What is the use of Bonitar 400 Tablet ?

Bonitar 400 Tablet is used to treat Philadelphia chromosome-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

Can a pregnant women take Bonitar 400 Tablet ?

Bonitar 400 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

When should I call my doctor right away?

You should call your doctor right away if you experience any of the following symptoms such as severe dizziness or fainting, difficulty breathing or shortness of breath, persistent nausea or vomiting, severe stomach pain or cramps, unusual bleeding or bruising, severe skin rash or itching and signs of an allergic reaction (such as swelling of the face, lips, or tongue).

How will you know that Bonitar 400 Tablet is working?

Regular scans will determine whether your tumour is responding to the treatment. Your doctor will decide when those scans should be done. Until your doctor advises you to stop taking Bonitar 400 Tablet , continue taking it.

What precautions should I take to reduce the chances of getting infected during treatment with Bonitar 400 Tablet ?

Bonitar 400 Tablet increases the risk of bleeding or infection since it reduces the number of platelets and white blood cells in your blood. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get fever, chills, cough.

Can Bonitar 400 Tablet affect my lungs? What should I do?

Yes, Bonitar 400 Tablet can affect your lungs. One of the potential side effects is pulmonary toxicity, which can lead to symptoms such as severe shortness of breath, dry cough, dizziness, and extreme tiredness. If you experience any of these symptoms, please consult your doctor immediately.

Does Bonitar 400 Tablet cause hair loss?

Bonitar 400 Tablet does not cause hair loss. However, if you notice hair loss while taking Bonitar 400 Tablet , please consult your doctor.

Are there any precautions for tingling sensation and numbness in my arms and legs?

Avoid sitting or standing in one position for too long. Change your posture frequently to relieve pressure on nerves Regular exercise can improve circulation and reduce the risk of nerve compression and ensure your diet includes essential vitamins and minerals, especially B vitamins, which are crucial for nerve health. However, consult your doctor for proper guidance.

I have noticed some changes in my skin after taking Bonitar 400 Tablet ? What should I do?

Changes in your skin such as rashes, dryness, or itching can be a side effect of Bonitar 400 Tablet . Use a gentle, fragrance-free moisturizer to keep your skin hydrated. Stay away from harsh soaps, detergents, and other potential skin irritants. If the skin changes are severe or persistent, please consult your doctor.

How to relieve constipation during the treatment?

To relieve constipation during treatment with Bonitar 400 Tablet , you can include more fibre-rich foods in your diet, such as fruits, vegetables, whole grains, and legumes. Drink plenty of water. Engage in regular physical activity to help stimulate bowel movements. However, if it persists, please consult your doctor.

I am experiencing nausea and extreme tiredness. Is this due to Bonitar 400 Tablet ?

Yes, nausea and extreme tiredness are known side effects of Bonitar 400 Tablet . Take some rest and avoid certain foods such as salty, spicy, fried, or fatty foods that can aggravate nausea and stay hydrated by drinking plenty of water. Eat and drink often in small amounts. These side effects can occur as your body adjusts to Bonitar 400 Tablet . However, if they become severe or persistent, please consult your doctor.

I am noticing a change in my taste. How shall I improve my taste?

Changes in taste, such as a metallic taste or loss of taste, are common side effects of Bonitar 400 Tablet . To overcome this side effect, rinse your mouth with a solution of salt and bicarbonate of soda before meals to neutralize bad tastes, use extra seasonings, herbs, and spices to enhance the flavour of your food. Stay hydrated by drinking plenty of water to help cleanse your palate. However, if this side effect persists please consult your doctor.

What are the side effects of Bonitar 400 Tablet ?

The common side effects of Bonitar 400 Tablet are rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, and dizziness. If any of these side effects persist or worsen, please consult your doctor.

Bonitar 400 Tablet 10's

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Bonitar 400 Tablet is used to treat certain cancers such as Philadelphia chromosome-positive chronic myeloid leukaemia. It contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduces the spread of cancer to other parts of the body.

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About Bonitar 400 Tablet

Bonitar 400 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bonitar 400 Tablet is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bonitar 400 Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bonitar 400 Tablet may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bonitar 400 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bonitar 400 Tablet based on the severity of your condition.

Bonitar 400 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bonitar 400 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment. Bonitar 400 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Uses of Bonitar 400 Tablet

Bonitar 400 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia. The detailed uses of Bonitar 400 Tablet are as follows:

Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) : Bonitar 400 Tablet is used in chronic, accelerated, or blast phases and often prescribed when patients are resistant or intolerant to previous treatments like imatinib.
Other Cancers (off-label or investigational) : Bonitar 400 Tablet is used to treat other cancers includes pancreatic, liver, kidney, thyroid, breast, and lung cancers, as well as gastrointestinal stromal tumors and soft tissue sarcomas.

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Directions for Use

Bonitar 400 Tablet should be taken with meals.
Recommended to take once daily; however, follow your doctor’s advice regarding the dosage and duration.
Swallow Bonitar 400 Tablet as a whole with a glass of water.
Do not crush, break, or chew it.

