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  1. Home
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  3. Apremex Capsule 10's

Apremex Capsule 10's, Pack of 10
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Composition :

MEXILETINE-150MG

Manufacturer/Marketer :

RMPL Pharma Llp

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Apremex Capsule 10's

Apremex Capsule 10's is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. Arrhythmia is a condition in which your heart beats irregularly, too fast, or too slow.

Apremex Capsule 10's contains Mexiletine, which works by reducing the sensitivity of heart muscle cells to electrical impulses. Thus, it slows down electrical conduction in the heart muscle. Therefore, it helps restore regular heart rhythm.

Take Apremex Capsule 10's as prescribed. You are advised to take Apremex Capsule 10's for as long as your doctor has recommended it based on your medical condition. In some cases, Apremex Capsule 10's may cause common side effects such as stomach pain, insomnia (difficulty sleeping), dyspepsia (indigestion), dizziness, tremors (involuntary shaking), chest discomfort or headache. Most of these side effects of Apremex Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Mexiletine, local anaesthetics, or other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Apremex Capsule 10's. Apremex Capsule 10's is not recommended for children and adolescents below 18 years of age. Avoid alcohol consumption with Apremex Capsule 10's as it may worsen dizziness or drowsiness. Apremex Capsule 10's may cause dizziness, drowsiness or blurred vision in some people. Therefore, drive only if you are alert after taking Apremex Capsule 10's. 

Uses of Apremex Capsule 10's

Apremex Capsule 10's is used in the treatment of ventricular arrhythmia (irregular heartbeats). The detailed use of Apremex Capsule 10's is as follows:<br/>• Treatment of ventricular arrhythmia (irregular heartbeats): Apremex Capsule 10's is used in the treatment of ventricular arrhythmia (irregular heartbeats) by stabilizing the heart rhythm and reducing abnormal electrical activity, by blocking sodium channels in the heart, which helps to normalize the heartbeat.<br/>

Directions for Use

• Apremex Capsule 10's can be taken with food to prevent stomach upset or as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Swallow Apremex Capsule 10's as a whole with a glass of water.• Do not chew, crush or break it.

Medicinal Benefits

Apremex Capsule 10's contains Mexiletine, which is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. It decreases the sensitivity of heart muscle cells to electrical impulses. Thus, it slows down electrical conduction in the heart muscle. Thereby, it helps restore regular heart rhythm. 

How Apremex Capsule 10's Works

Apremex Capsule 10's contains Mexiletine, which works by reducing the sensitivity of heart muscle cells to electrical impulses. Thus, it slows down electrical conduction in the heart muscle. Therefore, it helps restore regular heart rhythm.

Storage

• Store in a cool and dry place away from sunlight.• Keep Apremex Capsule 10's out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Apremex Capsule
  • Eat slowly and chew your food well to avoid swallowing air, which can make stomach pain worse.
  • Instead of going long periods without eating, try having smaller meals or snacks throughout the day to stop too much stomach acid from building up and causing pain.
  • Stay away from fatty, fried, or spicy foods. Instead, eat more healthy, fibre-rich foods.
  • Drink plenty of water to help with digestion and avoid soda or alcohol, which can make stomach pain worse.
  • Try to manage stress with relaxation techniques, and see a doctor if stress leads to chronic stomach pain.
  • Try antacids or medications like proton pump inhibitors to protect your stomach.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.

What if I have taken an overdose of Apremex Capsule 10's

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Apremex Capsule 10's may include confusion, drowsiness, nausea, feeling lightheaded, seizures, loss of consciousness, and a worsening irregular heartbeat. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Mexiletine, any local anaesthetics or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Apremex Capsule 10's. Apremex Capsule 10's is not recommended for children and adolescents below 18 years of age. Avoid intake of alcohol with Apremex Capsule 10's as it may worsen dizziness or drowsiness. Apremex Capsule 10's may cause dizziness, drowsiness or blurred vision in some people. Therefore, drive only if you are alert after taking Apremex Capsule 10's. Inform your doctor if you have a genetic problem with an enzyme in your body called CYP2D6 which breaks down (metabolizes) certain medicines in your body too slowly, because a different dose may be applicable to you. If you start to smoke or quit smoking while taking Apremex Capsule 10's, inform your doctor as smoking impacts the Mexiletine blood levels, and your dose may need to be adjusted accordingly.

