Apilok-O Tab 10'S

Prescription drug

MRP ₹68.5

(Inclusive of all Taxes)

₹10.3 Cashback (15%)

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Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Apilok-O Tablet is used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting. It contains Ranitidine and ondansetron, which reduces the amount of acid in the stomach and helps relieve acid-related heartburn and indigestion. Also, it blocks serotonin's action, a natural substance that may cause nausea and vomiting. As a result, it prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness. It may cause side effects such as diarrhoea, headache, constipation, fatigue, drowsiness, dryness in the mouth, muscle pain and skin flushing. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Apilok-O Tablet

Apilok-O Tablet belongs to a group of medications called ‘gastrointestinal agent’ and ' anti-emetics'. It is primarily used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting. GERD is a condition in which the valve (sphincter) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, stomach acid enters the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the natural response to the body to discharge the stomach contents forcefully.

Apilok-O Tablet is a combination of two medicines: Ranitidine (antacid) and ondansetron (antiemetics). Ranitidine, which is an H2 blocker (antacid) which reduces the amount of acid in the stomach and helps relieve acid-related heartburn and indigestion. On the other hand, 'Ondansetron' works by blocking serotonin's action, a natural substance that may cause nausea and vomiting. As a result, Apilok-O Tablet prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Take Apilok-O Tablet as prescribed by your doctor. You are advised to take Apilok-O Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. You may experience diarrhoea, headache, constipation, fatigue, drowsiness, dryness in the mouth, muscle pain and skin flushing. Most of these side effects of Apilok-O Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try to avoid caffeine-containing beverages (tea, coffee), spicy/deep fried/processed food, carbonated drinks, and acidic food like citrus fruits. Tell your doctor if you have allergic to Apilok-O Tablet , have stomach or intestinal cancer, liver problem, or will have an endoscopy in the future. Tell your doctor if you are facing liver, kidney, or heart disorders. A pregnant woman should tell their doctor about their pregnancy as this medicine cannot be used in pregnancy as it may cause a birth deformity in children. Apilok-O Tablet could pass in breastfeeding milk so it should not be given to a woman who is breastfeeding her baby.

Uses of Apilok-O Tablet

Apilok-O Tablet is used to treat gastrointestinal disorders. The detailed uses of Apilok-O Tablet are as follows:

Gastroesophageal reflux disease (GERD): Apilok-O Tablet reduces acid reflux, heartburn, and irritation in the esophagus.
Peptic ulcer: Apilok-O Tablet aids healing of ulcers in the stomach and upper intestine by lowering acid production.
Gastritis: Apilok-O Tablet protects the stomach lining and reduces inflammation caused by gastritis.
Nausea and vomiting: Apilok-O Tablet helps prevent and control feelings of nausea and vomiting.
Prevention of acid-related complications: Apilok-O Tablet protects the oesophagus and stomach lining from damage due to excess acid.

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Directions for Use

Take Apilok-O Tablet with or without food or as advised by a doctor.
Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
Swallow the medicine as a whole with glass of water.
Do not crush, break, or chew it.

Medicinal Benefits

Apilok-O Tablet is a combination of two medicines: Ranitidine (antacid), and ondansetron (antiemetics). It is primarily used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting. Apilok-O Tablet contains Ranitidine which helps reduce the excess amount of stomach acid. In turn, it prevents the formation of an ulcer in the stomach (peptic ulcer) or gastroesophageal reflux disease (GERD) with or without an ulcer. On the other hand, Apilok-O Tablet is used to prevent nausea and vomiting associated with cancer chemotherapy, radiotherapy, surgery, pregnancy and motion sickness in adults and children above four years of age. When serotonin level increases in the blood, it stimulates the CTZ receptor (chemoreceptor trigger zone) located in the brain responsible for controlling nausea and vomiting. Apilok-O Tablet acts by inhibiting the release of this serotonin, thereby preventing nausea and vomiting.

