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compositionComposition:BUSULFAN-2MG
prescription
Prescription Medicine
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Bucelon 2 Tablet is used to treat certain cancers. It contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUSULFAN-2MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bucelon 2 Tablet

Bucelon 2 Tablet is a prescription medicine used to treat chronic myeloid leukaemia, a type of blood cancer. It works by targeting and slowing the growth of abnormal white blood cells in your body. This helps keep your blood cell counts within a safer, more stable range.

To get the best results, you must take Bucelon 2 Tablet consistently at the same times every day as directed by your doctor. It is typically taken on an empty stomach to help ensure the medicine is absorbed consistently, though your care team will provide specific instructions based on your blood tests. Drinking plenty of fluids and maintaining a balanced, nutrient-rich diet can help support your body during this treatment.

While taking Bucelon 2 Tablet , you may experience common side effects such as nausea, vomiting, or temporary loss of appetite. However, it can also cause more serious health issues, such as a severe drop in blood cell counts or lung complications. Contact your healthcare team immediately if you develop unusual bruising, persistent fever, or a dry cough with shortness of breath.

Do not take this medicine if you have had a severe allergic reaction to it or any of its ingredients in the past. Before starting Bucelon 2 Tablet , it is crucial to tell your doctor if you have a history of lung disease, liver damage, or seizures. Women who are pregnant or planning to become pregnant must not take this medication, as it can cause serious harm to an unborn baby.

This medication can interact with other drugs, including common over-the-counter pain relievers like acetaminophen, which can increase the risk of liver damage. It is also important to avoid alcohol and smoking, as they can put extra stress on your liver and lungs. If you are breastfeeding or are an older adult, talk to your doctor or pharmacist about the specific risks and safety measures you need to follow.

Uses of Bucelon 2 Tablet

Your doctor may prescribe Bucelon 2 Tablet to treat or help manage the following conditions, depending on your medical condition and overall health:

  • Chronic myeloid leukaemia (CML): Bucelon 2 Tablet helps manage this chronic cancer of the white blood cells by slowing down the overproduction of abnormal cells in the bone marrow.
  • Conditioning treatment: In certain cases, doctors may use this medicine to help prepare the body for a bone marrow or stem cell transplant by clearing out diseased cells.

Key Benefits

Using Bucelon 2 Tablet as prescribed helps control the overproduction of abnormal white blood cells, manage symptoms, and reduce the risk of disease-related complications. Here are the key benefits you can expect:

  • Controls abnormal white blood cell levels: Helps keep white blood cell counts under control, reducing symptoms such as extreme fatigue, unexplained weight loss, and night sweats.
  • Reduces the risk of complications: By stabilising blood cell counts, it helps lower the risk of complications such as an enlarged spleen, allowing you to feel more comfortable and maintain your daily activities.
  • Convenient oral treatment: Provides an effective oral treatment option that can be taken at home under your doctor's supervision, reducing the need for frequent clinic-based intravenous therapies.
Side effects of Bucelon 2 Tablet
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.

Directions for Use

  • Bucelon 2 Tablet can be taken with or without food.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow the tablet as a whole with a glass of water.
  • Do not crush, chew or break it.

How Bucelon 2 Tablet Works

Bucelon 2 Tablet contains busulfan, an alkylating agent that works by interfering with the DNA of rapidly dividing cells, including the abnormal white blood cells produced in chronic myeloid leukaemia (CML). Busulfan binds directly to the DNA of these abnormal cells, forming cross-links that prevent them from copying their genetic material and dividing. As a result, the cancer cells are unable to multiply and gradually die. This helps reduce the number of abnormal white blood cells, allowing the body to maintain healthier blood cell levels and supporting the treatment of CML and other conditions for which Bucelon 2 Tablet is prescribed.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Bucelon 2 Tablet .

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Pregnancy

Unsafe

Bucelon 2 Tablet should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period after taking the final medication.

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Driving

Caution

Bucelon 2 Tablet may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing Bucelon 2 Tablet if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing Bucelon 2 Tablet .

