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  3. Atrest 12.5 Tablet 10's

Atrest 12.5 Tablet 10's, Pack of 10 TabletS
Atrest 12.5 Tablet 10's, Pack of 10 TabletS
Atrest 12.5 Tablet 10's, Pack of 10 TabletS
Atrest 12.5 Tablet 10's, Pack of 10 TabletS
Atrest 12.5 Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
ATREST 12.5 TABLET is used in the treatment of Huntington's disease. It contains Tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that helps in controlling body movements. It may cause common side effects such as nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

TETRABENAZINE-12.5MG

Manufacturer/Marketer :

Centaur Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About ATREST 12.5 TABLET

ATREST 12.5 TABLET is used to treat Huntington's disease. Huntington's disease (HD) is a hereditary disorder where brain nerve cells gradually degrade. It usually begins in the late 30s or early 40s. Progressive motor, cognitive, and mental symptoms are typically the outcome of Huntington's disease.

ATREST 12.5 TABLET contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

Use ATREST 12.5 TABLET as prescribed by your doctor. The common side-effects of ATREST 12.5 TABLET are nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Most of these side effects fade away gradually over time without the need for medical intervention. However, consult your doctor if you experience these side effects frequently.

To treat your condition effectually, continue using ATREST 12.5 TABLET for as long as your doctor has prescribed it. Do not use ATREST 12.5 TABLET without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using ATREST 12.5 TABLET if you are pregnant or breastfeeding. Do not use ATREST 12.5 TABLET in more than prescribed doses or for a longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking ATREST 12.5 TABLET to rule out any side effects.

Uses of ATREST 12.5 TABLET

Treatment of Huntingtons disease.

Directions for Use

• Take ATREST 12.5 TABLET with or without food as advised by your doctor.• It is advised to take ATREST 12.5 TABLET once daily; however, follow your doctor’s recommendation regarding the dosage and duration.• Swallow ATREST 12.5 TABLET as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Overactive secretion of chemicals like serotonin, norepinephrine, and dopamine in the brain causes degeneration of nerves, due to which you may lose the ability to control your thoughts, emotions, or movements. This ATREST 12.5 TABLET works by reducing the overactivity of these natural substances in the brain that transmit signals between the nerves and, in turn, lower brain signals that trigger involuntary muscle movements.

How ATREST 12.5 TABLET Works

ATREST 12.5 TABLET contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

Storage

Keep away from sight and reach of children
Side effects of Atrest 12.5 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

What if I have taken an overdose of ATREST 12.5 TABLET

Do not take more than the prescribed dose of ATREST 12.5 TABLET as it may cause overdose. The symptoms of overdose include nausea, vomiting, sweating, rapid eye movement, twisting or jerking movements, confusion, diarrhoea, extreme tiredness, redness of the skin, hallucinations, and uncontrollable shaking. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

You may have unusual changes in mood or behaviour, trouble sitting still, or feel nervous and irritable. Sit or stand slowly if you feel dizzy. Check the progress of ATREST 12.5 TABLET at regular doctor visits and keep track of the symptoms and side effects if you notice any. It may make some people severely depressed and increase the risks of suicidal thoughts and tendencies. Do not take these medicines together with other medications such as risperidone and MAO inhibitors. Do not use if you are severely depressed and are on current treatment with antidepressants.

Drug-Drug Interactions

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TetrabenazineFurazolidone
Critical
TetrabenazineTranylcypromine
Critical

Drug-Drug Interactions

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TetrabenazineFurazolidone
Critical
How does the drug interact with Atrest 12.5 Tablet:
Combining Furazolidone and Atrest 12.5 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Furazolidone and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineTranylcypromine
Critical
How does the drug interact with Atrest 12.5 Tablet:
Coadministration of Tranylcypromine and Atrest 12.5 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineCisapride
Critical
How does the drug interact with Atrest 12.5 Tablet:
Coadministration of Cisapride and Atrest 12.5 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Cisapride and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineThioridazine
Critical
How does the drug interact with Atrest 12.5 Tablet:
Coadministration of Thioridazine and Atrest 12.5 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Thioridazine and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting. Do not discontinue any medications without consulting your doctor.
TetrabenazineSelegiline
Critical
How does the drug interact with Atrest 12.5 Tablet:
Co-administration of Selegiline with Atrest 12.5 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Atrest 12.5 Tablet with Selegiline together can possibly result in an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, or lightheadedness. Do not stop taking any medications without consulting a doctor.
TetrabenazineMetoclopramide
Critical
How does the drug interact with Atrest 12.5 Tablet:
Coadministration of Atrest 12.5 Tablet and Metoclopramide can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Atrest 12.5 Tablet and Metoclopramide together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TetrabenazineZiprasidone
Critical
How does the drug interact with Atrest 12.5 Tablet:
Co-administration of Atrest 12.5 Tablet with Ziprasidone together can raise the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Atrest 12.5 Tablet with Ziprasidone together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
TetrabenazineSparfloxacin
Critical
How does the drug interact with Atrest 12.5 Tablet:
Taking Atrest 12.5 Tablet and Sparfloxacin can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Atrest 12.5 Tablet with Sparfloxacin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TetrabenazineIsocarboxazid
Critical
How does the drug interact with Atrest 12.5 Tablet:
Co-administration of Isocarboxazid and Atrest 12.5 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Isocarboxazid and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineProcarbazine
Critical
How does the drug interact with Atrest 12.5 Tablet:
Coadministration of Procarbazine and Atrest 12.5 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Procarbazine and Atrest 12.5 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy weight. Stay physically active.