Drug-Drug Interactions

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MexiletineArbutamine
Critical
MexiletineAminophylline
Severe

Drug-Drug Interactions

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MexiletineArbutamine
Critical
How does the drug interact with Apremex Capsule:
Co-administration of Arbutamine with Apremex Capsule can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Apremex Capsule with Arbutamine is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest tightness, blurred vision or nausea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineAminophylline
Severe
How does the drug interact with Apremex Capsule:
Co-administration of aminophylline with Apremex Capsule can increase the blood levels of aminophylline and increase the risk of serious side effects.

How to manage the interaction:
Taking Aminophylline with Apremex Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineTramadol
Severe
How does the drug interact with Apremex Capsule:
Co-administration of tramadol with Apremex Capsule can increase the risk or severity of seizures(fits).

How to manage the interaction:
Taking tramadol with Apremex Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. Avoid activities requiring mental focus such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
MexiletineBupivacaine
Severe
How does the drug interact with Apremex Capsule:
Taking Apremex Capsule with Bupivacaine may cause serious side effects including methemoglobinemia, a serious blood disorder in which too little oxygen is delivered to your cells and heart problems.

How to manage the interaction:
Although taking bupivacaine and Apremex Capsule together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you develop pale, grey, or blue-coloured skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, Jerking movements of the arms and legs, Loss of consciousness, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without talking to a doctor.
MexiletineDroperidol
Severe
How does the drug interact with Apremex Capsule:
Co-administration of droperidol with Apremex Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although taking droperidol and Apremex Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, vomiting, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineIohexol
Severe
How does the drug interact with Apremex Capsule:
Co-administration of iohexol with Apremex Capsule can increase the risk or severity of fits. The risk increases in patients with a history of fits, head and brain trauma, or undergoing alcohol or drug withdrawal.

How to manage the interaction:
Although taking iohexol and Apremex Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as pale, headache, rapid heart rate, shortness of breath, lightheadedness; or fatigue, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineBupropion
Severe
How does the drug interact with Apremex Capsule:
Co-administration of bupropion with Apremex Capsule can increase the risk or severity of seizures (fits).

How to manage the interaction:
Although taking bupropion and Apremex Capsule together can result in an interaction, it can be taken if a doctor has advised it. Refrain from engaging in tasks which require mental alertness. Do not discontinue any medications without consulting a doctor.
MexiletineIomeprol
Severe
How does the drug interact with Apremex Capsule:
Co-administration of iomeprol with Apremex Capsule can increase the risk or severity of fits. The risk increases in the elderly, patients undergoing alcohol or drug withdrawal, who have a history of fits or head trauma.

How to manage the interaction:
Although taking iomeprol and Apremex Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as pale, headache, rapid heart rate, shortness of breath, lightheadedness; or fatigue, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MexiletineChlorpheniramine
Severe
How does the drug interact with Apremex Capsule:
Co-administration of chlorpheniramine with Apremex Capsule may cause the side effects of Apremex Capsule.

How to manage the interaction:
Although taking chlorpheniramine and Apremex Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MexiletineTizanidine
Severe
How does the drug interact with Apremex Capsule:
Co-administration of tizanidine with Apremex Capsule can increase the effect of tizanidine. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking tizanidine with Apremex Capsule can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as nausea, vomiting, diarrhoea, loss of appetite, headache, tremors, confusion, restlessness, insomnia, seizures, heart palpitations, and/or irregular heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do regular exercise as it helps lower blood pressure and keeps blood vessels and the heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat a balanced and healthy diet that includes plenty of vegetables, fruits, and low-fat or fat-free products.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol while taking Apremex Capsule 10's as it may worsen dizziness or drowsiness.

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Pregnancy

Consult your doctor

Limited data are available on the effect of Apremex Capsule 10's in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Apremex Capsule 10's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, please inform your doctor before taking Apremex Capsule 10's. Mexiletine may be excreted in breast milk. Therefore, if your doctor prescribes Apremex Capsule 10's, you will be advised to choose an alternate method of feeding your baby.

