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  3. Arsikem 10Mg/10Ml Inj

Arsikem 10Mg/10Ml Inj, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Arsikem 10Mg/10Ml Inj is used to treat acute promyelocytic leukaemia. Acute promyelocytic leukaemia is a type of cancer in which there are too many immature blood cells in the blood and bone marrow. It contains Arsenic trioxide, which works by interfering with the growth of cancer cells and slowing their growth and spread in the body. Arsikem 10Mg/10Ml Inj may cause side effects such as fatigue, pain, fever, headache, nausea, vomiting, and diarrhoea.

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Composition :

ARSENIC TRIOXIDE-50MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Arsikem 10Mg/10Ml Inj

Arsikem 10Mg/10Ml Inj belongs to the group of medicines called anti-neoplastic agents used to treat acute promyelocytic leukaemia (APL). Acute promyelocytic leukaemia is a type of cancer in which there are too many immature blood cells in the blood and bone marrow.

Arsikem 10Mg/10Ml Inj contains Arsenic trioxide, which works by interfering with the growth of cancer cells and slowing their growth and spread in the body.

Arsikem 10Mg/10Ml Inj may cause side effects such as fatigue, pain, fever, headache, nausea, vomiting, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Arsikem 10Mg/10Ml Inj if you are pregnant or breastfeeding. This medicine may not be recommended for children as safety and effectiveness have not been established. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Arsikem 10Mg/10Ml Inj

Arsikem 10Mg/10Ml Inj used in the treatment of Acute promyelocytic leukaemia. The detailed use of Arsikem 10Mg/10Ml Inj is as follows:<br/>• Treatment of Acute promyelocytic leukaemia: Arsikem 10Mg/10Ml Inj provides relief in Acute Promyelocytic Leukemia by interfering with the growth of cancer cells, thereby slowing their growth and spread in the body, providing relief to patients.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Arsikem 10Mg/10Ml Inj should be given under the guidance of a doctor experienced in treating patients with acute leukemia.• Do not self-administer it.

Medicinal Benefits

Arsikem 10Mg/10Ml Inj belongs to the group of medicines called anti-neoplastic agents used to treat acute promyelocytic leukaemia (APL). Arsikem 10Mg/10Ml Inj contains Arsenic trioxide, which works by interfering with the growth of cancer cells and slowing their growth and spread in the body.

How Arsikem 10Mg/10Ml Inj Works

Arsikem 10Mg/10Ml Inj contains Arsenic trioxide, which works by interfering with the growth of cancer cells and slowing their growth and spread in the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Arsikem 10Mg/10Ml Inj out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Arsikem 10Mg/10Ml Inj
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • To increase your body temperature, take a soothing shower or soak in a warm bath.
  • Avoid cold foods and beverages since they can cause your body temperature to drop even more.
  • Stay indoors when it's cold, especially if you're feeling unwell.
  • Consult your doctor if your chills continue, get worse, or are accompanied by other unusual symptoms.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.

What if I have taken an overdose of Arsikem 10Mg/10Ml Inj

As Arsikem 10Mg/10Ml Inj is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not receive Arsikem 10Mg/10Ml Inj if you are allergic to any of its components. Inform the doctor if you have kidney or liver diseases. Seek immediate medical attention if you experience symptoms of low APL differentiation syndrome (fever, weight gain, shortness of breath, laboured breathing, chest pain, or cough), QT prolongation/heart rhythm problems or encephalopathy (confusion, loss of consciousness, seizures, speech changes, problems with coordination, balance, or walking, or visual changes such as decreased visual perception, reading problems, or double vision). Consult the doctor if you or your partner becomes pregnant while on treatment with this medication.

Drug-Drug Interactions

verifiedApollotooltip
Arsenic trioxideZiprasidone
Critical
Arsenic trioxideTrazodone
Critical

Drug-Drug Interactions

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Arsenic trioxideZiprasidone
Critical
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Co-administration of Arsikem 10Mg/10Ml Inj with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Ziprasidone and Arsikem 10Mg/10Ml Inj but can be taken together if prescribed by a doctor. Contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Arsenic trioxideTrazodone
Critical
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Taking Trazodone with Arsikem 10Mg/10Ml Inj can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Arsikem 10Mg/10Ml Inj with Trazodone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. do not discontinue any medications without consulting a doctor.
Arsenic trioxideAmphotericin b
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Using Arsikem 10Mg/10Ml Inj together with amphotericin B cholesteryl sulfate can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Amphotericin b with Arsikem 10Mg/10Ml Inj can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, or feeling sick to your stomach. Do not stop using any medications without talking to a doctor.
Arsenic trioxideFluconazole
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Taking Fluconazole with Arsikem 10Mg/10Ml Inj can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Arsikem 10Mg/10Ml Inj with Fluconazole together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience any symptoms like an irregular heart rhythm, dizziness, fainting, or difficulty breathing, it is important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
Arsenic trioxideFluoxetine
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Combining Fluoxetine with Arsikem 10Mg/10Ml Inj can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Arsikem 10Mg/10Ml Inj with Fluoxetine can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any fainting or irregular heartbeat, it's best to go to the hospital for check-ups. If you experience symptoms like fainting, irregular heartbeat, dizziness, or shortness of breath, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
Arsenic trioxideGoserelin
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Taking Arsikem 10Mg/10Ml Inj with Goserelin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Arsikem 10Mg/10Ml Inj and goserelin together is generally avoided as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Arsenic trioxideBicalutamide
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Taking Arsikem 10Mg/10Ml Inj with Bicalutamide can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Arsikem 10Mg/10Ml Inj and Bicalutamide, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
Arsenic trioxideBuprenorphine
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Using Arsikem 10Mg/10Ml Inj together with buprenorphine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Arsikem 10Mg/10Ml Inj with Buprenorphine together can result in an interaction, but it can be taken if a doctor has advised it. If you experience an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's electrical system, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, or heart palpitations contact a doctor right away. Do not stop using any medications without a doctor's advice.
Arsenic trioxideDisopyramide
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
The combined use of Arsikem 10Mg/10Ml Inj and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Arsikem 10Mg/10Ml Inj and Disopyramide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Arsenic trioxideImipramine
Severe
How does the drug interact with Arsikem 10Mg/10Ml Inj:
Taking Arsikem 10Mg/10Ml Inj and Imipramine can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Arsikem 10Mg/10Ml Inj and imipramine together can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Arsikem 10Mg/10Ml Inj Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol affects Arsikem 10Mg/10Ml Inj. Please consult your doctor.

