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compositionComposition:APREPITANT-125MG+APREPITANT-80MG
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Aprineon Kit is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

APREPITANT-125MG+APREPITANT-80MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aprineon Kit

Aprineon Kit is a prescription medicine used to prevent nausea and vomiting caused by cancer chemotherapy treatments. It is also used to prevent nausea and vomiting that can happen after surgical procedures. This medicine is specifically designed as a preventive measure and is not used to treat active nausea or vomiting that you already have.

You will typically take Aprineon Kit as a multi-day regimen, starting on your first day of chemotherapy or just before surgery. It can be taken with or without food, but it is important to take it exactly at the scheduled times. Aprineon Kit is commonly prescribed alongside other antiemetic medicines (such as a 5-HT3 antagonist like ondansetron and a corticosteroid like dexamethasone) as part of a multimodal combination regimen.

Some people taking this medicine may experience mild side effects, such as tiredness, hiccups, or a decreased appetite. While these are usually manageable, please contact your doctor right away if you experience serious symptoms like severe dizziness, yellowing of your skin or eyes, or signs of an allergic reaction.

Before starting Aprineon Kit, tell your doctor if you have a history of liver damage, as this medicine is processed by the liver. Do not take this if you are allergic to any of its ingredients or if you are currently taking certain medicines that can cause serious drug interactions.

Aprineon Kit can interact with several medicines, including hormonal birth control, making them less effective, so you should use an alternative contraceptive method during and for a month after treatment. Avoid drinking alcohol while taking this medicine as it can worsen drowsiness and stomach irritation. If you are pregnant, breastfeeding, or an elderly patient, discuss the potential risks and benefits with your doctor before starting this treatment.

Uses of Aprineon Kit

Aprineon Kit is used to prevent nausea and vomiting associated with chemotherapy and surgery. The detailed uses of Aprineon Kit are as follows:

  • Chemotherapy-induced nausea and vomiting: Aprineon Kit helps prevent both immediate and delayed nausea and vomiting associated with cancer chemotherapy drugs.
  • Post-operative nausea and vomiting: It is taken before surgery to help prevent nausea and vomiting that commonly occur during recovery from anaesthesia.

Key Benefits

Aprineon Kit provides important benefits by helping prevent nausea and vomiting during cancer treatment and surgical recovery. The key benefits of Aprineon Kit are as follows:

  • Comfort During Treatment: Using Aprineon Kit helps you manage your cancer treatment or surgical recovery with greater comfort by blocking the signals in the brain that trigger the urge to vomit.
  • Better Nutrition and Hydration: By preventing severe nausea, this medicine allows you to maintain better nutrition and hydration, which are essential for your body's healing process.
  • Peace of Mind: It provides peace of mind, reducing the anxiety of chemotherapy sessions by offering consistent, multi-day protection against delayed vomiting.
Side effects of Aprineon Kit
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.

Directions for Use

  • Aprineon Kit can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Aprineon Kit as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Aprineon Kit Works

Aprineon Kit contains an NK1 receptor antagonist that prevents nausea and vomiting by blocking specific signals in the central nervous system. Aprepitant works by targeting specific pathways in your central nervous system. During chemotherapy or surgery, your body releases a natural chemical called Substance P, which binds to neurokinin-1 (NK1) receptors in the brain to trigger the vomiting reflex. Aprepitant, as an NK1 receptor antagonist, selectively blocks these receptors. By preventing Substance P from binding to them, the medicine stops the brain from sending the signal that causes nausea and vomiting, helping you stay comfortable throughout your treatment cycle.
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Alcohol

Caution

The interaction of alcohol with Aprineon Kit is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Aprineon Kit. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking Aprineon Kit.

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Driving

Caution

Aprineon Kit may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking Aprineon Kit.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Aprineon Kit. Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Aprineon Kit.

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Children

Unsafe

Aprineon Kit is not recommended for children below 12 years of age.

