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  3. Agotine 25 mg Tablet 10's

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Agotine 25 mg Tablet 10's, Pack of 10 IndiaS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Agotine 25 mg Tablet is used to treat depression. It contains Agomelatine, which works by altering the levels of certain chemicals in the brain, which helps regulate mood and behaviour. In some cases, this medicine may cause side effects such as headache, nausea, dizziness, fatigue, anxiety, difficulty sleeping, abdominal pain, diarrhoea, constipation, and sleepiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

AGOMELATINE-25MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Agotine 25 mg Tablet

Agotine 25 mg Tablet is used for the treatment of depression and may also be used to prevent the relapse of depression symptoms. Major depressive disorder is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. Fortunately, it is also treatable. Depression causes feelings of sadness and/or a loss of interest in activities.

Agotine 25 mg Tablet contains 'Agomelatine', which works by altering the levels of certain chemicals in the brain, which helps in regulating the body clock (circadian natural cycle of physical, mental, and behavioural changes that the body goes through in a 24-hour cycle) with positive benefits on mood and sleep in patients suffering from depression.

Take Agotine 25 mg Tablet as prescribed by your doctor. You are advised to take Agotine 25 mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. You may experience headache, nausea, dizziness, fatigue, anxiety, insomnia (difficulty in sleeping), back pain, abdominal pain, change in body weight, diarrhoea, constipation, sleepiness, and Increased liver enzymes in some cases. Most of these side effects of Agotine 25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, stop the medicine, and please consult your doctor.

If you are allergic to Agotine 25 mg Tablet or any other medicines, please tell your doctor. Take the Agotine 25 mg Tablet as advised by your doctor. Before taking Agotine 25 mg Tablet , tell your doctor about the medicines which you are taking other than Agotine 25 mg Tablet . Before taking Agotine 25 mg Tablet , consult your doctor if you are pregnant/planning to get pregnant/breast-feeding women. Agotine 25 mg Tablet should be used with caution in electroconvulsive therapy patients and kidney and liver patients as there is an increased risk of adverse effects. Agotine 25 mg Tablet should be used with caution in elderly patients as there is an increased risk of adverse effects.

Uses of Agotine 25 mg Tablet

Treatment of Major depressive disorder

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Directions for Use

• Agotine 25 mg Tablet can be taken with or without food as advised by your doctor.• Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.• Swallow Agotine 25 mg Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Agotine 25 mg Tablet contains 'Agomelatine', which belongs to a class of antidepressants that works by altering the levels of certain chemicals in the brain. This helps regulate the body clock (circadian rhythm—the natural cycle of physical, mental, and behavioural changes that the body goes through in a 24-hour cycle) and has positive effects on mood and sleep in patients suffering from depression.

How Agotine 25 mg Tablet Works

Agotine 25 mg Tablet contains Agomelatine, which works by altering the levels of certain chemicals in the brain, which helps in regulating the body clock (circadian natural of physical, mental, and behavioural changes that the body goes through in a 24-hour cycle) with positive benefits on mood and sleep in patients suffering from depression.

Storage

stored at room temperature below 30°C
Side effects of Agotine 25 mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Keep regular sleeping hours.
  • Don’t consume nicotine, caffeine, or alcohol in the hours leading up to bed.
  • Practice relaxation exercises before bedtime.
  • Regular physical activity can promote deeper and better sleep. However, avoid intense exercise within 2-3 hours of bedtime, as it can disrupt your sleep.
  • If nightmares continue, cognitive behavioral therapy (CBT) may be a helpful treatment option. Your doctor may recommend CBT to address underlying issues and provide coping strategies to manage nightmares.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Agotine 25 mg Tablet

Take Agotine 25 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sleepiness, fatigue, anxiety, agitation, dizziness, tension, upper stomach pain, cyanosis (blue colouration of skin), and general discomfort. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Agotine 25 mg Tablet or any other medicines, please tell your doctor. Take the Agotine 25 mg Tablet as advised by your doctor. Before taking Agotine 25 mg Tablet , tell your doctor about the medicines which you are taking other than Agotine 25 mg Tablet . Before taking Agotine 25 mg Tablet , consult your doctor if you are pregnant/planning to get pregnant/breast-feeding women. Agotine 25 mg Tablet should be used with caution in electro-convulsive therapy patients and kidney and liver patients as there is an increased risk of adverse effects. Agotine 25 mg Tablet should be used with caution in elderly patients as there is an increased risk of adverse effects. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. Be vigilant about unusual darkening or any changes in the colour of your urine, light-colored stools, yellowing of skin or eyes, pain in the upper right part of your stomach and unusual fatigue, as these could be signs of liver problems. It is important to inform your doctor if you develop any unusual changes in mood or behaviour, new or worsening depression or suicidal thoughts. Agotine 25 mg Tablet  should be used with caution in patients with a history of bipolar disorder, mania or hypomania and should be discontinued if a patient develops manic symptoms. Caution should be taken in non-alcoholic fatty liver disease, obese and alcoholic patients and smokers.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take fish, nuts, fresh fruits, vegetables, meat and dairy products.
  • Do meditation, yoga and exercise regularly.
  • Take carbohydrates like whole grains and legumes in your diet.
  • Spend time with positive, supportive, loving people to help you through rocky times.
  • Avoid alcohol
  • Quit smoking

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Agotine 25 mg Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Consumption of alcohol is not recommended during treatment with this Agotine 25 mg Tablet due to the increased risk of severe adverse effects including liver damage.

