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compositionComposition:AZTREONAM-1000MG
prescription
Prescription Medicine
info
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Aztrefic 1G Injection 1's is used to treat bacterial infections. It contains Aztreonam which works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as dizziness, headache, sneezing, high temperature, and double vision. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZTREONAM-1000MG

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Aztrefic 1G Injection 1's

Aztrefic 1G Injection 1's is a prescription antibiotic injection used to treat severe infections caused by bacteria. It is commonly prescribed for serious conditions like deep lung infections, urinary tract infections, blood infections, and abdominal infections. Your healthcare provider will determine the exact schedule for your treatment, which is delivered directly into a vein or muscle.

To ensure the infection is completely cleared, this medication must be injected at regular intervals as directed by your doctor. Even if you start feeling better after a few days, it is vital to complete the entire course of treatment to prevent the bacteria from returning and becoming resistant. While undergoing treatment, staying well-hydrated and getting plenty of rest can help your body recover more efficiently.

While using Aztrefic 1G Injection 1's, you may experience mild side effects like redness or pain at the injection site, nausea, or mild diarrhoea. However, you must contact your doctor immediately if you develop severe watery diarrhoea, a skin rash, yellowing of your skin or eyes, or difficulty breathing.

Before starting treatment with Aztrefic 1G Injection 1's, tell your doctor if you have kidney or liver disease, or if you have ever had an allergic reaction to antibiotics. You should not take this medicine if you have a known severe allergy to it. Your doctor will carefully evaluate your medical history to ensure this treatment is safe for you.

It is important to inform your doctor about all other medicines you are taking, as some drugs can affect how your kidneys process this medication. While there is no direct interaction with alcohol, avoiding alcohol and smoking can support your immune system during recovery. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits with your healthcare provider before starting treatment.

Uses of Aztrefic 1G Injection 1's

The following are the common conditions for which Aztrefic 1G Injection 1's is prescribed:

  • Severe lung infections: Aztrefic 1G Injection 1's helps clear deep chest infections, such as serious pneumonia, by targeting and destroying the bacteria causing the illness.
  • Urinary tract infections: It effectively treats complicated bladder and kidney infections by stopping the growth of harmful bacteria in the urinary system.
  • Abdominal and gynecological infections: This medication helps cure complex infections inside the stomach area and reproductive organs by eliminating the responsible bacteria.
  • Blood infections: For serious, widespread infections in the bloodstream, Aztrefic 1G Injection 1's works quickly to clear the bacteria and prevent life-threatening complications.
  • Skin and bone infections: It treats deep-seated bacterial infections in the skin, soft tissues, and joints, promoting proper healing.

Key Benefits

The following benefits highlight how Aztrefic 1G Injection 1's helps treat severe bacterial infections and supports recovery:

  • Rapid control of bacterial infections: It begins fighting susceptible bacteria soon after administration, helping prevent the infection from spreading further.
  • Relieves infection-related symptoms: By eliminating the bacteria causing the illness, it helps reduce fever, pain, swelling, and inflammation as the infection resolves.
  • Treats a wide range of serious infections: It is effective against several severe Gram-negative bacterial infections affecting different parts of the body, including the lungs, urinary tract, abdomen, bloodstream, skin, and bones.
  • Suitable for selected patients with penicillin allergies: Because Aztrefic 1G Injection 1's has a unique antibiotic structure, it may be an appropriate alternative for many patients with penicillin allergies, although it should still be used with caution in people with a history of severe beta-lactam allergies.
Side effects of Aztrefic 1G Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • Stay hydrated by drinking plenty of water to help reduce swelling.
  • Include anti-inflammatory foods like turmeric, ginger, and omega-3 rich foods in your diet.
  • Avoid processed and high-sodium foods that can exacerbate swelling.
  • Utilize an ice pack wrapped in a cloth to cool the affected area, helping to alleviate swelling and discomfort.
  • Gently massage the site, if recommended by your healthcare provider, to promote lymphatic drainage.
  • Rotate injection sites to minimize irritation and swelling.
  • Allow your body time to rest and recuperate, limiting physically demanding tasks to facilitate a smoother recovery.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Aztrefic 1G Injection 1's will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Aztrefic 1G Injection 1's Works

Aztrefic 1G Injection 1's belongs to a class of medicines known as monobactam antibiotics. It works by interfering with the bacteria's ability to build their protective outer walls. Without a strong cell wall, the bacteria cannot survive, eventually bursting and dying off. This medication is highly specific, meaning it selectively targets certain types of bacteria while leaving other human cells unharmed. Because it resists many of the protective enzymes that bacteria use to defend themselves, it remains highly effective even against some hard-to-treat bacterial strains.
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Alcohol

Caution

The interaction of alcohol with Aztrefic 1G Injection 1's is unknown. Please consult a doctor before consuming alcohol while using Aztrefic 1G Injection 1's.

