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Antoff-OZ Plus Tablet is used to treat diarrhoea and dysentery caused by infections. It also helps prevent or treat various infections or diseases related to the stomach and intestines. This medication contains Lactobacillus, Ofloxacin, Ornidazole, and Saccharomyces boulardii, which work together to restore good bacteria in the gut and eliminate infection-causing bacteria and parasites. It may sometimes cause side effects such as gas, bloating, constipation, nausea, vomiting, diarrhoea, stomach pain, headache, and dizziness. Before taking this medication, inform your doctor if you are allergic to any of its ingredients, pregnant or breastfeeding, taking any other medications, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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More about the Product

About Antoff-OZ Plus Tablet

Antoff-OZ Plus Tablet is a prescription drug primarily used to treat infectious diarrhoea, dysentery, and mixed gastrointestinal infections caused by bacteria and parasites. It helps eliminate harmful pathogens in the gut while restoring the natural balance of beneficial digestive flora. Doctors prescribe this medicine to quickly resolve severe stomach upsets, cramping, and loose stools.

To achieve the best results, takeAntoff-OZ Plus Tablet at the exact times prescribed by your doctor, keeping your dosing schedule consistent every day. It is generally recommended to take this medicine with food to prevent stomach upset and irritation. Drinking plenty of fluids and eating bland, easily digestible foods will further assist your recovery.

While taking Antoff-OZ Plus Tablet, you may experience mild, temporary side effects such as nausea, a metallic taste in your mouth, or mild stomach discomfort. However, if you experience serious side effects like severe skin rashes, muscle weakness, or persistent joint pain, stop taking the medicine and seek medical attention immediately.

Do not take this if you have a known allergy to any of its ingredients or similar antibiotic medicines. Before starting this treatment, tell your doctor if you have a history of tendon problems, nerve disorders, epilepsy, or liver damage. It is also important to disclose any underlying kidney conditions, as your doctor may need to adjust your dose.

Avoid drinking alcohol during your treatment and for at least 3 days (72 hours) after your final dose. The ornidazole component in this medicine causes a severe disulfiram-like reaction when mixed with alcohol, leading to intense nausea, vomiting, rapid heart rate, and throbbing headaches. Tell your doctor about all other medicines you take, especially blood thinners or antacids, which can reduce how well this medicine works. Pregnant, breastfeeding, or elderly individuals must consult their healthcare provider before using this medicine to ensure safety.

Uses of Antoff-OZ Plus Tablet

Antoff-OZ Plus Tablet is used to treat various bacterial and parasitic gastrointestinal infections. The detailed uses of Antoff-OZ Plus Tablet are as follows:

  • Infectious diarrhoea: Antoff-OZ Plus Tablet helps clear severe bacterial infections in the gut, reducing stool frequency and relieving painful abdominal cramps.
  • Amoebic Dysentery: It targets and destroys parasites in the intestines, stopping blood and mucus in the stool and reducing gut inflammation.
  • Mixed Gastrointestinal Infections: The medicine treats dual infections caused by both bacteria and protozoa, helping to completely clear the digestive tract.
  • Antibiotic-Associated diarrhoea: By supplying beneficial microbes, it prevents and manages loose stools that often occur when taking strong antibiotics.

Key Benefits

Antoff-OZ Plus Tablet provides rapid, comprehensive relief from debilitating stomach infections by addressing both the root cause and the digestive aftermath. By combining infection-fighting agents with gut-protective probiotics, it shortens the duration of illness and helps you return to your normal daily activities faster. Key benefits of taking Antoff-OZ Plus Tablet include:

  • Rapid Symptom Relief: Quickly reduces the urgency, frequency, and watery consistency of loose stools.
  • Protects Digestive Health: Prevents the common 'wiped-out' feeling in the gut by restoring healthy bacteria, reducing the chance of secondary diarrhoea.
  • Fights Multiple Pathogens: Works simultaneously against bacteria and single-celled parasites, ensuring complete clearance of mixed infections.
  • Reduces Abdominal Cramping: By calming inflammation and eliminating toxins, it helps soothe painful stomach spasms.

Directions for Use

  • Antoff-OZ Plus Tablet can be taken with or without food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Antoff-OZ Plus Tablet as a whole with a glass of water.
  • Do not break, crush, or chew it.

