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compositionComposition:DOXORUBICIN-50MG
prescriptionPrescription Medicine

Adriamycin 50 mg Injection is an anti-cancer medicine used to treat cancer. It contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs; this causes double-helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, it treats cancer.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOXORUBICIN-50MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Adriamycin 50 mg Injection

Adriamycin 50 mg Injection is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Adriamycin 50 mg Injection is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Adriamycin 50 mg Injection contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Adriamycin 50 mg Injection may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Adriamycin 50 mg Injection. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Adriamycin 50 mg Injection should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Adriamycin 50 mg Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Adriamycin 50 mg Injection

Adriamycin 50 mg Injection is used to treat various types of cancer. The detailed uses of Adriamycin 50 mg Injection are as follows:

  • Treats solid tumors: Adriamycin 50 mg Injection is used alone or with other medicines to manage bladder, breast, lung, stomach, ovarian, and thyroid cancers, as well as certain soft tissue and bone sarcomas.
  • Treats blood cancers: Adriamycin 50 mg Injection helps treat Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and certain types of leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML, ANLL).
  • Manages childhood cancers: Adriamycin 50 mg Injection is also used to treat neuroblastoma and Wilms ’tumor (a kidney cancer in children) .

Key Benefits

Adriamycin 50 mg Injection contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Adriamycin 50 mg Injection is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Adriamycin 50 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Adriamycin 50 mg Injection Works

Adriamycin 50 mg Injection contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Adriamycin 50 mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Adriamycin 50 mg Injection. Use reliable methods of birth control while on treatment with Adriamycin 50 mg Injection.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Adriamycin 50 mg Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Adriamycin 50 mg Injection may cause dizziness and tiredness; therefore, avoid driving vehicles or operating machinery until you return to normal.

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Liver

Caution

Adriamycin 50 mg Injection should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Consult your doctor

Adriamycin 50 mg Injection is used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children). Your doctor may recommend a suitable dosage based on your child's condition.

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Heart

Caution

Adriamycin 50 mg Injection should be avoided or used with extreme caution in people with heart problems due to its high risk of cardiotoxicity. If necessary, close cardiac monitoring and consideration of safer alternatives are essential.

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Geriatrics

Caution

Geriatric patients can receive Adriamycin 50 mg Injection, but with extra caution due to increased risks of heart damage and bone marrow suppression. Close monitoring of cardiac function and organ health is essential throughout treatment.

What if I have taken an overdose of Adriamycin 50 mg Injection

Since Adriamycin 50 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Adriamycin 50 mg Injection may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Have a query?

How Soon It Starts Working

The time required for Adriamycin 50 mg Injection to start to work: The peak effect of Adriamycin 50 mg Injection starts immediately after the IV administration. The time for which the effects of Adriamycin 50 mg Injection last: The peak effect of Adriamycin 50 mg Injection lasts for 1 to 2 days.

What if you forget to take Adriamycin 50 mg Injection

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Adriamycin 50 mg Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Adriamycin 50 mg Injection should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Adriamycin 50 mg Injection is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Adriamycin 50 mg Injection without a doctor’s advice, as it can cause serious health conditions. Adriamycin 50 mg Injection is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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Drug-Drug Interactions: Adriamycin 50 mg Injection may interact with CYP3A4 inducers (phenytoin, phenobarbital, rifampicin), CYP3A4 inhibitors (clarithromycin, voriconazole, cyclosporine, chloramphenicol), CYP2D6 inhibitors (bupropion, fluoxetine, paroxetine), CYP2D6 inducers (dexamethasone, corticosterone, haloperidol).

Drug-Food Interactions: Avoid smoking and alcohol consumption.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, liver or kidney disease.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Adriamycin 50 mg Injection is used to treat Breast Cancer.

Adriamycin 50 mg Injection contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Adriamycin 50 mg Injection can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Adriamycin 50 mg Injection.

Yes, Adriamycin 50 mg Injection is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.

The common side effects of Adriamycin 50 mg Injection may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhoea, and pain at the injection site. Most of these side effects are mild and temporary, and they often resolve on their own over time. However, if you experience persistent, severe, or worsening side effects, it's crucial to consult your doctor.

It is not recommended for use in breastfeeding women as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before prescribing Adriamycin 50 mg Injection.

Adriamycin 50 mg Injection is an anti-cancer medication used to treat various types of cancer. It belongs to the class of anthracycline topoisomerase inhibitors.

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended during the treatment.

Disclaimer

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Author Details

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Country of origin

India

Manufacturer/Marketer address

AH-64, 5th Street, Shanthi Colony , Anna Nagar,Chennai -600040
Other Info - ADR0004
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