How Apilok-O Tablet Works

Apilok-O Tablet is a combination of two medicines: Ranitidine (antacid) and ondansetron (antiemetics). Ranitidine, which is an H2 blocker (antacid) which reduces the amount of acid in the stomach and helps relieve acid-related heartburn and indigestion. On the other hand, 'Ondansetron' works by blocking serotonin's action, a natural substance that may cause nausea and vomiting. As a result, Apilok-O Tablet prevents the sensation of nausea and vomiting caused due to conditions like surgery, cancer chemotherapy, pregnancy or motion sickness.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Apilok-O Tab

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drowsiness

Get enough sleep. Maintain a regular sleep cycle.
Eat a healthy diet and exercise regularly.
Manage stress with yoga or meditation.
Limit alcohol and caffeine.
Avoid driving or operating machinery unless you are alert.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Sensation Of Warmth/ Flushing

Avoid rubbing or scratching the affected area, as this can cause further irritation and discomfort.
Consider using a humidifier to add moisture to the air and help reduce the sensation.
Seek medical attention if the sensation is severe, persistent, or worsens over time.
Avoid extreme temperatures, such as hot or cold showers, that can exacerbate the sensation.
Wear light, breathable clothing to help keep the body cool and reduce the sensation.
Avoid triggers that can cause the sensation, such as spicy foods or hot drinks.
Use cool compresses or fans to help lower body temperature and reduce the sensation.

General Feeling Of Discomfort Or Unease

Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:

If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
Inform your doctor about the medication you're taking and the symptoms you're experiencing.
Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Apilok-O Tablet

Do not take more than the prescribed dose of Apilok-O Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

You should avoid taking Apilok-O Tablet if you are allergic to Apilok-O Tablet . Before taking Apilok-O Tablet , inform your doctor if you have stomach cancer, diabetes, or liver disease. People with an irregular heartbeat (arrhythmia) and phenylketonuria (too much protein phenylalanine in the blood) should not take Apilok-O Tablet as it may cause severe conditions. A pregnant woman should tell their doctor about their pregnancy as this medicine cannot be used in pregnancy as it may cause a birth deformity in children. Apilok-O Tablet could pass in breastfeeding milk, so it should not be given to a woman who is breastfeeding her baby. Apilok-O Tablet contains lactose so tell your doctor if you have an intolerance to some sugars.

Drug-Drug Interactions

OndansetronZiprasidone

Critical

RanitidineGefitinib

Severe

Drug-Drug Interactions

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OndansetronZiprasidone

Critical

How does the drug interact with Apilok-O Tab:
Taking Apilok-O Tab with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Apilok-O Tab with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

RanitidineGefitinib

Severe

How does the drug interact with Apilok-O Tab:
Coadministration of Gefitinib with Apilok-O Tab can reduce the acidity levels in the stomach and also decrease the effectiveness of gefitinib

How to manage the interaction:
Taking Gefitinib with Apilok-O Tab together can possibly result in an interaction, it can be taken if your doctor has advised it. It is recommended that gefitinib is either taken 6 hours before or 6 hours after Apilok-O Tab to help minimize the impact of the interaction. Do not stop using any medications without first talking to your doctor.

RanitidineAtazanavir

Severe

How does the drug interact with Apilok-O Tab:
Taking atazanavir with Apilok-O Tab can reduce the effectiveness of atazanavir.

How to manage the interaction:
Although taking Apilok-O Tab together with Atazanavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor if you experience unusual symptoms. Do not discontinue any medicine without consulting a doctor.

RanitidinePazopanib

Severe

How does the drug interact with Apilok-O Tab:
Using Pazopanib with Apilok-O Tab can reduce the effectiveness of pazopanib

How to manage the interaction:
Although taking Apilok-O Tab together with Pazopanib can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

RanitidineLoperamide

Severe

How does the drug interact with Apilok-O Tab:
Coadministration of loperamide with Apilok-O Tab may significantly increase the blood levels of loperamide. This can increase the risk of serious side effect like irregular heart rhythm.

How to manage the interaction:
Although taking loperamide with Apilok-O Tab together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

RanitidineDasatinib

Severe

How does the drug interact with Apilok-O Tab:
Taking Apilok-O Tab and Dasatinib together reduces the effectiveness of Dasatinib.

How to manage the interaction:
Although taking Apilok-O Tab together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience any unusual symptoms. Do not discontinue any medicine without consulting a doctor.

