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compositionComposition:BOSUTINIB-100MG
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Prescription Medicine
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Bosutris 100 mg Tablet is used to treat certain cancers such as Philadelphia chromosome-positive chronic myeloid leukaemia. It contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduces the spread of cancer to other parts of the body.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BOSUTINIB-100MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bosutris 100 mg Tablet

Bosutris 100 mg Tablet is a prescription medication used to treat adults with a specific type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It is prescribed both for newly diagnosed patients and for those who have not responded to or could not tolerate previous therapies.

For this medication to work effectively, you must take it consistently at the same time every day. You should always take your dose with food, as this significantly increases how well your body absorbs the medicine. Incorporating simple dietary adjustments, like eating bland foods and drinking plenty of fluids, can help support your body during treatment.

While taking Bosutris 100 mg Tablet , you may experience common side effects like stomach discomfort and mild skin rashes. However, it is vital to contact your healthcare team immediately if you notice serious signs such as severe diarrhoea, yellowing of your eyes or skin, or sudden swelling in your legs.

Do not take this if you have a known severe allergy to any of its ingredients. Before starting treatment, you must discuss your medical history with your doctor, especially if you have pre-existing liver damage, kidney disease, or cardiac complications.

This medicine interacts with several other substances, including certain over-the-counter stomach acid reducers, which can prevent the drug from working properly. If you are pregnant, planning to become pregnant, or breastfeeding, you should talk to your doctor immediately, as this medication can harm an unborn baby.

Uses of Bosutris 100 mg Tablet

This medication is specifically approved for the treatment of blood and bone marrow cancers. Your doctor may prescribe Bosutris 100 mg Tablet for the following indications:

  • Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) is a type of blood cancer caused by an abnormal gene change (called the Philadelphia chromosome) that makes certain white blood cells grow and multiply out of control. Bosutris 100 mg Tablet is used to treat this condition.
  • Resistant or intolerant Ph+ Chronic Myeloid Leukemia (CML): It is used to treat chronic, accelerated, or blast phase CML in adults who can no longer take other leukemia treatments due to severe side effects or because the previous medication stopped working.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Supports Healthy Blood Cells: The primary benefit of Bosutris 100 mg Tablet is its ability to target and control leukemia cells, which helps manage the disease and prevent it from progressing to more severe stages. By keeping the growth of abnormal blood cells in check, this treatment helps restore a healthier balance of red blood cells, white blood cells, and platelets in your body.
  • Supports Better Quality of Life: For many patients, successfully controlling the leukemia leads to a noticeable reduction in disease-related symptoms, such as severe fatigue, unexplained weight loss, and bone pain. This physical relief allows patients to maintain better energy levels and continue their daily routines with greater comfort.

Directions for Use

  • Bosutris 100 mg Tablet should be taken with meals.
  • Recommended to take once daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow Bosutris 100 mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Bosutris 100 mg Tablet Works

In people with Philadelphia chromosome-positive (Ph+) CML, an abnormal gene creates a protein called BCR-ABL tyrosine kinase. This protein acts like a constant 'growth switch,' telling abnormal white blood cells to keep growing and multiplying when they should not.  This medicine contains Bosutris 100 mg Tablet , works by directly binding to and blocking this abnormal BCR-ABL protein. By turning off this growth signal, the medication stops the cancer cells from dividing and multiplying, which helps reduce the number of leukemia cells in the bone marrow and bloodstream.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bosutris 100 mg Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

Bosutris 100 mg Tablet is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bosutris 100 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Bosutris 100 mg Tablet on breastfeeding. Bosutris 100 mg Tablet should be avoided during breastfeeding. Hence, inform your doctor if you are breastfeeding. Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Bosutris 100 mg Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Bosutris 100 mg Tablet or until you become alert.

