC 0.6MG INJECTION is a prescription injection used to treat severe pain that does not respond to non-opioid pain relievers. It is also utilised under medical supervision as an important component of treatment programs for opioid dependence. This medication works directly on the central nervous system to safely manage severe discomfort and help stabilise brain chemistry during recovery.

This injection is given at precise intervals scheduled by your healthcare provider to ensure consistent drug levels in your body. Because this medication is injected directly, it is not affected by food, meaning you do not need to coordinate your doses with meals. To support your treatment, incorporating lifestyle adjustments such as physical therapy, stress management, and gentle, regular movement can significantly improve your recovery results.

While using BUPRIGESIC 0.6MG INJECTION, you may experience mild side effects like drowsiness, mild dizziness, or nausea as your body adjusts. These are typically temporary, but you must contact your doctor immediately if you experience serious side effects, such as extreme sleepiness, slowed breathing, or symptoms of an allergic reaction.

Before you begin treatment, tell your doctor if you have a history of brain pressure, kidney problems, or lung conditions. Do not take this if you have severe breathing difficulties, severe asthma, or if you have had a life-threatening allergic reaction to similar opioid medications. Extreme caution is also required if you are taking sleeping medicines, alcohol, or other central nervous system (CNS) depressants, as combining these with BUPRIGESIC 0.6MG INJECTION can cause profound sedation, severe respiratory depression, or coma unless carefully supervised by your healthcare provider.

This medication can interact dangerously with alcohol, sleeping aids, or anxiety medications because combining them can severely slow down your breathing and brain activity. If you are pregnant, breastfeeding, or are an elderly individual, consult your doctor before starting BUPRIGESIC 0.6MG INJECTION to ensure it is safe for your specific situation.

Uses of BUPRIGESIC 0.6MG INJECTION

BUPRIGESIC 0.6MG INJECTION is used in the treatment of Opioid (drug) addiction and pain. The detailed uses of BUPRIGESIC 0.6MG INJECTION are as follows:

  • Severe pain relief: BUPRIGESIC 0.6MG INJECTION helps relieve moderate to severe pain by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain when alternative treatments cannot provide adequate relief.
  • Opioid dependence treatment: It helps reduce withdrawal symptoms and intense cravings in individuals undergoing supervised treatment for opioid use disorder.

Key Benefits

BUPRIGESIC 0.6MG INJECTION helps relieve severe pain and supports treatment for opioid dependence, helping you feel more stable and comfortable.

Benefits may include:

  • Helps provide long-lasting relief from severe pain.
  • Reduces withdrawal symptoms during opioid dependence treatment.
  • Improves comfort and ability to perform daily activities.
  • Supports long-term recovery from opioid dependence.
  • Promotes better participation in rehabilitation and counselling programs.
  • Provides greater physical stability to improve overall quality of life.
Side effects of Buprigesic 0.6mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • This medication is injected into a muscle, under the skin, or directly into a vein by a trained healthcare professional in a clinical setting.
  • If your doctor has authorised you to self-inject this medication at home, carefully follow the exact preparation and injection steps demonstrated by your healthcare team.
  • Always use a fresh, sterile needle and syringe for every single injection, and rotate your injection sites to prevent skin irritation, hard lumps, or tissue damage.
  • Never inject the liquid if it appears cloudy, discoloured, or contains visible floating particles.
  • Always follow your doctor's exact instructions regarding your treatment schedule and never alter your dose on your own.

How BUPRIGESIC 0.6MG INJECTION Works

BUPRIGESIC 0.6MG INJECTION contains 'Buprenorphine', which works by attaching to specific opioid receptors in the brain and spinal cord. Unlike many other opioids, it only partially activates these receptors. This helps relieve pain and reduce withdrawal symptoms and cravings without producing the same strong effects as full opioid medications. Because of the way it works, BUPRIGESIC 0.6MG INJECTION has a lower risk of causing severe breathing problems, physical dependence, and misuse than many other opioids. However, this risk is not completely eliminated, so it should always be used exactly as prescribed.
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Alcohol

Unsafe

BUPRIGESIC 0.6MG INJECTION may cause dizziness, drowsiness, blurred vision, or impaired thinking in some people. Alcohol consumption may even worsen these effects. Hence, do not consume alcohol while on treatment with this medicine.

