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  3. Adthal 50mg Capsule

Adthal 50mg Capsule, Pack of 1 Capsule
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Adthal 50mg Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (inflammatory disorder). It contains Thalidomide, which works by preventing the development of cancer cells and stimulating the immune system to attack the cancer cells. In some cases, this medicine may cause side effects such as constipation, dizziness, sleepiness, tiredness, tremors, low blood cell count, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

THALIDOMIDE-50MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

ORAL

Return Policy :

Not Returnable

About Adthal 50mg Capsule

Adthal 50mg Capsule is used to treat multiple myeloma. Adthal 50mg Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence. Multiple myeloma is a type of cancer that affects a type of white blood cells called plasma cells. ENL is an immune-mediated inflammatory complication of leprosy.
 
Adthal 50mg Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal 50mg Capsule helps treat multiple myeloma.

You are advised to take Adthal 50mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as constipation, dizziness, sleepiness, tiredness, tremors, dysaesthesia (abnormal sensation), low blood cell count, nausea, vomiting, and swelling of hands and feet. Speak with your doctor if you experience any of these side effects persistently.
 
Do not take Adthal 50mg Capsule if you are pregnant as it might cause severe birth defects or the death of an unborn baby. Avoid taking Adthal 50mg Capsule if you are breastfeeding. Adthal 50mg Capsule may cause dizziness, sleepiness, and blurred vision, so drive only if you are alert. Adthal 50mg Capsule is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid consuming alcohol along with Adthal 50mg Capsule as it could lead to increased dizziness. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Adthal 50mg Capsule

Treatment of Multiple myeloma, Erythema Nodosum Leprosum (ENL)

Directions for Use

• Adthal 50mg Capsule should be taken at least one hour after meals.• It is usually taken once daily, preferably at bedtime, or as prescribed by your doctor.• Swallow Adthal 50mg Capsule as a whole with a glass of water.• Do not crush, chew, or open it.

Medicinal Benefits

Adthal 50mg Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Adthal 50mg Capsule works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal 50mg Capsule helps treat multiple myeloma. Adthal 50mg Capsule is also used to treat and prevent skin symptoms of erythema nodosum leprosum and as maintenance therapy for prevention and suppression of erythema nodosum leprosum recurrence.

How Adthal 50mg Capsule Works

Adthal 50mg Capsule contains ‘Thalidomide’, which works by helping the body’s immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal 50mg Capsule helps treat multiple myeloma.

Storage

Keep Adthal 50mg Capsule out of reach and sight of children.
Side effects of Adthal 50mg Capsule
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Muscle weakness can be due to tiredness, which can be managed by eating often.
  • Observe your movements and understand why the muscle is weakening.
  • Regularly do strengthening exercises to improve blood flow throughout the body and reduce weakness.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet, quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of Adthal 50mg Capsule

Take Adthal 50mg Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Adthal 50mg Capsule if you are allergic to any of its components. Inform your doctor if you have/had blood clots, heart attack, neuropathy, slow heart rate, high blood pressure, low blood pressure, infections, viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems. Do not take Adthal 50mg Capsule if you are pregnant, as it might cause severe birth defects or the death of the unborn baby. Avoid taking Adthal 50mg Capsule if you are breastfeeding, as it is not unknown if it passes into breastmilk. Adthal 50mg Capsule may cause dizziness, sleepiness and blurred vision, so drive only if you are alert. Adthal 50mg Capsule is not recommended for children. Avoid consuming alcohol with Adthal 50mg Capsule as it could lead to increased dizziness and sleepiness. Adthal 50mg Capsule, when taken with dexamethasone, increases the risk of deep vein thrombosis and pulmonary embolism. Stop taking Adthal 50mg Capsule and consult a doctor immediately if you have think you are pregnant, if you have irregular periods, missed a period, have any change in menstrual bleeding, or if you have had sex without using two forms of birth control.