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Liver

Caution

Bosutris 100 mg Tablet is known to cause hepatotoxicity. Hence, inform your doctor if you have a pre-existing or a history of liver disease. A dose adjustment may be needed based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Bosutris 100 mg Tablet . Your doctor may reduce the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Bosutris 100 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

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Heart

Caution

Bosutris 100 mg Tablet should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Bosutris 100 mg Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before administering Bosutris 100 mg Tablet to geriatric patients. Your doctor will prescribe Bosutris 100 mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Bosutris 100 mg Tablet

If you accidentally take more than your prescribed dose, seek emergency medical care. Keep the medication packaging with you so the healthcare providers know exactly what you have taken.

Diet & Lifestyle Advise

  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice while taking this medication, as it can dangerously increase the levels of the drug in your blood.
  • Stay hydrated: Drink plenty of water throughout the day, especially if you experience diarrhoea, to prevent dehydration and support kidney function.
  • Eat small, frequent meals: If you struggle with nausea or loss of appetite, eating smaller, bland portions throughout the day may be easier to tolerate than three large meals.
  • Prioritise food safety: Because your immune system may be weakened, wash all fruits and vegetables thoroughly, and avoid eating raw or undercooked meats, seafood, or eggs.
  • Protect your skin: Use a gentle, unscented moisturiser to manage dry skin, and wear sunscreen when outdoors, as your skin may be more sensitive during treatment.
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How Soon It Starts Working

The time required for Bosutris 100 mg Tablet to start to work: The time required for Bosutris 100 mg Tablet to show its action is not clinically established. The time for which the effects of Bosutris 100 mg Tablet last: The duration of action for Bosutris 100 mg Tablet is not clinically established.

What if you forget to take Bosutris 100 mg Tablet

If you miss a dose, take it as soon as you remember, provided it is within 12 hours of your scheduled time. If more than 12 hours have passed since your missed dose, skip it entirely and take your next dose at your regular scheduled time. Do not take two doses at once to make up for a missed one.

Storage

• Store Bosutris 100 mg Tablet tablets at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check Tablet Before Use: Inspect each tablet before taking it; do not use any tablet that is broken, chipped, or cracked.
  • Safe Tablet Handling: Caregivers should wear disposable gloves if they must handle these tablets, and pregnant individuals should avoid handling them entirely.
  • Avoid Acid-Reducing Medicines: Avoid taking antacids, H2 blockers, or proton pump inhibitors (PPIs) close to your dose, as they lower stomach acid and reduce how well the medicine is absorbed.
  • Use Effective Birth Control: Use highly effective birth control during treatment and for at least 2 weeks after your very last dose to prevent pregnancy.
  • Attend Regular Blood Tests: Keep all appointments for your scheduled blood tests, as your doctor must regularly check your liver function and blood cell counts.
  • Avoid Driving if Dizzy: Do not drive or operate heavy machinery if you feel dizzy, lightheaded, or severely fatigued.

verifiedApollotooltip
  • Avoid Acid-Reducing Medicines: Some medicines can affect how your liver breaks down Bosutris 100 mg Tablet , changing the amount of medicine in your body. For example, certain antifungal medicines (such as ketoconazole), some antibiotics (such as clarithromycin), and other medicines that slow down this process can increase Bosutris 100 mg Tablet levels and raise the risk of side effects. On the other hand, medicines such as rifampin or the herbal supplement St. John's wort can make your body break down Bosutris 100 mg Tablet faster, making it less effective. Always tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, vitamins, and herbal supplements you take.