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Driving

Caution

Apremex Capsule 10's may cause dizziness, drowsiness or blurred vision in some people. Therefore, avoid driving if you experience such side effects after taking Apremex Capsule 10's.

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Liver

Caution

Apremex Capsule 10's should be used with caution in patients with mild to moderate liver dysfunction and is not recommended for patients with severe liver disease. Therefore, inform your doctor if you have any liver problems before taking Apremex Capsule 10's.

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Kidney

Caution

Apremex Capsule 10's is not recommended for patients with severe kidney disease. Therefore, inform your doctor if you have any kidney disease before taking Apremex Capsule 10's.

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Children

Unsafe

Apremex Capsule 10's is not recommended for children and adolescents below 18 years of age.

Have a query?

FAQs

Apremex Capsule 10's is used to treat life-threatening arrhythmias (irregular heartbeats) such as ventricular arrhythmia. Arrhythmia is a condition in which your heart beats irregularly, too fast, or too slow.

Apremex Capsule 10's contains Mexiletine which works by blocking certain electrical signals in the heart. Thereby, it helps to stabilize the heart rhythm.

Apremex Capsule 10's may cause blurred or double vision in some people. Therefore, drive only if your vision is clear after taking Apremex Capsule 10's.

If you take more than the recommended dose of Apremex Capsule 10's, it may be very harmful to your health. Therefore, you are advised to take Apremex Capsule 10's in the dose and for the duration prescribed by your doctor. However, if you have irregular heartbeats (faster or slower), low blood pressure, nausea, fits, or hallucinations, contact your doctor immediately.

The side effects of Apremex Capsule 10's include dizziness, headache, stomach pain, chest discomfort, insomnia (difficulty sleeping) and tremor. If these side effects persist or worsen, please consult your doctor.

No, Apremex Capsule 10's is not a beta blocker. It is a sodium channel blocker and belongs to the class of medicines called antiarrhythmics. It blocks the fast sodium channels in heart, and thus, helps in treating ventricular arrhythmia (abnormal electrical activity). It blocks specific electrical signals in the heart and stabilizes the heart rhythm.

Apremex Capsule 10's may lower heart rate. Also, it may also cause irregular heartbeats, palpitations, decrease in blood pressure and atrial fibrillation (abnormal heart rhythm). Thus, you will be hospitalized probably when you start using Apremex Capsule 10's. Your doctor will monitor you carefully during this time and for as long as you continue to take Apremex Capsule 10's.

Yes, Apremex Capsule 10's may cause liver damage. This may occur within a few weeks after starting Apremex Capsule 10's and is more likely to happen in patients with heart failure. Patients with impaired liver function are monitored carefully. Also, in patients with liver problems, Apremex Capsule 10's stays for more time in body. Inform your doctor if you notice symptoms such as dark or tea-colored urine, fatigue (overtiredness), loss of appetite for several days or longer, or pain and tenderness on the right side of the abdomen. If your skin or the white part of your eyes turn yellow (jaundice), consult your doctor immediately.

You are recommended not to stop taking Apremex Capsule 10's suddenly without consulting your doctor as it may cause arrhythmias to recur which could be harmful for you. It is advised to stop Apremex Capsule 10's gradually over 1-2 weeks. The treatment duration differs from person to person and though no exact guide is available, withdrawal of Apremex Capsule 10's should be attempted after a suitable arrhythmia-free period.

Yes, Apremex Capsule 10's should be taken with food or antacids to avoid stomach upset. Take it at the same time every day. Also, drink enough water while sitting in an upright position.

Country of origin

India

Manufacturer/Marketer address

OFFICE NO. S-1, GROUND FLOOR,SHARDA CHAMBERS PREMISES CO-OPERATIVE SOCIETY LIMITED, NEW MARINE LINES, CHURCHGATE, MUMBAI Mumbai, Maharashtra, India - 400020
Other Info - APR0166

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:03 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/13304/pil
  2. https://www.tga.gov.au/sites/default/files/2023-01/foi-4030-02.pdf
  3. https://medlineplus.gov/druginfo/meds/a607064.html
  4. https://www.drugs.com/cons/mexiletine.html
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