How Antoff-OZ Plus Tablet Works

Antoff-OZ Plus Tablet contains lactobacillus, ofloxacin, ornidazole, and Saccharomyces boulardii. Lactobacillus is a beneficial lactic acid-producing bacterium that protects your digestive system during treatment. It repopulates the gut, crowds out harmful microbes, and produces organic acids that make the environment unfavourable for infection-causing germs. Ofloxacin is a broad-spectrum fluoroquinolone antibiotic. It works by blocking vital enzymes (DNA gyrase and topoisomerase IV) that bacteria need to repair and copy their DNA. Without these enzymes, the bacteria cannot multiply or survive, halting the spread of the infection. Ornidazole is an antiprotozoal and antibacterial agent. It penetrates the cells of parasites and specific anaerobic bacteria (germs that thrive in low-oxygen areas like the intestines). Once inside, it damages their DNA, effectively stopping the infection from spreading. Saccharomyces boulardii is a therapeutic yeast probiotic. It binds to harmful toxins produced by pathogens, neutralises them, and supports the intestinal barrier. This yeast is naturally resistant to antibiotics, meaning it remains active and protective even while the infection is being cleared.
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Alcohol

Unsafe

Antoff-OZ Plus Tablet may interact with alcohol and increase the risk of side effects. Therefore, avoid consuming alcohol while using Antoff-OZ Plus Tablet.

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Pregnancy

Caution

Please consult your doctor before taking Antoff-OZ Plus Tablet if you are pregnant or planning to become pregnant. Your doctor will prescribe you Antoff-OZ Plus Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Antoff-OZ Plus Tablet may pass into breastmilk, so it is not recommended for breastfeeding women unless advised by a doctor and the benefits outweigh the risks.

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Driving

Caution

Antoff-OZ Plus Tablet may also cause dizziness, so avoid driving or operating machines until you are mentally alert.

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Liver

Caution

Antoff-OZ Plus Tablet should be used with caution in patients with liver impairment. Please inform your doctor if you have a history of liver disease. Your doctor may have to adjust the dose of Antoff-OZ Plus Tablet based on the severity of your condition.

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Kidney

Caution

Antoff-OZ Plus Tablet should be used with caution in patients with kidney impairment. Please inform your doctor if you have a history of kidney disease. Your doctor may have to adjust the dose of Antoff-OZ Plus Tablet based on the severity of your condition.

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Children

Unsafe

Antoff-OZ Plus Tablet should not be used in children under 18 years of age unless prescribed by your doctor.

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Heart

Consult your doctor

Please consult your doctor if you have any pre-existing heart disease before using Antoff-OZ Plus Tablet.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Antoff-OZ Plus Tablet in elderly patients.

What if I have taken an overdose of Antoff-OZ Plus Tablet

If you suspect an overdose or have taken more than the prescribed amount of Antoff-OZ Plus Tablet, seek immediate medical attention or visit the nearest emergency room. Symptoms of an overdose may include severe dizziness, confusion, nausea, vomiting, or seizures.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, such as oral rehydration solutions (ORS), clear broths, or coconut water, to replenish lost electrolytes and prevent dehydration.
  • Eat a bland diet: Follow the BRAT diet (bananas, rice, applesauce, toast) or eat easily digestible, low-fibre foods until your stomach settles.
  • Avoid dairy and high-fat foods: Steer clear of milk, cheese, butter, and fried foods, as these can irritate an already sensitive bowel and worsen diarrhoea.
  • Avoid caffeine and sugar: Limit drinks containing caffeine, alcohol, or high amounts of sugar, as they can stimulate your bowel and increase fluid loss.
  • Practice strict hygiene: Wash your hands thoroughly with soap and water before preparing or eating food, and after using the restroom, to prevent spreading the infection.
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Have a query?

How Soon It Starts Working

The time required for Antoff-OZ Plus Tablet to start to work: Antoff-OZ Plus Tablet shows its action within a few hours of administration. The time for which the effects of Antoff-OZ Plus Tablet last: The effect of Antoff-OZ Plus Tablet usually lasts for 12-24 hours.

What if you forget to take Antoff-OZ Plus Tablet

If you miss a dose of Antoff-OZ Plus Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects. If you are unsure, talk to your doctor or pharmacist.

Storage

•Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F), in a cool, dry place.•Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F), in a cool, dry place.

Drug Warnings

  • Complete the full course: Always finish the entire quantity of Antoff-OZ Plus Tablet prescribed by your doctor, even if your symptoms clear up after a couple of days.
  • Avoid direct sunlight: This medicine can make your skin more sensitive to UV light. Wear protective clothing and apply a broad-spectrum sunscreen when outdoors to avoid severe sunburns.
  • Rest your tendons: If you experience any sudden joint or tendon pain, stop exercising, rest the affected area, and contact your doctor immediately, as certain ingredients can increase the risk of tendon injury.
  • Do not drive if dizzy: This medicine may cause dizziness or sleepiness. Avoid driving, operating heavy machinery, or performing tasks that require full mental alertness until you know how it affects you.
  • Inspect the packaging: Do not take the tablets if the protective foil blister is torn, punctured, or shows signs of tampering.
  • Check for nerve changes: Inform your doctor immediately if you notice any numbness, tingling, or unusual sensitivity in your fingers or toes while taking Antoff-OZ Plus Tablet.

