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  1. Home
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  3. Apriglave M1 Tablet 10's

Apriglave M1 Tablet 10's, Pack of 10 TabletS
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Synonym :

GLIMEPIRIDE+METFORMIN HYDROCHLORIDE

Composition :

GLIMEPIRIDE-1MG + METFORMIN-500MG

Manufacturer/Marketer :

Dwivsonchem Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Apriglave M1 Tablet

Apriglave M1 Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Apriglave M1 Tablet contains Glimepiride and Metformin. Glimepiride helps the pancreas release more insulin, thereby lowering blood sugar levels. Metformin reduces the amount of sugar produced by the liver, slows down sugar absorption from food, and helps the body use insulin more effectively.

In some cases, Apriglave M1 Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Apriglave M1 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Apriglave M1 Tablet if you are allergic to any of its components. Apriglave M1 Tablet is not recommended during pregnancy, breastfeeding and in children. Avoid alcohol consumption with Apriglave M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Apriglave M1 Tablet

Apriglave M1 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Apriglave M1 Tablet are as follows:<br/>• Management of Type 2 Diabetes: Apriglave M1 Tablet helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.<br/>• Improvement of Insulin Sensitivity: Apriglave M1 Tablet enhances the action of insulin, making the body's tissues more responsive to it.<br/>• Reduction of Cardiovascular Risks: Regular use of Apriglave M1 Tablet can help reduce the risk of cardiovascular diseases in diabetic patients.<br/>• Control of Blood Sugar Levels Post Meals: Apriglave M1 Tablet assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.<br/>

Directions for Use

  • Apriglave M1 Tablet can be taken with meals or as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Apriglave M1 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

  • Apriglave M1 Tablet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type 2 diabetes.
  • It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.
  • Apriglave M1 Tablet contains Glimepiride and Metformin, which work together to offer a dual-action approach for effectively managing type 2 diabetes.
  • Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood.
  • Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Additionally, it enhances the sensitivity of muscle cells to insulin, allowing these cells to remove sugar more effectively from the bloodstream.

How Apriglave M1 Tablet Works

Apriglave M1 Tablet is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.

Storage

Keep Apriglave M1 Tablet out of reach and sight of children.

What if I have taken an overdose of Apriglave M1 Tablet

Take Apriglave M1 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypoglycaemia (low blood sugar) and lactic acidosis (buildup of lactic acid in the blood). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Apriglave M1 Tablet if you are allergic to any of its components, if you have type 1 diabetes mellitus, diabetic ketoacidosis or diabetic coma. 
  • Inform the doctor if you have liver or kidney problems, low blood sugar, or circulation problems.
  • Apriglave M1 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning to become pregnant. This medicine may pass into breast milk; therefore, it should be avoided in nursing mothers. 
  • Apriglave M1 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Apriglave M1 Tablet . 
  • Avoid alcohol consumption with Apriglave M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Beware of symptoms of hypoglycemia (low blood sugar), which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume candies, glucose biscuits, or honey/sugar. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interactions

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MetforminIoversol
Critical
MetforminIopamidol
Critical

Drug-Drug Interactions

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MetforminIoversol
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Ioversol with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Iopamidol with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopydol
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Iopydol with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Iopentol with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIoglicic acid
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Ioglicic acid with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Apriglave M1 Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Apriglave M1 Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Apriglave M1 Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Apriglave M1 Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodamide
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Apriglave M1 Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Apriglave M1 Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIoxitalamic acid
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Apriglave M1 Tablet and Ioxitalamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Apriglave M1 Tablet with Ioxitalamic acid is not recommended, please consult your doctor before taking it.
MetforminIotroxic acid
Critical
How does the drug interact with Apriglave M1 Tablet:
Co-administration of Iotroxic acid with Apriglave M1 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Apriglave M1 Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits, and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid the consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Apriglave M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Apriglave M1 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Apriglave M1 Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Apriglave M1 Tablet if you are breastfeeding.

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Driving

Caution

Apriglave M1 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Apriglave M1 Tablet .

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Liver

Caution

Take Apriglave M1 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Apriglave M1 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Unsafe

Apriglave M1 Tablet is not recommended for children as the safety and effectiveness were not established.

Have a query?

FAQs

Apriglave M1 Tablet is indicated in the treatment of type 2 diabetes mellitus.

Apriglave M1 Tablet works by decreasing the amount of glucose absorbed from the food and the amount of glucose made by the liver. It helps the pancreas to produce insulin and helps the body use insulin efficiently.

Apriglave M1 Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure, such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completely. In type 2 diabetes, though islet cells are working, the body doesn't respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Apriglave M1 Tablet on your own as discontinuing Apriglave M1 Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Apriglave M1 Tablet , please consult your doctor so that alternative medicine may be prescribed.

You are not recommended to take Apriglave M1 Tablet with phenytoin as it may reduce the effect of Apriglave M1 Tablet and increase blood sugar levels. However, please consult a doctor before using Apriglave M1 Tablet with other medicines.

Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.

Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.

You are advised to take Apriglave M1 Tablet for the duration recommended by the doctor.

Store Apriglave M1 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Apriglave M1 Tablet may cause lactic acidosis (builds up of lactic acid in the blood). Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.

Apriglave M1 Tablet is an anti-diabetic medicine used to treat type 2 diabetes mellitus, also known as noninsulin-dependent diabetes mellitus.

Side effects of Apriglave M1 Tablet are stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Long-term use of Apriglave M1 Tablet may lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.

You are recommended to avoid consumption of alcohol with Apriglave M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Apriglave M1 Tablet should be swallowed as a whole with water; do not crush, break or chew it.

Regularly monitor blood glucose levels. Have your meals regularly and never miss a meal. Always carry a source of sugar and consume it if you experience low blood sugar. If you are due to undergo any tests or surgery, inform the doctor that you are taking Apriglave M1 Tablet . Avoid drinking alcohol.

Other medicines should be taken with Apriglave M1 Tablet only if prescribed by the doctor. To prevent any interactions it is advised to consult the doctor before taking other medicines during treatment with Apriglave M1 Tablet .

Country of origin

India

Manufacturer/Marketer address

Street No 05, Shadu Nagar, Dera Basi, Sas Nagar, Mohali Punjab 140507
Other Info - APR0171

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

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Reference

  1. https://www.sanofi.in/-/media/Project/One-Sanofi-Web/Websites/Asia-Pacific/Sanofi-IN/Home/science-and-innovation/for-healthcare-professionals/product-information/Amaryl-M-PI--May-2018.pdf?la=en
  2. https://www.tmda.go.tz/uploads/1678353865-T20H0128SmPCV1.pdf
  3. https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/Feb_2022/Co-mepiryl-Forte.pdf
  4. https://www.centaurpharma.com/downloads/Glimitab-M2018.pdf
  5. https://simsrc.edu.in/pdf_df/M-drugs/Metformin%20+%20glimepiride.pdf

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