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Pregnancy

Unsafe

BUPRIGESIC 0.6MG INJECTION is not recommended during pregnancy as it may cause life-threatening withdrawal symptoms in the newborn. Hence, inform your doctor before administering BUPRIGESIC 0.6MG INJECTION if you are pregnant or planning pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It may be unsafe to use during breastfeeding as it passes into breastmilk and may cause sleepiness and decreased heart rate in your infant. It is not recommended for use in breastfeeding. Hence, if you are breastfeeding, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

BUPRIGESIC 0.6MG INJECTION may cause dizziness, blurred vision or drowsiness in some people. It is an offence to drive if BUPRIGESIC 0.6MG INJECTION affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience vision problems after administration of BUPRIGESIC 0.6MG INJECTION.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving BUPRIGESIC 0.6MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

BUPRIGESIC 0.6MG INJECTION is not recommended for use in children below 18 years of age as the safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using BUPRIGESIC 0.6MG INJECTION. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of BUPRIGESIC 0.6MG INJECTION in elderly patients. Please consult your doctor.

What if I have taken an overdose of BUPRIGESIC 0.6MG INJECTION

If you suspect an overdose, seek emergency medical help immediately. Symptoms of an overdose can include extreme drowsiness, cold or clammy skin, pinpoint pupils, severe muscle weakness, and dangerously slowed breathing.

Diet & Lifestyle Advise

  • Prevent constipation: Opioid medications commonly slow down bowel movements. Drink plenty of water throughout the day and eat a diet rich in fibre, including whole grains, fruits, and vegetables, to maintain healthy digestion.
  • Stand up slowly: This medication can lower your blood pressure, particularly when changing positions. Rise slowly from sitting or lying down to reduce the risk of dizziness, fainting, and falls.
  • Stay well-hydrated: Drinking adequate fluids supports your kidneys and liver, helping your body process and eliminate the medication efficiently.
  • Engage in guided movement: Participate in gentle, low-impact exercises like walking or stretching, as advised by your healthcare provider, to keep your muscles active and manage chronic pain naturally.
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How Soon It Starts Working

  • The time required for BUPRIGESIC 0.6MG INJECTION to start to work: BUPRIGESIC 0.6MG INJECTION ideally shows its action within 15 minutes after an intramuscular administration and 1 hour after intravenous administration of the dose.
  • The time for which the effects of BUPRIGESIC 0.6MG INJECTION last: The effect of BUPRIGESIC 0.6MG INJECTION lasts for 6 hours.

What if you forget to take BUPRIGESIC 0.6MG INJECTION

If you miss an appointment for your scheduled injection, contact your healthcare provider's office immediately to reschedule. If you self-inject at home and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and resume your regular schedule. Do not inject a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep BUPRIGESIC 0.6MG INJECTION out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the solution before use: Make sure the injection solution is clear and free of particles. Do not use it if it looks cloudy or has changed in appearance.
  • Rotate injection sites: Use a different injection site each time, such as different areas of your abdomen or thighs. This helps protect your skin and underlying tissue from damage.
  • Never share injection equipment: Do not share needles, syringes, or medicine vials with anyone. Sharing can spread serious blood-borne infections.
  • Be careful with activities requiring alertness: Avoid driving, cycling, or operating machinery until you know how this medicine affects you. It may reduce your concentration or make you feel drowsy.
  • Keep an injection record: Write down the date, time, and injection site each time you use the medicine. Share this record with your healthcare provider during your regular check-ups.
  • Keep naloxone available if advised: If you or your caregiver is using this medicine at home, ask your healthcare provider whether you should keep naloxone on hand. Make sure your family members or caregivers know how to recognise the signs of an opioid overdose and use naloxone while waiting for emergency medical help.

Drug-Drug Interactions

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  • Benzodiazepines and sleeping pills (e.g., diazepam, zolpidem): Combining BUPRIGESIC 0.6MG INJECTION with medications used to treat anxiety or sleep disorders can lead to extreme drowsiness, severe breathing difficulties, coma, or death.
  • Other opioid pain relievers (e.g., morphine, tramadol): Taking other opioids alongside this medication can trigger sudden withdrawal symptoms or reduce the pain-relieving effects of BUPRIGESIC 0.6MG INJECTION.
  • Antifungal medications (e.g., ketoconazole): These drugs can slow down how your body processes BUPRIGESIC 0.6MG INJECTION, leading to higher levels of the medication in your blood and increasing your risk of side effects.
BuprenorphineAlvimopan
Critical

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
How does the drug interact with Buprigesic 0.6mg Injection:
Using alvimopan together with Buprigesic 0.6mg Injection can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buprigesic 0.6mg Injection is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Ziprasidone with Buprigesic 0.6mg Injection can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buprigesic 0.6mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Coadministration of Buprigesic 0.6mg Injection with primidone can increase the risk or severity of side effects such as breathing problems.