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Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing Bucelon 2 Tablet if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Bucelon 2 Tablet .

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Bucelon 2 Tablet .

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Geriatrics

Caution

Bucelon 2 Tablet should be used with caution in elderly patients, as it may increase the risk of side effects.

What if I have taken an overdose of Bucelon 2 Tablet

If you take more than your prescribed dose, seek emergency medical care immediately or call a poison control centre. An overdose can cause serious damage to your bone marrow and organs.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink at least 8 to 10 glasses of water daily. Proper hydration is critical because it helps protect your kidneys when abnormal cells are being broken down by the medicine.
  • Avoid raw or undercooked foods: Because this medicine lowers your white blood cell count, your immune system will be weaker. Stick to fully cooked meals and wash fruits and vegetables thoroughly to prevent infections.
  • Practice good oral hygiene: Use a soft-bristled toothbrush to clean your teeth gently. This helps prevent mouth sores and reduces the risk of bleeding gums when your platelet counts are low.
  • Protect your skin from the sun: Bucelon 2 Tablet can cause your skin to darken and make it more sensitive to sunlight. Wear protective clothing and apply a broad-spectrum sunscreen when outdoors.
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How Soon It Starts Working

The time required for Bucelon 2 Tablet to start to work: The time required for Bucelon 2 Tablet to show its action is unknown. The time for which the effects of Bucelon 2 Tablet last: The duration of action for Bucelon 2 Tablet is unknown.

What if you forget to take Bucelon 2 Tablet

If you miss a dose of Bucelon 2 Tablet , do not take a double dose to make up for the missed one. Skip the missed dose entirely and take your next dose at your regularly scheduled time. Contact your doctor or pharmacist to let them know you missed a dose, as consistency is very important for this treatment.

Storage

• Store Bucelon 2 Tablet tablets at room temperature, generally between 15°C and 25°C (59°F and 77°F), unless your pharmacist or the product label specifically instructs otherwise.

Drug Warnings

  • Keep all laboratory appointments: You will need regular, frequent blood tests to monitor your blood cell counts and kidney/liver function. Do not skip these appointments.
  • Avoid contact sports or sharp objects: Since this medicine reduces blood platelets, you will bruise and bleed more easily. Take extra care to avoid injuries.
  • Avoid live vaccines: Talk to your doctor before getting any vaccinations. Because Bucelon 2 Tablet weakens your immune system, live vaccines (such as the measles, mumps, or rubella vaccine) can cause serious infections.
  • Use reliable birth control: Both men and women taking Bucelon 2 Tablet must use highly effective birth control during treatment and for a specified time afterward. Talk to your doctor about safe family planning options.
  • Report breathing changes immediately: Lung damage is a rare but serious risk. Contact your care team at the first sign of a persistent dry cough or shortness of breath.

Drug-Drug Interactions

verifiedApollotooltip
  • Acetaminophen: Taking this pain reliever may affect how your body handles Bucelon 2 Tablet and could increase the risk of side effects in some patients. Check with your doctor or pharmacist before using acetaminophen or any other over-the-counter pain reliever while taking Bucelon 2 Tablet .
  • Antifungal medications (like itraconazole or ketoconazole): These drugs can slow down how your body clears Bucelon 2 Tablet , raising the levels of the medicine in your blood and increasing the risk of severe side effects.
  • Seizure medications (like phenytoin): These can alter how quickly Bucelon 2 Tablet is broken down by your liver, which may make the treatment less effective or increase toxicity.
BusulfanBaricitinib
Severe
BusulfanCyclophosphamide
Severe

Drug-Drug Interactions

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BusulfanBaricitinib
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Baricitinib and Bucelon 2 Tablet can increase the risk of developing infections.

How to manage the interaction:
Although Baricitinib with Bucelon 2 Tablet can lead to an interaction, it can be taken if advised by the doctor. However, if you experience fever, sore throat, shortness of breath, body sores, or burning on urination, consult a doctor. Do not stop using any medications without talking to a doctor.
BusulfanCyclophosphamide
Severe
How does the drug interact with Bucelon 2 Tablet:
Co-administration of Cyclophosphamide with Bucelon 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Bucelon 2 Tablet and Cyclophosphamide, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanClozapine
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Bucelon 2 Tablet with Clozapine can increase the risk of developing infection.

