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compositionComposition:APREPITANT-125MG
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APREPEP 125MG/80MG TABLET is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking the neurokinin-1 receptor (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

APREPITANT-125MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About APREPEP 125MG/80MG TABLET

APREPEP 125MG/80MG TABLET is a prescription medicine used to prevent nausea and vomiting that may be caused by cancer chemotherapy treatments. It is also prescribed to prevent nausea and vomiting that can occur after surgical procedures under general anesthesia. This medicine is used as a preventive measure and is not intended to treat nausea or vomiting that has already started.

This medication is typically taken as a short-term course, starting shortly before your treatment or surgery. To achieve the best results, it is crucial to take APREPEP 125MG/80MG TABLET exactly as scheduled by your doctor, even if you are not currently feeling sick. You can take this medicine with or without food, swallowing the capsule whole with a glass of water. Adopting a diet of bland, small meals and maintaining proper hydration can also significantly support your recovery.

Some patients taking APREPEP 125MG/80MG TABLET may experience mild side effects, such as hiccups, fatigue, or indigestion. While these symptoms are generally mild, you must contact your healthcare provider immediately if you experience serious side effects like severe dizziness, skin rashes, or difficulty breathing. Always report any unusual or worsening symptoms to your medical team right away.

Before starting APREPEP 125MG/80MG TABLET , it is important to inform your doctor if you have a history of liver damage, as this organ processes the medicine. Do not take this medicine if you are allergic to any of its components or if you are currently taking medications like pimozide, cisapride, or terfenadine, as this can cause dangerous health risks.

This medication can interact with other substances, including hormonal contraceptives, which may make your birth control less effective during treatment. It is also important to consult your healthcare provider if you are pregnant, planning a pregnancy, or breastfeeding to evaluate the safety of this medicine for you. Additionally, avoid drinking alcohol or smoking while taking this medicine, as they can worsen stomach irritation and increase tiredness.

Uses of APREPEP 125MG/80MG TABLET

A healthcare professional may prescribe APREPEP 125MG/80MG TABLET to prevent nausea and vomiting associated with medical treatments and surgery. These include:

  • Chemotherapy-induced nausea and vomiting: APREPEP 125MG/80MG TABLET is used to prevent both the immediate and delayed nausea and vomiting associated with cancer chemotherapy treatments.
  • Postoperative nausea and vomiting: APREPEP 125MG/80MG TABLET helps prevent nausea and vomiting that can occur when waking up from general anesthesia after a surgical procedure.

Key Benefits

APREPEP 125MG/80MG TABLET helps prevent nausea and vomiting, making cancer treatment and recovery after surgery more comfortable. Key benefits include:

  • Prevents nausea and vomiting: APREPEP 125MG/80MG TABLET provides significant relief by helping to control the physical triggers that cause nausea, allowing you to undergo chemotherapy or surgery with greater physical comfort. By preventing severe nausea and vomiting, this medication helps you maintain your regular nutrition and fluid intake during critical treatment periods.
  • Provides long-lasting protection: Another key benefit is its long-lasting action, which helps prevent delayed nausea that often occurs several days after chemotherapy. This continuous protection supports a smoother, faster recovery process and reduces the need for emergency medical care for dehydration.
Side effects of Aprepep 125mg/80mg Tablet Kit
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.

Directions for Use

  • APREPEP 125MG/80MG TABLET can be taken with or without food because food does not impact its effectiveness.
  • It is usually taken once a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow APREPEP 125MG/80MG TABLET as a whole with a glass of water.
  • Do not break, chew, or crush it.

How APREPEP 125MG/80MG TABLET Works

APREPEP 125MG/80MG TABLET contains aprepitant. During treatments like chemotherapy or major surgery, the body releases a chemical messenger called substance P in the brain and gut. When substance P attaches to specific receptors, known as neurokinin-1 (NK1) receptors, it sends strong signals that trigger the vomiting reflex and cause feelings of intense nausea. APREPEP 125MG/80MG TABLET works as an NK1 receptor blocker. It binds tightly to these specific receptors in the brain and nervous system, preventing substance P from attaching to them. By blocking these signals, the medication effectively shuts down the communication pathway that triggers nausea and vomiting, helping to prevent these symptoms from developing.
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Alcohol

Consult your doctor

The interaction of alcohol with APREPEP 125MG/80MG TABLET is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking APREPEP 125MG/80MG TABLET . Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking APREPEP 125MG/80MG TABLET .