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verifiedApollotooltip
  • Avoid Grapefruit Products: Do not consume grapefruit, grapefruit juice, or Seville oranges during your treatment. These food products block the enzymes that break down the medication, which can lead to a dangerous buildup of the drug in your body. Always take this medication with food, as taking it on an empty stomach reduces its effectiveness.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Bosutris 100 mg Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Bosutris 100 mg Tablet contains Bosutinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.
Bosutris 100 mg Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.
You should call your doctor right away if you experience any of the following symptoms such as severe dizziness or fainting, difficulty breathing or shortness of breath, persistent nausea or vomiting, severe stomach pain or cramps, unusual bleeding or bruising, severe skin rash or itching and signs of an allergic reaction (such as swelling of the face, lips, or tongue).
Regular scans will determine whether your tumour is responding to the treatment. Your doctor will decide when those scans should be done. Until your doctor advises you to stop taking Bosutris 100 mg Tablet , continue taking it.
Bosutris 100 mg Tablet increases the risk of bleeding or infection since it reduces the number of platelets and white blood cells in your blood. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get fever, chills, cough.
Yes, Bosutris 100 mg Tablet can affect your lungs. One of the potential side effects is pulmonary toxicity, which can lead to symptoms such as severe shortness of breath, dry cough, dizziness, and extreme tiredness. If you experience any of these symptoms, please consult your doctor immediately.
Bosutris 100 mg Tablet does not cause hair loss. However, if you notice hair loss while taking Bosutris 100 mg Tablet , please consult your doctor.
Avoid sitting or standing in one position for too long. Change your posture frequently to relieve pressure on nerves Regular exercise can improve circulation and reduce the risk of nerve compression and ensure your diet includes essential vitamins and minerals, especially B vitamins, which are crucial for nerve health. However, consult your doctor for proper guidance.
Changes in your skin such as rashes, dryness, or itching can be a side effect of Bosutris 100 mg Tablet . Use a gentle, fragrance-free moisturizer to keep your skin hydrated. Stay away from harsh soaps, detergents, and other potential skin irritants. If the skin changes are severe or persistent, please consult your doctor.
To relieve constipation during treatment with Bosutris 100 mg Tablet , you can include more fibre-rich foods in your diet, such as fruits, vegetables, whole grains, and legumes. Drink plenty of water. Engage in regular physical activity to help stimulate bowel movements. However, if it persists, please consult your doctor.
Yes, nausea and extreme tiredness are known side effects of Bosutris 100 mg Tablet . Take some rest and avoid certain foods such as salty, spicy, fried, or fatty foods that can aggravate nausea and stay hydrated by drinking plenty of water. Eat and drink often in small amounts. These side effects can occur as your body adjusts to Bosutris 100 mg Tablet . However, if they become severe or persistent, please consult your doctor.
Changes in taste, such as a metallic taste or loss of taste, are common side effects of Bosutris 100 mg Tablet . To overcome this side effect, rinse your mouth with a solution of salt and bicarbonate of soda before meals to neutralize bad tastes, use extra seasonings, herbs, and spices to enhance the flavour of your food. Stay hydrated by drinking plenty of water to help cleanse your palate. However, if this side effect persists please consult your doctor.
The common side effects of Bosutris 100 mg Tablet are rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, and dizziness. If any of these side effects persist or worsen, please consult your doctor.
No. You must always take this medication with food. Taking it with a meal helps your body absorb the drug properly so that it can work effectively against the leukemia cells. If you have trouble eating, talk to your doctor or pharmacist.
Diarrhoea is a common side effect, but severe diarrhoea can lead to dangerous dehydration. Contact your doctor immediately if you experience persistent or watery diarrhea. They may prescribe an antidiarrheal medicine or adjust your treatment. Talk to your doctor before taking any over-the-counter anti-diarrheal remedies.
You should avoid proton pump inhibitors (like omeprazole) completely. For short-term relief, you may use local antacids, but you must space them out by taking them at least 2 hours before or 2 hours after your dose. Talk to your doctor or pharmacist for a safe acid-reduction plan.
You will need frequent blood tests, especially during the first few months of treatment. These tests allow your doctor to monitor your liver health, kidney function, and blood cell counts. Your doctor will tell you exactly how often you need to have your blood drawn.
It is best to avoid or strictly limit alcohol during your treatment. Both alcohol and this medication are processed by the liver, and combining them can increase your risk of developing liver damage. Talk to your doctor about what is safe for you.
Do not take a broken or chipped tablet. Because this is a specialised medication, direct contact with the active powder should be avoided. Wash your hands thoroughly with soap and water if you accidentally touch a damaged tablet, and contact your pharmacist for disposal instructions.
Treatment is typically long-term, continuing as long as the medication successfully controls your leukemia and you do not experience intolerable side effects. Your oncologist will regularly review your progress and decide how long you should continue. Talk to your doctor for personalised guidance.

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Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7Th To 12Th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - BOS0085
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