How to manage the interaction:
Although there is an interaction between Bucelon 2 Tablet and Clozapine, it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle pain, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BusulfanMetronidazole
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Bucelon 2 Tablet and Metronidazole may increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and Bucelon 2 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
BusulfanFingolimod
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Fingolimod with Bucelon 2 Tablet can increase the risk of developing infections.

How to manage the interaction:
Taking Bucelon 2 Tablet with Fingolimod together can result in an interaction, it can be taken if your doctor has advised it. If you notice any fever, muscle pain, sore throat, shortness of breath, or diarrhea, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanInfliximab
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Bucelon 2 Tablet and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Bucelon 2 Tablet and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing contact a doctor right away. Do not discontinue any medications without consulting a doctor.
BusulfanCladribine
Severe
How does the drug interact with Bucelon 2 Tablet:
Combining Cladribine with Bucelon 2 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and Bucelon 2 Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, and pain or burning urination. Do not stop using any medications without talking to your doctor.
BusulfanTofacitinib
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of tofacitinib with Bucelon 2 Tablet may increase the risk of serious infections.

How to manage the interaction:
Taking Bucelon 2 Tablet with Tofacitinib together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination. Do not discontinue any medications without consulting your doctor.
BusulfanLeflunomide
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of leflunomide with Bucelon 2 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Bucelon 2 Tablet and Leflunomide, you can take these medicines together if prescribed by your doctor. However, if you experience fever, diarrhea, sore throat, muscle aches, body sores, or burning during urination, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanThiotepa
Severe
How does the drug interact with Bucelon 2 Tablet:
Combining Bucelon 2 Tablet with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and Bucelon 2 Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Grapefruit can interfere with the enzymes that break down this medicine in your body, leading to unsafe levels of the drug in your system.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Bucelon 2 Tablet is used to treat Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.
Bucelon 2 Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.
Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.
If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.
It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, Bucelon 2 Tablet can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
With a high dose of Busulfan, women's periods may stop, fertility may be compromised, and menopause may begin early. Please seek medical advice from your doctor if you have any concerns regarding this.
Yes, Bucelon 2 Tablet can cause hair loss as a side effect. Some chemotherapy medications, including Bucelon 2 Tablet can causes this side effect. If you experience excessive hair loss, it's important to discuss this with your doctor.
Yes, Bucelon 2 Tablet is a vesicant (irritant).
The common side effects of Bucelon 2 Tablet are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection. If any of these side effects persist or worsen, please consult your doctor.
No, it is generally recommended to take Bucelon 2 Tablet on an empty stomach, either 1 hour before or 2 hours after a meal, to ensure the medicine is absorbed properly. Talk to your doctor or pharmacist for specific instructions.
It is highly recommended to avoid alcohol while taking this medicine, as alcohol can place extra stress on your liver and increase the risk of liver damage. Talk to your doctor for further guidance.
Regular blood tests are necessary to monitor your red blood cells, white blood cells, and platelets. Since Bucelon 2 Tablet lowers these cell counts, tracking them helps your doctor adjust your dose safely to avoid severe infections or bleeding. Talk to your doctor about your testing schedule.
No, you should not get pregnant while taking Bucelon 2 Tablet as it can cause serious birth defects or harm to the unborn baby. Both men and women should use effective birth control during treatment. Talk to your doctor about safe options.
Most oral Bucelon 2 Tablet tablets are stored at room temperature, generally between 15°C and 25°C (59°F and 77°F), unless the product label or your pharmacist gives different instructions. Keep the tablets in their original container, tightly closed, and protected from moisture and heat. Do not refrigerate them unless specifically advised.
You should contact your doctor immediately if you develop a dry cough, shortness of breath, or any difficulty breathing, as these can be early signs of serious lung irritation caused by the medicine. Talk to your doctor right away if these symptoms occur.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - BUC0004
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