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Pregnancy

Caution

The safety of Aztrefic 1G Injection 1's in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Aztrefic 1G Injection 1's is excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Aztrefic 1G Injection 1's cause double vision, dizziness as a side effect. So, avoid driving after receiving Aztrefic 1G Injection 1's.

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Liver

Caution

Take Aztrefic 1G Injection 1's with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Aztrefic 1G Injection 1's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Aztrefic 1G Injection 1's can be given safely to children, dose to be adjusted and recommended by a child specialist only.

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Heart

Caution

Aztrefic 1G Injection 1's should be administered with caution, especially if you have a history of heart problems. Please inform your doctor about any existing heart problems before using Aztrefic 1G Injection 1's.

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Geriatrics

Caution

Aztrefic 1G Injection 1's should be administered with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Aztrefic 1G Injection 1's

In case of an accidental overdose, seek immediate medical attention or call your local poison control centre. Symptoms of an overdose can include severe dizziness, seizures, or breathing difficulties, which require urgent medical evaluation.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, such as water or clear broths, to help your kidneys flush out the medication and support your body's recovery.
  • Support gut health: Since antibiotics can affect the natural balance of your gut bacteria, consider eating probiotic-rich foods like yogurt or kefir after finishing your treatment course.
  • Get adequate rest: Give your body ample time to heal by resting and avoiding strenuous physical activity while fighting off the infection.
  • Eat nutrient-dense meals: Focus on a balanced diet rich in vitamins and minerals to help rebuild your immune system and boost your strength.
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How Soon It Starts Working

The time required for Aztrefic 1G Injection 1's to start to work: Aztrefic 1G Injection 1's ideally shows its action within 1 hour after administration. The time for which the effects of Aztrefic 1G Injection 1's last: The effect of Aztrefic 1G Injection 1's lasts for 4 to 6 hours.

What if you forget to take Aztrefic 1G Injection 1's

If you miss a dose of Aztrefic 1G Injection 1's, contact your healthcare provider or pharmacist immediately for instructions. Do not inject a double dose to make up for a forgotten one, as this can increase the risk of side effects.

Storage

•Store the dry powder vials of Aztrefic 1G Injection 1's at controlled room temperature, between 15°C and 30°C (59°F to 86°F). •Keep the medicine in its original outer carton to protect it from direct light, and do not freeze it.

Drug Warnings

  • Inspect the solution: Always check the liquid before injecting. It should be clear and colourless to pale yellow; discard it immediately if you see cloudiness, particles, or discolouration.
  • Rotate injection sites: If you are receiving muscle injections, change the injection spot each time to reduce muscle soreness and prevent tissue damage.
  • Never reuse needles: Use a brand-new, sterile needle and syringe for every single injection to prevent serious blood infections.
  • Complete the full course: Finish the entire prescribed treatment, even if you feel completely better, to ensure the bacteria are fully eliminated.
  • Monitor kidney health: Since this drug is cleared by the kidneys, your doctor may perform regular blood tests to check your kidney function during treatment.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Aztrefic 1G Injection 1's and affect its safety or effectiveness:

  • Aminoglycosides: Combining this medicine with aminoglycoside antibiotics may increase the risk of kidney damage.
  • Strong Diuretics: Taking powerful water pills (such as furosemide) at the same time may put extra strain on your kidneys.
  • Oral Anticoagulants (Blood Thinners): This medicine may enhance the effect of blood thinners like warfarin, increasing the risk of bleeding. Your doctor may need to monitor your blood clotting times more closely.
AztreonamCholera, live attenuated
Severe
AztreonamBCG vaccine
Severe

Drug-Drug Interactions

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AztreonamCholera, live attenuated
Severe
How does the drug interact with Aztrefic 1G Injection:
Coadministration of Aztrefic 1G Injection with Cholera vaccine can reduce the effects of Cholera vaccine.

