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  3. Bortecine Injection

Bortecine Injection, Pack of 1 Injection
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Bortecine Injection is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

BORTEZOMIB-2MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Bortecine Injection

Bortecine Injection belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Bortecine Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Bortecine Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). Bortecine Injection must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of Bortecine Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Bortecine Injection for as long as your doctor has prescribed. Do not stop the Bortecine Injection midway. Talk to your doctor before taking Bortecine Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking Bortecine Injection if you are pregnant or breastfeeding because this Bortecine Injection can cause harmful effects on the unborn baby. Both women and men using this Bortecine Injection should use birth control to avoid pregnancy.

Uses of Bortecine Injection

Treatment of Multiple myeloma and Mantle cell lymphoma.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Bortecine Injection will be administered by a nurse or doctor.• Do not self-administer

Medicinal Benefits

Bortecine Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. Bortecine Injection is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

How Bortecine Injection Works

Bortecine Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Storage

Keep Bortecine Injection out of the sight and reach of children.
Side effects of Bortecine Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Bortecine Injection

Since this medication is given by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as dizziness, blurred vision, unusual bruising or bleeding, and fainting.

Drug Warnings

To treat your condition effectually, continue taking Bortecine Injection for as long as your doctor has prescribed. Do not stop the Bortecine Injection midway. Talk to your doctor before taking Bortecine Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with Bortecine Injection. Avoid taking Bortecine Injection if you are pregnant because this Bortecine Injection can cause harmful effects on the unborn baby. Both women and men using this Bortecine Injection should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with Bortecine Injection and four months after your final dose of Bortecine Injection.

Drug-Drug Interactions

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BortezomibPhenobarbital
Severe
BortezomibNatalizumab
Severe

Drug-Drug Interactions

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BortezomibPhenobarbital
Severe
How does the drug interact with Bortecine Injection:
Coadministration of Bortecine Injection and phenobarbital may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating a condition.

How to manage the interaction:
Although using Bortecine Injection and Phenobarbital together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
BortezomibNatalizumab
Severe
How does the drug interact with Bortecine Injection:
Coadministration of Bortecine Injection and natalizumab can increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and natalizumab together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibLeflunomide
Severe
How does the drug interact with Bortecine Injection:
Coadministration of leflunomide and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Leflunomide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibTeriflunomide
Severe
How does the drug interact with Bortecine Injection:
Coadministration of teriflunomide and Bortecine Injection may increase the risk of infections and may also cause liver problems.

How to manage the interaction:
Although using Bortecine Injection and teriflunomide together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, burning during urination, skin rash, fatigue, dark-colored urine, light-colored stools, or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
BortezomibLomitapide
Severe
How does the drug interact with Bortecine Injection:
Coadministration of lomitapide and Bortecine Injection can increases the risk of liver problems.

How to manage the interaction:
Although using Bortecine Injection and Lomitapide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, skin rash, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
BortezomibRifapentine
Severe
How does the drug interact with Bortecine Injection:
Coadministration of bortezumib and rifapentine may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortecine Injection and Rifapentine together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
BortezomibVoclosporin
Severe
How does the drug interact with Bortecine Injection:
Coadministration of voclosporin and Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibCarbamazepine
Severe
How does the drug interact with Bortecine Injection:
Taking Bortecine Injection with carbamazepine may reduce the blood levels of Bortecine Injection, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Bortecine Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
BortezomibClozapine
Severe
How does the drug interact with Bortecine Injection:
Coadministration of clozapine with Bortecine Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortecine Injection and Clozapine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibFosphenytoin
Severe
How does the drug interact with Bortecine Injection:
Coadministration of Bortecine Injection and fosphenytoin may reduce the blood levels of Bortecine Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortecine Injection and Fosphenytoin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, consult your doctor if your symptoms do not improve. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortecine Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Bortecine Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Bortecine Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Bortecine Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Bortecine Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Bortecine Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Bortecine Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Bortecine Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Bortecine Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Bortecine Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Bortecine Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

Have a query?

