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  3. Apripet 125/80 Capsule Combipack 3's

Apripet 125/80 Capsule Combipack 3's, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Apripet 125/80 Capsule Combipack 3's is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

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Composition :

APREPITANT-125MG + APREPITANT-80MG

Manufacturer/Marketer :

Bangalore Pharmaceutical and Research Laboratory Pvt Ltd (BPRL)

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Apripet 125/80 Capsule Combipack 3's

Apripet 125/80 Capsule Combipack 3's belongs to a class of drugs called anti-emetics. It is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Apripet 125/80 Capsule Combipack 3's contains Aprepitant. Aprepitant blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

Take Apripet 125/80 Capsule Combipack 3's as prescribed. You are recommended to take Apripet 125/80 Capsule Combipack 3's for as long as your doctor has advised it. In some cases, Apripet 125/80 Capsule Combipack 3's may cause common side effects such as headache, constipation, loss of appetite, tiredness, indigestion, and hiccups. Most of these side effects do not require medical attention and gradually resolve over time. However, inform your doctor if the side effects persist or worsen.

Please tell your doctor if you are allergic to Apripet 125/80 Capsule Combipack 3's or any other medicines. Apripet 125/80 Capsule Combipack 3's is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apripet 125/80 Capsule Combipack 3's. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Apripet 125/80 Capsule Combipack 3's. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's.

Uses of Apripet 125/80 Capsule Combipack 3's

Apripet 125/80 Capsule Combipack 3's is used in the treatment of Chemotherapy-induced nausea and vomiting. The detailed uses of Apripet 125/80 Capsule Combipack 3's are as follows:<br/>• Chemotherapy-induced nausea and vomiting (CINV) prevention: Apripet 125/80 Capsule Combipack 3's helps to prevent nausea and vomiting caused by chemotherapy, which improves patient comfort and quality of life.<br/>• Postoperative nausea and vomiting (PONV) prevention: Apripet 125/80 Capsule Combipack 3's can also be used to prevent nausea and vomiting after surgery, which reduces recovery time and complications.<br/>

Directions for Use

• Apripet 125/80 Capsule Combipack 3's can be taken with or without food.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Apripet 125/80 Capsule Combipack 3's as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Apripet 125/80 Capsule Combipack 3's contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

How Apripet 125/80 Capsule Combipack 3's Works

Apripet 125/80 Capsule Combipack 3's contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Apripet 125/80 Capsule 3's (Combipack)
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Apripet 125/80 Capsule Combipack 3's

Since Apripet 125/80 Capsule Combipack 3's is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Please tell your doctor if you are allergic to Apripet 125/80 Capsule Combipack 3's or any other medicines. Apripet 125/80 Capsule Combipack 3's is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apripet 125/80 Capsule Combipack 3's. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Apripet 125/80 Capsule Combipack 3's. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's.

Drug-Drug Interactions

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AprepitantFlibanserin
Critical
AprepitantPimozide
Critical

Drug-Drug Interactions

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AprepitantFlibanserin
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Using flibanserin together with Apripet 125/80 Capsule 3's (Combipack) can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Apripet 125/80 Capsule 3's (Combipack) together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Using pimozide together with Apripet 125/80 Capsule 3's (Combipack) may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Apripet 125/80 Capsule 3's (Combipack) and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Apripet 125/80 Capsule 3's (Combipack) combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Apripet 125/80 Capsule 3's (Combipack) and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Co-administration with Apripet 125/80 Capsule 3's (Combipack) and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Apripet 125/80 Capsule 3's (Combipack) and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Co-administration with Apripet 125/80 Capsule 3's (Combipack) and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Apripet 125/80 Capsule 3's (Combipack) and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Co-administration with Apripet 125/80 Capsule 3's (Combipack) and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Apripet 125/80 Capsule 3's (Combipack) and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantLomitapide
Critical
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Lomitapide blood levels can be significantly increased by combining it with Apripet 125/80 Capsule 3's (Combipack).

How to manage the interaction:
Although using Lomitapide and Apripet 125/80 Capsule 3's (Combipack) together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantOxycodone
Severe
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Apripet 125/80 Capsule 3's (Combipack) can significantly raise oxycodone levels in the blood. This has the potential to worsen side effects.

How to manage the interaction:
Although there is an interaction between Apripet 125/80 Capsule 3's (Combipack) and oxycodone, it can be taken if prescribed by a doctor. If you have dizziness, fainting, confusion, excessive drowsiness, a slow heart rate, and/or shallow or difficult breathing, consult a doctor. Do not discontinue any medications without consulting a doctor.
AprepitantAvanafil
Severe
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Apripet 125/80 Capsule 3's (Combipack) may considerably raise Avanafil levels in the blood. This increases the severity of side effects.

How to manage the interaction:
Although the co-administration of Apripet 125/80 Capsule 3's (Combipack) and Avanafil may result in an interaction, they can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: low blood pressure, dizziness, lightheadedness, fainting, visual problems, ringing sound in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, or priapism (prolonged and painful erection unrelated to sexual activity). Do not discontinue any medications without doctor's consultation.
AprepitantBosutinib
Severe
How does the drug interact with Apripet 125/80 Capsule 3's (Combipack):
Taking bosutinib with Apripet 125/80 Capsule 3's (Combipack) may significantly raise blood levels of bosutinib. This may raise the risk of side effects.

How to manage the interaction:
Although there is an interaction between Apripet 125/80 Capsule 3's (Combipack) and bosutinib, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience tiredness, dizziness, fainting, fever, diarrhea, sore throat, muscle aches, or pain during urination. Do not discontinue any medication without consulting with a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated.
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting.
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Apripet 125/80 Capsule Combipack 3's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

The interaction of alcohol with Apripet 125/80 Capsule Combipack 3's is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's.

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Driving

Caution

Apripet 125/80 Capsule Combipack 3's may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking Apripet 125/80 Capsule Combipack 3's.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's. Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Apripet 125/80 Capsule Combipack 3's.

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Children

Unsafe

Apripet 125/80 Capsule Combipack 3's is not recommended for children below 12 years of age.

Have a query?

FAQs

Apripet 125/80 Capsule Combipack 3's is used to treat Chemotherapy-induced nausea and vomiting.

Apripet 125/80 Capsule Combipack 3's contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

You are not recommended to take erythromycin with Apripet 125/80 Capsule Combipack 3's as it may increase the blood levels and effects of Apripet 125/80 Capsule Combipack 3's. Contact your doctor if your condition changes or you experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Apripet 125/80 Capsule Combipack 3's.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Apripet 125/80 Capsule Combipack 3's. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Apripet 125/80 Capsule Combipack 3's and for up to 2 months after using Apripet 125/80 Capsule Combipack 3's.

Country of origin

India

Manufacturer/Marketer address

163, Reservoir Street, Basavanagudi, Bengaluru, Karnataka - 560004
Other Info - APR0199

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:10 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.11261.pdf
  2. https://www.hpra.ie/img/uploaded/swedocuments/8c35c967-1b86-4814-8cd0-85846ece0a0a.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021549s017lbl.pdf

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