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Aprifast 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting. It contains Fosaprepitant, an anti-emetic (a drug used to treat nausea and vomiting) which is converted to aprepitant in the body. It works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aprifast 150 mg Injection

Aprifast 150 mg Injection is an injection used to prevent nausea and vomiting caused by chemotherapy treatments. It is prescribed as part of a treatment plan to help manage these common side effects of cancer therapy. This medicine helps ensure you feel more comfortable during and after your treatment cycles. Aprifast 150 mg Injection is usually given together with other anti-nausea medicines, such as corticosteroids or serotonin (5-HT3) blockers. These medicines work in different ways to provide better protection against nausea and vomiting caused by chemotherapy.

This medicine is typically given as a single dose on the first day of your chemotherapy cycle. Because it is given as an injection by a healthcare provider, you do not need to worry about taking it with or without food. Making simple dietary choices, like eating light and bland foods before your appointment, can support the medicine's effects.

While taking Aprifast 150 mg Injection, some people may experience mild side effects like headaches, tiredness, or mild irritation where the injection was given. These are usually temporary, but you must contact your healthcare provider immediately if you experience severe symptoms, such as difficulty breathing or signs of liver damage.

Do not take this if you are allergic to Aprifast 150 mg Injection or any of its ingredients. Before starting treatment, you must tell your healthcare provider if you have a history of liver disease or other serious health problems. Also tell your healthcare provider if you have kidney problems or are receiving dialysis, as this information helps your cancer care team plan and monitor your overall treatment safely. Your doctor will determine if this medicine is safe for your specific situation.

This medicine can interact with other drugs, including blood thinners and hormonal birth control, which may make your birth control less effective. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss the risks and benefits of this treatment. When this medicine is used in children or adolescents, the dose and treatment plan are carefully decided by a specialist. Its use may not be suitable for all younger children, depending on their age and body weight.

Uses of Aprifast 150 mg Injection

Your doctor may prescribe Aprifast 150 mg Injection to help manage the following conditions:

  • Chemotherapy-induced nausea and vomiting: Aprifast 150 mg Injection is used to prevent both the immediate and delayed nausea and vomiting that can occur with strong chemotherapy medications.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Relieves Chemotherapy-Related Nausea and Vomiting: Aprifast 150 mg Injection provides effective relief from severe nausea and vomiting, allowing patients to complete their scheduled chemotherapy cycles with less physical distress. By blocking the body's sickness signals, it helps you maintain your strength and appetite during treatment.
  • Supports Recovery After Chemotherapy: Because this medicine works to prevent delayed symptoms, it continues to provide protection for several days after your chemotherapy session. This long-lasting effect reduces the need for multiple daily oral anti-nausea medications, making your recovery process easier to manage.
Side effects of Aprifast 150 mg Injection
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • The doctor or healthcare professional will administer Aprifast 150 mg Injection.
  • Do not self-administer.

How Aprifast 150 mg Injection Works

Aprifast 150 mg Injection contains fosaprepitant, which is given as an injection into a vein, where your body quickly converts it into its active form. Once active, it works by blocking specific chemical receptors in your brain and digestive system called neurokinin-1 (NK1) receptors. By blocking these receptors, the medicine prevents a natural chemical in your body known as substance P from binding to them. Because substance P is the primary trigger for the vomiting reflex during chemotherapy, blocking this pathway stops the signals that make you feel sick and vomit.
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Alcohol

Consult your doctor

The interaction of alcohol with Aprifast 150 mg Injection is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Aprifast 150 mg Injection. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Fosaprepitant is excreted in breast milk. Hence, if you are a nursing mother, discuss with your doctor about the best way to feed your baby if you receive Aprifast 150 mg Injection.

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Driving

Caution

Aprifast 150 mg Injection may cause dizziness or sleepiness in some people. Therefore, if you feel dizzy or sleepy after receiving Aprifast 150 mg Injection, avoid driving or operating machinery.

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Liver

Caution

If you have liver disease, inform your doctor before receiving Aprifast 150 mg Injection.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before receiving Aprifast 150 mg Injection.

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Children

Caution

If you have any concerns regarding the use of Aprifast 150 mg Injection in children, please consult a doctor.

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Heart

Caution

Aprifast 150 mg Injection should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Aprifast 150 mg Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Aprifast 150 mg Injection to geriatric patients. Your doctor will prescribe Aprifast 150 mg Injection if the benefits outweigh the risks.

What if I have taken an overdose of Aprifast 150 mg Injection

Since this medicine is prepared and given by trained medical professionals, an overdose is extremely rare. However, if you suspect you have received too much or if you experience severe, unusual symptoms after your infusion, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat Smaller Meals More Often: Eat small, frequent meals throughout the day instead of three large meals to keep your stomach settled.
  • Choose Gentle, Low-Fat Foods: Choose bland, dry foods like crackers, toast, oatmeal, or plain rice, and avoid greasy, fried, or very spicy foods.
  • Sip Fluids Between Meals: Stay hydrated by sipping clear liquids, water, ginger ale, or herbal teas slowly between your meals rather than during them.
  • Avoid Lying Down After Eating: Avoid lying down flat for at least 30 to 60 minutes after eating; keeping your head elevated supports healthy digestion.
  • Avoid Tight Clothing Around Your Waist: Wear loose, comfortable clothing around your stomach to prevent unnecessary pressure on your abdomen.
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How Soon It Starts Working

The time required for Aprifast 150 mg Injection to start to work: Aprifast 150 mg Injection ideally shows its action within 30 minutes after administration. The time for which the effects of Aprifast 150 mg Injection last: The duration of action for Aprifast 150 mg Injection is unknown.