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Driving

Caution

APREPEP 125MG/80MG TABLET may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking APREPEP 125MG/80MG TABLET .

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Liver

Caution

If you have liver disease, inform your doctor before taking APREPEP 125MG/80MG TABLET . Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before taking APREPEP 125MG/80MG TABLET .

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Children

Unsafe

APREPEP 125MG/80MG TABLET is not recommended for children below 12 years of age.

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Heart

Consult your doctor

Please consult your doctor before receiving APREPEP 125MG/80MG TABLET if you have pre-existing heart problems. Your doctor will prescribe APREPEP 125MG/80MG TABLET if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available about the use of APREPEP 125MG/80MG TABLET in geriatric patients. Please consult your physician.

What if I have taken an overdose of APREPEP 125MG/80MG TABLET

If you suspect an accidental overdose, seek emergency medical care immediately. Watch for symptoms such as extreme fatigue or a severe headache.

Diet & Lifestyle Advise

  • Eat small, frequent meals: Eat small, frequent meals throughout the day rather than three large meals to reduce pressure on your stomach.
  • Choose bland foods: Choose dry, bland foods like crackers, toast, plain rice, or oatmeal, and avoid greasy, fried, spicy, or very sweet foods that can trigger nausea.
  • Stay hydrated: Drink clear liquids, such as water, clear broths, or ginger tea, in small sips throughout the day. Try to drink fluids between meals instead of during meals.
  • Avoid lying down after eating: Avoid lying down completely flat for at least 30–60 minutes after eating to help prevent acid reflux and nausea.
  • Avoid strong smells: Sit in a well-ventilated room with fresh air, and avoid strong cooking smells or perfumes that can stimulate the vomiting reflex.
health query

Have a query?

How Soon It Starts Working

The time required for APREPEP 125MG/80MG TABLET to start to work: The onset of time for APREPEP 125MG/80MG TABLET is unknown. The time for which the effects of APREPEP 125MG/80MG TABLET last: The duration of APREPEP 125MG/80MG TABLET effect is unknown.

What if you forget to take APREPEP 125MG/80MG TABLET

If you miss a dose of APREPEP 125MG/80MG TABLET , contact your doctor or pharmacist immediately to get instructions on what to do. Do not take a double dose to make up for a missed one, as this is a highly scheduled preventive therapy.

Storage

• Store APREPEP 125MG/80MG TABLET oral capsules at room temperature, between 20°C and 25°C.

Drug Warnings

  • Check the medicine pack: Always check your medicine pack before use to ensure the blister seal is fully intact and undamaged.
  • Use backup contraception: This medicine can significantly reduce the effectiveness of hormonal contraceptives, such as birth control pills, patches, or implants. Use a reliable non-hormonal backup method, such as condoms, while taking this medicine and for 28 days after your final dose.
  • Monitor blood clotting: If you take blood thinners such as warfarin, your doctor may perform extra blood tests to monitor your blood clotting levels after you complete treatment.
  • Avoid driving if affected: Do not drive, operate heavy machinery, or perform hazardous tasks if you feel dizzy or unusually tired after taking this medicine.
  • Inform your healthcare team: Make sure your healthcare team has a complete list of all medicines you take, including prescription medicines, over-the-counter products, and herbal supplements, before you start treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Hormonal Contraceptives: May decrease the effectiveness of birth control pills, patches, or rings.
  • Blood Thinners (such as Warfarin): May reduce the effect of the blood thinner, requiring close monitoring of your blood clotting times.
  • Certain Anti-seizure Medications (such as Carbamazepine, Phenytoin): May lower the levels of APREPEP 125MG/80MG TABLET in your body, making it less effective.
  • Certain Antifungals and Antibiotics (such as Ketoconazole, Clarithromycin): May increase the levels of APREPEP 125MG/80MG TABLET in your blood, increasing the risk of side effects.
AprepitantFlibanserin
Critical
AprepitantPimozide
Critical

Drug-Drug Interactions

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AprepitantFlibanserin
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Using flibanserin together with Aprepep 125mg/80mg Tablet Kit can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprepep 125mg/80mg Tablet Kit together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantPimozide
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Using pimozide together with Aprepep 125mg/80mg Tablet Kit may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprepep 125mg/80mg Tablet Kit and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Lomitapide blood levels can be significantly increased by combining it with Aprepep 125mg/80mg Tablet Kit.

