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compositionComposition:PAMIDRONATE-60MG
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Prescription Medicine
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Biodronate 60 mg Injection is used in the treatment of Hypercalcemia in Malignancy, Paget's disease, and Osteolytic bone metastases of breast cancer. It contains Pamidronate as an active ingredient, which belongs to the class of bisphosphonates. It works by inhibiting the osteoclast bone resorption, which causes bone breakdown. When bone is broken down, the calcium in the bone is released into the bloodstream. Thus, it helps retain the normal density of bones and restores bone integrity, bone strength and bone health.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PAMIDRONATE-60MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Biodronate 60 mg Injection

Biodronate 60 mg Injection is a specialised injection used to lower dangerously high calcium levels in the blood, which can happen with certain types of cancer. It is also prescribed to treat and prevent bone damage caused by breast cancer or multiple myeloma, as well as to manage Paget's disease of the bone. This medicine plays an important role in protecting your bones from breaking and reducing bone pain.

Because Biodronate 60 mg Injection is given as an injection directly into a vein, you will receive it at a clinic or hospital rather than taking it at home. The frequency of your treatment depends on your specific condition, ranging from a single session to doses repeated every few weeks. Since it bypasses your stomach, you do not need to worry about taking it with food, but it is highly beneficial to stay well-hydrated and follow a diet rich in essential bone nutrients if advised by your doctor.

While receiving this treatment, you might experience mild, temporary side effects like a light fever, shivering, or some soreness where the medicine was injected. However, if you notice more severe symptoms such as muscle spasms, numbness around your mouth, or severe jaw pain, you must contact your doctor immediately.

Before starting your treatment, it is vital to tell your healthcare provider if you have a history of kidney issues, low blood calcium, or upcoming dental procedures. Do not take this if you have had a severe allergic reaction to similar bone medications in the past.

Certain medications, like strong antibiotics or water pills, can interact with Biodronate 60 mg Injection and increase the risk of kidney strain. Always let your doctor know if you are pregnant, breastfeeding, or managing other chronic health conditions before starting your therapy.

Uses of Biodronate 60 mg Injection

Biodronate 60 mg Injection is used to treat high blood calcium levels caused by cancer and certain bone disorders. The detailed uses of Biodronate 60 mg Injection are as follows:

  • High blood calcium levels caused by cancer: Biodronate 60 mg Injection helps lower dangerously high calcium levels in the blood by preventing bone breakdown.
  • Bone damage from breast cancer or multiple myeloma: It helps strengthen bones, reducing the risk of painful bone fractures and the need for radiation therapy.
  • Paget's disease of bone: It helps slow down abnormal bone remodelling, which reduces bone pain and helps prevent future deformities or fractures.

Key Benefits

Biodronate 60 mg Injection helps protect your bones, reduce complications associated with bone disease, and improve your overall quality of life. The key benefits of Biodronate 60 mg Injection are as follows:

  • Reduces bone pain: By slowing down bone destruction, Biodronate 60 mg Injection helps ease chronic bone pain, allowing patients to move more comfortably and improve their daily quality of life.
  • Prevents bone fractures: It strengthens bones weakened by cancer or Paget's disease, significantly lowering the risk of painful breaks and fractures.
  • Lowers dangerous calcium levels: It rapidly and safely reduces high calcium levels in the blood, which helps relieve severe fatigue, nausea, confusion, and protects kidney function.
Side effects of Biodronate 60 mg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Biodronate 60 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Biodronate 60 mg Injection Works

Biodronate 60 mg Injection contains pamidronate, which belongs to a group of medicines called bisphosphonates. It works by binding directly to the minerals in your bones. Once attached, it slows down the activity of osteoclasts, which are the specialised cells responsible for breaking down bone tissue. By reducing the activity of these cells, Biodronate 60 mg Injection helps preserve bone density, prevents the release of excess calcium into your bloodstream, and allows bone-forming cells to rebuild and strengthen the bone structure.
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Alcohol

Unsafe

Consuming alcohol while on treatment with Biodronate 60 mg Injection is not recommended as it may result in unpleasant side effects or make you more susceptible to the effects of alcohol.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Biodronate 60 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Biodronate 60 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Biodronate 60 mg Injection will be administered in the hospital setting. Hence, avoid driving vehicles.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Biodronate 60 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Biodronate 60 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Biodronate 60 mg Injection is not recommended for children as the safety and effectiveness have not been established.

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Heart

Caution

Take Biodronate 60 mg Injection with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Consult your doctor

Limited information available about the use of Biodronate 60 mg Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of Biodronate 60 mg Injection

Because Biodronate 60 mg Injection is prepared and injected by healthcare professionals, an overdose is highly unlikely. However, if you suspect an overdose or experience severe symptoms like extreme muscle spasms or numbness, seek immediate medical attention.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water before, during, and after your treatment to help your kidneys flush out waste and protect them from damage.
  • Monitor calcium and vitamin D intake: Depending on why you are receiving Biodronate 60 mg Injection, your doctor may recommend taking daily calcium and vitamin D supplements, or conversely, limiting them if your calcium levels are too high. Always follow your doctor's specific advice.
  • Maintain good oral hygiene: Brush and floss your teeth regularly, and visit your dentist before starting treatment. Excellent dental health helps reduce the risk of rare but serious jaw bone issues.
  • Engage in safe, weight-bearing exercise: If approved by your doctor, light activities like walking can help support bone strength and mobility.
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Have a query?

