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compositionComposition:DULAGLUTIDE-0.75MG
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Prescription Medicine
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₹2245 with coupons & bank offers*

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Aplevant 0.75 mg Injection is an anti-diabetic medicine used in the treatment of Type II diabetes. This medicine increases insulin release from the pancreas during high blood sugar levels (after meals) and decreases the amount of sugar the liver produces, thereby helping to control blood sugar levels. This medicine may cause common side effects like nausea, vomiting, diarrhoea, decreased appetite, stomach pain, constipation, and feeling tired.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

DULAGLUTIDE-0.75MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aplevant 0.75 mg Injection

Aplevant 0.75 mg Injection is an injectable prescription medicine used to help manage blood sugar levels in adults with type 2 diabetes. It is prescribed to lower blood sugar when used alongside a healthy diet and regular exercise.

Additionally, it helps reduce the risk of major heart-related events like heart attacks or strokes in adults who have both type 2 diabetes and heart disease.

This medicine is taken on a regular schedule as prescribed by your doctor to maintain consistent blood sugar control. You can inject this medicine with or without food, at any time of the day. To achieve the best health results, you should combine this treatment with a balanced diet and regular physical activity.

While taking Aplevant 0.75 mg Injection, you may experience common, mild side effects such as nausea, diarrhoea, vomiting, and stomach discomfort. These symptoms are typically temporary, but you must contact your doctor immediately if you experience severe, continuous stomach pain that spreads to your back.

Before starting this treatment, talk to your doctor if you have a history of pancreas problems, severe digestive issues, or kidney disease. Do not take this medicine if you or anyone in your family has ever had a type of thyroid cancer called medullary thyroid carcinoma, or if you have Multiple Endocrine Neoplasia syndrome type 2.

This medicine can interact with other diabetes medications like insulin, which may increase your risk of low blood sugar, and drinking alcohol can also cause unpredictable blood sugar changes. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should consult your doctor or pharmacist to ensure this treatment is safe for you.

Uses of Aplevant 0.75 mg Injection

Your doctor may prescribe Aplevant 0.75 mg Injection to help manage the following conditions:

  • Type 2 Diabetes Mellitus: It helps lower blood sugar levels in adults when used in combination with diet and exercise.
  • Cardiovascular Risk Reduction: It helps reduce the risk of serious heart-related events, such as heart attacks, strokes, or cardiovascular death, in adults with type 2 diabetes who have established heart disease or multiple heart disease risk factors.

Key Benefits

Aplevant 0.75 mg Injection offers significant everyday benefits that help improve your quality of life while managing a chronic condition:

  • Steady Blood Sugar Control: By keeping your blood sugar levels stable, it helps prevent the fatigue, extreme thirst, and frequent urination associated with high blood sugar.
  • Heart Protection: It provides reassurance by actively lowering your risk of life-threatening cardiovascular complications.
  • Convenient Schedule: Because it is not a daily injection, it easily fits into a busy lifestyle, reducing the daily burden of medication management.
  • Supports Weight Management: Although not a weight loss drug, it slows down stomach emptying, which helps you feel full longer and can support moderate weight reduction.
Side effects of Aplevant 0.75 mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To manage high lipase levels, take the prescribed medication as directed by your doctor.
  • Avoid alcohol to prevent irritation of the pancreas and liver and to prevent interactions with your medications.
  • Follow a low-fat, high-fibre, and low-red meat diet.
  • Stay well-hydrated by drinking 8-12 cups of fluids daily.
  • If you are diagnosed with pancreatitis, you may need to stay in the hospital for fluids, pain relief, and to manage nausea, with a gradual transition to an easy-to-digest diet.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration of treatment.
  • Check the label for directions and use it as advised by the doctor. Aplevant 0.75 mg Injection should be injected subcutaneously (under the skin) on your stomach, thigh, or upper arm.
  • Rotate the injection site each time.
  • Never reuse or share dosing pens.

How Aplevant 0.75 mg Injection Works

Aplevant 0.75 mg Injection contains dulaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that helps improve blood sugar control in people with type 2 diabetes. Dulaglutide works by mimicking the action of GLP-1, a natural hormone released after eating. It increases the release of insulin from the pancreas only when blood sugar levels are high and reduces the release of glucagon, a hormone that signals the liver to produce glucose. This helps lower blood sugar while reducing the risk of low blood sugar when used on its own. It also slows the rate at which food leaves your stomach, helping you feel full for longer and reducing the rise in blood sugar after meals. Together, these actions help improve blood sugar control and may support weight management.
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Alcohol

Unsafe

It is advised to limit alcohol intake since it may worsen the side effects and increase the risk of developing low blood sugar levels.

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Pregnancy

Consult your doctor

Please consult your doctor before starting Aplevant 0.75 mg Injection if you are pregnant or planning to conceive. Your doctor will prescribe only if the benefit outweighs the risk.

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Breast Feeding

Consult your doctor

There is insufficient data on how Aplevant 0.75 mg Injection affects breastfeeding. It is safe to seek medical advice before starting Aplevant 0.75 mg Injection if you are lactating.

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Driving

Caution

Do not drive or operate machinery if you experience any signs of low blood sugar.

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Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases or hepatic impairment when prescribed Aplevant 0.75 mg Injection.

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Kidney

Consult your doctor

Let your doctor know if you have any history of kidney disease when you are prescribed Aplevant 0.75 mg Injection.

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Children

Unsafe

Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

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Heart

Caution

Aplevant 0.75 mg Injection should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before receiving Aplevant 0.75 mg Injection.