FAQs

Bortecine Injection is used to treat multiple myeloma (a cancer of plasma cells) and mantle cell lymphoma (blood cancer).

Bortecine Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.

Bortecine Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Bortecine Injection must not be administered into your spinal fluid (intrathecally).

Yes, Bortecine Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Avoid taking Bortecine Injection if you are pregnant because Bortecine Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Bortecine Injection.

Before you receive treatment with Bortecine Injection, tell your doctor about all of your medical conditions. You should not receive Bortecine Injection if you are allergic to bortezomib or any contents in Bortecine Injection.

If not given an inappropriate dose, Bortecine Injection can cause toxic effects, although not everyone gets it. So, Bortecine Injection is prescribed by a doctor experienced in using medications to treat cancer only.

Bortecine Injection contains bortezomib as its active substance. It belongs to a group of anti-cancer medicines.

No, Bortecine Injection does not have any habit-forming potential.

Your doctor decides the dose of Bortecine Injection based on your medical condition. Taking a double dose can lead to potential side effects.

You should call your doctor right away if you experience side effects like wheezing, chest tightness, swelling of the face or throat, difficulty breathing, seizures, or any unusual skin reactions. Also, seek immediate medical help if you have a sudden change in vision, numbness or tingling, severe stomach issues, unexplained bruising or bleeding, or if your symptoms worsen. Always contact your doctor if you notice any concerning changes in your condition.

You will know if Bortecine Injection is working by noticing improvements in your condition. Regular scans will show if your tumor is reacting to the treatment. Your doctor will decide when these scans should be done. Always follow the doctor's advice as they will monitor your progress to assess its effectiveness.

To minimize the risk of infection while using Bortecine Injection, maintain good hygiene, wash your hands frequently, and avoid contact with sick people. Protect any open wounds and be cautious with food handling. Take care not to harm yourself when using sharp objects like razor or nail cutters. Use a toothbrush with soft bristles to stop gum bleeding.

Bortecine Injection may affect your lungs. However, it might cause allergies with symptoms like trouble breathing or chest tightness. If this happens, stop using Bortecine Injection and get medical attention immediately

Yes, Bortecine Injection may cause hair loss. If you experience unexpected hair thinning or loss, consult your doctor to avoid potential causes or talk if you have any concerns.

Avoid putting prolonged pressure on your limbs, maintain proper posture, be cautious when moving around and follow your doctor's recommendations for managing the symptoms. If you experience tingling or numbness in your arms or legs, inform your doctor immediately, as these could indicate nerve-related issues.

It is important to avoid prolonged sun exposure and UV light, as Bortecine Injection can make your skin more sensitive. Wear protective clothing, sunglasses, and sunscreen to shield your skin. Keep track of your symptoms and consult your doctor to determine if Bortecine Injection is the cause. Your doctor may adjust your treatment or suggest ways to manage the skin changes. Always follow their advice to ensure the treatment remains safe and effective.

To relieve constipation during treatment, focus on eating more fibre, staying hydrated, and staying active with light exercise. You can also consider using stool softeners after consulting your doctor. Establishing a routine for bowel movements and avoiding strain can also help. Always talk to your healthcare provider before trying new remedies.

You may experience nausea and extreme tiredness due to Bortecine Injection, as these are among the side effects.These do not require any medical treatment as they will gradually reduce over time. However, please contact a doctor if these persist longer.

If you are experiencing a change in taste while using Bortecine Injection, try staying hydrated, by using sugar-free gum or mint. Practicing good oral hygiene by brushing your teeth and tongue can also help. If the issue persists, consult your doctor for further advice on managing the side effect.

Country of origin

India

Manufacturer/Marketer address

Plot No. 156, Ground Floor, Phase-1, Industrial Area, ISO 9001:2015 Certified Company, Panchkula - 134113, Haryana, India
Other Info - BO97924

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:50 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/206927s000lbl.pdfhttp://chemocare.com/chemotherapy/drug-info/bortezomib.aspx
  2. https://www.velcade.com/
  3. https://www.medicines.org.uk/emc/files/pil.10551.pdf
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