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  • Antacids and Mineral Supplements: Taking medicines containing magnesium, aluminium, iron, or zinc close to your dose can significantly lower the absorption of Antoff-OZ Plus Tablet, making it less effective. Take these supplements at least 2 hours before or 2 hours after this medicine.
  • Blood Thinners (e.g., Warfarin): This medicine can enhance the effects of blood thinners, increasing your risk of bleeding. Your doctor may need to monitor your blood clotting times more closely.
  • Corticosteroids: Combining this medicine with oral steroids can increase the risk of tendon inflammation or rupture, especially in older adults.
  • Pain Relievers (NSAIDs): Taking nonsteroidal anti-inflammatory drugs like ibuprofen alongside this medicine can increase the risk of central nervous system side effects, including seizures.
  • QT-Prolonging Medicines: Combining this medicine with other drugs that affect heart rhythm (such as azithromycin, certain antihistamines, or antipsychotics) increases the risk of serious heart rhythm abnormalities.

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  • Dairy Products and Calcium-Fortified Juices: Consuming large amounts of calcium-rich foods or drinks directly with your dose can interfere with how the medicine is absorbed. Keep a gap of at least 2 hours between consuming these items and taking your tablet.
  • Caffeine: This medicine can slow down how your body processes caffeine, leading to increased heart rate, nervousness, or sleep issues.

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS, ANTIPROTOZOALS, ANTIDIARRHEALS]

FAQs

Antoff-OZ Plus Tablet is an antibacterial medication primarily used to treat diarrhoea and dysentery caused by infections. It also helps prevent or treat various other conditions, such as inflammatory bowel disease, irritable bowel syndrome, intra-abdominal infections, recurrent infections caused by Clostridium difficile, and postoperative infections
Antoff-OZ Plus Tablet contains four active ingredients: Lactobacillus, Ofloxacin, Ornidazole, and Saccharomyces boulardii. Lactobacillus and Saccharomyces boulardii are probiotics that help restore good bacteria while preventing the growth of harmful bacteria in the gut. Ofloxacin is an antibiotic that kills bacteria by inhibiting the activity of an enzyme (DNA gyrase) required by bacteria for replicating and repairing its genetic material (DNA). Ornidazole is an antiprotozoal/antibiotic that kills bacteria and parasites by inhibiting protein synthesis and damaging their DNA, leading to cell death. Together, Antoff-OZ Plus Tablet effectively treats diarrhoea and dysentery by clearing the infections in the stomach and intestines.
Antoff-OZ Plus Tablet may cause common side effects such as gas, bloating, constipation, nausea, vomiting, diarrhoea, stomach pain, headache, and dizziness. Most of these side effects will gradually resolve over time without requiring medical attention. However, if you experience any of these side effects persistently, please consult your doctor.
Antoff-OZ Plus Tablet should not be taken with antacids or medications containing iron or zinc at the same time. You should maintain a gap of 2 hours between the two medications.
Consult your doctor if you do not get better even after completing the course of treatment or if your condition worsens during treatment with Antoff-OZ Plus Tablet. Your doctor may adjust the dose or prescribe alternate medication based on your condition.
Antoff-OZ Plus Tablet contains ofloxacin, which may interfere with the results of urine tests for drugs (such as opioids). Therefore, inform your healthcare provider before undergoing urine screening that you are taking Antoff-OZ Plus Tablet.
Do not discontinue Antoff-OZ Plus Tablet without consulting your doctor, even if you feel better. To treat your condition effectively, keep taking Antoff-OZ Plus Tablet for the prescribed duration.
Antibiotics can destroy both harmful and beneficial bacteria in your gut, which often causes secondary diarrhoea. Antoff-OZ Plus Tablet includes beneficial bacteria and yeast probiotics to replenish and protect your natural gut flora, minimising stomach upset and helping your digestive system recover faster. Talk to your doctor for more information.
Antoff-OZ Plus Tablet is generally not recommended during pregnancy unless your doctor decides that the benefits outweigh the potential risks to the developing baby. Certain components in this medicine may affect fetal development. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before taking this medicine.
Yes, one of the active ingredients in Antoff-OZ Plus Tablet can make your skin highly sensitive to ultraviolet (UV) light, which may lead to severe sunburns or skin rashes. Avoid prolonged exposure to direct sunlight, tanning beds, and sunlamps. Apply a broad-spectrum sunscreen and wear protective clothing when going outdoors. If you experience skin irritation, talk to your doctor.
If you develop sudden pain, swelling, or inflammation in your joints or tendons (especially your Achilles tendon), stop taking the medicine immediately, rest the affected limb, and contact your healthcare provider right away. Certain antibiotics in this combination are linked to a rare but serious risk of tendon injury. Talk to your doctor to find a safe alternative treatment.
Yes, experiencing a metallic or bitter taste in your mouth is a common and temporary side effect of Antoff-OZ Plus Tablet. It typically goes away once you complete your course of treatment. Staying hydrated, chewing sugar-free gum, or sucking on hard candies can help manage this discomfort. If the taste is highly bothersome or is accompanied by other severe symptoms, talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - AN32828
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