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Geriatrics

Caution

Aplevant 0.75 mg Injection should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Aplevant 0.75 mg Injection

If you suspect an overdose or experience severe symptoms like extreme nausea, vomiting, or signs of low blood sugar, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat smaller meals: To help manage initial mild nausea, try eating smaller, more frequent portions throughout the day instead of three large meals.
  • Avoid trigger foods: Limit fried, greasy, or highly sugary foods, as these are more likely to cause or worsen stomach upset.
  • Stay well-hydrated: Drink plenty of water and clear fluids throughout the day, especially if you experience vomiting or diarrhoea, to prevent dehydration.
  • Stay active: Engage in regular, moderate exercise like brisk walking, which works alongside Aplevant 0.75 mg Injection to improve insulin sensitivity and support heart health.
  • Monitor blood sugar: Keep a regular log of your blood sugar readings as recommended by your doctor to help track how well your treatment plan is working.
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Have a query?

How Soon It Starts Working

The time required for Aplevant 0.75 mg Injection to start to work: The exact onset time of Aplevant 0.75 mg Injection has not been clinically established. The time for which the effects of Aplevant 0.75 mg Injection last: The duration of Aplevant 0.75 mg Injection’s effect is clinically not established.

What if you forget to take Aplevant 0.75 mg Injection

If you miss a dose, inject it as soon as you remember, as long as your next scheduled dose is at least 3 days (72 hours) away. If there are fewer than 3 days until your next scheduled dose, skip the missed dose entirely and take your next dose on your regular scheduled day. Do not take two doses within 3 days of each other.

Storage

• Store Aplevant 0.75 mg Injection in the refrigerator between 2°C and 8°C (36°F and 46°F). • Do not freeze this medicine, and do not use it if it has been frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the liquid: Always look at the medicine through the device window before injecting. The liquid must be clear and colourless; do not use it if it looks cloudy, discoloured, or has visible particles.
  • Never share pens: Never share your injection pen or device with anyone else, even if you have changed the needle, to prevent the spread of blood-borne infections.
  • Rotate your injection sites: Switch your injection spot with each dose between your abdomen, thigh, or upper arm to keep your skin healthy and ensure proper absorption.
  • Double-check your medicine: Always read the label on the carton before injecting to make sure you are taking Aplevant 0.75 mg Injection and not another medicine by mistake.
  • Keep a backup handy: Always have a spare injection device available in case your current one is damaged, lost, or stops working.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Aplevant 0.75 mg Injection: 

  • Insulin and Sulfonylureas: Taking Aplevant 0.75 mg Injection with these medications may significantly increase your risk of low blood sugar. Your doctor may need to lower your dose of these other medicines.
  • Oral Medications: Because Aplevant 0.75 mg Injection slows down stomach emptying, it can potentially delay the absorption of other medicines taken by mouth. Tell your doctor about all oral medications you take.
DulaglutideBexarotene
Severe
DulaglutideGatifloxacin
Severe

Drug-Drug Interactions

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DulaglutideBexarotene
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Bexarotene may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Bexarotene, you can take these medicines together if prescribed by a doctor. If you're having symptoms like vomiting, stomach pain, or vomiting, contact a doctor right away. Do not stop using any medications without talking to a doctor.
DulaglutideGatifloxacin
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Gatifloxacin may increase the risk or severity of low blood sugar.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Gatifloxacin, you can take these medicines together if prescribed by a doctor. However, if you experience sweating, headache, shortness of breath, or palpitations, contact a doctor immediately. Do not discontinue any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Some foods or drinks may affect how well Aplevant 0.75 mg Injection works:

  • Alcohol: Drinking alcohol can cause unpredictable blood sugar fluctuations and may increase your risk of low blood sugar or stomach discomfort when combined with Aplevant 0.75 mg Injection.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

You can take (inject) Aplevant 0.75 mg Injection at any time of the day, with or without food. Try to use it on the same day each week. Talk to your doctor or pharmacist if you need help planning your dosing schedule.
Aplevant 0.75 mg Injection is not approved for weight loss. However, many people lose weight during treatment because it slows stomach emptying, helps you feel full for longer, and may reduce appetite. Individual results vary. Talk to your doctor about what to expect.
Store unused Aplevant 0.75 mg Injection in a refrigerator (2°C–8°C), protected from light. Do not freeze it. When traveling, keep it cool (preferably in an insulated travel cooler) and protect it from freezing. If refrigeration is unavailable, it may be kept at room temperature (15°C–30°C) for up to 14 days.
Take the missed dose as soon as you remember, provided your next scheduled dose is at least 3 days (72 hours) away. If your next dose is due in less than 3 days, skip the missed dose and continue with your regular schedule. Do not take two doses together.
Aplevant 0.75 mg Injection on its own rarely causes low blood sugar, but the risk increases if you take it with other diabetes medicines like insulin or sulfonylureas. Talk to your doctor about how to recognise and manage low blood sugar.
You can inject this medicine under the skin of your stomach, thigh, or upper arm. Remember to change your injection spot with each dose to protect your skin. Talk to your doctor or pharmacist if you need a demonstration on how to inject properly.
No, you must never share your injection pen or device with anyone else, even if the needle has been changed, as this can transmit serious blood infections. Talk to your doctor if you have safety concerns.
Nausea is a common side effect when starting this medicine. Eating smaller meals, avoiding greasy foods, and staying hydrated can help ease this symptom. Talk to your doctor if the nausea is severe or does not go away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - APL0045
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