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Pregnancy

Caution

Agotine 25 mg Tablet is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential risks and benefits associated with the use of this medicine.

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Breast Feeding

Caution

Agotine 25 mg Tablet is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

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Driving

Caution

Agotine 25 mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Agotine 25 mg Tablet should be used with caution in patients who are at risk of liver injuries such as diabetic patients, obese or overweight patients, etc., due to the increased risk of liver damage. Regular assessment of liver function is necessary before initiating the therapy with this medicine and during the therapy. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

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Kidney

Caution

Agotine 25 mg Tablet should be used with caution in patients with kidney disease. No dose adjustment of Agotine 25 mg Tablet is recommended.However, talk to your doctor if you have any underlying kidney disease.

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Children

Caution

Agotine 25 mg Tablet is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

FAQs

Agotine 25 mg Tablet used for the treatment of symptoms of depression. It may also be used to prevent the relapse of depression symptoms. This medicine helps in regulating the body clock (circadian rhythm) with positive benefits on mood and sleep in patients suffering from depression.

Common side effects of Agotine 25 mg Tablet are headache, nausea, dizziness, fatigue, anxiety, insomnia (difficulty in sleeping), back pain, abdominal pain, change in body weight, diarrhea, constipation, sleepiness, Increased liver enzymes in some cases. Most of these side effects of Agotine 25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, stop the medicine and please consult your doctor.

No, do not stop Agotine 25 mg Tablet suddenly is unlikely to cause unpleasant withdrawal symptoms, but you may become unwell again.so please consult your doctor before stopping the Agotine 25 mg Tablet .

Yes, Agotine 25 mg Tablet may cause drowsiness or affect concentration and co-ordination. Therefore, it is recommended to avoid driving or any other activities that require mental alertness after taking Agotine 25 mg Tablet .

Agotine 25 mg Tablet should be used with extreme caution due to the increased risk of suicidal tendencies. Patients should be closely monitored for any change in mood or behavior. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Agotine 25 mg Tablet works by altering the levels of certain chemicals in the brain, which helps in regulating the body clock (circadian natural cycle of physical, mental, and behavioural changes that the body goes through in a 24-hour cycle) with positive benefits on mood and sleep in patients suffering from depression.

Before starting treatment with Agotine 25 mg Tablet , inform your doctor if you are allergic to any of ingredients in Agotine 25 mg Tablet , if you have a history of bipolar disorder, mania, or hypomania, if your liver does not function properly (e.g., non-alcoholic fatty liver disease), or if you are taking fluvoxamine (an antidepressant) or ciprofloxacin (an antibiotic).

Yes, Agotine 25 mg Tablet can potentially damage your liver, especially if you already have liver problems. Inform your doctor immediately if you notice unusual darkening or any changes in the colour of your urine, light-coloured stools, yellowing of the skin or eyes, pain in the upper right part of your abdomen, or unusual fatigue, as these could be signs of liver problems.

If your doctor changes your previous antidepressant to Agotine 25 mg Tablet , they will guide you on how to safely discontinue the previous medication while starting Agotine 25 mg Tablet . You may experience withdrawal symptoms such as dizziness, numbness, trouble sleeping, feelings of anxiety or restlessness, headaches, nausea, vomiting, or shaking. These symptoms are usually mild to moderate and should resolve on their own within a few days. If your symptoms worsen, inform your doctor right away.

Store Agotine 25 mg Tablet in its original package to protect it from moisture. This medicine doesn't need special temperature conditions. Keep it out of sight and reach of children.

No, Agotine 25 mg Tablet is not recommended for children below 18 years of age, as its safety and efficacy have not been established for this age group.

Country of origin

India

Manufacturer/Marketer address

Unichem Laboratories Ltd., Unichem Bhavan, Prabhat Estate, Off S.V.Road, Jogeshwari (West), Mumbai ? 400 102.
Other Info - AGO0007

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:46 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/6564/smpc#PRODUCTINFO
  2. https://www.mims.com/malaysia/drug/info/agomelatine?mtype=generic
  3. https://www.news-medical.net/drugs/Valdoxan.aspx

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