Medicinal Benefits

Bonitar 400 Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

How Bonitar 400 Tablet Works

Bonitar 400 Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Storage

• Store in a cool and dry place away from sunlight.• Keep Bonitar 400 Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Bonitar 400 Tablet

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Bonitar 400 Tablet

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Bonitar 400 Tablet or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Bonitar 400 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bonitar 400 Tablet in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bonitar 400 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

BosutinibYellow fever vaccine

Critical

BosutinibClarithromycin

Severe

Drug-Drug Interactions

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BosutinibYellow fever vaccine

Critical

How does the drug interact with Bonitar 400 Tablet:
Combining Yellow fever vaccine with Bonitar 400 Tablet can increase the risk of infection.

How to manage the interaction:
Taking Yellow fever vaccine with Bonitar 400 Tablet can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

BosutinibClarithromycin

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with clarithromycin may raise blood levels of Bonitar 400 Tablet, increasing the risk of side effects.

How to manage the interaction:
Although there is an interaction between clarithromycin and Bonitar 400 Tablet, they can be taken together if prescribed by the doctor. However, if you experience fatigue, dizziness, diarrhea, sore throat, muscle aches, red or inflamed skin, pain during urination. Do not discontinue the medication without consulting a doctor.

BosutinibFexofenadine

Severe

How does the drug interact with Bonitar 400 Tablet:
Fexofenadine can considerably increase blood levels of Bonitar 400 Tablet. This may exacerbate the adverse effects of Bonitar 400 Tablet.

How to manage the interaction:
Although there is a possible interaction between Bonitar 400 Tablet and Fexofenadine, you can take these medicines together if prescribed by your doctor. Do not discontinue any medications without consulting your doctor.

BosutinibTelaprevir

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with telaprevir can considerably increase blood levels of Bonitar 400 Tablet, which can lead to an increased risk of side effects.

How to manage the interaction:
Although there is an interaction between Bonitar 400 Tablet and telaprevir, they can be taken together if prescribed by a doctor. However, if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

BosutinibEtravirine

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with etravirine can decrease the blood levels and effects of Bonitar 400 Tablet.

How to manage the interaction:
Although there is an interaction between etravirine and Bonitar 400 Tablet, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

BosutinibLetermovir

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with Letermovir can increase the levels of Bonitar 400 Tablet in the blood which can lead to an increased risk of side effects such as nausea, vomiting, abdominal pain, diarrhea, and liver problems.

How to manage the interaction:
Although there is an interaction between Letermovir and Bonitar 400 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

BosutinibCladribine

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Cladribine with Bonitar 400 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction between Bonitar 400 Tablet and Cladribine, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

BosutinibGolimumab

Severe

How does the drug interact with Bonitar 400 Tablet:
Coadministration of Bonitar 400 Tablet and golimumab may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Bonitar 400 Tablet and Golimumab, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

BosutinibRifabutin

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with rifabutin can significantly reduce the blood levels of Bonitar 400 Tablet.

How to manage the interaction:
Although there is an interaction between Bonitar 400 Tablet and Rifabutin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

BosutinibAtazanavir

Severe

How does the drug interact with Bonitar 400 Tablet:
Taking Bonitar 400 Tablet with atazanavir may increase the blood levels of Bonitar 400 Tablet. This can increase side effects such as nausea, vomiting, abdominal pain, and diarrhea.

How to manage the interaction:
Although there is an interaction between Bonitar 400 Tablet and Atazanavir, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

BOSUTINIB-400MGGrapefruit and Grapefruit Juice

Moderate

Drug-Food Interactions

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BOSUTINIB-400MGGrapefruit and Grapefruit Juice

Moderate

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit or grapefruit juice with Bonitar 400 Tablet can increase the blood levels and effects of Bonitar 400 Tablet, which may increase the risk of side effects. Avoid the consumption of grapefruit and grapefruit juice.

Diet & Lifestyle Advise

After your treatment begins, several dietary adjustments can help you control side effects.
Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
Eat a healthy diet and exercise regularly to maintain proper weight.
Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
Get optimal sleep; rest well.
Avoid smoking and alcohol consumption.
Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bonitar 400 Tablet to prevent serious adverse effects.

Pregnancy

Unsafe

Bonitar 400 Tablet is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bonitar 400 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

Breast Feeding

Caution

Limited data is available on the effect of Bonitar 400 Tablet on breastfeeding. Bonitar 400 Tablet should be avoided during breastfeeding. Hence, inform your doctor if you are breastfeeding. Your doctor may prescribe an alternative based on the symptoms and health condition.

Driving

Unsafe

Bonitar 400 Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Bonitar 400 Tablet or until you become alert.

Liver

Caution

Bonitar 400 Tablet is known to cause hepatotoxicity. Hence, inform your doctor if you have a pre-existing or a history of liver disease. A dose adjustment may be needed based on your condition.

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Bonitar 400 Tablet . Your doctor may reduce the dose of this medicine or prescribe a suitable alternative based on your condition.

Children

Unsafe

Bonitar 400 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Heart

Bonitar 400 Tablet should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Bonitar 400 Tablet .

Geriatrics

Consult your doctor

Please consult a doctor before administering Bonitar 400 Tablet to geriatric patients. Your doctor will prescribe Bonitar 400 Tablet if the benefits outweigh the risks.

FAQs

Country of origin

INDIA

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063

Other Info - BON0485

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 22, 2025 | 7:26 AM IST

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