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Heart

Safe if prescribed

Aprineon Kit is generally considered safe, but it’s still important to proceed with medical guidance.

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Geriatrics

Safe if prescribed

Aprineon Kit is generally safe for geriatric individuals. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Aprineon Kit

If you take more than your prescribed dose, call emergency services (112) or go to the nearest hospital emergency room immediately. Watch for signs of extreme sleepiness or severe headache, and ensure you bring the original medicine packaging with you.

Diet & Lifestyle Advise

  • Eat Small, Frequent Meals: Eat small, frequent meals throughout the day instead of three large ones to keep your stomach settled.
  • Choose Bland Foods: Choose bland foods like toast, crackers, oatmeal, or plain rice, and avoid spicy, greasy, or highly sweet foods that can trigger nausea.
  • Sip Clear Liquids: Sip cool, clear liquids such as water, clear broths, or ginger tea slowly between meals rather than during meals.
  • Stay Upright After Eating: Sit upright for at least 30 to 60 minutes after eating to help digestion and prevent nausea.
  • Avoid Strong Odours: Avoid strong odours from cooking, perfumes, or smoke, as these can easily trigger a wave of nausea during your treatment period.
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How Soon It Starts Working

The time required for Aprineon Kit to start to work: Aprineon Kit shows its actions within 4 hours of administration. The time for which the effects of Aprineon Kit last: The effect of Aprineon Kit usually lasts approximately for 24 hours.

What if you forget to take Aprineon Kit

If you miss a dose of Aprineon Kit, contact your doctor or pharmacist immediately for instructions. Because this medicine is carefully timed with your chemotherapy or surgery, missing a dose can reduce its ability to prevent nausea. Do not take a double dose to make up for a missed one.

Storage

• Store Aprineon Kit at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the Packaging: Inspect the capsule packaging before use; do not take the medicine if the blister seal is broken or damaged.
  • Take the First Dose on Time: Always take the first dose of Aprineon Kit at least 1 hour before your chemotherapy session begins to ensure maximum preventive effect.
  • Use Backup Contraception: If you use hormonal birth control (like pills, patches, or implants), use a backup, non-hormonal contraceptive method (like condoms) while taking this medicine and for 1 month after your last dose.
  • Avoid Driving and Operating Machinery: Avoid driving, operating machinery, or performing dangerous tasks until you know how this medicine affects you, as it can cause drowsiness or dizziness.
  • Keep a Dose Record: Keep a written record of when you take each dose to ensure you strictly adhere to the multi-day schedule prescribed by your doctor.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood Thinners: May alter the effects of blood thinners (like warfarin) due to complex enzyme effects (initial inhibition followed by induction), requiring close INR monitoring by your doctor.
  • Hormonal Contraceptives: Decreases the effectiveness of hormonal contraceptives during treatment and for up to 28 days afterwards due to temporary liver enzyme induction (even though the medicine itself clears from the body in a few days).
  • Certain Medicines: Combining Aprineon Kit with certain medicines (like ketoconazole, clarithromycin, or diltiazem) can increase the levels of Aprineon Kit in your body, raising the risk of side effects.
  • Chemotherapeutic Agents and Corticosteroids: Can significantly increase the levels of certain chemotherapeutic agents or corticosteroids (like dexamethasone), which may require your doctor to adjust your steroid dose.
AprepitantFlibanserin
Critical
AprepitantPimozide
Critical

Drug-Drug Interactions

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AprepitantFlibanserin
Critical
How does the drug interact with Aprineon Kit:
Using flibanserin together with Aprineon Kit can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprineon Kit together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Aprineon Kit:
Using pimozide together with Aprineon Kit may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprineon Kit and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprineon Kit:
Lomitapide blood levels can be significantly increased by combining it with Aprineon Kit.