What if you forget to take Aprifast 150 mg Injection

Because this medicine is given in a clinic or hospital setting by a healthcare professional, missing a dose is highly unlikely. If you miss your scheduled appointment or if your chemotherapy is delayed, contact your healthcare provider immediately to reschedule your infusion.

Storage

• Unopened vials of Aprifast 150 mg Injection powder are stored in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze the vials.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do Not Receive This Medicine if Advised Otherwise: Tell your doctor if you have ever had an allergic reaction to Aprifast 150 mg Injection or if you are taking pimozide. If you have severe liver disease, your doctor will carefully decide whether this medicine is suitable for you.
  • Watch for Injection Site Reactions: Watch the injection site closely during your infusion and tell your nurse immediately if you feel any burning, stinging, coldness, or pain.
  • Check IV Solution Before Use: Ensure that the liquid solution in the IV line is clear and free of any visible particles before the infusion begins.
  • Use Backup Birth Control: If you use hormonal birth control (such as pills, patches, or vaginal rings), use a reliable backup barrier method (like condoms) during your treatment and for at least one month after your last dose, as Aprifast 150 mg Injection can make hormonal contraceptives less effective.
  • Tell Your Doctor About Blood Thinners: Inform your healthcare provider if you are taking blood thinners, as you may need extra blood tests to monitor your clotting times after receiving this medicine.
  • Avoid Driving if Drowsy or Dizzy: Avoid driving, operating machinery, or performing dangerous tasks if you feel dizzy or extremely tired after your infusion.

Drug-Drug Interactions

verifiedApollotooltip
  • Pimozide: Do not take Aprifast 150 mg Injection if you are taking pimozide, as this combination can cause severe and life-threatening heart rhythm issues.
  • Hormonal Contraceptives: May decrease the effectiveness of birth control pills, patches, or implants, which increases the risk of pregnancy.
  • Warfarin: Can decrease the effectiveness of warfarin, increasing the risk of blood clots. Your doctor may need to monitor your blood clotting levels closely.
  • Dexamethasone or Methylprednisolone: May increase the levels of these steroid medicines in your body, so your doctor may choose to lower your steroid dose.
  • Share Your Complete Medication List: Aprifast 150 mg Injection can also interact with many other prescription medicines, over-the-counter medicines, vitamins, and herbal supplements because it affects the way certain liver enzymes process medicines. Always give your healthcare provider a complete list of everything you take before starting treatment. 
AprepitantFlibanserin
Critical

Drug-Drug Interactions

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How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Aprifast 150 mg Injection:
Using flibanserin together with Aprifast 150 mg Injection can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprifast 150 mg Injection together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprifast 150 mg Injection:
Aprifast 150 mg Injection combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprifast 150 mg Injection:
Lomitapide blood levels can be significantly increased by combining it with Aprifast 150 mg Injection.

How to manage the interaction:
Although using Lomitapide and Aprifast 150 mg Injection together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
Using pimozide together with Aprifast 150 mg Injection may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
How does the drug interact with Aprifast 150 mg Injection:
When used with bromocriptine, Aprifast 150 mg Injection may raise blood levels of bromocriptine.

How to manage the interaction:
Although co-administration of Aprifast 150 mg Injection and bromocriptine may result in an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any of the following symptoms: nausea, headache, dizziness, drowsiness, lightheadedness, or compulsive behaviors (e.g., gambling or sexual urges; uncontrolled spending). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
Coadministration of Aprifast 150 mg Injection can significantly increase the blood levels of Acalabrutinib.

How to manage the interaction:
Although there is an interaction between Aprifast 150 mg Injection and acalabrutinib, it can be taken if prescribed by a doctor. A doctor should be consulted if you experience any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in the phlegm, red or irritated skin, body sores, and discomfort when urinating. Without consulting a doctor, never stop taking medicines.
AprepitantVenetoclax
Severe
How does the drug interact with Aprifast 150 mg Injection:
Using venetoclax in conjunction with Aprifast 150 mg Injection may drastically increase venetoclax blood levels and effects.

How to manage the interaction:
Although using Venetoclax and Aprifast 150 mg Injection together may cause an interaction, it can be used if advised by a doctor. Consult a doctor if you have any of the following symptoms: nausea, vomiting, diarrhea, weakness, paleness, or unusual bleeding. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Aprifast 150 mg Injection when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Aprifast 150 mg Injection is used to treat Chemotherapy-induced nausea and vomiting.
Aprifast 150 mg Injection works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps prevent nausea and vomiting caused by anti-cancer medicines.
Aprifast 150 mg Injection may cause constipation as a common side effect. However, if the condition persists or worsens, please consult your doctor.
You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain intrauterine devices (IUDs) as they may not work properly when taken together with Aprifast 150 mg Injection. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Aprifast 150 mg Injection and for up to 1 month after using Aprifast 150 mg Injection.
Aprifast 150 mg Injection is given as an intravenous infusion (an injection into a vein) by a healthcare provider in a clinic or hospital. Talk to your doctor if you have questions about your injection schedule.
It is not fully known if Aprifast 150 mg Injection is safe to use during pregnancy. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the benefits and risks of this treatment.
No, Aprifast 150 mg Injection is specifically used to prevent nausea and vomiting caused by chemotherapy treatments. It is not meant for motion sickness or other general causes of stomach upset. Talk to your doctor for more details.
Mild pain or redness can occur at the injection site. However, if the pain is severe, or if you notice swelling, warmth, or skin peeling, contact your doctor immediately.
Alcohol can worsen chemotherapy side effects like nausea, dizziness, and dehydration. It is best to avoid alcohol during your treatment. Talk to your doctor or pharmacist for personalised advice.
No, Aprifast 150 mg Injection is used to prevent nausea and vomiting before it starts, rather than treating active symptoms. Talk to your doctor about other medicines if you are currently feeling sick.

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Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - APR0134
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