How to manage the interaction:
Although there is an interaction between Buprigesic 0.6mg Injection and primidone, it can be taken if your doctor has advised it. However, if you experience abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, weight loss, excessive sweating, goose bumps, fever, chills, watery eyes, runny nose, sneezing, or yawning, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Buprigesic 0.6mg Injection with citalopram increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of Buprigesic 0.6mg Injection alongside citalopram can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Buprigesic 0.6mg Injection with Moxifloxacin increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Coadministration of Buprigesic 0.6mg Injection alongside Moxifloxacin can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking Zolpidem with Buprigesic 0.6mg Injection can cause central nervous system depression, leading to breathing difficulty and unconsciousness.

How to manage the interaction:
Although taking Buprigesic 0.6mg Injection and Zolpidem together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, or reaction speed, consult a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.
How does the drug interact with Buprigesic 0.6mg Injection:
Co-administration of Buprigesic 0.6mg Injection with Baclofen can increase the risk of side effects.

How to manage the interaction:
Co-administration of Buprigesic 0.6mg Injection alongside Baclofen can result in an interaction. However, it can be taken if a doctor has advised it. If you experience shortness of breath, chest discomfort, dizziness, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
When Buprigesic 0.6mg Injection is used with aripiprazole, it may possibly lead to significant adverse effects such as respiratory distress, unconsciousness.

How to manage the interaction:
Co-administration of Buprigesic 0.6mg Injection alongside aripiprazole can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Using Buprigesic 0.6mg Injection together with Clomipramine can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking clomipramine and Buprigesic 0.6mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, contact a doctor immediately if you experience any symptoms such as confusion, hallucinations, seizures, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic 0.6mg Injection:
Taking ceritinib together with Buprigesic 0.6mg Injection can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Buprigesic 0.6mg Injection and ceritinib, but can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Drinking alcohol while using this injection is highly dangerous and can cause life-threatening breathing problems, extreme sedation, and severe dizziness.
  • Grapefruit juice: Avoid consuming large quantities of grapefruit or grapefruit juice, as it can raise the level of the medication in your system and increase side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

BUPRIGESIC 0.6MG INJECTION is used to treat opioid addiction.
BUPRIGESIC 0.6MG INJECTION consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.
Yes, BUPRIGESIC 0.6MG INJECTION may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while receiving BUPRIGESIC 0.6MG INJECTION, do not stop administration suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with BUPRIGESIC 0.6MG INJECTION if you think you may want to have a baby in the future.
No, you are not recommended to use BUPRIGESIC 0.6MG INJECTION with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis), as co-administration of these medicines with BUPRIGESIC 0.6MG INJECTION may cause life-threatening respiratory depression and death has occurred. However, please consult a doctor before receiving BUPRIGESIC 0.6MG INJECTION with other medicines.
Yes, BUPRIGESIC 0.6MG INJECTION may cause addiction, especially if used for a prolonged time. Therefore, BUPRIGESIC 0.6MG INJECTION should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. BUPRIGESIC 0.6MG INJECTION should be administered only as advised by a doctor as overuse, or misuse of BUPRIGESIC 0.6MG INJECTION can lead to overdose or death.
Mild redness, warmth, or soreness at the injection site is common and usually resolves within a few days. However, if you notice spreading redness, significant swelling, leaking fluid, or experience worsening pain, it could indicate an infection. Talk to your doctor right away.
No, you must completely avoid alcohol while using this medication. Combining alcohol with this injection can cause life-threatening respiratory depression, extreme drowsiness, coma, or death. Talk to your doctor if you need support in avoiding alcohol.
Using this medication during pregnancy can lead to your baby experiencing opioid withdrawal symptoms after birth, which can be serious. However, stopping treatment suddenly can also carry severe risks for both you and the pregnancy. Talk to your doctor to carefully weigh the benefits and risks for your situation.
Unlike many other opioid medicines, BUPRIGESIC 0.6MG INJECTION is a partial opioid agonist. This means it activates opioid receptors just enough to provide effective pain relief while producing less intense effects than full opioids. Because of the way it works, it has a lower risk of causing severe breathing problems than many other opioid medicines. However, this protection is not complete. Serious or life-threatening breathing problems can still occur, especially if BUPRIGESIC 0.6MG INJECTION is taken in higher-than-prescribed doses or combined with alcohol, benzodiazepines, sleeping medicines, or other drugs that slow the central nervous system. Always take this medicine exactly as prescribed, and speak with your doctor if you have any questions or concerns.
Yes. Your healthcare provider may recommend keeping naloxone readily available, especially if you use opioids at home, have other risk factors for overdose, or take medicines such as benzodiazepines that can slow breathing. Family members and caregivers should know where naloxone is stored, how to administer it, recognise the signs of an opioid overdose, and call emergency medical services immediately after giving it. Naloxone is an emergency treatment and does not replace medical care.

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Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - BUP0006
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