How to manage the interaction:
Taking Aztrefic 1G Injection with Cholera vaccine together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
AztreonamBCG vaccine
Severe
How does the drug interact with Aztrefic 1G Injection:
When BCG vaccine is used together with Aztrefic 1G Injection, its effectiveness may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Aztrefic 1G Injection and BCG vaccine, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Aztrefic 1G Injection 1's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Aztrefic 1G Injection 1's contains Aztreonam, an antibiotic that works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Thereby damages the bacterial cell wall and kills bacteria.
No. You should complete the full course of Aztrefic 1G Injection 1's as prescribed by your doctor. After completing the full course of Aztrefic 1G Injection 1's will work. It is important that you take Aztrefic 1G Injection 1's at the right dose, right times, and for the right numbers of days.
Aztrefic 1G Injection 1's is used to treat serious bacterial infections that require injectable antibiotic therapy. It may be used alone or in combination with other antibiotics depending on the type and severity of the infection. It does not work against viral infections such as the common cold, viral cough, or influenza, and should only be used when prescribed for a bacterial infection.
Aztrefic 1G Injection 1's may cause dizziness and double vision. So, drive only if you are alert and avoid driving and operating machinery if you feel dizzy or experience vision changes.
Aztrefic 1G Injection 1's causes side effects such as dizziness, chest pain, headache, double vision, bad breath, vaginal irritation, and a blocked nose. However, please contact a doctor if these side effects worsen or persist longer.
Aztrefic 1G Injection 1's cannot be taken as an oral pill because it is not absorbed well through the stomach or intestines. It must be given as an injection, either directly into a vein (intravenously) or into a large muscle (intramuscularly), depending on your condition and your doctor's recommendation. It is usually administered by a doctor or nurse in a hospital or clinic, although some patients may receive it at home after appropriate training. Your healthcare provider will decide the most suitable method and dosage for your treatment.
Yes. Aztrefic 1G Injection 1's is generally considered safe for most people with a penicillin allergy because it is a monobactam antibiotic with a different chemical structure from penicillins and has minimal cross-reactivity. However, you should always inform your doctor about any previous allergic reactions to antibiotics, especially severe reactions, so that appropriate precautions can be taken during treatment.
While there is no direct, dangerous interaction between Aztrefic 1G Injection 1's and alcohol, it is best to avoid alcohol during treatment. Alcohol can dehydrate your body and weaken your immune system, making it harder for your body to fight off the infection. Talk to your doctor or pharmacist for personalised advice.
Aztrefic 1G Injection 1's should only be used during pregnancy if it is clearly needed and prescribed by a doctor. Studies suggest it does not carry a high risk of birth defects, but your healthcare provider will weigh the benefits against any potential risks to your baby. Talk to your doctor if you are pregnant or planning to become pregnant.
It is very important to receive this medicine on a consistent schedule. If you miss a dose, contact your healthcare provider or clinic right away to find out when to receive your next injection. Talk to your doctor or pharmacist to help set up a reliable dosing schedule.
Mild diarrhoea can be a common side effect of antibiotics. However, if you develop severe, watery, or bloody diarrhoea along with stomach cramps, contact your healthcare provider immediately, as this could be a sign of a serious gut infection. Talk to your doctor before taking any anti-diarrhoea medications.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3773 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Aztreonam [Prescribing Information]. [Accessed on 29 Mar. 2019]Check here
  3. Aztreonam [Product label]. 2022. [Accessed on 14 Mar. 2025]Check here
  4. Azactam 1g Powder for Solution for Injection or Infusion, vial - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 17 June 2022]Check here
  5. Azactam 1g Powder for Solution for Injection or Infusion, vial - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 17 June 2022]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here
  7. Chambers HF, Dech DH Beta-Lactam Antibiotics & Other Cell Wall Synthesis Inhibitors. In: Trevor AJ, Katzung BG, Kruidering-Hall M, eds. Katzung & Trevor's Pharmacology: Examination & Board Review. 11 th ed. McGraw-Hill Education: New York, New York; 2015Check here

Country of origin

India

Manufacturer/Marketer address

National Highway, NO.8 NR Grid Kabil, Pore Narsari, GJ 396445 IN.
Other Info - AZT0088
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