Drug-Drug Interactions

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ThalidomideLetrozole
Severe
ThalidomideTriamcinolone
Severe

Drug-Drug Interactions

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ThalidomideLetrozole
Severe
How does the drug interact with Adthal 50mg Capsule:
Coadministration of Adthal 50mg Capsule and letrozole may increase the risk of blood clots.

How to manage the interaction:
Although taking Letrozole and Adthal 50mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor. Do not discontinue any medications without a doctor's advice.
ThalidomideTriamcinolone
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with triamcinolone may increase the risk of blood clots and other complications.

How to manage the interaction:
Although there is an interaction between Adthal 50mg Capsule and triamcinolone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideMercaptopurine
Severe
How does the drug interact with Adthal 50mg Capsule:
Co-administration of Adthal 50mg Capsule together with Mercaptopurine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal 50mg Capsule and mercaptopurine together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideFludarabine
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with fludarabine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal 50mg Capsule and fludarabine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideMethylprednisolone
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with Methylprednisolone may increase the risk of blood clots.

How to manage the interaction:
Although taking Adthal 50mg Capsule and methylprednisolone together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideOxaliplatin
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with oxaliplatin may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal 50mg Capsule and oxaliplatin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideVinblastine
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with vinblastine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal 50mg Capsule and vinblastine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideOspemifene
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule together with ospemifene may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Adthal 50mg Capsule and ospemifene together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideHydrocortisone
Severe
How does the drug interact with Adthal 50mg Capsule:
Coadministration of Adthal 50mg Capsule and hydrocortisone can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Adthal 50mg Capsule and hydrocortisone can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and pain, redness ,or swelling in an arm or leg, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
ThalidomideInfliximab
Severe
How does the drug interact with Adthal 50mg Capsule:
Taking Adthal 50mg Capsule with Infliximab may increase the risk of infection.

How to manage the interaction:
Although taking Adthal 50mg Capsule and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include food rich in iron, such as lean red meat, raisins, bell peppers, Brussel sprouts, and broccoli.

  • To prevent constipation, consume fibre rich foods such as whole grains, broccoli, dried fruits, nuts, beans, apples, oranges, and pears. 

Habit Forming

No

Therapeutic Class

ANTILEPROTICS

Adthal 50mg Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Adthal 50mg Capsule as it might cause increased sleepiness.

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Pregnancy

Unsafe

Adthal 50mg Capsule belongs to pregnancy category X. Adthal 50mg Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Adthal 50mg Capsule as it is unknown if Adthal 50mg Capsule passes into breastmilk.

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Driving

Unsafe

Adthal 50mg Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

bannner image

Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Adthal 50mg Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

Have a query?

FAQs

Adthal 50mg Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Adthal 50mg Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.

Adthal 50mg Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Adthal 50mg Capsule helps treat multiple myeloma.

Do not stop taking Adthal 50mg Capsule on your own. You are advised to take Adthal 50mg Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Adthal 50mg Capsule.

Orthostatic hypotension could be a side-effect of Adthal 50mg Capsule. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.

No, it is not safe to father a child while taking Adthal 50mg Capsule. Thalidomide is present in the semen of male patients taking Adthal 50mg Capsule; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Adthal 50mg Capsule and for at least 4weeks after discontinuing Adthal 50mg Capsule, even if you have undergone a successful vasectomy. Male patients taking Adthal 50mg Capsule must not donate semen.

Patients taking Adthal 50mg Capsule must not donate blood during the treatment with Adthal 50mg Capsule and for 4weeks after discontinuation of Adthal 50mg Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.

People with multiple myeloma taking Adthal 50mg Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Adthal 50mg Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.

Adthal 50mg Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.

If you forget to take a dose of Adthal 50mg Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

Manufacturer/Marketer address

Wockhardt Towers, Bandra Kurla Complex, Bandra (East), Mumbai 400051, Maharashtra, India
Other Info - AD12110

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:53 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6317.pdf
  2. https://packageinserts.bms.com/pi/pi_thalomid.pdf
  3. https://medlineplus.gov/druginfo/meds/a699032.html
  4. https://www.drugs.com/pregnancy/thalidomide.html
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