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Pregnancy

Unsafe

Arsenic trioxide belongs to pregnancy category D. Arsikem 10Mg/10Ml Inj may cause harm to the unborn baby when used by pregnant women. If you are pregnant, planning for pregnancy or think you may be pregnant, talk to the doctor for advice.

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Breast Feeding

Unsafe

Arsenic trioxide passes into breast milk and may harm the baby. Therefore, avoid breastfeeding during treatment with Arsikem 10Mg/10Ml Inj.

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Driving

Safe if prescribed

Arsikem 10Mg/10Ml Inj has no or very little effect on your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Arsikem 10Mg/10Ml Inj.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Arsikem 10Mg/10Ml Inj. Caution is advised for patients with kidney failure.

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Children

Caution

Arsikem 10Mg/10Ml Inj may not be recommended for children below 18 years. Please consult the doctor if you have any concerns.

Have a query?

FAQs

Arsikem 10Mg/10Ml Inj is used to treat Acute promyelocytic leukaemia.

Arsikem 10Mg/10Ml Inj works by interfering with the growth of cancer cells and slowing their growth and spread in the body.

Arsikem 10Mg/10Ml Inj may reduce fertility in men. Discuss with the doctor about the risks of receiving Arsikem 10Mg/10Ml Inj if you are planning to father a child.

Arsikem 10Mg/10Ml Inj may cause increased blood sugar levels. Therefore, if you are diabetic or if you notice changes in blood sugar levels, consult the doctor.

In rare cases, Arsikem 10Mg/10Ml Inj may cause serious side effects in some individuals such as severe fever, breathing problems, heart issues, confusion, severe allergic reactions, vomit that is bloody, and decreased urination. It's important to watch for these symptoms and seek medical help right away if they happen.

Before taking Arsikem 10Mg/10Ml Inj, inform your doctor if you have any allergies, especially to any of Arsikem 10Mg/10Ml Inj ingredients. Inform if you are having any medical issues, as well as any medications you're taking. Also, inform your doctor if you're pregnant or planning to become pregnant or breastfeeding.

Generally, doctors may advise blood tests and ECGs to monitor blood counts, heart function, and other potential side effects. In necessary cases, your doctor may also include any other test based on individual health status.

Arsikem 10Mg/10Ml Inj may cause harm to the foetus. Discuss with your doctor if you're pregnant or planning to become pregnant before prescribing Arsikem 10Mg/10Ml Inj.

Arsikem 10Mg/10Ml Inj can pass into breast milk and may harm the baby. Discuss with your doctor if you're breastfeeding. In necessary or possible conditions, the doctor may probably tell you not to breastfeed during your treatment.

Arsikem 10Mg/10Ml Inj can be used to treat certain leukemia in pediatric patients under controlled doses and careful monitoring.

It may be due to Arsikem 10Mg/10Ml Inj. Because nausea and extreme tiredness are the reported side effects of the Arsikem 10Mg/10Ml Inj. In most cases, they usually vanish over time. If these effects worsen and are persistent please contact your doctor to find the actual reason and relief.

The use of Arsikem 10Mg/10Ml Inj can cause hyperglycemia. If you're diabetic, inform your doctor. Additionally, if you notice symptoms like extreme thirst, frequent urination, or blurred vision, contact your doctor immediately.

To relieve diarrhea while on Arsikem 10Mg/10Ml Inj, stay hydrated with water or electrolyte-rich drinks. Natural remedies like bananas, ginger, and probiotic-rich yogurt may help. If symptoms worsen, inform your doctor for prescribed medication or anti-diarrheal measures. Don’t take any medication without a prescription by your doctor.

Inform your doctor about the skin changes. They will assess and provide guidance on managing any skin reactions or recommend further treatment.

The common side effects of the Arsikem 10Mg/10Ml Inj are fatigue, pain, fever, headache, nausea, vomiting, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. If any of the side effects become persistent or worsen, inform your doctor for relief.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ARS0027

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10278.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21248lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a608017.html
  4. https://www.nps.org.au/assets/medicines/c9727623-8e52-460d-837f-ac8d00ae4caa-reduced.pdf
  5. https://www.drugs.com/drug-interactions/arsenic-trioxide.html
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