  • Consume fresh fruits and vegetables. Avoid spicy, salty, and deep-fried foods. Eating healthy can help you to recover faster.

  • Avoid tea, coffee, and cold drinks.

  • Drink plenty of fluids to stay hydrated. Fluids are necessary to maintain blood flow in your body.

  • Avoid the intake of alcoholic beverages as it can make you dehydrated and also can affect your sleep.

  • Avoid physical and psychological stress.

Habit Forming

No

Therapeutic Class

CENTRAL NERVOUS SYSTEM AGENTS
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Alcohol

Caution

It causes excessive sleepiness if you consume alcohol while taking this ATREST 12.5 TABLET .

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Pregnancy

Caution

If you are pregnant or trying to get pregnant, speak to your doctor before taking the ATREST 12.5 TABLET . It may harm the unborn baby.

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Breast Feeding

Caution

Do not take ATREST 12.5 TABLET or stop using it immediately if you are breastfeeding.

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Driving

Caution

It causes drowsiness and impairs your ability to drive carefully.

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Liver

Caution

If you have a history of liver disease/conditions, ATREST 12.5 TABLET should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

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Kidney

Caution

If you have a history of kidney diseases, ATREST 12.5 TABLET should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

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Children

Unsafe

It is not recommended for treatment in children.

Have a query?

FAQs

ATREST 12.5 TABLET is used to treat Huntington's disease. Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with defective genes.

ATREST 12.5 TABLET contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that helps in controlling body movements.

No, if you forget to take one dose, never make up for the missing dose by doubling it at the next time. Instead, please continue with the next dose when it is due.

No, if taken more than the recommended dose, you may develop drowsiness, sweating, low blood pressure, and extremely low body temperature. Contact your doctor right away in this case.

No, do not take ATREST 12.5 TABLET instead reach out to your doctor if you are intolerant to sugars because these tablets contain lactose.

No, do not stop taking ATREST 12.5 TABLET on your own unless instructed by your doctor. Abruptly stopping may lead recurrence of disease conditions.

If necessary, ATREST 12.5 TABLET may be broken in half, but they should not be crushed or chewed.

ATREST 12.5 TABLET contains Tetrabenazine is formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.

ATREST 12.5 TABLET is a medication used to manage chorea, a movement disorder often associated with Huntington's disease. It works by reducing the levels of certain neurotransmitters in the brain. While it can be effective in controlling involuntary movements, it's important to be aware of potential side effects like depression, sleepiness, and dizziness. If you're considering tetrabenazine or have questions about its use, consult with a healthcare professional for personalized advice.

To avoid side effects while taking ATREST 12.5 TABLET , try to limit your alcohol intake, and be cautious about combining it with other medications. Be mindful of activities that require alertness, as tetrabenazine can cause drowsiness. If you’re pregnant or breastfeeding, talk to your doctor before taking it.

If you're considering stopping or adjusting your tetrabenazine dosage, it's essential to discuss it with your doctor. They can help you determine if it's safe to make changes and provide personalized recommendations. Remember, abruptly stopping tetrabenazine can lead to a worsening of your chorea symptoms.

It's generally not recommended to consume alcohol while taking tetrabenazine. Alcohol can interact with tetrabenazine and increase the risk of side effects.

ATREST 12.5 TABLET can influence blood pressure. Some individuals may experience low blood pressure (hypotension) as a side effect of taking this medication. This is more likely to occur if you have a history of low blood pressure or if you're taking other medications that can lower your blood pressure. If you notice symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, it's crucial to inform your doctor. They may adjust your dosage or recommend additional monitoring to manage this side effect effectively.

The common side-effects of ATREST 12.5 TABLET are nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Most of these side effects fade away gradually over time without the need for medical intervention. However, consult your doctor if you experience these side effects frequently.

Country of origin

INDIA

Manufacturer/Marketer address

CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Other Info - ATR0116

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a618009.html
  2. https://go.drugbank.com/drugs/DB04844#pharmacology-header
  3. https://www.medicines.org.uk/emc/product/2668/pil
  4. https://www.mayoclinic.org/drugs-supplements/tetrabenazine-oral-route/precautions/drg-20072216
  5. https://www.singlecare.com/prescription/tetrabenazine/what-is#overview

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