How to manage the interaction:
Although using Lomitapide and Aprineon Kit together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprineon Kit:
Aprineon Kit combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprineon Kit and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprineon Kit:
Co-administration with Aprineon Kit and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprineon Kit and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantTerfenadine
Critical
How does the drug interact with Aprineon Kit:
Co-administration with Aprineon Kit and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprineon Kit and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Aprineon Kit:
Co-administration with Aprineon Kit and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprineon Kit and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantRanolazine
Severe
How does the drug interact with Aprineon Kit:
Aprineon Kit can considerably raise ranolazine levels in the blood. High ranolazine levels in the blood can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Aprineon Kit and ranolazine, it can be taken if prescribed by a doctor. If you develop dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor. Do not discontinue any medications without to a doctor.
AprepitantVoclosporin
Severe
How does the drug interact with Aprineon Kit:
Using venetoclax together with Aprineon Kit may significantly raise voclosporin blood levels and side effects.

How to manage the interaction:
Although using Venetoclax and Aprineon Kit together may cause an interaction, it can be used if advised by a doctor. Consult a doctor if you have any of the following symptoms: kidney problems (poor hunger, swollen feet or hands, shortness of breath, tiredness, blood in urine, difficulty sleeping, itchy skin); high blood pressure; nervous system problems (numbness or tingling sensation in limbs, weakness, loss of muscle strength); high levels of potassium in your blood (abdominal pain, diarrhea, nausea and vomiting, palpitations); and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
AprepitantBrexpiprazole
Severe
How does the drug interact with Aprineon Kit:
Coadministration of Aprineon Kit may raise Brexpiprazole levels in the blood when taken together.

How to manage the interaction:
Even though Aprineon Kit and Brexpiprazole interact, they can be used if prescribed by a doctor. If you have anxiety, irritability, confusion, fits, muscle cramps, lip smacking, chewing, puckering, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, restlessness, foot tapping, low blood pressure such as dizziness, lightheadedness, fainting, and/or an elevated pulse or heart rate call a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit: Avoid consuming grapefruit or grapefruit juice, as it can interfere with how your body breaks down this medicine, potentially leading to increased side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Aprineon Kit is used to treat Chemotherapy-induced nausea and vomiting.
Aprineon Kit contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.
You are not recommended to take erythromycin with Aprineon Kit as it may increase the blood levels and effects of Aprineon Kit. Contact your doctor if your condition changes or you experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Aprineon Kit.
No, Aprineon Kit is designed to prevent nausea and vomiting before it starts. It is not effective for treating active nausea or vomiting that has already begun. Talk to your doctor if you need medicine to treat active symptoms.
If you throw up shortly after swallowing your dose, do not take another capsule on your own. Contact your doctor or healthcare team immediately to ask for guidance on whether to take another dose.
Yes, feeling tired, weak, or sleepy is a common side effect of Aprineon Kit. You should avoid driving, riding a bicycle, or operating machinery until you know how this medicine affects you. Talk to your doctor if the fatigue becomes severe.
Some pain medicines can interact with Aprineon Kit. It is important to provide your doctor or pharmacist with a complete list of all prescription and over-the-counter medicines you are currently taking before starting your treatment.
Aprineon Kit is cleared from your body within a few days after your last dose. However, because it temporarily affects how your liver processes certain medicines, interactions with drugs like birth control can continue for up to 28 days. Talk to your doctor for specific advice.
You should avoid drinking alcohol while taking this medicine. Alcohol can increase the risk of side effects like extreme drowsiness, dizziness, and stomach irritation. Talk to your doctor if you have concerns.
No, you should swallow the capsule whole with water. Do not crush, chew, or open the capsule, as this can change how the medicine is absorbed and make it less effective. Talk to your doctor or pharmacist if you have trouble swallowing capsules.
Yes. Aprineon Kit can reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, and implants. Use an effective non-hormonal back-up method, such as condoms, during treatment and for 28 days (1 month) after your last dose. Talk to your doctor about the most appropriate contraception for you.

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Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - APR0145

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