How Soon It Starts Working

The time required for Biodronate 60 mg Injection to start to work: The onset of time for Biodronate 60 mg Injection is unknown. The time for which the effects of Biodronate 60 mg Injection last: The duration of Biodronate 60 mg Injection effect is unknown.

What if you forget to take Biodronate 60 mg Injection

Since this medicine is scheduled and given by a healthcare professional in a clinic, contact your doctor or clinic immediately to reschedule if you miss your appointment.

Storage

• Unopened vials of Biodronate 60 mg Injection should be stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F). • Do not freeze the medicine.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Check the liquid: If preparing or inspecting the solution, ensure it is clear, colourless, and free of any visible particles before injection. Do not use if cloudy or discoloured.
  • Dental warning: Avoid invasive dental procedures (like tooth extractions or dental implants) while receiving Biodronate 60 mg Injection, as this can increase the risk of serious jaw bone damage. Tell your dentist you are on this medication.
  • Kidney checks: Your doctor will likely order regular blood tests to check your kidney function and mineral levels before each dose. Do not skip these tests.
  • Report new thigh pain: Contact your doctor immediately if you develop any unusual or new pain in your thigh, hip, or groin, as this can be an early sign of an atypical bone break.

Drug-Drug Interactions

verifiedApollotooltip
  • Nephrotoxic medicines (such as aminoglycoside antibiotics or NSAIDs): May increase the risk of severe kidney damage when combined with other medicines that affect the kidneys, such as certain antibiotics (aminoglycosides) or strong pain relievers (NSAIDs like ibuprofen).
  • Loop diuretics (water pills): May cause blood calcium levels to drop too low if taken alongside strong water pills (loop diuretics).
Pamidronic acidHuman immunoglobulin
Severe

Drug-Drug Interactions

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Pamidronic acidHuman immunoglobulin
Severe
How does the drug interact with Biodronate 60 mg Injection:
Taking Human immunoglobulin with Biodronate 60 mg Injection, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Human immunoglobulin with Biodronate 60 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Biodronate 60 mg Injection when used as directed.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HYPOCALCEMIC AGENTS]

FAQs

Biodronate 60 mg Injection is used to treat Hypercalcemia in Malignancy, Paget’s disease, and Osteolytic bone metastases of breast cancer.
Biodronate 60 mg Injection contains Pamidronate as an active ingredient, which works by inhibiting osteoclast bone resorption that causes bone breakdown.
Biodronate 60 mg Injection helps regulate the calcium level in the blood. This maintains bone formation and also helps the body to reverse bone loss. Due to this, the number of cells that damage bones becomes comparatively less.
The frequency of Biodronate 60 mg Injection administration depends on the condition being treated. Therefore, follow your doctor's instructions for the best results.
Biodronate 60 mg Injection is not recommended for pregnant women as it may cause fetal harm. It is unknown whether Biodronate 60 mg Injection is excreted in human milk. Therefore, if you are a breastfeeding mother, please inform your doctor before taking Biodronate 60 mg Injection.
Yes, Biodronate 60 mg Injection may cause hair loss, but this is not a common side effect. If you experience hair loss while taking Biodronate 60 mg Injection, please inform your doctor.
Biodronate 60 mg Injection is safe if used under the supervision of a doctor. Follow your doctor’s instructions carefully and inform your doctor if you experience any side effects.
Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support your overall health. Try to consume calcium and vitamin D in their diet as it helps make stronger bones and avoid everyday osteoporosis dangers. Regular exercise like weight-bearing exercises are important for maintaining bone health. Smoking can weaken bones, and excessive alcohol consumption can interfere with bone health. It's best to quit smoking and limit alcohol intake. Please consult your doctor if you have any concerns.
The common side effects of Biodronate 60 mg Injection are injection site reactions, stomach pain, loss of appetite, nausea, vomiting, fever, headache, dizziness, mouth sores, constipation, and cough. If any of these side effects persist or worsen, please consult your doctor.
Biodronate 60 mg Injection is given as an intravenous (IV) infusion, meaning it is slowly dripped directly into a vein. This must be done by a healthcare professional in a clinic or hospital. Talk to your doctor if you have questions about the infusion process.
It is best to avoid invasive dental procedures, like extractions or implants, during treatment because Biodronate 60 mg Injection can increase the risk of a rare jaw bone problem. Have a dental exam before starting treatment, and tell your dentist you are using this medicine. Talk to your doctor about any planned dental care.
Drinking plenty of fluids helps protect your kidneys, as Biodronate 60 mg Injection is cleared from your body through your urine. Staying hydrated helps prevent kidney strain and damage. Talk to your doctor about how much water you should drink.
Yes, it is very common to experience mild fever, chills, and muscle aches within the first three days after your infusion. These symptoms are usually temporary and go away on their own. Talk to your doctor if they become severe or do not improve.
Biodronate 60 mg Injection does not cure bone cancer, but it helps manage symptoms, strengthen bones, and lower high blood calcium levels. For Paget's disease, bisphosphonate treatment like Biodronate 60 mg Injection can induce long-term clinical remission by normalising abnormal bone remodelling. Talk to your doctor about what to expect from your treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - BIO0577
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