How to manage the interaction:
Although using Lomitapide and Aprepep 125mg/80mg Tablet Kit together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Aprepep 125mg/80mg Tablet Kit combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprepep 125mg/80mg Tablet Kit and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Co-administration with Aprepep 125mg/80mg Tablet Kit and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprepep 125mg/80mg Tablet Kit and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantTerfenadine
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Co-administration with Aprepep 125mg/80mg Tablet Kit and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprepep 125mg/80mg Tablet Kit and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Co-administration with Aprepep 125mg/80mg Tablet Kit and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprepep 125mg/80mg Tablet Kit and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantRanolazine
Severe
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Aprepep 125mg/80mg Tablet Kit can considerably raise ranolazine levels in the blood. High ranolazine levels in the blood can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Aprepep 125mg/80mg Tablet Kit and ranolazine, it can be taken if prescribed by a doctor. If you develop dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor. Do not discontinue any medications without to a doctor.
AprepitantVoclosporin
Severe
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Using venetoclax together with Aprepep 125mg/80mg Tablet Kit may significantly raise voclosporin blood levels and side effects.

How to manage the interaction:
Although using Venetoclax and Aprepep 125mg/80mg Tablet Kit together may cause an interaction, it can be used if advised by a doctor. Consult a doctor if you have any of the following symptoms: kidney problems (poor hunger, swollen feet or hands, shortness of breath, tiredness, blood in urine, difficulty sleeping, itchy skin); high blood pressure; nervous system problems (numbness or tingling sensation in limbs, weakness, loss of muscle strength); high levels of potassium in your blood (abdominal pain, diarrhea, nausea and vomiting, palpitations); and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
AprepitantBrexpiprazole
Severe
How does the drug interact with Aprepep 125mg/80mg Tablet Kit:
Coadministration of Aprepep 125mg/80mg Tablet Kit may raise Brexpiprazole levels in the blood when taken together.

How to manage the interaction:
Even though Aprepep 125mg/80mg Tablet Kit and Brexpiprazole interact, they can be used if prescribed by a doctor. If you have anxiety, irritability, confusion, fits, muscle cramps, lip smacking, chewing, puckering, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, restlessness, foot tapping, low blood pressure such as dizziness, lightheadedness, fainting, and/or an elevated pulse or heart rate call a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Consuming grapefruit products can increase the levels of APREPEP 125MG/80MG TABLET in your system, raising your risk of side effects. Avoid these products during your treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

APREPEP 125MG/80MG TABLET is used to treat Chemotherapy-induced nausea and vomiting.
APREPEP 125MG/80MG TABLET works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.
You are not recommended to take erythromycin with APREPEP 125MG/80MG TABLET as it may increase the blood levels and effects of APREPEP 125MG/80MG TABLET . Contact your doctor if your condition changes or experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with APREPEP 125MG/80MG TABLET .
No, APREPEP 125MG/80MG TABLET is a preventive medication and must be taken before you start feeling sick to be effective. It is not designed to stop active vomiting that has already started. Talk to your doctor for options if you are currently vomiting.
Yes, fatigue and sleepiness are known side effects for some patients taking this medicine. Avoid activities that require mental alertness, like driving, if you feel tired. Talk to your doctor if this tiredness persists or worsens.
You should take your first dose of APREPEP 125MG/80MG TABLET before your chemotherapy session or surgery begins, exactly at the time directed by your healthcare team. Talk to your doctor if you are unsure about your exact dosing timeline.
Yes, you can take this medicine with or without food. Be sure to swallow the capsule whole with water. Talk to your doctor or pharmacist if you have questions about taking your dose.
Yes. APREPEP 125MG/80MG TABLET can make hormonal birth control methods, including birth control pills, implants, skin patches, and certain intrauterine devices (IUDs), less effective during treatment and for up to 2 months after your last dose. You should use a non-hormonal backup method, such as condoms, during this time. Talk to your doctor about the most appropriate birth control options for you.
If you throw up shortly after taking your dose, do not take an extra capsule on your own. Contact your healthcare team immediately for guidance on what to do next. Talk to your doctor for specific advice.
It is best to avoid alcohol while taking this medicine, as alcohol can increase side effects like dizziness and drowsiness and can irritate your stomach. Talk to your doctor if you have questions about alcohol use.
The safety of this medicine during pregnancy is not fully known, and it should only be used if absolutely necessary. Talk to your doctor to discuss the potential benefits and risks before starting this treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - APR0079

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