RanitidineMesalazine

Severe

How does the drug interact with Apilok-O Tab:
Co-administration of Apilok-O Tab with Mesalazine can decrease the levels of Mesalazine, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesalazine with Apilok-O Tab, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

RanitidineRilpivirine

Severe

How does the drug interact with Apilok-O Tab:
Coadministration of Rilpivirine with Apilok-O Tab can reduce the acidity levels in the stomach and also decrease the effectiveness of Rilpivirine.

How to manage the interaction:
Although taking Apilok-O Tab together with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. To reduce the chance of interaction, take Apilok-O Tab at least 12 hours before or 4 hours after taking rilpivirine. Do not discontinue any medicine without consulting a doctor.

OndansetronMirtazapine

Severe

How does the drug interact with Apilok-O Tab:
Using Apilok-O Tab with mirtazapine might raise serotonin hormone levels in the body, affects the brain and nerve cells.

How to manage the interaction:
Co-administration of Apilok-O Tab along with mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor. Do not discontinue any medications without a doctor's advice.

OndansetronTranylcypromine

Severe

How does the drug interact with Apilok-O Tab:
When Apilok-O Tab, is taken with tranylcypromine it increases the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
Although taking Apilok-O Tab along with tranylcypromine can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, see a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Avoid intake of acid or heartburn triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing backflow of the stomach acid back into the food pipe.
A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils and low-fat dairy products will help to keep a person in good health and avoid chances of nausea and vomiting.
One should avoid taking greasy or oily foods as this food triggers nausea and vomit.
Eat cool foods instead of hot and spicy foods.
Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up which has got lost due to vomiting.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

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Alcohol

Unsafe

One should avoid consuming alcohol while taking Apilok-O Tablet as this medicine can interact with alcohol and may worsen the side effects.

Pregnancy

Unsafe

Apilok-O Tablet is not allowed to use in pregnancy as Apilok-O Tablet can seriously affect the fetus or unborn baby.

Breast Feeding

Caution

Apilok-O Tablet contains Ondansetron that can pass into breast milk, so a lactating mother should tell their doctor before taking this medicine.

Driving

Caution

Apilok-O Tablet may cause dizziness, low blood pressure, headache, drowsiness as a side effect. A person taking Apilok-O Tablet should avoid driving or operating any heavy machinery or tasks requiring mental alertness.

Liver

Caution

If you have or had a history or evidence of any liver-related diseases, please consult the doctor before taking Apilok-O Tablet .

Kidney

Caution

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking Apilok-O Tablet .

Children

Safe if prescribed

For children, Apilok-O Tablet is used safely and effectively. The dose needs to be adjusted and recommended by a child specialist.

Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

Geriatrics

Safe if prescribed

Apilok-O Tablet can be safely given in elderly patients if recommended by the physician.

FAQs

What is the use of Apilok-O Tablet ?

Apilok-O Tablet is used to treat gastro-oesophageal reflux disease (GERD), indigestion, heartburn, acid reflux, nausea, and vomiting.

Dose Apilok-O Tablet cause gastric bleeding?

No, Apilok-O Tablet prevents excess production of stomach acid, causing acid reflux and heartburn. If blood is coming in your stool or mucous, immediately contact the doctor.

I am facing severe constipation, so should I take Apilok-O Tablet ?

Tell your doctor if you are facing severe constipation as after checking your condition, the doctor will decide that you can take this medicine or not.

Can I drive a car after taking Apilok-O Tablet ?

Apilok-O Tablet may cause dizziness, low blood pressure, headache, and drowsiness as a side effect. So, one should avoid driving or operating any machine that requires mental alertness.

What are the serious side effects of Apilok-O Tablet ?

Apilok-O Tablet may have some serious side effects, but these are rare. These side effects may include hives, skin rash, itching and difficulty breathing. Inform your doctor in case you notice any of these side effects.

Can a woman who is breast feeding her child take Apilok-O Tablet ?

Apilok-O Tablet may pass into a mother's milk, so mothers who are taking Apilok-O Tablet should not breastfeed their child. A woman should tell their doctor if they are breastfeeding mother.

Is Apilok-O Tablet addictive or habit forming?

No, Apilok-O Tablet does not have any addictive effects.

Country of origin

India

Manufacturer/Marketer address

No. 8/2, Sarvpriya Vihar, Sarvapriya Vihar, New Delhi-110016, Delhi, India

Other Info - API0115

Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 3, 2025 | 7:31 AM IST

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